AT325807T - purine derivatives - Google Patents

purine derivatives

Info

Publication number
AT325807T
AT325807T AT01902583T AT01902583T AT325807T AT 325807 T AT325807 T AT 325807T AT 01902583 T AT01902583 T AT 01902583T AT 01902583 T AT01902583 T AT 01902583T AT 325807 T AT325807 T AT 325807T
Authority
AT
Austria
Prior art keywords
purine derivatives
purine
derivatives
Prior art date
Application number
AT01902583T
Other languages
German (de)
Inventor
Simon John Mantell
Sandra M Monaghan
Peter T Stephenson
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB0003960.2A priority Critical patent/GB0003960D0/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AT325807T publication Critical patent/AT325807T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
AT01902583T 2000-02-18 2001-02-09 purine derivatives AT325807T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GBGB0003960.2A GB0003960D0 (en) 2000-02-18 2000-02-18 Purine derivatives

Publications (1)

Publication Number Publication Date
AT325807T true AT325807T (en) 2006-06-15

Family

ID=9886026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01902583T AT325807T (en) 2000-02-18 2001-02-09 purine derivatives

Country Status (39)

Country Link
US (1) US6525032B2 (en)
EP (1) EP1255764B8 (en)
JP (1) JP2004508284A (en)
KR (1) KR20030036138A (en)
CN (1) CN1400975A (en)
AP (1) AP200202598A0 (en)
AR (1) AR027437A1 (en)
AT (1) AT325807T (en)
AU (1) AU3044001A (en)
BG (1) BG106906A (en)
BR (1) BR0108408A (en)
CA (1) CA2400619A1 (en)
CO (1) CO5271668A1 (en)
CR (1) CR6722A (en)
CZ (1) CZ20022703A3 (en)
DE (1) DE60119492T2 (en)
EA (1) EA004987B1 (en)
EE (1) EE200200452A (en)
ES (1) ES2260199T3 (en)
GB (1) GB0003960D0 (en)
GT (1) GT200100027A (en)
HN (1) HN2001000027A (en)
HR (1) HRP20020676A2 (en)
HU (1) HU0301055A2 (en)
IL (1) IL150543D0 (en)
IS (1) IS6458A (en)
MA (1) MA26873A1 (en)
MX (1) MXPA02008068A (en)
NO (1) NO20023894L (en)
NZ (1) NZ519971A (en)
OA (1) OA12177A (en)
PA (1) PA8511801A1 (en)
PE (1) PE20011122A1 (en)
PL (1) PL357220A1 (en)
SK (1) SK11692002A3 (en)
SV (1) SV2002000317A (en)
TN (1) TNSN01028A1 (en)
WO (1) WO2001060835A1 (en)
ZA (1) ZA200206526B (en)

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US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
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US6921753B2 (en) 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
US6624158B2 (en) 2000-09-15 2003-09-23 Pfizer Inc Purine derivatives
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GB0129273D0 (en) * 2001-12-06 2002-01-23 Pfizer Ltd Crystalline drug form
GB0129270D0 (en) * 2001-12-06 2002-01-23 Pfizer Ltd Pharmaceutical combination
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US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
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MXPA06013560A (en) * 2004-05-26 2007-03-15 Inotek Pharmaceuticals Corp Purine derivatives as adenosine a1.
JP5046930B2 (en) * 2004-08-02 2012-10-10 アデノシン・セラピューティクス・リミテッド・ライアビリティ・カンパニーAdenosine Therapeutics LLC 2-propynyladenosine analogs with modified 5'-ribose groups having A2A agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7442687B2 (en) * 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
EP1802316B1 (en) * 2004-09-20 2011-11-02 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
GT200500281A (en) 2004-10-22 2006-04-24 Novartis Ag organic compounds.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0500785D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
JP5006330B2 (en) 2005-10-21 2012-08-22 ノバルティス アーゲー Human antibodies against IL13 and therapeutic uses
CA2627319A1 (en) * 2005-11-30 2007-06-07 Prakash Jagtap Purine derivatives and methods of use thereof
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2007092936A2 (en) * 2006-02-08 2007-08-16 University Of Virginia Patent Foundation Method to treat gastric lesions
US8178509B2 (en) 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
GB0607950D0 (en) 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607951D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
US8258141B2 (en) * 2006-04-21 2012-09-04 Novartis Ag Organic compounds
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
AT502943T (en) 2006-09-29 2011-04-15 Novartis Ag Pyrazolopyrimidine as pi3k lipid kinase inhibitor
BRPI0718266A2 (en) 2006-10-30 2014-01-07 Novartis Ag Heterocyclic compounds as anti-inflammatory agents.
WO2008133129A1 (en) * 2007-04-16 2008-11-06 Santen Pharmaceutical Co., Ltd. Therapeutic agent for glaucoma comprising adenosine a2a receptor agonist as active ingredient
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
KR20100113557A (en) 2008-01-11 2010-10-21 노파르티스 아게 Pyrimidines as kinase inhibitors
AR075104A1 (en) 2008-12-18 2011-03-09 Lilly Co Eli Compound piperazin-aryl-purine, their use for preparing a medicament useful for treating pain and pharmaceutical composition comprising
US20110281917A1 (en) 2009-01-29 2011-11-17 Darrin Stuart Substituted Benzimidazoles for the Treatment of Astrocytomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
KR20120089643A (en) 2009-08-12 2012-08-13 노파르티스 아게 Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
PL2467141T3 (en) 2009-08-17 2019-04-30 Intellikine, Llc Heterocyclic compounds and uses thereof
EA201200318A1 (en) 2009-08-20 2012-09-28 Новартис Аг Heterocyclic oximes
CA2784908A1 (en) 2010-01-11 2011-07-14 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
EP2569325A4 (en) 2010-03-26 2013-10-09 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 - cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
JP2014505088A (en) 2011-02-10 2014-02-27 ノバルティス アーゲー [1,2,4] Triazolo [4,3-b] pyridazine compounds as C-MET tyrosine kinase inhibitors
JP5808826B2 (en) 2011-02-23 2015-11-10 インテリカイン, エルエルシー Heterocyclic compounds and uses thereof
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
EA026655B1 (en) 2011-09-15 2017-05-31 Новартис Аг 6-SUBSTITUTED 3-(QUINOLIN-6-YLTHIO)[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS c-Met TYROSINE KINASE INHIBITORS
WO2013078440A2 (en) 2011-11-23 2013-05-30 Intellikine, Llc Enhanced treatment regimens using mtor inhibitors
RS56150B1 (en) 2012-01-26 2017-11-30 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
WO2013149581A1 (en) 2012-04-03 2013-10-10 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
CN105246482A (en) 2013-03-15 2016-01-13 因特利凯有限责任公司 Combination of kinase inhibitors and uses thereof
AU2014239222A1 (en) 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation Ophthalmic formulations
TW201605450A (en) 2013-12-03 2016-02-16 Novartis Ag Mdm2 inhibitor combination of BRAF inhibitors and their use
MX2017001461A (en) 2014-07-31 2017-05-11 Novartis Ag Combination therapy.

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US5140015A (en) * 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5189027A (en) * 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
IT1254915B (en) * 1992-04-24 1995-10-11 Gloria Cristalli adenosine derivatives to attivita 'a2 agonist
DE69932173T2 (en) * 1998-10-16 2007-06-06 Pfizer Inc. adenine
GB9913932D0 (en) 1999-06-15 1999-08-18 Pfizer Ltd Purine derivatives
GB9924363D0 (en) 1999-10-14 1999-12-15 Pfizer Central Res Purine derivatives
GB9924361D0 (en) 1999-10-14 1999-12-15 Pfizer Ltd Purine derivatives

Also Published As

Publication number Publication date
JP2004508284A (en) 2004-03-18
IL150543D0 (en) 2003-02-12
EP1255764B1 (en) 2006-05-10
HRP20020676A2 (en) 2004-12-31
OA12177A (en) 2006-05-09
TNSN01028A1 (en) 2005-11-10
WO2001060835A8 (en) 2001-11-29
MA26873A1 (en) 2004-12-20
MXPA02008068A (en) 2004-04-05
KR20030036138A (en) 2003-05-09
US6525032B2 (en) 2003-02-25
EE200200452A (en) 2003-12-15
SV2002000317A (en) 2002-07-16
NZ519971A (en) 2004-04-30
NO20023894D0 (en) 2002-08-16
IS6458A (en) 2002-07-05
PA8511801A1 (en) 2002-02-21
HN2001000027A (en) 2001-09-11
PE20011122A1 (en) 2001-11-06
EA004987B1 (en) 2004-10-28
ZA200206526B (en) 2003-10-16
WO2001060835A1 (en) 2001-08-23
CR6722A (en) 2003-11-25
NO20023894L (en) 2002-10-01
GT200100027A (en) 2001-12-19
EA200200770A1 (en) 2002-12-26
HU0301055A2 (en) 2003-08-28
PL357220A1 (en) 2004-07-26
CN1400975A (en) 2003-03-05
AU3044001A (en) 2001-08-27
SK11692002A3 (en) 2003-11-04
EP1255764A1 (en) 2002-11-13
AP200202598A0 (en) 2002-09-30
EP1255764B8 (en) 2006-06-28
BR0108408A (en) 2002-11-26
US20010020089A1 (en) 2001-09-06
CO5271668A1 (en) 2003-04-30
CZ20022703A3 (en) 2003-09-17
CA2400619A1 (en) 2001-08-23
BG106906A (en) 2003-04-30
DE60119492T2 (en) 2006-11-09
DE60119492D1 (en) 2006-06-14
ES2260199T3 (en) 2006-11-01
AR027437A1 (en) 2003-03-26
GB0003960D0 (en) 2000-04-12

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties