AT312812T - Vanilloid analog resiniferatoxin- the pharmacophore containing as active vanilloid receptor agonists and analgesics, compositions and their use - Google Patents

Vanilloid analog resiniferatoxin- the pharmacophore containing as active vanilloid receptor agonists and analgesics, compositions and their use

Info

Publication number
AT312812T
AT312812T AT00905438T AT00905438T AT312812T AT 312812 T AT312812 T AT 312812T AT 00905438 T AT00905438 T AT 00905438T AT 00905438 T AT00905438 T AT 00905438T AT 312812 T AT312812 T AT 312812T
Authority
AT
Austria
Prior art keywords
vanilloid
resiniferatoxin
analgesics
analog
compositions
Prior art date
Application number
AT00905438T
Other languages
German (de)
Inventor
Jeewoo Lee
Uhtaek Oh
Young-Ger Suh
Hyeung-Geun Park
Hee-Doo Kim
Original Assignee
Pacific Corp
Digital Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR19990005751 priority Critical
Application filed by Pacific Corp, Digital Biotech Co Ltd filed Critical Pacific Corp
Priority to PCT/KR2000/000137 priority patent/WO2000050387A1/en
Publication of AT312812T publication Critical patent/AT312812T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/06Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
AT00905438T 1999-02-22 2000-02-21 Vanilloid analog resiniferatoxin- the pharmacophore containing as active vanilloid receptor agonists and analgesics, compositions and their use AT312812T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR19990005751 1999-02-22
PCT/KR2000/000137 WO2000050387A1 (en) 1999-02-22 2000-02-21 Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

Publications (1)

Publication Number Publication Date
AT312812T true AT312812T (en) 2005-12-15

Family

ID=36578904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00905438T AT312812T (en) 1999-02-22 2000-02-21 Vanilloid analog resiniferatoxin- the pharmacophore containing as active vanilloid receptor agonists and analgesics, compositions and their use

Country Status (12)

Country Link
US (1) US6476076B1 (en)
EP (1) EP1154989B1 (en)
JP (1) JP3727851B2 (en)
CN (1) CN1210254C (en)
AT (1) AT312812T (en)
AU (1) AU763824B2 (en)
CA (1) CA2363531C (en)
DE (1) DE60024785T2 (en)
ES (1) ES2253208T3 (en)
HK (1) HK1042472A1 (en)
MX (1) MXPA01008403A (en)
WO (1) WO2000050387A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3501775B2 (en) * 2000-05-31 2004-03-02 ファイザー株式会社 Vanilloid receptor-like protein
AU8066701A (en) * 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
DE60120421T2 (en) 2000-08-21 2006-12-28 Pacific Corp. New (thio) urea compounds and drug compositions containing them
CA2417507A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
CA2442049C (en) * 2001-03-22 2010-06-01 Michael J. Iadarola Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist
US20040146590A1 (en) 2001-03-22 2004-07-29 Iadarola Michael J Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin
EP1414788A1 (en) * 2001-07-31 2004-05-06 Bayer HealthCare AG Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists
PE04172003A1 (en) 2001-09-13 2003-08-06 Smithkline Beecham Plc Urea derivatives as vanilloid receptor antagonists
US6872748B2 (en) * 2001-09-27 2005-03-29 Digital Biotech Co., Ltd. Simplified resiniferatoxin analogues as vanilloid receptor agonist showing excellent analgesic activity and the pharmaceutical compositions containing the same
WO2003029199A1 (en) * 2001-09-28 2003-04-10 Takeda Chemical Industries, Ltd. Benzene derivatives, process for preparing the same and use thereof
JP2005513154A (en) * 2001-12-26 2005-05-12 バイエル・ヘルスケア・アクチェンゲゼルシャフトBayer HealthCare AG Urea derivatives
RS63204A (en) * 2002-01-17 2006-10-27 Neurogen Corporation Substituted quinazolin-4-ylamine analogues as modulators of capsaicin
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
DE60325834D1 (en) * 2002-02-20 2009-03-05 Abbott Lab Condensed azabicyclischeverbindungen as inhibitors of the vanilloid receptor 1 (VR1)
EP1506167B1 (en) 2002-05-08 2007-08-29 Bayer HealthCare AG Hydroxy tetrahydro-naphthalenylurea derivatives
DE10224107A1 (en) * 2002-05-29 2003-12-11 Gruenenthal Gmbh Combination of selected opioids with other drugs for the treatment of urinary incontinence
ES2291725T3 (en) 2002-12-06 2008-03-01 Xention Limited Derivatives tetrahydronaphthalene.
EP1572632B1 (en) 2002-12-09 2008-08-13 Xention Limited Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
EP1438942A1 (en) * 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
ES2293217T3 (en) 2003-02-12 2008-03-16 Bayer Healthcare Ag Hydroxy derivatives tetrahydro-naphthalenylurea-.
US20040202735A1 (en) * 2003-04-08 2004-10-14 Moore Bob M. Method and kit for controlling bleeding
EA012599B1 (en) 2003-04-10 2009-10-30 Ньюроджескс, Инк. Methods and compositions for administration of trpv1 agonists
KR100707123B1 (en) * 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 4-methylsulfonylaminophenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical composition containing the same
DE602004019294D1 (en) 2003-10-01 2009-03-19 Xention Ltd Tetrahydronaphthalene and urea derivatives
WO2005035471A1 (en) 2003-10-14 2005-04-21 Ajinomoto Co., Inc. Ether derivative
JP2007523888A (en) 2003-11-08 2007-08-23 バイエル・ヘルスケア・アクチェンゲゼルシャフトBayer HealthCare AG Tetrahydro - quinolinyl urea derivatives
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
MX2007011466A (en) * 2005-03-19 2008-01-16 Amorepacific Corp Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same.
EP1946132B1 (en) 2005-11-04 2010-04-14 Nxp B.V. Integrated circuit test method and test apparatus
CA2661898A1 (en) 2006-08-25 2008-02-28 Abbott Laboratories Indazole derivatives that inhibit trpv1 and uses thereof
EP2450346A1 (en) 2006-12-20 2012-05-09 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
EP2323989A4 (en) 2008-03-20 2011-06-22 Abbott Lab Methods for making central nervous system agents that are trpv1 antagonists
WO2010119877A1 (en) * 2009-04-13 2010-10-21 味の素株式会社 Process for production of amidine derivative
EP2629610B1 (en) 2010-07-27 2017-09-06 Flex Pharma, Inc. Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
EP2646107A2 (en) 2010-12-01 2013-10-09 Spinal Modulation Inc. Agent delivery systems for selective neuromodulation
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021450A (en) * 1989-05-30 1991-06-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof
US5431914A (en) * 1992-04-17 1995-07-11 Adekunle; Michael Method of treating an internal condition by external application of capsaicin without the need for systemic absorption

Also Published As

Publication number Publication date
AU763824B2 (en) 2003-07-31
DE60024785T2 (en) 2006-09-14
CN1210254C (en) 2005-07-13
DE60024785D1 (en) 2006-01-19
CA2363531C (en) 2007-07-31
EP1154989A1 (en) 2001-11-21
MXPA01008403A (en) 2003-06-06
CN1342138A (en) 2002-03-27
CA2363531A1 (en) 2000-08-31
EP1154989B1 (en) 2005-12-14
JP3727851B2 (en) 2005-12-21
AU2697600A (en) 2000-09-14
WO2000050387A1 (en) 2000-08-31
JP2002537373A (en) 2002-11-05
ES2253208T3 (en) 2006-06-01
HK1042472A1 (en) 2005-12-09
US6476076B1 (en) 2002-11-05

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties