AT349447T - Alkylamino-substituted bicyclic heterocycles as p38 protein kinase inhibitors - Google Patents

Alkylamino-substituted bicyclic heterocycles as p38 protein kinase inhibitors

Info

Publication number
AT349447T
AT349447T AT00972755T AT00972755T AT349447T AT 349447 T AT349447 T AT 349447T AT 00972755 T AT00972755 T AT 00972755T AT 00972755 T AT00972755 T AT 00972755T AT 349447 T AT349447 T AT 349447T
Authority
AT
Austria
Prior art keywords
alkylamino
protein kinase
kinase inhibitors
substituted bicyclic
bicyclic heterocycles
Prior art date
Application number
AT00972755T
Other languages
German (de)
Inventor
James Patrick Dunn
David Michael Goldstein
William Harris
Ian Edward David Smith
Teresa Rosanne Welch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US16080499P priority Critical
Priority to US21371800P priority
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AT349447T publication Critical patent/AT349447T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
AT00972755T 1999-10-21 2000-10-13 Alkylamino-substituted bicyclic heterocycles as p38 protein kinase inhibitors AT349447T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16080499P true 1999-10-21 1999-10-21
US21371800P true 2000-06-22 2000-06-22

Publications (1)

Publication Number Publication Date
AT349447T true AT349447T (en) 2007-01-15

Family

ID=26857242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00972755T AT349447T (en) 1999-10-21 2000-10-13 Alkylamino-substituted bicyclic heterocycles as p38 protein kinase inhibitors

Country Status (25)

Country Link
US (1) US6642241B1 (en)
EP (1) EP1226144B1 (en)
JP (1) JP4028236B2 (en)
CN (1) CN1156477C (en)
AR (1) AR026187A1 (en)
AT (1) AT349447T (en)
AU (1) AU776695B2 (en)
BR (1) BR0014973A (en)
CA (1) CA2388140C (en)
CO (1) CO5251408A1 (en)
CZ (1) CZ20021743A3 (en)
DE (1) DE60032623T2 (en)
ES (1) ES2277858T3 (en)
HK (1) HK1051040A1 (en)
HR (1) HRP20020327A2 (en)
HU (1) HU0203477A3 (en)
IL (1) IL149230D0 (en)
MA (1) MA26836A1 (en)
MX (1) MXPA02003841A (en)
NO (1) NO20021783L (en)
PE (1) PE20010760A1 (en)
PL (1) PL357494A1 (en)
TR (1) TR200201058T2 (en)
WO (1) WO2001029041A1 (en)
YU (1) YU29202A (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402177T (en) 1998-05-26 2008-08-15 Warner Lambert Co Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cell reproduction
US20040044012A1 (en) * 1998-05-26 2004-03-04 Dobrusin Ellen Myra Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
CA2482022A1 (en) * 2002-04-19 2003-10-30 Smithkline Beecham Corporation Novel compounds
EP1534282B1 (en) 2002-07-09 2006-12-27 Boehringer Ingelheim Pharma GmbH & Co.KG Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
PA8577501A1 (en) 2002-07-25 2004-02-07 Warner Lambert Co Kinase inhibitors
RU2324695C2 (en) * 2002-08-06 2008-05-20 Ф.Хоффманн-Ля Рош Аг 6-ALCOXYPYRIDOPYRIMIDINES AND PHARMACEUTICAL COMPOUND POSSESSING ACTIVITY OF MAP p38 KINASE INHIBITORS
KR100793688B1 (en) * 2002-08-06 2008-01-10 에프. 호프만-라 로슈 아게 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7112676B2 (en) * 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
WO2004089955A1 (en) 2003-04-10 2004-10-21 F.Hoffmann-La Roche Ag Pyrimido compounds
US20080131370A1 (en) * 2004-04-27 2008-06-05 Takeda Pharmaceutical Company Limited Screening Method
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
MX2007002089A (en) 2004-08-31 2007-03-29 Hoffmann La Roche Amide derivatives of 7-amino-3-phenyl-dihydropyrimido [4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents.
CA2576818A1 (en) 2004-08-31 2006-03-09 F. Hoffmann-La Roche Ag Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Indolinone derivatives for the treatment or prevention of fibrotic diseases
ES2329419T3 (en) 2006-01-31 2009-11-25 F. Hoffmann-La Roche Ag 7h-pirido (3,4-d) pirimidin-8-onas, its preparation and use as inhibitors of kinase proteins.
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
EP2108641A1 (en) * 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
CA2876689A1 (en) 2012-06-13 2014-01-09 Incyte Corporation Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
IL240605D0 (en) 2013-03-15 2015-09-24 Sanofi Sa Heteroaryl compounds and uses thereof
MX2015011514A (en) 2013-03-15 2016-08-11 Celgene Avilomics Res Inc Heteroaryl compounds and uses thereof.
TWI647220B (en) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 Heteroaryl aryl compounds and their use
EA201592005A1 (en) 2013-04-19 2016-02-29 Инсайт Холдингс Корпорейшн Bicyclic heterocycles as fgfr inhibitors
BR112017017727A2 (en) 2015-02-20 2018-04-10 Incyte Corp bicyclic heterocycles as fgfr4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
JP2018511573A (en) 2015-02-20 2018-04-26 インサイト・コーポレイションIncyte Corporation Bicyclic heterocycles as FGFR inhibitors
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814352D0 (en) 1988-06-16 1988-07-20 Smith Kline French Lab Chemical compounds
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
WO1999020624A1 (en) * 1997-10-20 1999-04-29 F.Hoffmann-La Roche Ag Bicyclic kinase inhibitors
AT402177T (en) * 1998-05-26 2008-08-15 Warner Lambert Co Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cell reproduction
CA2347474C (en) * 1998-10-23 2008-08-26 F. Hoffmann-La Roche Ag Bicyclic nitrogen heterocycles

Also Published As

Publication number Publication date
HRP20020327A2 (en) 2004-02-29
WO2001029041A1 (en) 2001-04-26
US6642241B1 (en) 2003-11-04
HU0203477A3 (en) 2004-12-28
AR026187A1 (en) 2003-01-29
EP1226144B1 (en) 2006-12-27
MA26836A1 (en) 2004-12-20
JP4028236B2 (en) 2007-12-26
HK1051040A1 (en) 2005-01-28
EP1226144A1 (en) 2002-07-31
NO20021783D0 (en) 2002-04-16
DE60032623D1 (en) 2007-02-08
HU0203477A2 (en) 2003-01-28
PE20010760A1 (en) 2001-07-21
PL357494A1 (en) 2004-07-26
AU1137501A (en) 2001-04-30
YU29202A (en) 2004-12-31
CA2388140A1 (en) 2001-04-26
CN1382142A (en) 2002-11-27
NO20021783L (en) 2002-04-16
ES2277858T3 (en) 2007-08-01
CA2388140C (en) 2008-09-02
JP2003512377A (en) 2003-04-02
CO5251408A1 (en) 2003-02-28
CZ20021743A3 (en) 2002-08-14
MXPA02003841A (en) 2002-09-30
AU776695B2 (en) 2004-09-16
CN1156477C (en) 2004-07-07
DE60032623T2 (en) 2007-10-11
IL149230D0 (en) 2002-11-10
TR200201058T2 (en) 2002-07-22
BR0014973A (en) 2002-07-16

Similar Documents

Publication Publication Date Title
DE50008690D1 (en) p-Tolyl heterocycles as herbicides
DK1562589T3 (en) Diaminotriazoles useful as inhibitors of protein kinases
DE60223482D1 (en) System for vesticular stimulation
DE60044382D1 (en) NPYY5 antagonists
DK1117659T3 (en) Substituted 3-cyanoquinolines as inhibitors of protein tyrosine kinases
DE60037211D1 (en) Indazole compounds and pharmaceutical compositions for inhibiting protein kinase and methods for their use
DE60214703D1 (en) Thiazol compounds suitable as inhibitors of protein kinases
DE60327999D1 (en) Azolylaminoazines as inhibitors of protein kinases
DK1114051T3 (en) Inhibitors of p38
DK1315715T3 (en) Quinazoline derivatives as kinase inhibitors
DE60011494D1 (en) Coated milling insert
DK2020408T3 (en) Pyrrole-substituted 2-indolinone as protein kinase inhibitor
DE60119777D1 (en) Pyrazol compounds as protein kinase hemmer
DE60124744D1 (en) Pyrazol compounds as protein kinase hemmer
DK0986382T3 (en) RAF kinase inhibitors
DK1161428T3 (en) pyrimidine
DE60026155D1 (en) Some alkylendiamine-substituted heterocycles
DK1355889T3 (en) Substituted triazole diamine derivatives as kinase inhibitors
DE60202200D1 (en) IMIDAZO [1,2-A] pyridine derivatives as MGLUR5 antagonists
DK1077943T3 (en) Heterocyclic inhibitors of p38
DE60314603D1 (en) Compositions necessary as protein kinase inhibitors
DE60112611T2 (en) Macroheterocyclic compounds as kinase inhibitors
DE60323749D1 (en) Substituted pyrrolins as kinase inhibitors
DK1318992T3 (en) Imidazole derivatives as Raf kinase inhibitors
DK1370554T3 (en) 3- (4-amidopyrrol-2-ylmethylidene) -2-indolinone derivatives as protein kinase inhibitors

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties