AT377585T - Aminoindanderivate - Google Patents

Aminoindanderivate

Info

Publication number
AT377585T
AT377585T AT05002578T AT05002578T AT377585T AT 377585 T AT377585 T AT 377585T AT 05002578 T AT05002578 T AT 05002578T AT 05002578 T AT05002578 T AT 05002578T AT 377585 T AT377585 T AT 377585T
Authority
AT
Austria
Prior art keywords
aminoindanderivate
Prior art date
Application number
AT05002578T
Other languages
German (de)
Inventor
Michel Chorev
Tamar Goren
Yacov Herzig
Jeffrey Sterling
Marta Weinstock-Rosin
Moussa Youdim
Original Assignee
Teva Pharma
Yissum Res Dev Co
Technion Res & Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL11985396A priority Critical patent/IL119853D0/en
Priority to IL12051097A priority patent/IL120510D0/en
Application filed by Teva Pharma, Yissum Res Dev Co, Technion Res & Dev Foundation filed Critical Teva Pharma
Publication of AT377585T publication Critical patent/AT377585T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02Monothiocarbamic acids; Derivatives thereof
    • C07C333/04Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
AT05002578T 1996-12-18 1997-12-18 Aminoindanderivate AT377585T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL11985396A IL119853D0 (en) 1996-12-18 1996-12-18 Aminoindan derivatives
IL12051097A IL120510D0 (en) 1997-03-24 1997-03-24 Phenylethylamine derivatives

Publications (1)

Publication Number Publication Date
AT377585T true AT377585T (en) 2007-11-15

Family

ID=26323338

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97953541T AT292619T (en) 1996-12-18 1997-12-18 Aminoindanderivate
AT05002578T AT377585T (en) 1996-12-18 1997-12-18 Aminoindanderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT97953541T AT292619T (en) 1996-12-18 1997-12-18 Aminoindanderivate

Country Status (14)

Country Link
US (4) US6303650B1 (en)
EP (2) EP0966435B1 (en)
JP (1) JP4222632B2 (en)
AT (2) AT292619T (en)
AU (1) AU5726898A (en)
CA (1) CA2275425C (en)
DE (2) DE69732984T2 (en)
DK (1) DK0966435T3 (en)
ES (1) ES2241064T3 (en)
HK (2) HK1024462A1 (en)
HU (1) HU229507B1 (en)
IL (1) IL130528A (en)
PT (1) PT966435E (en)
WO (1) WO1998027055A1 (en)

Families Citing this family (53)

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DK0966435T3 (en) * 1996-12-18 2005-08-15 Teva Pharma Aminoindanderivater
CA2334412A1 (en) * 1998-06-03 1999-12-09 Nissan Chemical Industries, Ltd. Indan derivatives
AT331508T (en) 1999-10-27 2006-07-15 Teva Pharma Use of 1-aminoindane derivatives for the treatment of manion in conjunction with man-depressive disease
CA2477218A1 (en) * 2002-02-27 2003-09-04 Teva Pharmaceutical Industries, Ltd. Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
CA2505476C (en) * 2002-11-07 2015-05-26 Technion Research And Development Foundation Ltd. Neuroprotective iron chelators and pharmaceutical compositions comprising them
US8097608B2 (en) 2003-11-25 2012-01-17 Technion Research And Development Foundation Ltd. Methods for treatment of cardiovascular disorders and diseases
WO2005051371A1 (en) * 2003-11-25 2005-06-09 Technion Research & Development Foundation Ltd. Compositions and methods for treatment of cardiovascular disorders and diseases
JP2005232148A (en) * 2004-02-03 2005-09-02 Technion Research & Development Foundation Ltd Use of propargylamine as neuroprotective agent
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US20060018957A1 (en) * 2004-07-26 2006-01-26 Lerner E I Pharmaceutical dosage forms including rasagiline
WO2006014968A2 (en) * 2004-07-27 2006-02-09 Teva Pharmaceutical Industries, Ltd. Propargyl nitroxydes and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
EP1797030A1 (en) * 2004-09-08 2007-06-20 Teva Pharmaceuticals USA, Inc. Improved process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates
CA2596664A1 (en) * 2005-02-17 2006-08-24 Teva Pharmaceutical Industries Ltd. Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
CA2600008A1 (en) * 2005-02-22 2006-11-16 Teva Pharmaceutical Industries Ltd. Improved process for the synthesis of enantiomeric indanylamine derivatives
NZ560660A (en) 2005-02-23 2010-11-26 Teva Pharma Rasagiline ( R(+)-N-propargyl-1-aminodan ) formulations of improved content uniformity
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US7335685B2 (en) * 2005-02-24 2008-02-26 Teva Pharmaceutical Industries, Ltd. Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof
WO2006130726A2 (en) * 2005-06-01 2006-12-07 Teva Pharmaceutical Industries, Ltd. Use of ladostigil for the treatment of multiple sclerosis
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US20070088082A1 (en) * 2005-09-28 2007-04-19 Judith Aronhime Polymorphic forms of ladostigil tartrate
US8263655B2 (en) * 2005-10-06 2012-09-11 Technion Research And Development Foundation Ltd Methods for treatment of renal failure
US20070238893A1 (en) * 2005-11-04 2007-10-11 Lee Boulton Asymmetric hydrogenation of acyl enamides
WO2007056455A2 (en) * 2005-11-07 2007-05-18 Teva Pharmaceutical Industries Ltd. N-protected aminoindanes and methods of their preparation
AU2006316585B2 (en) * 2005-11-17 2012-09-20 Teva Pharmaceutical Industries, Ltd. Methods for isolating propargylated aminoindans
US7572834B1 (en) 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
JP2009518433A (en) * 2005-12-09 2009-05-07 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム Use of low-dose radostigil for neuroprotection
US20070135518A1 (en) * 2005-12-09 2007-06-14 Marta Weinstock-Rosin Use of low-dose ladostigil for neuroprotection
EP1991214B1 (en) 2006-02-21 2015-08-05 Teva Pharmaceutical Industries, Ltd. Use of rasagiline for the treatment of multiple system atrophy
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
US20070232691A1 (en) * 2006-03-31 2007-10-04 Tamar Goren Use of ladostigil for the treatment of schizophrenia
CN101442997B (en) * 2006-04-03 2012-11-14 泰华制药工业有限公司 Use of rasagiline for the treatment of restless legs syndrome
EP1892233A1 (en) * 2006-08-18 2008-02-27 Ratiopharm GmbH New salts of the active component rasagiline
US7547806B2 (en) 2006-12-14 2009-06-16 Teva Pharmaceutical Industries, Ltd. Tannate salt of rasagiline
WO2008076348A1 (en) * 2006-12-14 2008-06-26 Teva Pharmaceutical Industries, Ltd. Crystalline solid rasagiline base
EP1987816A1 (en) * 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate of a rasagiline salt with a water-soluble inactive ingredient
US8188149B2 (en) * 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
EA201070842A1 (en) * 2008-01-11 2011-04-29 Тева Фармасьютикал Индастриз, Лтд. Preparative forms of razagilina, their reception and application
ES2389353T3 (en) * 2008-06-10 2012-10-25 Teva Pharmaceutical Industries Ltd. Rasagiline soft gelatin capsules
EP2296462A4 (en) * 2008-06-13 2011-06-15 Teva Pharma Rasagiline for parkinson's disease modification
EP2299993A4 (en) * 2008-06-19 2014-08-20 Teva Pharma Process for purifying rasagiline base
EP2299992A4 (en) 2008-06-19 2015-10-21 Teva Pharma Process for preparing and drying solid rasagiline base
US20100189791A1 (en) * 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline malate formulation
SI2451771T1 (en) 2009-07-09 2014-10-30 Ratiopharm Gmbh Salts of rasagiline and pharmaceutical preparations thereof
PL2531181T3 (en) 2010-02-03 2019-09-30 Pharma Two B Ltd. Extended release formulations of rasagiline and uses thereof
AU2011282716A1 (en) 2010-07-27 2013-03-14 Teva Pharmaceutical Industries Ltd. Dispersions of rasagiline citrate
EP2603212A4 (en) 2010-07-27 2014-01-08 Teva Pharma Use of rasagiline for the treatment of olfactory dysfunction
KR20140084153A (en) 2011-10-10 2014-07-04 테바 파마슈티컬 인더스트리즈 리미티드 R(+)-n-methyl-propargyl-aminoindan
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Also Published As

Publication number Publication date
EP0966435B1 (en) 2005-04-06
EP0966435A4 (en) 2003-04-16
ES2241064T3 (en) 2005-10-16
HK1076098A1 (en) 2008-05-30
JP4222632B2 (en) 2009-02-12
IL130528A (en) 2004-12-15
HU0101130A2 (en) 2001-08-28
DE69738275T2 (en) 2008-08-28
PT966435E (en) 2005-06-30
EP1535902B1 (en) 2007-11-07
AU5726898A (en) 1998-07-15
CA2275425C (en) 2009-08-04
DE69732984T2 (en) 2006-02-16
CA2275425A1 (en) 1998-06-25
US20020188020A1 (en) 2002-12-12
HK1024462A1 (en) 2005-09-30
EP1535902A1 (en) 2005-06-01
JP2001506269A (en) 2001-05-15
DE69732984D1 (en) 2005-05-12
US6303650B1 (en) 2001-10-16
DE69738275D1 (en) 2007-12-20
EP0966435A1 (en) 1999-12-29
HU229507B1 (en) 2014-01-28
DK0966435T3 (en) 2005-08-15
WO1998027055A1 (en) 1998-06-25
AT292619T (en) 2005-04-15
HU0101130A3 (en) 2003-02-28
US6462222B1 (en) 2002-10-08
US6538025B2 (en) 2003-03-25
USRE39616E1 (en) 2007-05-08

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