AT333284T - Method using immunostimulatory nucleic acids induced by interferon - Google Patents

Method using immunostimulatory nucleic acids induced by interferon

Info

Publication number
AT333284T
AT333284T AT00965477T AT00965477T AT333284T AT 333284 T AT333284 T AT 333284T AT 00965477 T AT00965477 T AT 00965477T AT 00965477 T AT00965477 T AT 00965477T AT 333284 T AT333284 T AT 333284T
Authority
AT
Austria
Prior art keywords
interferon
method
nucleic acids
immunostimulatory nucleic
acids induced
Prior art date
Application number
AT00965477T
Other languages
German (de)
Inventor
Gunther Hartmann
Robert L Bratzler
Arthur Krieg
Original Assignee
Coley Pharm Group Inc
Univ Iowa Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US15614799P priority Critical
Application filed by Coley Pharm Group Inc, Univ Iowa Res Found filed Critical Coley Pharm Group Inc
Publication of AT333284T publication Critical patent/AT333284T/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22558308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT333284(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells, macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05Adjuvants
    • C12N2501/056Immunostimulating oligonucleotides, e.g. CpG
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/22Colony stimulating factors (G-CSF, GM-CSF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
AT00965477T 1999-09-27 2000-09-27 Method using immunostimulatory nucleic acids induced by interferon AT333284T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15614799P true 1999-09-27 1999-09-27

Publications (1)

Publication Number Publication Date
AT333284T true AT333284T (en) 2006-08-15

Family

ID=22558308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00965477T AT333284T (en) 1999-09-27 2000-09-27 Method using immunostimulatory nucleic acids induced by interferon

Country Status (12)

