AT33839T - New camptothecin derivatives and method for the production thereof. - Google Patents

New camptothecin derivatives and method for the production thereof.

Info

Publication number
AT33839T
AT33839T AT84108257T AT84108257T AT33839T AT 33839 T AT33839 T AT 33839T AT 84108257 T AT84108257 T AT 84108257T AT 84108257 T AT84108257 T AT 84108257T AT 33839 T AT33839 T AT 33839T
Authority
AT
Austria
Prior art keywords
production
method
camptothecin derivatives
new camptothecin
new
Prior art date
Application number
AT84108257T
Other languages
German (de)
Inventor
Tadashi Miyasaka
Seigo Sawada
Kenichiro Nokata
Eiichi Sugino
Masahiko Mutai
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP58126946A priority Critical patent/JPH034077B2/ja
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Priority to EP84108257A priority patent/EP0137145B1/en
Publication of AT33839T publication Critical patent/AT33839T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
AT84108257T 1983-07-14 1984-07-13 New camptothecin derivatives and method for the production thereof. AT33839T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP58126946A JPH034077B2 (en) 1983-07-14 1983-07-14
EP84108257A EP0137145B1 (en) 1983-07-14 1984-07-13 New camptothecin derivatives and process for preparing same

Publications (1)

Publication Number Publication Date
AT33839T true AT33839T (en) 1988-05-15

Family

ID=14947803

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84108257T AT33839T (en) 1983-07-14 1984-07-13 New camptothecin derivatives and method for the production thereof.

Country Status (8)

Country Link
US (1) US4604463A (en)
EP (1) EP0137145B1 (en)
JP (1) JPH034077B2 (en)
AT (1) AT33839T (en)
CA (1) CA1235415A (en)
DE (2) DE137145T1 (en)
LU (1) LU90074I2 (en)
NL (1) NL980026I2 (en)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (en) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 Novel camptothecin derivative
US5049668A (en) * 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6407115B1 (en) * 1991-01-16 2002-06-18 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
US5658920A (en) * 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
EP1393729A3 (en) 1991-11-15 2004-03-17 Smithkline Beecham Corporation Combination chemotherapy involving topotecan and a platinum coordination compound
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
US5446047A (en) * 1992-07-23 1995-08-29 Sloan-Kettering Institute For Cancer Research Camptothecin analogues
AP9300587A0 (en) * 1992-11-12 1995-05-05 Glaxo Inc Water soluble camptothecin derivatives.
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5604233A (en) * 1994-04-28 1997-02-18 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof
US5597829A (en) * 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US6177439B1 (en) 1995-06-06 2001-01-23 Reddy's Research Foundation Water soluble analogues of 20(S)-camptothecin
US6214836B1 (en) 1995-06-06 2001-04-10 Dr. Reddy's Research Foundation Water soluble analogues of 20(S)-camptothecin
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
CA2223484A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
AU7732996A (en) * 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6395541B1 (en) 1996-05-23 2002-05-28 The Rockefeller University Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
JP2001513105A (en) * 1997-02-27 2001-08-28 フアルマシア・アンド・アツプジヨン・カンパニー Tamoxifen as a treatment for reducing irinotecan hydrochloride-induced diarrhea
JP3046258B2 (en) * 1997-04-11 2000-05-29 株式会社ヤクルト本社 Method for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof
ID23424A (en) 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat of 20 (s) -kamptotesin
US6214821B1 (en) 1998-03-05 2001-04-10 Washington State University Research Foundation Methods and composition for the inhibition of cancer cells
HU0103314A3 (en) * 1998-08-05 2002-07-29 Aventis Pharma Sa Use of camptothecin derivatives, with reduced gastrointestinal toxicity
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US20050281821A1 (en) * 1999-01-06 2005-12-22 Flavia Pernasetti Method and composition for angiogenesis inhibition
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6228855B1 (en) * 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
JP4776843B2 (en) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド Cancer composition and method using immunoconjugate and chemotherapeutic agent
US6159935A (en) 1999-11-29 2000-12-12 Pharmacia & Upjohn Co. Method for preventing diarrhea
HU0300848A3 (en) 2000-02-28 2005-03-29 Aventis Pharma Sa A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
US6545010B2 (en) 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
AR027687A1 (en) * 2000-03-22 2003-04-09 Yakult Honsha Kk Process for preparing camptothecin
AU6147301A (en) * 2000-05-15 2001-11-26 Celgene Corp Compositions and methods for the treatment of colorectal cancer
NZ522767A (en) 2000-05-15 2004-07-30 Celgene Corp Thalidomide and a topoisomerase inhibitor for the treatment of cancer
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
PL365685A1 (en) 2000-10-27 2005-01-10 Aventis Pharma S.A. A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US7365167B2 (en) * 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7390885B2 (en) * 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
CN1649627A (en) * 2002-04-26 2005-08-03 法赫马西亚及普强有限公司 Methods and conpositions for treating, preventing or delaying onset of a neoplasm
KR101086533B1 (en) 2002-05-24 2011-11-23 쉐링 코포레이션 Neutralizing human anti-IGFR antibody, a method for producing it and a composition comprising it
CN100363366C (en) * 2002-06-27 2008-01-23 中国科学院上海药物研究所 Camptothecin derviative and preparation process thereof
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
AU2004238358B2 (en) 2003-05-12 2010-05-13 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
CZ299329B6 (en) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Process for preparing 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy camptothecin
PE20050928A1 (en) * 2003-11-21 2005-11-08 Schering Corp therapeutic combinations of anti-IGFR1
CZ299593B6 (en) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Process for preparing 7-ethyl-10-hydroxycamptothecine
US7700612B2 (en) * 2003-12-23 2010-04-20 Abraxis Bioscience, Llc Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
WO2005077370A1 (en) * 2004-02-13 2005-08-25 Kabushiki Kaisha Yakult Honsha Aqueous solution preparation containing camptothecins
CN1946421B (en) * 2004-04-27 2013-07-17 威尔斯达特生物制剂公司 Cancer treatment using viruses and camptothecins
US20050267141A1 (en) * 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
JP4885715B2 (en) 2004-06-01 2012-02-29 テルモ株式会社 Irinotecan formulation
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
JP5221134B2 (en) 2004-09-07 2013-06-26 バイオコンパティブルズ ユーケー リミテッド Drug delivery from embolic agents
WO2006038526A1 (en) * 2004-10-01 2006-04-13 Kabushiki Kaisha Yakult Honsha Acid addition salt of irinotecan
US7205385B2 (en) * 2004-11-12 2007-04-17 General Electric Company Polymerization method for the synthesis of polypeptide imaging agents
MX2007008810A (en) 2005-01-21 2007-11-21 Astex Therapeutics Ltd Pharmaceutical compounds.
WO2006082053A1 (en) * 2005-02-02 2006-08-10 Heidelberg Pharma Gmbh 7-ethyl-10-hydroxy-camptothecin lipid ester derivatives
EP1846412B1 (en) * 2005-02-07 2009-10-21 Fermion Oy Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin
ES2437573T3 (en) * 2005-02-08 2014-01-13 Fermion Oy Procedure for the preparation of irinotecan hydrochloride
PL1846371T3 (en) * 2005-02-08 2014-01-31 Fermion Oy Process for producing [1,4']bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
CN101193644A (en) * 2005-03-04 2008-06-04 诺瓦西股份有限公司 Treatment of hyperproliferative diseases with anthraquinones
US20070117784A1 (en) * 2005-03-04 2007-05-24 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
JP4875064B2 (en) * 2005-04-15 2012-02-15 シェーリング コーポレイションSchering Corporation Methods and compositions for treating or preventing cancer
US7994186B2 (en) * 2005-04-18 2011-08-09 Kabushiki Kaisha Yakult Honsha Pharmaceutical compositions containing camptothecins
CN101400368B (en) * 2005-07-14 2012-10-03 威尔斯达特生物制剂公司 Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN102335163A (en) * 2005-07-18 2012-02-01 彼帕科学公司 Treatment of cancer
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
US7608740B2 (en) * 2005-08-03 2009-10-27 Avra Laboratories Pvt. Ltd Method of synthesizing key intermediates for the production of camptothecin derivatives
JP4994618B2 (en) * 2005-08-11 2012-08-08 学校法人北里研究所 Chemoradiation with TS-1 / camptothecins
EP1928497A2 (en) * 2005-08-24 2008-06-11 Cell-Matrix, Inc. Combination therapies for inhibiting integrin-extracellular matrix interactions
EP2082741A1 (en) 2005-09-20 2009-07-29 Scinopharm Singapore Pte, Ltd. Novel crystal form of irinotecan hydrochloride
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
EP1803725A1 (en) 2005-12-13 2007-07-04 W.C. Heraeus GmbH Methods for preparing irinotecan
CN1982313B (en) * 2005-12-13 2010-12-01 深圳市天和医药科技开发有限公司 Camptothecin compound containing multiple organic hydroxy-acid group on 10-bit substituent, its production and composition
US20070208050A1 (en) * 2006-02-24 2007-09-06 Palle Venkata Raghavendra Acha Process for preparing irinotecan
CN101033230B (en) * 2006-03-10 2010-12-08 中国科学院上海药物研究所 Cmptothecine derivative and application thereof
WO2007113687A2 (en) 2006-03-30 2007-10-11 Diatos S.A. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
AR060635A1 (en) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd I derived from 1,2-dihydro-3H-pyrazolo [3,4-d] pyrimidin-3-one, pharmaceutical compositions comprising them and their use in the treatment of cancer
JP2008081492A (en) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd New aminopyridine derivative having aurora a selective inhibitory action
CA2662337A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
WO2008030883A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
JP2010504318A (en) * 2006-09-22 2010-02-12 ラボファーム (バルバドス) リミテッド Compositions and methods for pH targeted drug delivery
KR20090094804A (en) * 2006-10-06 2009-09-08 다케다 야쿠힌 고교 가부시키가이샤 Combination drug
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US20090062323A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched irinotecan
US20090149417A1 (en) * 2007-10-19 2009-06-11 Valeria Ossovskaya Methods and compositions for the treatment of cancer using benzopyrone-type PARP inhibitors
US8329711B2 (en) 2007-10-23 2012-12-11 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
CN101917982B (en) 2007-11-12 2013-03-20 彼帕科学公司 Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
WO2009124064A1 (en) 2008-03-31 2009-10-08 Boston Medical Center Corporation Predictive marker for topoisomerase i inhibitors
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CN101397301A (en) * 2008-09-10 2009-04-01 重庆医科大学医药研究所 Water-soluble derivates containing 10-hydroxycamptothecin and preparation method
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
WO2010075554A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Synthesis of purine nucleosides
EP2401281A4 (en) 2009-02-25 2012-08-15 Msd Kk Pyrimidopyrimidoindazole derivative
US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
SG10201702025SA (en) 2010-03-31 2017-04-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
ES2655737T3 (en) 2009-11-13 2018-02-21 Daiichi Sankyo Europe Gmbh Materials and methods to treat or prevent diseases associated with HER-3
US8546573B2 (en) 2009-11-18 2013-10-01 Cadila Healthcare Limited Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate
EA023503B1 (en) * 2009-11-18 2016-06-30 Нектар Терапьютикс Hydrohalide salt form of a multi-arm polymer-drug conjugate and a medicament, method for preparation thereof, compositions and method of treating cancer
ES2575160T3 (en) 2010-03-15 2016-06-24 The Board Of Trustees Of The University Of Illinois Inhibitors of the interactions that bind the alpha subunit of beta integrin-protein G
US8530444B2 (en) * 2010-06-01 2013-09-10 Aposense Ltd. Pharmaceutical compounds
AU2011286407A1 (en) 2010-08-06 2013-02-21 Amgen Use of HER3 binding agents in prostate treatment
EP2655401B1 (en) 2010-12-20 2016-03-09 The Regents of the University of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
WO2013093931A2 (en) 2011-09-19 2013-06-27 Sun Pharma Advanced Research Company Ltd. Novel prodrugs of phenolic drugs
CA2850296A1 (en) 2011-10-03 2013-04-11 Moreinx Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
CN103848840A (en) * 2012-12-03 2014-06-11 中国人民解放军军事医学科学院毒物药物研究所 Camptothecin derivatives and medical application thereof
CN103864810A (en) * 2012-12-07 2014-06-18 天津科技大学 Preparation method of novel 10-hydroxycamptothecine 10-position derivatives and application in antitumor drugs
TWI641374B (en) 2013-03-27 2018-11-21 大鵬藥品工業股份有限公司 Antineoplastic agent containing low-dose irinotecan hydrochloride hydrate
WO2014157443A1 (en) 2013-03-27 2014-10-02 大鵬薬品工業株式会社 Antitumor agent including irinotecan hydrochloride hydrate
AR095962A1 (en) 2013-04-01 2015-11-25 Moreinx Ab Nanoparticles composed of sterol and saponin Quillaja saponaria molina of, process for preparation and use thereof as carriers for hydrophobic or amphipathic molecules in the field of medicine including cancer treatment and food related compounds
EP2881396A1 (en) * 2013-12-03 2015-06-10 Synbias Pharma AG Method for the synthesis of irinotecan
AU2015289124A1 (en) 2014-07-18 2017-02-09 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
JP2018505214A (en) 2015-01-26 2018-02-22 ザ ユニバーシティー オブ シカゴ CAR T cells recognizing cancer-specific IL13Rα2
EP3250609A4 (en) 2015-01-26 2018-07-11 The University of Chicago Il13ra alpha 2 binding agents and use thereof in cancer treatment
WO2016203352A2 (en) * 2015-06-14 2016-12-22 Mohan M Alapati Compositions and methods for the treatment of cancer
WO2016203337A2 (en) * 2015-06-14 2016-12-22 Mohan M Alapati Compositions and methods for the treatment of cancer
JP2018528184A (en) 2015-08-20 2018-09-27 イプセン バイオファーム リミティド Combination therapy using liposomal irinotecan and PARP inhibitors for cancer treatment
US9980953B2 (en) * 2016-09-26 2018-05-29 Chong Kun Dang Pharmaceutical Corp. Combined composition for preventing or treating cancer comprising a benzophenone thiazole derivatives as a VDA and topoisomerase inhibitor
CN111246883A (en) 2017-08-07 2020-06-05 美国安进公司 Treatment of triple negative breast cancer or colorectal cancer with anti-PD-L1 antibody and oncolytic virus with liver metastasis
TW202002952A (en) 2018-03-15 2020-01-16 美商艾伯維有限公司 ABBV-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
WO2019178438A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of cancer
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS6247195B2 (en) * 1981-09-04 1987-10-06 Yakult Honsha Kk
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS636072B2 (en) * 1982-03-10 1988-02-08 Yakult Honsha Kk
JPS6247873B2 (en) * 1982-03-10 1987-10-09 Yakult Honsha Kk
JPS58154582A (en) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
JPH0312070B2 (en) * 1982-09-17 1991-02-19 Yakult Honsha Kk

Also Published As

Publication number Publication date
LU90074A9 (en)
EP0137145B1 (en) 1988-04-27
NL980026I1 (en) 1998-11-02
CA1235415A1 (en)
JPH034077B2 (en) 1991-01-22
LU90074I2 (en) 1997-08-21
US4604463A (en) 1986-08-05
DE137145T1 (en) 1985-11-21
CA1235415A (en) 1988-04-19
NL980026I2 (en) 1999-02-01
DE3470744D1 (en) 1988-06-01
EP0137145A1 (en) 1985-04-17
JPS6019790A (en) 1985-01-31

Similar Documents

Publication Publication Date Title
DE3769174D1 (en) Indolicine derivatives, method for the production and compositions thereof.
DE69115379T2 (en) New arylethenylene derivatives and method for the production thereof
DE3871114D1 (en) Plaster elements and method for the production thereof.
AT22889T (en) 8-chlorine-1,5-benzothiazepine derivatives, method for the production and pharmaceutical compositions.
DE3585171D1 (en) Multilayer and method for the production thereof.
AT27761T (en) Nutrient bar and method for the production thereof.
DE3683799D1 (en) Zirconphosphate and method for the production thereof.
DE347588T1 (en) Heparine derivatives and method for the production thereof.
DE3587045T2 (en) Substituted imidazole derivatives and method for the production and use thereof.
DE3483085D1 (en) Desulfatohirudine, method for the production thereof and pharmaceutical agents.
DE3686649T2 (en) Pyrazol-oxim derivatives, method for the production and use thereof.
PT74877B (en) Cephalosporine derivatives and method for the production thereof
DE3482814D1 (en) Container and method for the production thereof.
DE3578578D1 (en) Hirudin-pa and its derivatives, method for the production and use thereof.
AT20073T (en) Homogeneous human-interleukin-2 and method for the production thereof.
AT105219T (en) Insert and method for the production thereof.
AT15362T (en) New dibenzoyl-methane derivatives, method for their production and their use.
DE3211185A1 (en) New quartaere 6,11-dihydro-dibenzo- (b, e) -thiepin-11-n-alkyl-norscopinether and method for the production thereof
AT127801T (en) Pyrazolopyridine compounds and method for the production thereof.
AT39696T (en) Cephalosporine derivatives and method for their production.
DE3601517A1 (en) New method for producing 1-subst.-aryl-1,4-dihydro-4-oxonaphthyridine derivatives, intermediate products thereof and method for producing the interim products
AT96775T (en) N-phenylalkyl substituted alphaaminocarboxamide derivatives and method for the production thereof.
AT112280T (en) New hetrazepines and method for their production.
DE68906552D1 (en) Camptothecin derivatives and method for the production thereof.
DE3524489A1 (en) 2-phenylpyridine derivatives and method for the production thereof

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
ESZA Application filed for a certificate of protection (e-series)

Free format text: SZ 24/1997, 19970630

EEZF Grant for a certificate of protection (e-series)

Free format text: SZ 24/1997, 19970630, EXPIRES:20090713

EELA Cancelled due to lapse of time