AT366726T - Stereoselective synthesis of certain trifluoromethyl substituted alcohols - Google Patents

Stereoselective synthesis of certain trifluoromethyl substituted alcohols

Info

Publication number
AT366726T
AT366726T AT04789408T AT04789408T AT366726T AT 366726 T AT366726 T AT 366726T AT 04789408 T AT04789408 T AT 04789408T AT 04789408 T AT04789408 T AT 04789408T AT 366726 T AT366726 T AT 366726T
Authority
AT
Austria
Prior art keywords
stereoselective synthesis
substituted alcohols
trifluoromethyl substituted
certain trifluoromethyl
certain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AT04789408T
Other languages
German (de)
Inventor
Jinhua J Song
Zhulin Tan
Jinghua Xu
Nathan K Yee
Chris H Senanayake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US51174403P priority Critical
Application filed by Boehringer Ingelheim Pharma GmbH Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AT366726T publication Critical patent/AT366726T/en
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring heteroatom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals substituted by singly or doubly bound oxygen atoms
    • C07D303/18Compounds containing oxirane rings with hydrocarbon radicals substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
AT04789408T 2003-10-16 2004-09-30 Stereoselective synthesis of certain trifluoromethyl substituted alcohols Active AT366726T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US51174403P true 2003-10-16 2003-10-16

Publications (1)

Publication Number Publication Date
AT366726T true AT366726T (en) 2007-08-15

Family

ID=34520036

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04789408T Active AT366726T (en) 2003-10-16 2004-09-30 Stereoselective synthesis of certain trifluoromethyl substituted alcohols

Country Status (8)

Country Link
US (1) US7507843B2 (en)
EP (1) EP1675839B1 (en)
JP (1) JP4468369B2 (en)
AT (1) AT366726T (en)
CA (1) CA2542741A1 (en)
DE (1) DE602004007539T2 (en)
ES (1) ES2290769T3 (en)
WO (1) WO2005040145A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903215B2 (en) * 2002-03-26 2005-06-07 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EA011095B1 (en) * 2002-08-29 2008-12-30 Бёрингер Ингельхайм Фармасьютиклз, Инк. 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
UY28526A1 (en) * 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Glucocorticoid mimetics, methods of preparing pharmaceutical compositions and uses thereof
US7795272B2 (en) * 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
WO2006071609A2 (en) * 2004-12-27 2006-07-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7943651B2 (en) 2006-04-20 2011-05-17 Glaxo Group Limited Compounds
EP2102170A2 (en) * 2006-12-06 2009-09-23 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
PT2300472E (en) * 2008-06-06 2012-02-20 Boehringer Ingelheim Int Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20110130578A1 (en) * 2009-06-03 2011-06-02 Boehringer Ingelheim International Gmbh Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
JP5472217B2 (en) * 2011-06-29 2014-04-16 信越化学工業株式会社 Method for producing photoacid generator using 2,2-bis (fluoroalkyl) oxirane

Family Cites Families (28)

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NL8402755A (en) 1983-09-22 1985-04-16 Sandoz Ag Azole-derivatives, process for their preparation, compositions containing them, and use thereof.
GB8406000D0 (en) 1984-03-07 1984-04-11 Ici Plc Olefine derivatives
GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
GB8617653D0 (en) 1986-07-18 1986-08-28 Ici Plc Amide derivatives
US5039691A (en) 1989-06-08 1991-08-13 Marion Merrell Dow Inc. 5-(1-(imidazol)methyl)-3,3-disubstituted-2(3H)furanone derivatives
DE69533180T2 (en) 1994-12-22 2005-07-14 Ligand Pharmaceuticals, Inc., San Diego Steroid receptor modulator compounds and methods
WO1997027852A1 (en) 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE19723722A1 (en) 1997-05-30 1998-12-10 Schering Ag nonsteroidal progestins
KR20010040935A (en) 1998-02-13 2001-05-15 스티븐 에프. 웨인스톡 Glucocorticoid-selective anti-inflammatory agents
US6506766B1 (en) 1998-02-13 2003-01-14 Abbott Laboratories Glucocortiocoid-selective antinflammatory agents
DE19856475A1 (en) 1998-11-27 2000-05-31 Schering Ag NSAIDs
US6187918B1 (en) * 1999-03-15 2001-02-13 Dupont Pharmaceuticals Company Catalysts for asymmetric addition of organozinc reagents to aldehydes and method for preparation
RS52134B (en) 1999-04-30 2012-08-31 Pfizer Products Inc. Glucocorticoid receptor modulators
US6329534B1 (en) 1999-09-01 2001-12-11 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
US6436986B1 (en) 1999-09-01 2002-08-20 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
DE10038639A1 (en) 2000-07-28 2002-02-21 Schering Ag New and known N-aryl 2-hydroxy-omega-arylalkanamide derivatives, useful e.g. for treating inflammatory diseases such as rheumatism
US6583180B2 (en) 2001-02-14 2003-06-24 Abbott Laboratories Glucocorticoid receptor modulators
DE60233111D1 (en) 2001-02-14 2009-09-10 Karobio Ab Glucocorticoid receptors modulators
DE60309829T2 (en) 2002-01-14 2007-09-13 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Glucocorticoidmimetics, method for the production thereof, pharmaceutical formulations containing them and their uses
US7268152B2 (en) 2002-03-26 2007-09-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE10215316C1 (en) 2002-04-02 2003-12-18 Schering Ag Quinoline and isoquinoline derivatives, a pharmaceutical agent and their use as anti-inflammatory agents
US6897224B2 (en) 2002-04-02 2005-05-24 Schering Ag Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP1532113B1 (en) 2002-08-21 2008-08-06 Boehringer Ingelheim Pharmaceuticals Inc. Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EA011095B1 (en) 2002-08-29 2008-12-30 Бёрингер Ингельхайм Фармасьютиклз, Инк. 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
BR0317928A (en) 2003-01-03 2005-11-29 Boehringer Ingelheim Pharma 1-Propanol and 1-Propylamine derivatives and their use as glycorticoid binders
US20040224992A1 (en) 2003-02-27 2004-11-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Also Published As

Publication number Publication date
ES2290769T3 (en) 2008-02-16
DE602004007539T2 (en) 2007-10-25
JP2007509069A (en) 2007-04-12
EP1675839B1 (en) 2007-07-11
JP4468369B2 (en) 2010-05-26
CA2542741A1 (en) 2005-05-06
US7507843B2 (en) 2009-03-24
DE602004007539D1 (en) 2007-08-23
WO2005040145A1 (en) 2005-05-06
EP1675839A1 (en) 2006-07-05
US20050131241A1 (en) 2005-06-16

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