AT350665T - Homogeneous test system for the determination of an analyte - Google Patents

Homogeneous test system for the determination of an analyte

Info

Publication number
AT350665T
AT350665T AT99121547T AT99121547T AT350665T AT 350665 T AT350665 T AT 350665T AT 99121547 T AT99121547 T AT 99121547T AT 99121547 T AT99121547 T AT 99121547T AT 350665 T AT350665 T AT 350665T
Authority
AT
Austria
Prior art keywords
analyte
determination
test system
homogeneous test
homogeneous
Prior art date
Application number
AT99121547T
Other languages
German (de)
Inventor
Edwin F Ullman
Hrair Kirakossian
John S Pease
Daniel B Wagner
Yuri Daniloff
Original Assignee
Dade Behring Marburg Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/704,569 priority Critical patent/US6251581B1/en
Priority to US07/718,490 priority patent/US5340716A/en
Application filed by Dade Behring Marburg Gmbh filed Critical Dade Behring Marburg Gmbh
Publication of AT350665T publication Critical patent/AT350665T/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/121,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06Six-membered rings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56977HLA or MHC typing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
AT99121547T 1991-05-22 1992-05-21 Homogeneous test system for the determination of an analyte AT350665T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US07/704,569 US6251581B1 (en) 1991-05-22 1991-05-22 Assay method utilizing induced luminescence
US07/718,490 US5340716A (en) 1991-06-20 1991-06-20 Assay method utilizing photoactivated chemiluminescent label

Publications (1)

Publication Number Publication Date
AT350665T true AT350665T (en) 2007-01-15

Family

ID=27107346

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99121547T AT350665T (en) 1991-05-22 1992-05-21 Homogeneous test system for the determination of an analyte
AT99121551T AT246360T (en) 1991-05-22 1992-05-21 Particles that include a composition comprising a chemiluminescent compound
AT92304630T AT208039T (en) 1991-05-22 1992-05-21 Determination methods of using induced luminescence

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT99121551T AT246360T (en) 1991-05-22 1992-05-21 Particles that include a composition comprising a chemiluminescent compound
AT92304630T AT208039T (en) 1991-05-22 1992-05-21 Determination methods of using induced luminescence

Country Status (10)

Country Link
EP (4) EP1418430A3 (en)
JP (1) JP3892912B2 (en)
AT (3) AT350665T (en)
AU (1) AU657134B2 (en)
CA (1) CA2069145C (en)
DE (6) DE69233146T2 (en)
DK (1) DK0984282T3 (en)
ES (3) ES2280110T3 (en)
IL (1) IL101945A (en)
PT (1) PT984282E (en)

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US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
DK0653066T3 (en) * 1992-07-31 1998-09-23 Dade Behring Marburg Gmbh Photoactivatable chemiluminescent matrices
EP0716746B1 (en) * 1993-09-03 1999-03-17 Behringwerke Ag Fluorescent oxygen channeling immunoassays
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
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WO1997041442A1 (en) * 1996-05-01 1997-11-06 Behringwerke Aktiengesellschaft Chemiluminescent compositions and their use in the detection of hydrogen peroxide
DE19756782A1 (en) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Detection and determination solid phase-associated factors
DE19756773A1 (en) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh New method and diagnostic agent for hemostasis diagnostics
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
JP2002504689A (en) 1998-02-18 2002-02-12 デイド・ベーリング・インコーポレイテッド Chemiluminescent compositions for use in the detection of multiple analytes
DE19811017A1 (en) 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh New method for determination of plasma proteins and factors of hemostasis and a new, implantable measuring device
US6303325B1 (en) 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
AUPP405098A0 (en) * 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
EP1110970B1 (en) 1999-12-22 2008-05-14 Dade Behring Marburg GmbH Anti-Procalcitonin antibodies, their production and use
DE50014159D1 (en) 1999-12-22 2007-04-26 Dade Behring Marburg Gmbh Solutions of human procalcitonin
DE60134219D1 (en) * 2000-02-28 2008-07-10 Daiichi Pure Chemicals Co Ltd Measurement methods based on fluorescence energy transfer long with a donor fluorescence lifetime
CA2400993C (en) 2000-03-06 2011-06-07 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US6346384B1 (en) * 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
ES2370232T3 (en) 2000-05-04 2011-12-13 Siemens Healthcare Diagnostics Products Gmbh Procedure for detecting multiple analytes.
DE10064827A1 (en) 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Sandwich assay for detecting analyte, useful e.g. for hormones, with detection or correction of the hook effect by measuring detection signals twice
EP1377220B1 (en) * 2001-03-16 2017-01-18 University of Utah Research Foundation Fluorescent cobalamins and uses thereof
WO2004005917A1 (en) 2002-07-08 2004-01-15 Daiichi Pure Chemicals Co., Ltd. Fluorescent probe
US6764819B2 (en) * 2002-07-16 2004-07-20 Emp Biotech Gmbh Method for chemiluminescent detection
US7696245B2 (en) 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
EP1695083A1 (en) 2003-12-01 2006-08-30 Dade Behring Marburg GmbH Homogeneous detection method
JP2005194244A (en) 2004-01-09 2005-07-21 Dai Ichi Pure Chem Co Ltd Zinc ion fluorescence sensor
DE102005026163A1 (en) 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Against the Marburg I polymorphism of the factor VII-activating protease (FSAP) directed antibodies, their preparation and use
DE102004042124B4 (en) * 2004-08-30 2006-07-06 Dade Behring Marburg Gmbh Homogeneous method for determining an analyte in the presence of an excess of cross-reacting substances
WO2006034417A2 (en) * 2004-09-17 2006-03-30 Novartis Vaccines And Diagnostics Inc. Trivalent metal mediated homogeneous luminescent proximity assay
US20060166376A1 (en) 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
IL168184A (en) * 2005-04-21 2011-11-30 Univ Ariel Res & Dev Co Ltd Use of a ligand-photosensitizer conjugate in combination with a chemiluminescent agent in the manufacture of a medicament for photodynamic therapy
DE102005022047A1 (en) 2005-05-09 2006-11-30 Dade Behring Marburg Gmbh Binding partner of placental growth factor, in particular against the placental growth factor antibodies directed, their preparation and use
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
US7732153B2 (en) * 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US20080213797A1 (en) * 2007-03-01 2008-09-04 Abbott Laboratories Immunoassays exhibiting a reduction in prozone phenomena
DE102007017906A1 (en) 2007-04-17 2008-10-23 Dade Behring Marburg Gmbh Method for determining the reaction lag phase in an analyte-dependent reaction
US7790401B2 (en) * 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
DE102008049601A1 (en) 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antibody for the determination of prothrombin fragment F2 / F1 + 2 in a homogeneous immunoassay
EP2177624A1 (en) 2008-10-02 2010-04-21 Siemens Healthcare Diagnostics Products GmbH Blood coagulation assays
JP5419775B2 (en) * 2010-03-30 2014-02-19 日本電信電話株式会社 Measuring substrate, and method for measuring biochemical bond formation and biochemical binding amount using the same
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EP2471945A1 (en) 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Method for determining coagulation inhibitors
RU2473885C2 (en) * 2011-02-02 2013-01-27 Государственное образовательное учреждение высшего профессионального образования "Самарский государственный университет" Quantitative analysis of thiourea and sodium fluorescein simultaneously present in formation water
DE102011007546A1 (en) 2011-04-15 2012-10-18 Humboldt-Universität Zu Berlin Measuring device for measuring a singlet oxygen luminescence
ES2535726T3 (en) 2012-09-18 2015-05-14 Siemens Healthcare Diagnostics Products Gmbh Procedure for determining platelet-associated analytes
DE102012220083B3 (en) * 2012-11-05 2014-03-06 Technische Universität Dresden Method and system for direct, non-radiative energy transfer by liquid phase boundaries
EP2972245A4 (en) * 2013-03-15 2016-11-23 Siemens Healthcare Diagnostics Inc Heterogeneous luminescent oxygen channeling immunoassays
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Also Published As

Publication number Publication date
DE69233674D1 (en) 2007-02-15
EP0515194B1 (en) 2001-10-31
ES2280110T3 (en) 2007-09-01
EP0984281A2 (en) 2000-03-08
JPH05180773A (en) 1993-07-23
CA2069145A1 (en) 1992-11-23
EP1418430A2 (en) 2004-05-12
AU657134B2 (en) 1995-03-02
EP0984281A3 (en) 2000-06-07
EP0984281B1 (en) 2007-01-03
EP1418430A3 (en) 2004-09-01
JP3892912B2 (en) 2007-03-14
EP0515194A2 (en) 1992-11-25
EP0984282B1 (en) 2003-07-30
AT246360T (en) 2003-08-15
IL101945A (en) 1998-02-08
EP0984282A3 (en) 2000-06-07
DE69233146D1 (en) 2003-09-04
ES2168092T3 (en) 2002-06-01
IL101945D0 (en) 1992-12-30
AT208039T (en) 2001-11-15
DE69233146T2 (en) 2004-04-29
CA2069145C (en) 2007-07-31
EP0984282A2 (en) 2000-03-08
ES2204050T3 (en) 2004-04-16
AU1706892A (en) 1992-11-26
DE69232161D1 (en) 2001-12-06
DE69233674T2 (en) 2007-10-18
DE69232161T2 (en) 2002-05-16
EP0515194A3 (en) 1993-10-20
PT984282E (en) 2003-12-31
DK0984282T3 (en) 2003-11-17

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