AT300611T - Receptor based working screening procedures for protein interactions - Google Patents

Receptor based working screening procedures for protein interactions

Info

Publication number
AT300611T
AT300611T AT01960237T AT01960237T AT300611T AT 300611 T AT300611 T AT 300611T AT 01960237 T AT01960237 T AT 01960237T AT 01960237 T AT01960237 T AT 01960237T AT 300611 T AT300611 T AT 300611T
Authority
AT
Austria
Prior art keywords
protein interactions
screening procedures
receptor based
based working
working screening
Prior art date
Application number
AT01960237T
Other languages
German (de)
Inventor
Sven Eyckerman
Ostade Xaveer Van
Joel Vandekerckhove
Annick Verhee
Jan Tavernier
Original Assignee
Vlaams Interuniv Inst Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP00201771 priority Critical
Application filed by Vlaams Interuniv Inst Biotech filed Critical Vlaams Interuniv Inst Biotech
Priority to PCT/EP2001/005916 priority patent/WO2001090188A2/en
Publication of AT300611T publication Critical patent/AT300611T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1055Protein x Protein interaction, e.g. two hybrid selection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/90Fusion polypeptide containing a motif for post-translational modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/06Uses of viruses as vector in vitro
AT01960237T 2000-05-22 2001-05-22 Receptor based working screening procedures for protein interactions AT300611T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00201771 2000-05-22
PCT/EP2001/005916 WO2001090188A2 (en) 2000-05-22 2001-05-22 Receptor-based interaction trap

Publications (1)

Publication Number Publication Date
AT300611T true AT300611T (en) 2005-08-15

Family

ID=8171515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01960237T AT300611T (en) 2000-05-22 2001-05-22 Receptor based working screening procedures for protein interactions

Country Status (8)

Country Link
US (2) US7855270B2 (en)
EP (2) EP1283878B1 (en)
JP (1) JP4756813B2 (en)
AT (1) AT300611T (en)
AU (2) AU2001281784B2 (en)
CA (1) CA2407872C (en)
DE (1) DE60112282T2 (en)
WO (1) WO2001090188A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60239097D1 (en) 2001-03-02 2011-03-17 Gpc Biotech Ag Three-hybrid assay system
AT539154T (en) 2001-07-03 2012-01-15 Vlaams Interuniv Inst Biotech Reversed mammals protein protein interaction trap
GB201103453D0 (en) 2011-03-01 2011-04-13 Vib Vzw Kinase substrate sensor
US9746470B2 (en) * 2011-05-09 2017-08-29 Whitehead Institute For Biomedical Research Chaperone interaction assays and uses thereof
CA2866097A1 (en) 2012-03-06 2013-09-12 Vib Vzw Membrane span-kinase fusion protein and the uses thereof
US10444245B2 (en) 2012-05-24 2019-10-15 Vib Vzw Trapping mammalian protein-protein complexes in virus-like particles utilizing HIV-1 GAG-bait fusion proteins
GB201504859D0 (en) 2015-03-23 2015-05-06 Vib Vzw Viral particle based small molecule-protein interaction trap

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EP1541682A3 (en) 1988-09-02 2005-07-06 Dyax Corp. Generation and selection of recombinant varied binding proteins
ES2139598T3 (en) 1990-07-10 2000-02-16 Medical Res Council Procedures for producing members of specific binding partners.
CN1119876A (en) 1993-02-12 1996-04-03 莱兰斯坦福初级大学评议会 Regulated transcription of targeted genes and other biological events
US5521066A (en) * 1993-09-13 1996-05-28 Bristol-Myers Squibb Company Periplasmic membrane-bound system for detecting protein-protein interactions
US5935797A (en) * 1994-06-16 1999-08-10 Stanford University Interaction of MHC Class II proteins with members of the PCNA family of proteins
US5716622A (en) * 1995-01-06 1998-02-10 The Rockefeller University Functionally active regions of signal transducer and activators of transcription
US5712149A (en) * 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US5637463A (en) 1995-05-04 1997-06-10 Hoffmann-La Roche Inc. Method to detect protein-protein interactions
GB9511935D0 (en) 1995-06-13 1995-08-09 Smithkline Beecham Plc Novel compound
SE9503151D0 (en) 1995-09-13 1995-09-13 Bioinvent Internatioal Ab Combined ligand and receptor display
US5972621A (en) * 1995-11-27 1999-10-26 Millennium Pharmaceuticals, Inc. Methods of identifying compounds that modulate body weight using the OB receptor
AU1406497A (en) 1995-12-06 1997-06-27 Schering Corporation Mutational variants of mammalian ob gene proteins
US7063958B1 (en) 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
CA2246300A1 (en) * 1996-02-23 1997-08-28 Ariad Pharmaceuticals, Inc. Cell-based assay
WO1997032017A1 (en) 1996-02-26 1997-09-04 Morphosys Gesellschaft Für Proteinoptimierung Mbh Novel method for the identification of nucleic acid sequences encoding two or more interacting (poly)peptides
TR199802534T2 (en) 1996-06-06 1999-03-22 Smithkline Beecham P.L.C. Leptin (OB protein) fragments
US6001816A (en) * 1996-06-20 1999-12-14 Merck & Co., Inc. Gene therapy for leptin deficiency
US5843697A (en) * 1996-07-17 1998-12-01 University Of Medicine And Dentistry Of New Jersey Cells expressing IL-10 receptor and the CRFB4 gene product, an IL-10 receptor accessory protein
US5776689A (en) 1996-07-19 1998-07-07 The Regents Of The University Of California Protein recruitment system
HU9904023A3 (en) 1996-09-20 2002-01-28 Hoechst Ag Use of leptin antagonists for treating insulin resistance in type ii diabetes
WO1998020158A1 (en) 1996-11-01 1998-05-14 Smithkline Beecham Plc Method for the detection of compounds that modulate the effects of the obese (ob) protein
AU5143099A (en) * 1998-07-30 2000-02-21 Universite De Montreal Protein fragment complementation assays for the detection of biological or drug interactions
CA2196496A1 (en) * 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US6294330B1 (en) * 1997-01-31 2001-09-25 Odyssey Pharmaceuticals Inc. Protein fragment complementation assays for the detection of biological or drug interactions
US6342345B1 (en) * 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
AU8405998A (en) * 1997-07-15 1999-02-10 Aurora Biosciences Corporation Compositions and methods for identifying modulators of transducisomes, a ew class of therapeutic targets
US5885779A (en) * 1997-09-09 1999-03-23 University Of British Columbia Repressed trans-activator system for characterization of protein-protein interactions
WO1999040946A2 (en) 1998-02-11 1999-08-19 Beth Israel Deaconess Medical Center Methods and compositions for modulating leptin activity
CA2335107C (en) 1998-07-28 2010-01-19 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Leptin-mediated gene-induction
WO2000006722A1 (en) * 1998-07-28 2000-02-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Eukaryotic cell-based gene interaction cloning
AT394491T (en) * 2000-06-13 2008-05-15 Bayer Healthcare Ag Regulation of a human transmembrane serine protease
DE60130686T2 (en) 2000-11-14 2008-06-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Functional fragment of leptin receptor
BR0207018A (en) 2001-02-06 2004-02-03 Merck Patent Gmbh Modified leptin with reduced immunogenicity
EP1812038A1 (en) * 2004-11-18 2007-08-01 VIB vzw Fibronectin iii domain as leptin receptor antagonists

Also Published As

Publication number Publication date
CA2407872A1 (en) 2001-11-29
US20100173408A1 (en) 2010-07-08
DE60112282D1 (en) 2005-09-01
US8003757B2 (en) 2011-08-23
DE60112282T2 (en) 2006-04-20
JP4756813B2 (en) 2011-08-24
AU2001281784B2 (en) 2005-09-15
US7855270B2 (en) 2010-12-21
WO2001090188A3 (en) 2002-06-13
WO2001090188A9 (en) 2002-09-19
EP1612221A3 (en) 2008-07-23
EP1612221A2 (en) 2006-01-04
WO2001090188A2 (en) 2001-11-29
US20030100021A1 (en) 2003-05-29
JP2003533998A (en) 2003-11-18
AU8178401A (en) 2001-12-03
EP1283878A2 (en) 2003-02-19
CA2407872C (en) 2013-11-12
EP1283878B1 (en) 2005-07-27

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