AT346947T - Codon-optimized papilloma virus sequences - Google Patents

Codon-optimized papilloma virus sequences

Info

Publication number
AT346947T
AT346947T AT01953199T AT01953199T AT346947T AT 346947 T AT346947 T AT 346947T AT 01953199 T AT01953199 T AT 01953199T AT 01953199 T AT01953199 T AT 01953199T AT 346947 T AT346947 T AT 346947T
Authority
AT
Austria
Prior art keywords
codon
optimized
papilloma virus
virus sequences
sequences
Prior art date
Application number
AT01953199T
Other languages
German (de)
Inventor
Peter F Ertl
Gerald W Gough
Christopher J Ring
Sarah Walcott
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0017990A priority Critical patent/GB0017990D0/en
Priority to GB0025802A priority patent/GB0025802D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AT346947T publication Critical patent/AT346947T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses
    • C12N2710/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses dsDNA Viruses
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses
    • C12N2710/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses dsDNA Viruses
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
AT01953199T 2000-07-21 2001-07-20 Codon-optimized papilloma virus sequences AT346947T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0017990A GB0017990D0 (en) 2000-07-21 2000-07-21 Papilloma virus sequences
GB0025802A GB0025802D0 (en) 2000-10-20 2000-10-20 Papilloma virus sequences

Publications (1)

Publication Number Publication Date
AT346947T true AT346947T (en) 2006-12-15

Family

ID=26244703

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01953199T AT346947T (en) 2000-07-21 2001-07-20 Codon-optimized papilloma virus sequences

Country Status (21)

Country Link
EP (1) EP1301614B1 (en)
JP (1) JP2004504057A (en)
KR (1) KR100874552B1 (en)
CN (1) CN1262665C (en)
AT (1) AT346947T (en)
AU (2) AU2001275695B9 (en)
BR (1) BR0112637A (en)
CA (1) CA2416488A1 (en)
CZ (1) CZ2003180A3 (en)
DE (1) DE60124918T2 (en)
DK (1) DK1301614T3 (en)
ES (1) ES2277605T3 (en)
HK (1) HK1056195A1 (en)
HU (1) HU0300745A3 (en)
IL (1) IL154009D0 (en)
MX (1) MXPA03000554A (en)
NO (1) NO20030219L (en)
NZ (1) NZ523683A (en)
PL (1) PL365385A1 (en)
PT (1) PT1301614E (en)
WO (1) WO2002008435A1 (en)

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DE50214801D1 (en) 2001-06-05 2011-01-13 Curevac Gmbh Stabilized mRNA with increased G / C content, coding for a viral antigen
WO2003018055A1 (en) * 2001-08-23 2003-03-06 Merck & Co., Inc. Vaccine using papilloma virus e proteins delivered by viral vector
DE10162480A1 (en) 2001-12-19 2003-08-07 Ingmar Hoerr The application of mRNA for use as a therapeutic agent against tumor diseases
AU2003213060A1 (en) * 2002-02-14 2003-09-04 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
GB0222953D0 (en) 2002-10-03 2002-11-13 Glaxo Group Ltd Novel Compounds
RU2356943C2 (en) 2003-03-24 2009-05-27 Мерк Энд Ко., Инк. Nucleic acid molecule encoding hpv 31 l1, expression vector, host cell, virus-like particle and method of its obtainment, vaccine, pharmaceutical composition and methods involving them
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
JP4833962B2 (en) 2004-03-24 2011-12-07 メルク・シャープ・エンド・ドーム・コーポレイション Optimized expression of HPV52L1 in yeast
GB0617387D0 (en) * 2006-09-04 2006-10-11 Glaxo Group Ltd Synthetic gene
EP2099486A2 (en) * 2006-11-30 2009-09-16 Government Of The United States Of America, As Represented by the Secretary Codon modified immunogenic compositions and methods of use
GB0700914D0 (en) * 2007-01-18 2007-02-28 Animal Health Inst Polynucleotides and uses thereof
CN101617052A (en) 2007-01-30 2009-12-30 特兰斯吉恩股份有限公司 Papillomavirus e2 polypeptide used for vaccination
CN100532548C (en) 2007-02-14 2009-08-26 马润林;陈小江 Method of increasing yield of human papilloma virus L1 albumen pronucleus expression
GB0710538D0 (en) * 2007-06-01 2007-07-11 Glaxo Group Ltd Vaccine
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857413A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR20190099538A (en) 2011-10-03 2019-08-27 모더나 세라퓨틱스, 인코포레이티드 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
AU2012352180A1 (en) 2011-12-16 2014-07-31 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US20150064235A1 (en) 2012-03-30 2015-03-05 Moderna Therapeutics, Inc. Modified polynucleotides
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2833921A2 (en) 2012-04-02 2015-02-11 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドModernaTX,Inc. Chemically modified mRNA
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015051214A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2017015463A2 (en) 2015-07-21 2017-01-26 Modernatx, Inc. Infectious disease vaccines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464936A (en) * 1990-12-21 1995-11-07 Cetus Oncology Corporation Compositions for identification of papillomavirus replication inhibitors
DE4123760C2 (en) * 1991-07-18 2000-01-20 Dade Behring Marburg Gmbh Seroreactive regions on the HPV 16 proteins E1 and E2
JP2001512308A (en) * 1997-02-07 2001-08-21 メルク エンド カンパニー インコーポレーテッド Synthetic hiv gag gene
ES2291039T3 (en) * 1998-09-04 2008-02-16 Sanofi Pasteur Limited Treatment of cervical cancer.
ES2233437T3 (en) * 1999-08-25 2005-06-16 MERCK & CO., INC. Synthetic genes of papilomavirus optimized for expression in human cells.

Also Published As

Publication number Publication date
AU2001275695B2 (en) 2005-01-27
CN1262665C (en) 2006-07-05
JP2004504057A (en) 2004-02-12
IL154009D0 (en) 2003-07-31
WO2002008435A1 (en) 2002-01-31
KR20030074586A (en) 2003-09-19
KR100874552B1 (en) 2008-12-16
AU2001275695B9 (en) 2005-05-26
NO20030219L (en) 2003-03-20
AU7569501A (en) 2002-02-05
EP1301614B1 (en) 2006-11-29
CZ2003180A3 (en) 2003-08-13
ES2277605T3 (en) 2007-07-16
HK1056195A1 (en) 2007-06-22
CA2416488A1 (en) 2002-01-31
PL365385A1 (en) 2005-01-10
CN1462309A (en) 2003-12-17
HU0300745A3 (en) 2010-01-28
NO20030219D0 (en) 2003-01-16
DE60124918T2 (en) 2007-08-02
WO2002008435A8 (en) 2002-04-04
BR0112637A (en) 2003-06-10
DK1301614T3 (en) 2007-04-02
DE60124918D1 (en) 2007-01-11
MXPA03000554A (en) 2004-12-13
EP1301614A1 (en) 2003-04-16
HU0300745A2 (en) 2003-08-28
NZ523683A (en) 2004-08-27
PT1301614E (en) 2007-02-28

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