AT348101T - Carbolin derivatives as phosphophodiesterase 5 (pde5) inhibitors for the treatment of cardiovascular diseases and the effective dysfunction - Google Patents

Carbolin derivatives as phosphophodiesterase 5 (pde5) inhibitors for the treatment of cardiovascular diseases and the effective dysfunction

Info

Publication number
AT348101T
AT348101T AT02766739T AT02766739T AT348101T AT 348101 T AT348101 T AT 348101T AT 02766739 T AT02766739 T AT 02766739T AT 02766739 T AT02766739 T AT 02766739T AT 348101 T AT348101 T AT 348101T
Authority
AT
Austria
Prior art keywords
phosphophodiesterase
carbolin
pde5
dysfunction
inhibitors
Prior art date
Application number
AT02766739T
Other languages
German (de)
Inventor
Jason Scott Sawyer
Mark W Orme
James D Copp
Original Assignee
Lilly Icos Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US28673001P priority Critical
Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc
Publication of AT348101T publication Critical patent/AT348101T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
AT02766739T 2001-04-25 2002-04-02 Carbolin derivatives as phosphophodiesterase 5 (pde5) inhibitors for the treatment of cardiovascular diseases and the effective dysfunction AT348101T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US28673001P true 2001-04-25 2001-04-25

Publications (1)

Publication Number Publication Date
AT348101T true AT348101T (en) 2007-01-15

Family

ID=23099912

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02766739T AT348101T (en) 2001-04-25 2002-04-02 Carbolin derivatives as phosphophodiesterase 5 (pde5) inhibitors for the treatment of cardiovascular diseases and the effective dysfunction

Country Status (9)

Country Link
US (1) US7115621B2 (en)
EP (1) EP1383765B1 (en)
JP (1) JP4216606B2 (en)
AT (1) AT348101T (en)
CA (1) CA2441792C (en)
DE (1) DE60216745T2 (en)
ES (1) ES2278956T3 (en)
MX (1) MXPA03009750A (en)
WO (1) WO2002088123A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
JP4671123B2 (en) 2003-06-23 2011-04-13 小野薬品工業株式会社 New tricyclic heterocyclic compounds
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
EP1737461B1 (en) * 2004-03-15 2012-12-12 PTC Therapeutics, Inc. Carboline derivatives useful in the inhibition of angiogenesis
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
EP1804582A4 (en) * 2004-10-28 2009-12-09 Reddys Lab Ltd Dr Polymorphic forms of tadalafil
AR051780A1 (en) * 2004-11-29 2007-02-07 Japan Tobacco Inc Fused ring compounds containing nitrogen and utilization thereof
ES2459742T3 (en) 2004-12-22 2014-05-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
EP1747779A1 (en) 2005-07-28 2007-01-31 Laboratorios Del Dr. Esteve, S.A. Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands
WO2007016361A2 (en) * 2005-07-29 2007-02-08 Concert Pharmaceuticals Inc. Novel pharmaceutical compounds
WO2007020521A1 (en) * 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Pyridoyrazinones as pde-5 inhibitors
EP2004644A1 (en) * 2006-03-24 2008-12-24 Glenmark Pharmaceuticals Limited Process for the preparation of tadalafil
CA2700160A1 (en) * 2007-09-20 2009-03-26 D2E, Llc Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
CA2727055C (en) 2008-01-11 2016-12-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
WO2011003007A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (en) * 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ, インコーポレイテッド Azinone-substituted azepino [B] indoles and pyrido-pyrrolo-azepine MCH-1 antagonists and methods for making and using the same
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
DK2592081T3 (en) 2010-07-06 2017-06-06 Ono Pharmaceutical Co Tetrahydrocarbolinderivat
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
CN102391323B (en) * 2011-10-18 2013-09-25 首都医科大学 Tetrahydro-beta-carboline derivative, preparation method thereof and use thereof
TW201710258A (en) 2015-06-23 2017-03-16 碩騰服務公司 Carboline antiparasitics

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES273769A1 (en) * 1961-01-18 1962-06-01 Geigy Ag J R Process for the preparation of novel derivatives of acid amides of beta-carboline-carboxylic
JPS5543475B2 (en) * 1972-09-14 1980-11-06
US4336260A (en) * 1977-12-08 1982-06-22 The Dow Chemical Company Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression
JPS5936676A (en) * 1982-08-20 1984-02-28 Tanabe Seiyaku Co Ltd Novel preparation of beta-carboline
FR2663935A1 (en) 1990-06-27 1992-01-03 Adir Novel 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles and 1,2,3,4-tetrahydrobethacarbolines, processes for preparing them and pharmaceutical compositions containing them
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
DK0891187T3 (en) * 1996-04-04 2002-04-29 Hoffmann La Roche Use of tetrahydro-beta-carboline derivatives as anti-metastatic agents
US6043252A (en) * 1997-05-05 2000-03-28 Icos Corporation Carboline derivatives
HU9901478A3 (en) * 1996-05-10 1999-11-29 Icos Corp Bothell Carboline derivatives, their use, production thereof and medicaments containing the same
CA2253910A1 (en) 1996-05-11 1997-11-20 King's College London Pyrazines
JP2002524564A (en) * 1998-09-16 2002-08-06 アイコス コーポレイション Carboline derivatives as cGMP phosphodiesterase inhibitors
DE60039357D1 (en) * 1999-08-03 2008-08-14 Lilly Icos Llc Pharmaceutical composition containing tadalafil
US6492358B2 (en) * 2000-05-17 2002-12-10 Ortho-Mcneil Pharmaceutical, Inc. β-carboline derivatives useful as inhibitors of phosphodiesterase
JP2004501124A (en) * 2000-06-07 2004-01-15 リリー アイコス リミテッド ライアビリティ カンパニー Compound
CA2411010A1 (en) * 2000-06-08 2001-12-13 Lilly Icos Llc Tetracyclic diketopiperazine compounds as pdev inhibitors
AU1342102A (en) * 2000-10-03 2002-04-15 Lilly Icos Llc Chemical compounds
US6878711B2 (en) 2000-11-06 2005-04-12 Lilly Icos Llc Indole derivatives as PDE5-inhibitors

Also Published As

Publication number Publication date
CA2441792A1 (en) 2002-11-07
ES2278956T3 (en) 2007-08-16
EP1383765A1 (en) 2004-01-28
US20040147542A1 (en) 2004-07-29
EP1383765B1 (en) 2006-12-13
JP2004532852A (en) 2004-10-28
MXPA03009750A (en) 2004-06-30
DE60216745T2 (en) 2007-05-16
CA2441792C (en) 2010-08-03
DE60216745D1 (en) 2007-01-25
JP4216606B2 (en) 2009-01-28
US7115621B2 (en) 2006-10-03
WO2002088123A1 (en) 2002-11-07

Similar Documents

Publication Publication Date Title
DE60219793D1 (en) Method for the treatment of cytokin-mediated illnesses
DE60019556D1 (en) 2-amino-benzoxazine derivatives for the treatment of fatibility
DE60223715D1 (en) Glyt1 transporter inhibitors and their use in the treatment of neurological and neuropsychiative diseases
DE60135732D1 (en) Topoisomerase inhibitors for the treatment of surgical applications
DK1278748T3 (en) Inhibitors of human phosphatidyl-inositol 3-kinase delta
DK1274728T3 (en) Methods and compositions for the prevention and treatment of anemia
DE60301350D1 (en) Process for the preparation of 7-substituted -3-chinolin and 3-chinol-4-on carbonitrile
DK1248606T3 (en) Use of fumaric acid derivatives for the treatment of mitochondrial-related diseases
DE60020100D1 (en) Dimerbindungen and as inhibitors of neuramidinase
DE60233414D1 (en) Combinations for the treatment of inflammatory diseases
DE60226912D1 (en) Quinoline and chianzoline derivatives for the treatment of tumors
DK1343773T3 (en) Thiazole derivatives for the treatment of PPAR-related disorders
DE50306850D1 (en) Benzodiazepine-substituted piperdines for use in the treatment of cardiovascular diseases
DE60134453D1 (en) Pharmaceutical compositions for the treatment of CNS and other diseases
DE60220422D1 (en) Substituted pyrazoic compounds for the treatment of inflammation
DK1373215T3 (en) Gelanamycin derivatives suitable for the treatment of cancer
DE60321929D1 (en) Pharmaceutical compositions with dextromethorphane and chinidine for the treatment of neurological illnesses
DK1423381T3 (en) 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen-dependent diseases
DK1175214T3 (en) Cyclooxygenase-2 inhibitor compositions with rapid onset of therapeutic effect
DE60023128D1 (en) Pyrazolecarboxamide for the treatment of fatibility and other diseases
DK1448564T3 (en) Substituted indolizine-like compounds and methods of use
DK1373224T3 (en) Novel spirotric cyclic derivatives and their use as phosphodiesterase 7 inhibitors
DE60232251D1 (en) Pharmaceutical compositions for the treatment of asthma
DE60236413D1 (en) Inhibitors of hmgb1 for the treatment of tissue diseases
DE60234167D1 (en) Bipiperidin derivatives and their use as inhibitors of chemokin receptors

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties