AT260911T - Tri-substituted phenyl derivatives, to processes for their preparation and their use as phosphodiesterase (type IV) inhibitors - Google Patents

Tri-substituted phenyl derivatives, to processes for their preparation and their use as phosphodiesterase (type IV) inhibitors

Info

Publication number
AT260911T
AT260911T AT95903871T AT95903871T AT260911T AT 260911 T AT260911 T AT 260911T AT 95903871 T AT95903871 T AT 95903871T AT 95903871 T AT95903871 T AT 95903871T AT 260911 T AT260911 T AT 260911T
Authority
AT
Austria
Prior art keywords
phosphodiesterase
tri
inhibitors
processes
preparation
Prior art date
Application number
AT95903871T
Other languages
German (de)
Inventor
Graham John Warrellow
Ewan Campbell Boyd
Rikki Peter Alexander
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB939326179A priority Critical patent/GB9326179D0/en
Priority to GB9412598A priority patent/GB9412598D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Priority to PCT/GB1994/002784 priority patent/WO1995017399A1/en
Publication of AT260911T publication Critical patent/AT260911T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
AT95903871T 1993-12-22 1994-12-21 Tri-substituted phenyl derivatives, to processes for their preparation and their use as phosphodiesterase (type IV) inhibitors AT260911T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB939326179A GB9326179D0 (en) 1993-12-22 1993-12-22 Chemical compounds
GB9412598A GB9412598D0 (en) 1994-06-23 1994-06-23 Chemical compounds
PCT/GB1994/002784 WO1995017399A1 (en) 1993-12-22 1994-12-21 Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors

Publications (1)

Publication Number Publication Date
AT260911T true AT260911T (en) 2004-03-15

Family

ID=26304071

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95903871T AT260911T (en) 1993-12-22 1994-12-21 Tri-substituted phenyl derivatives, to processes for their preparation and their use as phosphodiesterase (type IV) inhibitors

Country Status (6)

