AT311402T - Peptide nucleic acids with increased binding affinity, sequence specificity and solubility - Google Patents

Peptide nucleic acids with increased binding affinity, sequence specificity and solubility

Info

Publication number
AT311402T
AT311402T AT97935053T AT97935053T AT311402T AT 311402 T AT311402 T AT 311402T AT 97935053 T AT97935053 T AT 97935053T AT 97935053 T AT97935053 T AT 97935053T AT 311402 T AT311402 T AT 311402T
Authority
AT
Austria
Prior art keywords
solubility
nucleic acids
binding affinity
peptide nucleic
increased binding
Prior art date
Application number
AT97935053T
Other languages
German (de)
Inventor
Peter E Nielsen
Michael Egholm
Rolf H Berg
Ole Buchardt
Original Assignee
Buchardt Dorte
Nielsen Peter Eigil Prof Dr
Michael Egholm
Berg Rolf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US08/685,484 priority Critical patent/US5719262A/en
Priority to US08/686,116 priority patent/US5714331A/en
Priority to US08/686,113 priority patent/US5766855A/en
Priority to US08/686,114 priority patent/US6414112B1/en
Priority to US5100297P priority
Application filed by Buchardt Dorte, Nielsen Peter Eigil Prof Dr, Michael Egholm, Berg Rolf filed Critical Buchardt Dorte
Priority to PCT/US1997/012811 priority patent/WO1998003542A1/en
Publication of AT311402T publication Critical patent/AT311402T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003Peptide-nucleic acids (PNAs)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
AT97935053T 1991-05-24 1997-07-24 Peptide nucleic acids with increased binding affinity, sequence specificity and solubility AT311402T (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US08/685,484 US5719262A (en) 1993-11-22 1996-07-24 Peptide nucleic acids having amino acid side chains
US08/686,116 US5714331A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US08/686,113 US5766855A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity and sequence specificity
US08/686,114 US6414112B1 (en) 1991-05-24 1996-07-24 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US5100297P true 1997-05-29 1997-05-29
PCT/US1997/012811 WO1998003542A1 (en) 1996-07-24 1997-07-24 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

Publications (1)

Publication Number Publication Date
AT311402T true AT311402T (en) 2005-12-15

Family

ID=27535143

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97935053T AT311402T (en) 1991-05-24 1997-07-24 Peptide nucleic acids with increased binding affinity, sequence specificity and solubility

Country Status (7)

Country Link
EP (1) EP0960121B1 (en)
JP (2) JP3306073B2 (en)
AT (1) AT311402T (en)
AU (1) AU717387B2 (en)
CA (1) CA2261566A1 (en)
DE (2) DE69734783D1 (en)
WO (1) WO1998003542A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653646A1 (en) * 1996-12-20 1998-06-25 Hoechst Ag Substituted purine derivatives, processes for their preparation, to compositions comprising them and their use
US5985558A (en) * 1997-04-14 1999-11-16 Isis Pharmaceuticals Inc. Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US7892737B2 (en) 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
EP1954838B1 (en) 2005-11-14 2014-02-26 Life Technologies Corporation Coded molecules for detecting target analytes
WO2008005674A2 (en) 2006-06-30 2008-01-10 Applera Corporation Methods of analyzing binding interactions
DE102006034319A1 (en) 2006-07-21 2008-01-31 Ugichem Gmbh Chiral with Phosponsäurester- or phosphonic acid substituted compounds
US20100284959A1 (en) * 2008-01-23 2010-11-11 Gene Arrest Ltd. Sequence specific double-stranded dna/rna binding compounds and uses thereof
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
MX342945B (en) 2009-07-06 2016-10-18 Ontorii Inc * Novel nucleic acid prodrugs and methods use thereof.
KR20140068884A (en) 2011-07-19 2014-06-09 웨이브 라이프 사이언시스 피티이. 리미티드 Methods for the synthesis of functionalized nucleic acids
KR101850319B1 (en) 2012-07-13 2018-04-20 웨이브 라이프 사이언시스 리미티드 Asymmetric auxiliary group
JP6246121B2 (en) 2012-07-13 2017-12-13 株式会社新日本科学 Chiral-nucleic acid adjuvants
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
KR101830700B1 (en) * 2013-11-11 2018-02-21 주식회사 파나진 Method for the detection of multiple target nucleic acids using clamping probes and detection probes
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
WO2015108047A1 (en) 2014-01-15 2015-07-23 株式会社新日本科学 Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
SG11201605782UA (en) 2014-01-16 2016-08-30 Wave Life Sciences Ltd Chiral design
DE102014007158A1 (en) * 2014-05-16 2015-11-19 Ugichem Gmbh New peptide nucleic acid monomers and oligomers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS200063B1 (en) * 1978-08-24 1980-08-29 Milan Strasak Method of preparing alkylene-n,n'-bis-histidines
JPH0577667B2 (en) * 1984-09-05 1993-10-27 Microbial Chem Res Found
AU5410786A (en) * 1985-03-04 1986-09-11 Fujisawa Pharmaceutical Co., Ltd. Amino acid derivatives and processes for preparation thereof
AT124999T (en) * 1985-03-15 1995-07-15 Antivirals Inc Immunotestmittel for polynucleotide and procedures.
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
DK51092D0 (en) * 1991-05-24 1992-04-15 Ole Buchardt The oligonucleotide analog designated PNA monomer synthons and process for their preparation and uses thereof
DE4408528A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag Peptide-oligonucleotide derivatives, their preparation and use
DE19532553A1 (en) * 1995-09-04 1997-03-06 Hoechst Ag Process for preparing substituted N-ethyl-glycine

Also Published As

Publication number Publication date
EP0960121A1 (en) 1999-12-01
EP0960121B1 (en) 2005-11-30
CA2261566A1 (en) 1998-01-29
DE69734783T2 (en) 2006-08-17
JP3306073B2 (en) 2002-07-24
JP2000503671A (en) 2000-03-28
DE69734783D1 (en) 2006-01-05
WO1998003542A1 (en) 1998-01-29
EP0960121A4 (en) 2003-05-28
JP2002105059A (en) 2002-04-10
AU717387B2 (en) 2000-03-23
AU3808197A (en) 1998-02-10

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties