AT297946T - Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease - Google Patents

Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease

Info

Publication number
AT297946T
AT297946T AT01924516T AT01924516T AT297946T AT 297946 T AT297946 T AT 297946T AT 01924516 T AT01924516 T AT 01924516T AT 01924516 T AT01924516 T AT 01924516T AT 297946 T AT297946 T AT 297946T
Authority
AT
Austria
Prior art keywords
inhibitors
serine proteases
ns3 protease
virus ns3
particularly hepatitis
Prior art date
Application number
AT01924516T
Other languages
German (de)
Inventor
Robert Perni
John Court
Ethan O'malley
Govinda Rao Bhisetti
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US19456300P priority Critical
Priority to US19833000P priority
Application filed by Vertex Pharma filed Critical Vertex Pharma
Priority to PCT/US2001/010367 priority patent/WO2001074768A2/en
Publication of AT297946T publication Critical patent/AT297946T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
AT01924516T 2000-04-03 2001-03-29 Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease AT297946T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US19456300P true 2000-04-03 2000-04-03
US19833000P true 2000-04-18 2000-04-18
PCT/US2001/010367 WO2001074768A2 (en) 2000-04-03 2001-03-29 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (1)

Publication Number Publication Date
AT297946T true AT297946T (en) 2005-07-15

Family

ID=26890159

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01924516T AT297946T (en) 2000-04-03 2001-03-29 Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease

Country Status (11)

Country Link
US (1) US7494988B2 (en)
EP (1) EP1268519B1 (en)
JP (1) JP4806154B2 (en)
AT (1) AT297946T (en)
AU (1) AU5116501A (en)
CA (1) CA2405043A1 (en)
DE (1) DE60111509T2 (en)
ES (1) ES2240446T3 (en)
IL (2) IL152022D0 (en)
PT (1) PT1268519E (en)
WO (1) WO2001074768A2 (en)

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PE13502001A1 (en) 2000-05-19 2002-01-15 Vertex Pharma Prodrug CONVERTING ENZYME INHIBITOR A INTERLEUKIN-1ß (ICE)
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Family Cites Families (15)

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US6900238B1 (en) * 1995-12-07 2005-05-31 The Scripps Research Institute HIV protease inhibitors
IN183120B (en) * 1996-10-18 1999-09-11 Vertex Pharma Process for preparing inhibitors of serine proteases particularly hepatitis C virus ns3 proteases
AU3376699A (en) * 1998-03-31 1999-10-18 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
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WO2003006490A1 (en) * 2001-07-11 2003-01-23 Vertex Pharmaceuticals Incorporated Bridged bicyclic serine protease inhibitors
JP4460294B2 (en) * 2001-10-24 2010-05-12 ジョン・エイチ・バン・ドリーJohn H. Van Drie Incorporating a condensed ring system, serine proteases, especially c hepatitis ns3-NS4A protease inhibitors
TW200510391A (en) * 2003-04-11 2005-03-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
AU2004230946A1 (en) * 2003-04-11 2004-10-28 Vertex Pharmaceuticals, Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
NZ561851A (en) * 2002-04-11 2009-05-31 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis C virus NS3 - NS4 protease
CN1852920B (en) * 2003-07-18 2010-12-15 沃泰克斯药物股份有限公司 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
AR045596A1 (en) * 2003-09-05 2005-11-02 Vertex Pharma Serine protease inhibitors particularly NS3-NS4A protease of HCV
AU2004274468B2 (en) * 2003-09-18 2009-07-23 Vertex Pharmaceuticals, Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
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CA2554999A1 (en) * 2004-02-04 2005-08-25 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
AR055395A1 (en) * 2005-08-26 2007-08-22 Vertex Pharma Compounds activity inhibitors of serine NS3-NS4A protease of Hepatitis C virus

Also Published As

Publication number Publication date
US20030236242A1 (en) 2003-12-25
EP1268519A2 (en) 2003-01-02
AU5116501A (en) 2001-10-15
EP1268519B1 (en) 2005-06-15
WO2001074768A3 (en) 2002-06-06
PT1268519E (en) 2005-08-31
ES2240446T3 (en) 2005-10-16
JP2003529583A (en) 2003-10-07
DE60111509D1 (en) 2005-07-21
DE60111509T2 (en) 2006-05-11
JP4806154B2 (en) 2011-11-02
CA2405043A1 (en) 2001-10-11
IL152022D0 (en) 2003-04-10
IL152022A (en) 2008-07-08
US7494988B2 (en) 2009-02-24
WO2001074768A2 (en) 2001-10-11

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