Country Link
US (1) US5866593A (en)
EP (1) EP0738268B1 (en)
JP (1) JP3806144B2 (en)
AT (1) AT260911T (en)
DE (2) DE69433594T2 (en)
WO (1) WO1995017399A1 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412573D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
EP0946523A1 (en) 1996-12-23 1999-10-06 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
CN1202865C (en) 1999-08-21 2005-05-25 奥坦纳医药公司 Synergistic combination
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
US6399636B2 (en) * 2000-03-23 2002-06-04 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
AU2001261962B2 (en) 2000-05-25 2005-04-21 Merck Frosst Canada Ltd Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en) 2000-12-20 2004-05-25 Merck & Co., Inc. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
US7205320B2 (en) * 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US6699890B2 (en) 2000-12-22 2004-03-02 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
DE10064997A1 (en) 2000-12-23 2002-06-27 Merck Patent Gmbh New 1-benzoyl-3-phenyl-tetrahydropyridazine derivatives, useful for treating e.g. allergy, are selective inhibitors of phosphodiesterase IV, and new intermediates
US7153871B2 (en) * 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
DE60205899T2 (en) 2001-05-24 2006-06-29 Merck Frosst Canada & Co, Kirkland 1-biaryl-1,8-naphthyridin-4-one as phosphodieseterase inhibitors
RU2330024C2 (en) * 2001-05-29 2008-07-27 Шеринг Акциенгезельшафт Inhibitin cdk-kinases pyrimidines and their application as medicines
JO2311B1 (en) 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyne-aryl phosphodiesterase-4 inhibitors
NZ537724A (en) 2002-07-19 2006-10-27 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
JP2006502995A (en) * 2002-07-19 2006-01-26 メモリー・ファーマシューティカルズ・コーポレイションMemory Pharmaceuticals Corporation 6-amino-1H-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
RU2356893C2 (en) * 2002-11-19 2009-05-27 Мемори Фармасьютиклз Корпорейшн Phosphodiesterase 4 inhibitors
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MXPA05010373A (en) 2003-04-01 2005-12-05 Applied Research Systems Inhibitors of phosphodiesterases in infertility.
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
WO2005100291A2 (en) 2004-04-08 2005-10-27 Wyeth Method for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
WO2007104035A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2026813A2 (en) * 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008030651A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008036678A2 (en) * 2006-09-19 2008-03-27 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2627848T3 (en) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (en) 2011-03-01 2018-10-19 辛纳吉制药公司 The method for preparing guanosine cyclic mono-phosphate agonist
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EA201592263A1 (en) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ultrascular agonists of guanylacyclase c, method of their receiving and using
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2257272B1 (en) * 1974-01-15 1978-08-25 Pharmascience Labo
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
DE2413935C2 (en) * 1974-03-20 1988-05-26 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De
DE2541855A1 (en) * 1975-09-18 1977-03-31 Schering Ag 4- (polyalkoxy-phenyl) -2-pyrrolidone ii
SU888821A3 (en) * 1976-12-03 1981-12-07 Шеринг Аг (Инофирма) Method of preparing 5-(substituted phehyl)-oxazolidinones or their sulphur-containing analogs
DE2962383D1 (en) * 1978-06-15 1982-05-06 Ici Plc Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture
IT1161221B (en) * 1983-04-21 1987-03-18 Ripharm Srl Compound for the treatment of psoriasis
US4876252A (en) * 1986-01-13 1989-10-24 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
AT135699T (en) * 1986-01-13 1996-04-15 American Cyanamid Co 4,5,6-substituted-2-pyrimidinamine
US4788195A (en) * 1986-01-13 1988-11-29 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
HU215433B (en) * 1986-04-29 2000-05-28 Pfizer Inc. A process for new 2-oxo-5-phenyl-pyrimidine derivatives
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4921862A (en) * 1986-05-29 1990-05-01 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
US5274002A (en) * 1987-04-14 1993-12-28 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
ES2058332T3 (en) * 1987-06-11 1994-11-01 Ciba Geigy Ag Microbicides.
US5128358A (en) * 1988-01-19 1992-07-07 Pfizer Inc. Aryl substituted nitrogen heterocyclic antidepressants
US4966622A (en) * 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
US4897396A (en) * 1988-06-03 1990-01-30 Ciba-Geigy Corporation 2-phenylamino pyrimidine derivatives and their uses as microbicides
WO1990012789A1 (en) * 1989-04-17 1990-11-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel arylpyridazines, their manufacture, use and medicaments containing them
JPH0377923A (en) * 1989-08-18 1991-04-03 Sekisui Chem Co Ltd Organic nonlinear optical material
JPH075572B2 (en) * 1989-08-18 1995-01-25 積水化学工業株式会社 2- [2- (2-hydroxyphenyl) vinyl pyrazine and their preparation
DE4003919A1 (en) * 1990-02-09 1991-08-14 Basf Ag Heteroarylalkene, process and intermediates for their production and their use
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
WO1991016892A1 (en) * 1990-04-27 1991-11-14 Rorer International (Holdings), Inc. Styryl compounds which inhibit egf receptor protein tyrosine kinase
WO1992000968A1 (en) * 1990-07-10 1992-01-23 Smithkline Beecham Corporation Oxamides
US5124455A (en) * 1990-08-08 1992-06-23 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
JPH06501254A (en) * 1990-09-28 1994-02-10
AT168101T (en) * 1990-10-16 1998-07-15 Byk Gulden Lomberg Chem Fab Arylpyridazinone
IE913855A1 (en) * 1990-11-06 1992-05-22 Smithkline Beecham Corp Imidazolidinone compounds
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
IE71647B1 (en) * 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
EP0581805A1 (en) * 1991-04-26 1994-02-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyridazines
US5191084A (en) * 1991-05-01 1993-03-02 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
PT100441A (en) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinones, its preparation process, pharmaceutical compositions that contain them and use
EP0540165A1 (en) * 1991-10-03 1993-05-05 Zeneca Limited Alkanoic acid derivatives
CA2080554A1 (en) * 1991-10-15 1993-04-16 Mitsubishi Chemical Corporation Styrene derivatives
DE4136921A1 (en) * 1991-11-11 1993-05-13 Knoll Ag A process for the separation of 5-methyl-tetrahydrofolic acid
US5326898A (en) * 1992-02-11 1994-07-05 Allergan, Inc. Substituted phenylethenyl compounds having retinoid-like biological activity
JP3195353B2 (en) * 1992-04-02 2001-08-06 スミスクライン・ビーチャム・コーポレイション Compounds useful in the production inhibition of treatment and tumor necrosis factor of inflammatory diseases
TW225528B (en) * 1992-04-03 1994-06-21 Ciba Geigy Ag
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
GB9212673D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds
GB9212693D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds
CA2140441C (en) * 1992-07-28 2006-11-21 Garry Fenton Inhibitors of c-amp phosphodiesterase and tnf
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
NZ257955A (en) * 1992-12-02 1996-05-28 Pfizer Catechol diethers pharmaceutical compositions
BR9307664A (en) * 1992-12-17 1999-06-29 Pfizer Substituted pyrazoles as antagonists
US5622977A (en) * 1992-12-23 1997-04-22 Celltech Therapeutics Limited Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
TW263495B (en) * 1992-12-23 1995-11-21 Celltech Ltd
GB9226830D0 (en) * 1992-12-23 1993-02-17 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
EP0672035A1 (en) * 1993-10-01 1995-09-20 Novartis AG Pyrimidineamine derivatives and processes for the preparation thereof
PT672041E (en) * 1993-10-01 2002-04-29 Novartis Ag Pharmacologically active pyridine derivatives and processes for their preparation
PT672042E (en) * 1993-10-01 2006-08-31 Novartis Ag Pharmacologically active pyrimidineamine derivatives and processes for their preparation
US5543520A (en) * 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process
US5559137A (en) * 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
KR100263429B1 (en) * 1994-06-06 2000-08-01 디. 제이. 우드 Substituted pyrazoles having corticotropin-releasingfactor(crf) antagonist activity
US6245774B1 (en) * 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412672D0 (en) * 1994-06-23 1994-08-10 Celltech Ltd Chemical compounds
DE69532817T2 (en) * 1994-11-10 2005-01-13 Millenium Pharmaceuticals, Inc., Cambridge Use of pyrazole compounds for the treatment of glomerulonephritis, cancer, atherosclerosis or restenosis
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
US5776699A (en) * 1995-09-01 1998-07-07 Allergan, Inc. Method of identifying negative hormone and/or antagonist activities

Also Published As

Publication number Publication date
JPH09506893A (en) 1997-07-08
EP0738268A1 (en) 1996-10-23
JP3806144B2 (en) 2006-08-09
US5866593A (en) 1999-02-02
DE69433594D1 (en) 2004-04-08
WO1995017399A1 (en) 1995-06-29
EP0738268B1 (en) 2004-03-03
DE69433594T2 (en) 2004-08-05

Similar Documents

Publication Publication Date Title
DE10399006I2 (en) Tetracyclic derivatives, to processes for their preparation and their use.
DE68929520D1 (en) Quinoline derivatives as leukotriene D4 antagonists, compositions containing them and processes for their preparation
DE59010323D1 (en) Organophosphate, to processes for their preparation and their use as dispersants
AT135706T (en) Erythromycin derivatives, their process for manufacture and their use as pharmaceuticals
DE69321589D1 (en) Hydroxypropyl-substituted 2-nitro-p-phenylenediamines, processes for their preparation and their use as colorants of keratin fibers
DE69425671T2 (en) Glucosamine disaccharide, process for their preparation, pharmaceutical compositions thereof, and their use
DE69210067D1 (en) Hydraxamsäurederivate, processes for their preparation and their use
DE69531749D1 (en) Nucleoside monophosphate derivatives, processes for their preparation and their use as immunosuppressive drugs
DE69622992D1 (en) Substituted heterocyclic compounds, methods for their preparation and pharmaceutical compositions containing them
DE69310396T2 (en) Photocurable glycosaminoglycan derivatives of cross-linked glycosaminoglycans and to processes for their preparation
AT218141T (en) Erythromycin derivatives, methods for their manufacture and their use as medicines
DE69129606D1 (en) N-substituted heterocyclic derivatives, processes for their preparation, compositions containing them
AT135709T (en) Erythromycin derivatives, their process for manufacture and their use as pharmaceuticals
AT96787T (en) Substituted pyrimidine derivatives, processes for their manufacture and their use as tool.
DE10299016I1 (en) Pyrimidine derivatives and processes for their preparation
DE59406637D1 (en) nor-bile acid derivatives, processes for their preparation and use of these compounds as medicaments
DE10299041I1 (en) Carboxy substituted phenyl group containing carbapenems processes for their preparation intermediates and use as antibiotics
DE69232060T2 (en) Nitrogen-containing bicyclic compounds, processes for their preparation, their use as medicaments and compositions containing
AT228352T (en) Particulate synthetic support, as well as processes for their preparation
DE59309902D1 (en) Azachinoxaline, processes for their preparation and their use
AT208779T (en) Substituted spiroheterocyclic 1 H-3-aryl-pyrrolidine-2,4-dione derivatives, processes for their preparation and their use as pesticides
DE69405497T2 (en) Styryl derivatives, their preparation and use as inhibitors of PDE IV
DE69020918T2 (en) Decahydroisoquinolin derivatives, processes for their preparation and their use as medicaments.
DE69820552D1 (en) 4,4-dihydroxy-5-one derivatives, processes for their preparation and use as cosmetics
AT228499T (en) Benzamide derivatives, intermediates and processes for their preparation and their use as fungicides

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties