AT365731T - 4-amino-5-cyanopyrimidinderivate - Google Patents

4-amino-5-cyanopyrimidinderivate

Info

Publication number
AT365731T
AT365731T AT05738867T AT05738867T AT365731T AT 365731 T AT365731 T AT 365731T AT 05738867 T AT05738867 T AT 05738867T AT 05738867 T AT05738867 T AT 05738867T AT 365731 T AT365731 T AT 365731T
Authority
AT
Austria
Prior art keywords
cyanopyrimidinderivate
amino
Prior art date
Application number
AT05738867T
Other languages
English (en)
Inventor
Masaya Kato
Norifumi Sato
Minoru Okada
Tetsuyuki Uno
Nobuaki Ito
Yasuhiro Takeji
Hisashi Shinohara
Masahiro Fuwa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2004135999 priority Critical
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AT365731T publication Critical patent/AT365731T/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AT05738867T 2004-04-30 2005-04-28 4-amino-5-cyanopyrimidinderivate AT365731T (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2004135999 2004-04-30

Publications (1)

Publication Number Publication Date
AT365731T true AT365731T (de) 2007-07-15

Family

ID=35242255

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05738867T AT365731T (de) 2004-04-30 2005-04-28 4-amino-5-cyanopyrimidinderivate

Country Status (21)

Country Link
US (2) US7834002B2 (de)
EP (1) EP1740574B1 (de)
KR (1) KR101279689B1 (de)
CN (1) CN1976922B (de)
AR (1) AR049085A1 (de)
AT (1) AT365731T (de)
AU (1) AU2005238391B2 (de)
BR (1) BRPI0509454A (de)
CA (1) CA2563846C (de)
DE (1) DE602005001508T2 (de)
DK (1) DK1740574T3 (de)
ES (1) ES2288744T3 (de)
HK (1) HK1100775A1 (de)
MX (1) MXPA06012639A (de)
MY (1) MY138996A (de)
PL (1) PL1740574T3 (de)
PT (1) PT1740574E (de)
RU (1) RU2386628C2 (de)
SI (1) SI1740574T1 (de)
TW (1) TWI346109B (de)
WO (1) WO2005105778A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008042399A2 (en) * 2006-10-03 2008-04-10 The Trustees Of The University Of Pennsylvania Method for treatment of macular degeneration
TWI452044B (zh) 2007-06-15 2014-09-11 Mitsubishi Tanabe Pharma Corp 嗎啉衍生物
US8466176B2 (en) 2008-03-19 2013-06-18 Bayer Cropscience Ag Fungicide hydroximoyl-tetrazole derivatives
AR075196A1 (es) * 2009-02-03 2011-03-16 Otsuka Pharma Co Ltd A CYANOPIRIMIDINE DERIVATIVE FOR THE TREATMENT OF AN EYE DISEASE
SG11201403979TA (en) * 2012-01-26 2014-08-28 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
EP2816023A4 (de) * 2012-02-13 2015-09-09 Takeda Pharmaceutical Aromatische ringverbindung
US20210163454A1 (en) * 2017-09-08 2021-06-03 President And Fellows Of Harvard College Small molecule inhibitors of ebola and lassa fever viruses and methods of use
WO2019072143A1 (zh) * 2017-10-11 2019-04-18 上海迪诺医药科技有限公司 4-氨基吡啶衍生物、其药物组合物、制备方法及应用

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* Cited by examiner, † Cited by third party
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JPH0133477B2 (de) 1985-10-25 1989-07-13 Yamasa Shoyu Kk
US4968697A (en) 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
EP0444196B1 (de) 1988-11-15 1994-06-08 Yamasa Shoyu Kabushiki Kaisha Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen
IT1254915B (it) 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
US5877180A (en) 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
CO4990969A1 (es) 1998-02-14 2000-12-26 Glaxo Group Ltd Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol
GB9813565D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
GB9813540D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
KR20010071591A (ko) 1998-06-23 2001-07-28 그레이엄 브레레톤, 레슬리 에드워즈 2-(퓨린-9-일)-테트라히드로푸란-3,4-디올 유도체
GB9813535D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
JP2002173427A (ja) 1998-09-01 2002-06-21 Yamasa Shoyu Co Ltd 眼疾患治療用医薬組成物
DE69932173T2 (de) 1998-10-16 2007-06-06 Pfizer Inc. Adeninderivate
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
GB9913932D0 (en) 1999-06-15 1999-08-18 Pfizer Ltd Purine derivatives
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
EP1194441B1 (de) 1999-06-22 2003-10-22 Cv Therapeutics, Inc. A2a rezeptor agonisten
US6180615B1 (en) 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
DE19947154A1 (de) 1999-10-01 2001-10-04 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
GB9924361D0 (en) 1999-10-14 1999-12-15 Pfizer Ltd Purine derivatives
DE10110438A1 (de) 2001-03-05 2002-09-19 Bayer Ag Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110747A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
DE10110754A1 (de) 2001-03-07 2002-09-19 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115922A1 (de) 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115945A1 (de) 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10134481A1 (de) 2001-07-16 2003-01-30 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
JP2003055395A (ja) 2001-08-10 2003-02-26 Toa Eiyo Ltd アデノシン誘導体
DE10238113A1 (de) 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
JP2003206230A (ja) 2002-01-10 2003-07-22 Yamanouchi Pharmaceut Co Ltd シアノヘテロ環誘導体又はその塩

Also Published As

Publication number Publication date
CN1976922B (zh) 2012-09-05
KR20070008715A (ko) 2007-01-17
TW200540161A (en) 2005-12-16
CA2563846C (en) 2011-12-20
AR049085A1 (es) 2006-06-28
WO2005105778A2 (en) 2005-11-10
ES2288744T3 (es) 2008-01-16
MXPA06012639A (es) 2006-12-15
MY138996A (en) 2009-08-28
US20080182854A1 (en) 2008-07-31
KR101279689B1 (ko) 2013-06-27
DK1740574T3 (da) 2007-10-15
EP1740574B1 (de) 2007-06-27
PT1740574E (pt) 2007-09-06
US20110009620A1 (en) 2011-01-13
PL1740574T3 (pl) 2007-11-30
SI1740574T1 (sl) 2007-12-31
BRPI0509454A (pt) 2007-09-04
AU2005238391A1 (en) 2005-11-10
RU2386628C2 (ru) 2010-04-20
DE602005001508D1 (de) 2007-08-09
CN1976922A (zh) 2007-06-06
WO2005105778A3 (en) 2006-10-26
AU2005238391B2 (en) 2010-12-16
HK1100775A1 (en) 2007-09-28
CA2563846A1 (en) 2005-11-10
DE602005001508T2 (de) 2008-02-28
US7989446B2 (en) 2011-08-02
EP1740574A2 (de) 2007-01-10
TWI346109B (en) 2011-08-01
RU2006142323A (ru) 2008-06-10
US7834002B2 (en) 2010-11-16

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