AT265855T - 4- (2- (N - (- 2-carboxamidoindole) aminiethyl) - benzensulfonamide or sulfonylureas as PDGF antagoniste - Google Patents

4- (2- (N - (- 2-carboxamidoindole) aminiethyl) - benzensulfonamide or sulfonylureas as PDGF antagoniste

Info

Publication number
AT265855T
AT265855T AT96916719T AT96916719T AT265855T AT 265855 T AT265855 T AT 265855T AT 96916719 T AT96916719 T AT 96916719T AT 96916719 T AT96916719 T AT 96916719T AT 265855 T AT265855 T AT 265855T
Authority
AT
Austria
Prior art keywords
aminiethyl
carboxamidoindole
antagoniste
benzensulfonamide
sulfonylureas
Prior art date
Application number
AT96916719T
Other languages
German (de)
Inventor
Charles E Hart
Mark W Orme
Kristen M Moynihan
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US74395P priority Critical
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to PCT/US1996/007881 priority patent/WO1997002036A1/en
Publication of AT265855T publication Critical patent/AT265855T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/64Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
AT96916719T 1995-06-30 1996-05-29 4- (2- (N - (- 2-carboxamidoindole) aminiethyl) - benzensulfonamide or sulfonylureas as PDGF antagoniste AT265855T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US74395P true 1995-06-30 1995-06-30
PCT/US1996/007881 WO1997002036A1 (en) 1995-06-30 1996-05-29 4-(2-(n-2-carboxamidoindole)aminoethyl)-benzenesulfonamides or sulfonylureas as pdgf antagonists

Publications (1)

Publication Number Publication Date
AT265855T true AT265855T (en) 2004-05-15

Family

ID=21692834

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916719T AT265855T (en) 1995-06-30 1996-05-29 4- (2- (N - (- 2-carboxamidoindole) aminiethyl) - benzensulfonamide or sulfonylureas as PDGF antagoniste

Country Status (9)

Country Link
US (1) US5731326A (en)
EP (1) EP0835115B1 (en)
JP (1) JP3195363B2 (en)
AT (1) AT265855T (en)
AU (1) AU5938696A (en)
DE (2) DE69632402D1 (en)
DK (1) DK0835115T3 (en)
ES (1) ES2217313T3 (en)
WO (1) WO1997002036A1 (en)

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US8128963B2 (en) * 1996-09-27 2012-03-06 The Trustees Of Columbia University In The City Of New York Methods for treating ischemic disorders using carbon monoxide
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US8303609B2 (en) 2000-09-29 2012-11-06 Cordis Corporation Coated medical devices
US7678390B2 (en) * 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
SG147305A1 (en) * 2001-06-21 2008-11-28 Beth Israel Hospital Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
EP1480658B1 (en) * 2002-02-13 2017-01-25 Beth Israel Deaconess Medical Center, Inc. Methods of treating vascular disease
JP2005522521A (en) 2002-04-15 2005-07-28 ベス イスラエル デアコネス メディカル センター Using heme oxygenase-1 and heme degradation products
EP1499333B1 (en) * 2002-04-15 2015-06-24 University of Pittsburgh - Of the Commonwealth System of Higher Education Carbon monoxide for use in a method of treating ileus
JP4585765B2 (en) * 2002-04-15 2010-11-24 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション A method of treatment of necrotizing enterocolitis
MXPA04011426A (en) 2002-05-17 2005-10-19 Univ Yale Methods of treating hepatitis.
CN1674922A (en) * 2002-06-05 2005-09-28 耶鲁大学 Methods of treating angiogenesis, tumor growth, and metastasis
RS20050344A (en) * 2002-11-07 2007-11-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education, Treatment for hemorrhagic shock
CA2903196A1 (en) 2003-08-27 2005-03-10 Ophthotech Corporation Combination therapy for the treatment of ocular neovascular disorders
JP2009235057A (en) * 2007-10-31 2009-10-15 Santen Pharmaceut Co Ltd New indole derivative having anti-angiogenesis activity
WO2010099139A2 (en) 2009-02-25 2010-09-02 Osi Pharmaceuticals, Inc. Combination anti-cancer therapy
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
EP2401614A1 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670700B2 (en) * 1966-05-14 1978-06-22 Hoechst Ag, 6000 Frankfurt
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
CA2094858C (en) * 1992-04-28 2004-06-15 Robert D. Mitchell Method of treating hyperproliferative vascular disease
JP3465247B2 (en) * 1992-12-28 2003-11-10 アベンティス ファーマ株式会社 Arteriosclerosis prophylactic and therapeutic agent
US5976534A (en) * 1993-02-25 1999-11-02 Zymogenetics, Inc. Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin

Also Published As

Publication number Publication date
US5731326A (en) 1998-03-24
DE69632402T2 (en) 2005-05-19
DK835115T3 (en)
EP0835115B1 (en) 2004-05-06
JP2001502292A (en) 2001-02-20
ES2217313T3 (en) 2004-11-01
AU5938696A (en) 1997-02-05
DE69632402D1 (en) 2004-06-09
EP0835115A1 (en) 1998-04-15
JP3195363B2 (en) 2001-08-06
WO1997002036A1 (en) 1997-01-23
DK0835115T3 (en) 2004-08-02

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