AT265415T - 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their preparation - Google Patents

2-alkyl-5-halogen-pent-4-ene carboxylic acids and their preparation

Info

Publication number
AT265415T
AT265415T AT00940109T AT00940109T AT265415T AT 265415 T AT265415 T AT 265415T AT 00940109 T AT00940109 T AT 00940109T AT 00940109 T AT00940109 T AT 00940109T AT 265415 T AT265415 T AT 265415T
Authority
AT
Austria
Prior art keywords
pent
halogen
alkyl
preparation
carboxylic acids
Prior art date
Application number
AT00940109T
Other languages
German (de)
Inventor
Peter Herold
Stefan Stutz
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH140199 priority Critical
Priority to CH442000 priority
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Priority to PCT/CH2000/000385 priority patent/WO2001009079A1/en
Publication of AT265415T publication Critical patent/AT265415T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • C07C247/02Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64Acyl halides
    • C07C57/76Acyl halides containing halogen outside the carbonyl halide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62Halogen-containing esters
    • C07C69/65Halogen-containing esters of unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • C07D263/22Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
AT00940109T 1999-07-29 2000-07-13 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their preparation AT265415T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH140199 1999-07-29
CH442000 2000-01-11
PCT/CH2000/000385 WO2001009079A1 (en) 1999-07-29 2000-07-13 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their production

Publications (1)

Publication Number Publication Date
AT265415T true AT265415T (en) 2004-05-15

Family

ID=25687539

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00940108T AT406346T (en) 1999-07-29 2000-07-13 Preparation of n-substituted 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamides
AT00940109T AT265415T (en) 1999-07-29 2000-07-13 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00940108T AT406346T (en) 1999-07-29 2000-07-13 Preparation of n-substituted 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamides

Country Status (10)

Country Link
US (3) US6777574B1 (en)
EP (2) EP1200390B1 (en)
JP (2) JP4580606B2 (en)
AT (2) AT406346T (en)
AU (2) AU5518400A (en)
DE (2) DE50015330D1 (en)
DK (2) DK1200390T3 (en)
ES (2) ES2312346T3 (en)
PT (2) PT1200384E (en)
WO (2) WO2001009079A1 (en)

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CA2445014C (en) 2001-05-15 2011-10-11 Speedel Pharma Ag Process for the preparation of substituted carboxylic acid esters by enzymatic hydrolysis
AU2003238007A1 (en) * 2002-06-11 2003-12-22 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
ES2281675T5 (en) 2002-12-09 2015-01-22 Asahi Glass Company, Limited Process for producing an ester (4E) -5-chloro-2-isopropyl-4-pentenoate and an optically active isomer of this ester
EP1626093A1 (en) * 2004-08-11 2006-02-15 Dow Global Technologies Inc Process for the production of (S)-5-chloro-2-isopropylpent-4-enoic acid esters
JP2008536810A (en) * 2005-03-09 2008-09-11 ディーエスエム ファイン ケミカルズ オーストリア エヌエフジー ゲーエムベーハー ウント ツェーオー カーゲー Process for producing enantiopure E- (2S) -alkyl-5-halopent-4-enoic acid and ester
US20080171892A1 (en) * 2005-03-17 2008-07-17 Basf Aktiengesellschaft Method for Producing Optically Active 3-Phenylpropionic Acid Derivatives and Follow-On Products of the Latter
WO2006117057A1 (en) * 2005-05-02 2006-11-09 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for preparing enantiomerically enriched e-(2s)- and (2r)-alkyl-5-halopent-4-enecarboxylic acids or their esters
AT502257B1 (en) * 2005-07-25 2007-04-15 Dsm Fine Chem Austria Gmbh PROCESS FOR PREPARING RACEMIC ALKYL-5-HALOGEN-PENT-4-EN-CARBOXYLIC ACIDES BZW. carboxylic acid esters
DE102005042458A1 (en) * 2005-09-06 2007-03-22 Basf Ag Process for the preparation of 2-substituted carboxylic acids
WO2007036491A1 (en) * 2005-09-30 2007-04-05 Basf Aktiengesellschaft Method for the production of alpha-substituted carboxylic acids
GB0521083D0 (en) * 2005-10-17 2005-11-23 Novartis Ag Organic compounds
GB2431654A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431640A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (en) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Process for the preparation of chiral octenoic acid derivatives
CA2631409C (en) * 2005-12-16 2014-11-18 Asahi Glass Company, Limited Method for producing optically active (4e)-5-chloro-2-isopropyl-4-pentenoic acid or basic amino acid salt thereof
TW200837046A (en) * 2006-11-08 2008-09-16 Speedel Experimenta Ag Process for preparing organic compounds
EP1958666A1 (en) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
DE102007049039A1 (en) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Process for the preparation of 8-hydrazino-8-aryl-octanoyl derivatives and their use
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
PT2225200E (en) * 2007-12-24 2014-01-21 Dsm Ip Assets Bv Convergent synthesis of renin inhibitors and intermediates useful therein
WO2009143423A1 (en) * 2008-05-23 2009-11-26 Teva Pharmaceutical Industries Ltd. Aliskiren monofumarate and processes for preparation thereof
EP2189442B1 (en) 2008-11-20 2014-10-01 Krka Tovarna Zdravil, D.D., Novo Mesto Process and intermediates for the preparation of aliskiren
EA201190091A1 (en) 2009-02-05 2012-01-30 Крка, Товарна Здравил, Д. Д., Ново Место Activated moisture granulation method
WO2011051853A1 (en) 2009-10-29 2011-05-05 CarboDesign LLC Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren
CN101774986B (en) 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 Method for preparing aliskiren and intermediate thereof
TR201002256A1 (en) * 2010-03-24 2011-10-21 Sanovel İlaç Sanayi Ve Ticaret Anonim Şirketi Stable formulations of aliskiren
US20110268797A1 (en) 2010-04-30 2011-11-03 Sanovel IIac Sanayi Ve Ticaret Anonim Sirketi Multicoated aliskiren formulations
RS53772B1 (en) 2010-10-19 2015-06-30 Mylan Laboratories Limited Synthesis of aliskiren
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
WO2013121443A1 (en) 2012-02-17 2013-08-22 Mylan Laboratories Ltd. An improved process for the preparation of aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN103130677B (en) * 2013-03-12 2015-01-07 博瑞生物医药技术(苏州)有限公司 Preparation method of aliskiren
ES2683245T3 (en) * 2013-06-27 2018-09-25 Patheon Austria Gmbh & Co Kg Preparation of Grignard reagents using a fluidized bed
CN103351300A (en) * 2013-06-30 2013-10-16 北京万全德众医药生物技术有限公司 Preparation method of aliskiren intermediate side chain ((s)-methyl-2-bromoisovalerate)
CN105294478B (en) * 2014-07-01 2017-06-13 华润双鹤药业股份有限公司 A kind of diastereoisomer of aliskiren, Preparation Method And The Use

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CA2247580A1 (en) * 1997-10-03 1999-04-03 F. Hoffmann-La Roche Ag Process for preparing chiral succinic acid derivatives

Also Published As

Publication number Publication date
US7132569B2 (en) 2006-11-07
DK1200390T3 (en) 2008-12-01
AT406346T (en) 2008-09-15
US20060041169A1 (en) 2006-02-23
PT1200384E (en) 2004-09-30
DE50015330D1 (en) 2008-10-09
WO2001009083A1 (en) 2001-02-08
ES2218173T3 (en) 2004-11-16
EP1200390A1 (en) 2002-05-02
US6777574B1 (en) 2004-08-17
WO2001009079A1 (en) 2001-02-08
EP1200390B1 (en) 2008-08-27
DK1200384T3 (en) 2004-08-02
JP4580606B2 (en) 2010-11-17
ES2312346T3 (en) 2009-03-01
JP2003506347A (en) 2003-02-18
DE50006271D1 (en) 2004-06-03
PT1200390E (en) 2008-12-05
JP2003506345A (en) 2003-02-18
EP1200384B1 (en) 2004-04-28
EP1200384A1 (en) 2002-05-02
JP4922521B2 (en) 2012-04-25
AU5518400A (en) 2001-02-19
AU5518500A (en) 2001-02-19
US7009078B1 (en) 2006-03-07

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