Country Link
EP (1) EP1220684B2 (en)
JP (1) JP2003510290A (en)
AT (1) AT333284T (en)
AU (1) AU783118B2 (en)
CA (1) CA2386019C (en)
DE (1) DE60029460T3 (en)
ES (1) ES2265980T5 (en)
IL (1) IL148844D0 (en)
MX (1) MXPA02003059A (en)
NZ (1) NZ517928A (en)
WO (1) WO2001022990A2 (en)
ZA (1) ZA200201959B (en)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
EP0855184A1 (en) 1997-01-23 1998-07-29 Klaus Prof.-Dr. Heeg Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
DE60044236D1 (en) 1999-02-17 2010-06-02 Csl Ltd Immunogenic complex and methods with respect to these
EP1176966B1 (en) 1999-04-12 2013-04-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Oligodeoxynucleotide and its use to induce an immune response
EP1204425B1 (en) 1999-08-19 2009-01-07 Dynavax Technologies Corporation Methods of modulating an immune response using immunostimulatory sequences and compositions for use therein
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
EP1322655B1 (en) 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
CA2398756A1 (en) 2000-01-31 2001-08-02 Eyal Raz Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
US6613751B2 (en) 2000-02-23 2003-09-02 The Regents Of The University Of California Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7129222B2 (en) 2000-03-10 2006-10-31 Dynavax Technologies Corporation Immunomodulatory formulations and methods for use thereof
US7033594B2 (en) 2000-03-31 2006-04-25 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
DK1366077T3 (en) 2000-09-15 2011-09-12 Coley Pharm Gmbh A method for screening of large amounts of CpG-based immunoagonister / antagonists
JP4188687B2 (en) 2000-12-27 2008-11-26 ダイナバックス テクノロジーズ コーポレイション Immune modulation polynucleotides and methods of use thereof
KR20020083634A (en) * 2001-04-27 2002-11-04 크레아젠 주식회사 Pharmaceutical Compositions Comprising Dendritic Cells for Immunotherapy of Autoimmune Disease and Treatment Method Using the Same
ES2487645T3 (en) 2001-06-21 2014-08-22 Dynavax Technologies Corporation chimeric immunomodulatory compounds and methods of use thereof
AU2002326561B2 (en) 2001-08-07 2008-04-03 Dynavax Technologies Corporation Immunomodulatory compositions, formulations, and methods for use thereof
KR100991644B1 (en) 2001-08-17 2010-11-02 유니버시티 오브 아이오와 리써치 파운데이션 Combination Motif Immune Stimulatory Oligonucleotides with Improved Activity
EP2196217A1 (en) 2001-09-14 2010-06-16 Cytos Biotechnology AG Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
NZ573064A (en) 2002-04-04 2011-02-25 Coley Pharm Gmbh Immunostimulatory G,U-containing oligoribonucleotides
CN101160399A (en) * 2002-04-22 2008-04-09 拜奥尼茨生命科学公司 Oligonucleotide compositions and their use for the modulation of immune responses
CA2388049A1 (en) 2002-05-30 2003-11-30 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof
AU2003247880B2 (en) * 2002-07-03 2010-09-02 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
SG166673A1 (en) * 2002-08-19 2010-12-29 Coley Pharm Group Inc Immunostimulatory nucleic acids
AR040996A1 (en) * 2002-08-19 2005-04-27 Coley Pharm Group Inc Immunostimulatory Nucleic Acids
JP2006515277A (en) 2002-10-29 2006-05-25 コーリー ファーマシューティカル グループ, リミテッド Methods and products for the treatment and prevention of hepatitis C viral infection
EP1572122A4 (en) 2002-11-01 2008-04-09 Us Gov Health & Human Serv Method of preventing infections from bioterrorism agents with immunostimulatory cpg oligonucleotides
CN100546998C (en) * 2002-12-23 2009-10-07 戴纳伐克斯技术股份有限公司 Immunostimulatory sequence oligonucleotides and methods of using the same
US8158768B2 (en) 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
AU2004224761A1 (en) * 2003-03-26 2004-10-07 Cytos Biotechnology Ag HIV-peptide-carrier-conjugates
JP4673217B2 (en) * 2003-04-23 2011-04-20 由紀夫 佐藤 Methylated CpG polynucleotide
EP1625850B1 (en) * 2003-05-15 2012-02-29 Japan Science and Technology Agency Immunostimulating agents
JP3976742B2 (en) * 2004-02-27 2007-09-19 国立大学法人福井大学 Immunostimulatory oligonucleotides to induce interferon alpha
KR100958505B1 (en) 2004-07-18 2010-05-17 씨에스엘 리미티드 Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses
JP2008000001A (en) * 2004-09-30 2008-01-10 Osaka Univ Immune stimulating oligonucleotide and use in pharmaceutical
DE102005005642A1 (en) * 2005-02-06 2006-08-10 Phenion Gmbh & Co. Kg Cosmetic or pharmaceutical preparations containing nucleic acids comprising the formation of stem-loop secondary structures suitable sequences
JP2008535862A (en) 2005-04-08 2008-09-04 キメリクス,インコーポレイテッド Compounds for the treatment of poxvirus infections, the compositions and methods
DE602006008473D1 (en) 2005-07-01 2009-09-24 Index Pharmaceuticals Ab Modulating the response to steroids
EP2380584B1 (en) 2005-07-01 2013-10-16 Index Pharmaceuticals AB Immunostimulatory method
EP1929014B1 (en) * 2005-08-31 2014-08-13 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Methods of altering an immune response induced by d-type cpg oligodeoxynucleotides
AU2006306805A1 (en) 2005-10-28 2007-05-03 Index Pharmaceuticals Ab Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
EP1957647B1 (en) 2005-11-25 2015-03-04 Zoetis Belgium S.A. Immunostimulatory oligoribonucleotides
RU2451523C2 (en) 2005-12-14 2012-05-27 Цитос Биотехнологи Аг Particles packed in immunostimulating nucleic acid that intended for hypersensitivity treatment
SG172696A1 (en) 2006-06-12 2011-07-28 Cytos Biotechnology Ag Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages
US8168164B2 (en) 2006-02-03 2012-05-01 Purdue Research Foundation Targeted conjugates and radiation
CA2653939C (en) 2006-05-31 2013-01-22 Toray Industries, Inc. Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
US20100178272A1 (en) 2006-08-08 2010-07-15 Klinische Pharmakologie Structure and use of 5'phosphate oligonucleotides
NZ575437A (en) 2006-09-27 2012-02-24 Coley Pharm Gmbh Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity
EP1920775B1 (en) 2006-10-10 2012-12-19 Gunther Prof. Dr. Hartmann 5'Triphosphate oligonucleotide induces anti-viral response
WO2008139262A2 (en) * 2006-10-26 2008-11-20 Coley Pharmaceutical Gmbh Oligoribonucleotides and uses thereof
CA2671873C (en) 2006-12-12 2018-10-09 Brian Stephen Sproat Oligonucleotides containing high concentrations of guanine monomers
RU2009142211A (en) 2007-05-17 2011-05-27 Коли Фармасьютикал Груп, Инк. (Us) Class oligonucleotides with immunostimulatory activity
US9200287B2 (en) 2007-05-18 2015-12-01 Adiutide Pharmaceuticals Gmbh Phosphate-modified oligonucleotide analogs with enhanced immunostimulatory activity
DE102007044093A1 (en) * 2007-09-14 2009-03-19 Phenion Gmbh & Co. Kg Nucleic acid-containing cosmetic and / or pharmaceutical preparations for the induction of antimicrobial peptides in epithelial tissues Deck
CN101820908A (en) 2007-10-09 2010-09-01 科利制药公司 Immune stimulatory oligonucleotide analogs containing modified sugar moieties
EP3085377A1 (en) 2008-01-25 2016-10-26 Chimerix, Inc. Methods of treating viral infections
WO2009141146A1 (en) 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
HUE028497T2 (en) 2008-10-16 2016-12-28 The Univ Of Saskatchewan Combination adjuvant formulation
WO2010049438A2 (en) * 2008-10-30 2010-05-06 Innate Pharma Improved methods of using phosphoantigens for the treatment of diseases
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
WO2010067286A2 (en) 2008-12-09 2010-06-17 Pfizer Vaccines Llc IgE CH3 PEPTIDE VACCINE
AU2010243285B2 (en) 2009-04-30 2013-06-06 Coley Pharmaceutical Group, Inc. Pneumococcal vaccine and uses thereof
MX342945B (en) 2009-07-06 2016-10-18 Ontorii Inc * Novel nucleic acid prodrugs and methods use thereof.
CA2846746A1 (en) 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
KR101528021B1 (en) 2010-05-28 2015-06-10 조에티스 벨지엄 에스.에이. Vaccines comprising cholefsterol and cpg as sole adjuvant - carrier molecules
WO2011154878A1 (en) 2010-06-07 2011-12-15 Pfizer Vaccines Llc Ige ch3 peptide vaccine
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
CA2837207A1 (en) 2011-06-01 2012-12-06 Janus Biotherapeutics, Inc. Novel immune system modulators
WO2013007703A1 (en) 2011-07-08 2013-01-17 Universität Zürich CLASS A CpG OLIGONUCLEOTIDES FOR PREVENTION OF VIRAL INFECTION IN CATS
KR20140068884A (en) 2011-07-19 2014-06-09 웨이브 라이프 사이언시스 피티이. 리미티드 Methods for the synthesis of functionalized nucleic acids
EP2763677A4 (en) 2011-10-04 2015-05-20 Janus Biotherapeutics Inc Novel imidazole quinoline-based immune system modulators
JP6246121B2 (en) * 2012-07-13 2017-12-13 株式会社新日本科学 Chiral-nucleic acid adjuvants
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
KR101850319B1 (en) 2012-07-13 2018-04-20 웨이브 라이프 사이언시스 리미티드 Asymmetric auxiliary group
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
EP3095459A4 (en) * 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
WO2015108047A1 (en) * 2014-01-15 2015-07-23 株式会社新日本科学 Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108046A1 (en) * 2014-01-15 2017-03-23 株式会社新日本科学 Chiral acid adjuvants and an antiallergic agent having an anti-allergic action
SG11201605782UA (en) 2014-01-16 2016-08-30 Wave Life Sciences Ltd Chiral design
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
JP2017525711A (en) 2014-08-22 2017-09-07 ジャナス バイオセラピューティクス,インク. Novel n2, n4, n7,6- tetrasubstituted pteridine 2,4,7-triamine and 2,4,6,7-tetrasubstituted pteridine compounds and synthetic methods and uses thereof
WO2017121494A1 (en) * 2016-01-15 2017-07-20 Riboxx Gmbh 5'-triphosphated short immunostimulatory nucleotides, oligonucleotides and polynucleotides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
EP0855184A1 (en) * 1997-01-23 1998-07-29 Klaus Prof.-Dr. Heeg Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
GB9702021D0 (en) * 1997-01-31 1997-03-19 Imperial College Medicaments
CA2301575C (en) * 1997-05-20 2003-12-23 Heather L. Davis Vectors and methods for immunization or therapeutic protocols
EP1067956B1 (en) * 1998-04-03 2007-03-14 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
CA2333854A1 (en) * 1998-07-27 2000-02-10 University Of Iowa Research Foundation Stereoisomers of cpg oligonucleotides and related methods

Also Published As

Publication number Publication date
MXPA02003059A (en) 2002-09-30
EP1220684B2 (en) 2010-07-14
ES2265980T5 (en) 2010-12-28
AU7619000A (en) 2001-04-30
WO2001022990A3 (en) 2001-10-04
AU783118B2 (en) 2005-09-29
DE60029460T3 (en) 2011-02-10
NZ517928A (en) 2004-09-24
EP1220684A2 (en) 2002-07-10
CA2386019A1 (en) 2001-04-05
EP1220684B1 (en) 2006-07-19
JP2003510290A (en) 2003-03-18
IL148844D0 (en) 2002-09-12
ZA200201959B (en) 2003-05-28
CA2386019C (en) 2011-06-21
DE60029460T2 (en) 2007-03-15
DE60029460D1 (en) 2006-08-31
ES2265980T3 (en) 2007-03-01
WO2001022990A2 (en) 2001-04-05

Similar Documents

Publication Publication Date Title
DE59900103D1 (en) Imaging method for determining the state of tissue
DE60044907D1 (en) A method for determining of glycoproteins
AT466951T (en) The method for sequencing of nucleic acid molecules
AT462774T (en) A method for producing ceramic agglomerate
DE60219507D1 (en) Method for thermoforming bellows structures arrayed
DE69804274D1 (en) Method for reinforcing structural elements
AT412002T (en) Groups for capture of nucleic acids
DE50202503D1 (en) Vliesperforierungsvorrichtung process together with
DE60126491D1 (en) A method for sequence analysis
AT294809T (en) A process for preparing 6-O-alkenyl- subsitutierten erythromycin derivative
DE60039310D1 (en) A method for the determination of amyloidogenic proteins
DE50105694D1 (en) A process for the operation of an elevator
AT444956T (en) Dihydroxypyrimidine-carboxylic acids as viral polymerase inhibitors
DE60036403D1 (en) A process for the preparation of purified HCV RNA by isolation of exosomes
DE69929099D1 (en) Device for the extraction of nucleic acids
AT306783T (en) Method for charging for online call number inquiry services
DE60332373D1 (en) Method of heating molds
AT421583T (en) Isolation of nucleic acids
AT233987T (en) Method of checking to placement
DE60016720D1 (en) A method of attaching piezoelectric elements
DE50202216D1 (en) A method of controlling an inverter system
DE69720473D1 (en) A method for purifying nucleic acids
DE50309540D1 (en) Immune stimulation by chemically modified rna
DE60040679D1 (en) Handzeichnungseinfang by interface surface
DE69922544D1 (en) Method of hats of polyphenylene ethers

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties