AT255093T - Benzamide compound and their medical use - Google Patents

Benzamide compound and their medical use

Info

Publication number
AT255093T
AT255093T AT95915333T AT95915333T AT255093T AT 255093 T AT255093 T AT 255093T AT 95915333 T AT95915333 T AT 95915333T AT 95915333 T AT95915333 T AT 95915333T AT 255093 T AT255093 T AT 255093T
Authority
AT
Austria
Prior art keywords
medical use
benzamide compound
benzamide
compound
medical
Prior art date
Application number
AT95915333T
Other languages
German (de)
Inventor
Masafumi Arita
Tadamasa Saitoh
Masanori Minoguchi
Keiji Yamagami
Hiroyuki Satoh
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP7828094 priority Critical
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Priority to PCT/JP1995/000747 priority patent/WO1995028387A1/en
Publication of AT255093T publication Critical patent/AT255093T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulfur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulfur or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
AT95915333T 1994-04-18 1995-04-17 Benzamide compound and their medical use AT255093T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP7828094 1994-04-18
PCT/JP1995/000747 WO1995028387A1 (en) 1994-04-18 1995-04-17 Benzamide compound and medicinal use thereof

Publications (1)

Publication Number Publication Date
AT255093T true AT255093T (en) 2003-12-15

Family

ID=13657559

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95915333T AT255093T (en) 1994-04-18 1995-04-17 Benzamide compound and their medical use

Country Status (7)

Country Link
US (2) US5958944A (en)
EP (3) EP1195372A1 (en)
AT (1) AT255093T (en)
CA (1) CA2188164C (en)
DE (2) DE69532195D1 (en)
ES (2) ES2388917T3 (en)
WO (1) WO1995028387A1 (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE9900050A (en) * 1996-08-12 1999-08-16 Yoshitomi Pharmaceutical Industries, Ltd. A pharmaceutical agent containing a Rho kinase inhibitor
JP4783774B2 (en) * 1996-08-12 2011-09-28 田辺三菱製薬株式会社 Medicament containing Rho kinase inhibitor
ES2372572T3 (en) 1998-08-17 2012-01-23 Mitsubishi Tanabe Pharma Corporation Agent for profilaxis and treatment of glaucoma.
US6316503B1 (en) * 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
CA2369552A1 (en) * 1999-04-22 2000-11-02 Hisashi Kai Agent for prophylaxis and treatment of angiostenosis
ES2365692T3 (en) 1999-04-27 2011-10-10 Mitsubishi Tanabe Pharma Corporation Medicinal for the prevention or therapeutic treatment of hepatic diseases.
JP2003506388A (en) * 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド Methods for treating or preventing pain and anxiety
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
JP2003531856A (en) * 2000-05-02 2003-10-28 スミスクライン・ビーチャム・コーポレイション Phosphate transport inhibitors
CA2422488A1 (en) 2000-09-20 2002-03-28 Merck Patent Gesellschaft Mit Beschraenkter Haftung 4-amino-quinazolines
CA2422560A1 (en) * 2000-09-20 2002-03-28 Merck Patent Gesellschaft Mit Beschraenkter Haftung 4-amino-quinazolines
US7829566B2 (en) * 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6995162B2 (en) * 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US20030134836A1 (en) * 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US7105682B2 (en) * 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
PE20021011A1 (en) * 2001-03-23 2003-02-01 Bayer Corp Quinazolinicos derivatives as inhibitors of rho kinase
TWI336328B (en) * 2001-03-23 2011-01-21 Bayer Healthcare Llc Rho-kinase inhibitors
JP4204326B2 (en) * 2001-04-11 2009-01-07 千寿製薬株式会社 Visual function disorder improving agent
DE60227794D1 (en) * 2001-04-26 2008-09-04 Eisai R&D Man Co Ltd Nitrogenic compound with condensed ring and pyrazolyl group as a substituent and medical composition thereof
CA2472619A1 (en) * 2002-01-10 2003-07-24 Bayer Corporation Fused pyrimidine derivates as rho-kinase inhibitors
JP4423043B2 (en) * 2002-01-23 2010-03-03 バイエル ファーマセチカル コーポレーション Rho-kinase inhibitor
MXPA04007191A (en) * 2002-01-23 2005-03-31 Bayer Pharmaceuticals Corp Pyrimidine derivatives as rho-kinase inhibitors.
WO2003063796A2 (en) * 2002-01-30 2003-08-07 Tularik Inc. Heterocyclic arylsulfonamidobenzylic compounds
CA2474433A1 (en) * 2002-01-30 2003-08-07 Tularik Inc. Arylsulfonamidobenzylic compounds
US20040028716A1 (en) * 2002-06-14 2004-02-12 Marks Andrew R. Use of Y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation
EP1539693B9 (en) 2002-06-19 2008-10-08 Schering Corporation Cannabinoid receptor agonists
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
JP4314433B2 (en) 2002-11-18 2009-08-19 参天製薬株式会社 Glaucoma treatment agent comprising Rho kinase inhibitor and β-blocker
US6861422B2 (en) * 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
MXPA06001566A (en) * 2003-08-12 2006-05-15 Amgen Inc Arylsulfonamidobenzylic compounds.
EP1696920B8 (en) 2003-12-19 2015-05-06 Plexxikon Inc. Compounds and methods for development of ret modulators
GB0403635D0 (en) * 2004-02-18 2004-03-24 Devgen Nv Pyridinocarboxamides with improved activity as kinase inhibitors
CN1795196B (en) * 2004-06-03 2013-07-24 千寿制药株式会社 Use of amide in preparing compound agent for repairing corneal sensitivity
DE102004033670A1 (en) * 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg New pyridodihydropyrazinone, process for its preparation and its use as a medicament
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US7728134B2 (en) * 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US7759485B2 (en) * 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
DE102004058337A1 (en) 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the preparation of fused piperazin-2-one derivatives
WO2007006546A1 (en) * 2005-07-11 2007-01-18 Devgen N.V. Amide derivatives as kinase inhibitors
WO2007042321A2 (en) * 2005-10-13 2007-04-19 Devgen N.V. Kinase inhibitors
US8247556B2 (en) * 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
BRPI0714782A2 (en) 2006-07-31 2013-07-16 Senju Pharma Co aqueous liquid preparation containing amide compound
US8063082B2 (en) * 2006-08-02 2011-11-22 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
US8071625B2 (en) * 2006-08-02 2011-12-06 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
WO2008049000A2 (en) * 2006-10-18 2008-04-24 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008070823A2 (en) * 2006-12-07 2008-06-12 University Of South Florida Substrate-mimetic akt inhibitor
EP2170830B1 (en) 2007-07-17 2014-10-15 Plexxikon, Inc. 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS
EP2185559A1 (en) * 2007-08-03 2010-05-19 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative
US8088793B2 (en) 2007-08-15 2012-01-03 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
PL2414356T3 (en) 2009-04-03 2016-02-29 Hoffmann La Roche Propane-i-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof
TW201103904A (en) * 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
GB0914726D0 (en) * 2009-08-24 2009-09-30 Univ Manchester Kinase inhibitors
NZ599866A (en) 2009-11-06 2014-09-26 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2011080984A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
PT2672967T (en) 2011-02-07 2018-12-07 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
TWI558702B (en) 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
US20150044178A1 (en) 2011-12-28 2015-02-12 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US20150031699A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
WO2015016371A1 (en) 2013-07-30 2015-02-05 京都府公立大学法人 Corneal endothelial cell marker
CA2927898A1 (en) 2013-10-31 2015-05-07 Kyoto Prefectural Public University Corporation Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium
JP6470286B2 (en) 2013-11-27 2019-02-13 京都府公立大学法人 Application of laminin to corneal endothelial cell culture
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
JP2019510509A (en) 2016-02-15 2019-04-18 京都府公立大学法人 Human functional corneal endothelial cells and their applications

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2520896A1 (en) * 1975-05-10 1976-11-25 Basf Ag Azo pigments of the beta-hydroxynaphthoesaeurereihe
ES438120A1 (en) * 1975-06-02 1977-02-01 Gallardo Antonio Sa Process for the preparation of aromatic amides.
US4093734A (en) * 1975-11-03 1978-06-06 Boehringer Ingelheim Gmbh Amino-benzoic acid amides
ES456989A1 (en) 1977-03-18 1978-07-16 Lafarquim Procedure for obtaining a derivative of 4-aminopiridinay salts.
IT1126509B (en) * 1979-12-07 1986-05-21 Medea Res Srl Benzimidi to attivita 'local anesthetic and antiarrhythmic, process for their preparation and pharmaceutical compositions containing them
EP0208621B1 (en) * 1985-07-11 1989-04-12 Rhone-Poulenc Sante Substituted amides, their preparation and compositions containing them
JPS6229566A (en) * 1985-07-30 1987-02-07 Taiyo Yakuhin Kogyo Kk Novel guanidinomthylbenzoic acid derivative
JPS6290657A (en) * 1985-10-17 1987-04-25 Fuji Photo Film Co Ltd Production of two equivalent coupler monomer
JPS62158253A (en) * 1985-12-28 1987-07-14 Kirin Brewery Co Ltd 4-aminopyridinamide derivative
JPS62158252A (en) * 1985-12-28 1987-07-14 Kirin Brewery Co Ltd 4-aminopyridinebenzamide derivative
FR2592882B2 (en) * 1986-01-16 1988-03-11 Rhone Poulenc Sante New substituted amides, their preparation and medicines containing them
JPS63126860A (en) * 1986-11-17 1988-05-30 Nippon Haipotsukusu:Kk Guanidinomethylbenzoic acid derivative
JPS63277622A (en) * 1986-12-17 1988-11-15 Glaxo Group Ltd Medicine
EP0303445A1 (en) * 1987-08-13 1989-02-15 Walton S.A. Clebopride transdermal patch
DE3804346A1 (en) * 1988-02-12 1989-08-24 Boehringer Mannheim Gmbh tert-Butylphenylpyridyl amides, process for their preparation, and medicaments containing these compounds
US4948891A (en) * 1988-05-24 1990-08-14 Pfizer Inc. Benzamide protease inhibitors
WO1990005723A1 (en) * 1988-11-24 1990-05-31 Yoshitomi Pharmaceutical Industries, Ltd. Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use
EP0641781B1 (en) * 1991-09-06 2000-07-26 Yoshitomi Pharmaceutical Industries, Ltd. 4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof

Also Published As

Publication number Publication date
CA2188164A1 (en) 1995-10-26
EP0757038B1 (en) 2003-11-26
US5958944A (en) 1999-09-28
DE69532195D1 (en) 2004-01-08
WO1995028387A1 (en) 1995-10-26
ES2388917T3 (en) 2012-10-19
DE69532195T2 (en) 2004-09-02
CA2188164C (en) 2005-08-09
EP1195372A1 (en) 2002-04-10
EP1391454A1 (en) 2004-02-25
ES2208678T3 (en) 2004-06-16
EP0757038A4 (en) 1997-08-06
EP1391454B1 (en) 2012-05-30
US6156766A (en) 2000-12-05
KR970702255A (en) 1997-05-13
EP0757038A1 (en) 1997-02-05

Similar Documents

Publication Publication Date Title
DE69526820T2 (en) Velcro fastening
DE69528043T2 (en) Unit of catheter and check valve
DE69527377T2 (en) Increased antimicrobial effectiveness
DE69430772T2 (en) Surgical fastener
DE69433101D1 (en) Surgical fastener
DK0703454T3 (en) Methods of monitoring and devices for use therewith
DK0928207T3 (en) Adhesive and use of this agent
DE69334260D1 (en) Medical inhaler
DE69530355D1 (en) Medical intervention device
DE69333480D1 (en) Medical probe
DE69333731D1 (en) Glialmitogenic factors, their manufacture and use
DK0906292T3 (en) Triazolylmercaptides and their use as microbicides
DE69722397D1 (en) Insulin derivatives and their use
DE69434259D1 (en) Stentzuführvorrichtung and procedure
DK0841929T3 (en) Quinolones and their therapeutic use
DE69534588D1 (en) Protocadherine proteins and uses thereof
DE69721766D1 (en) New medical formulation
DE69529228T2 (en) Plaster of the matrix type
DE69534306D1 (en) drug
DK0616508T4 (en) Gas-filled liposomes and their use as ultrasonic contrast agents
DE69532664D1 (en) toothpick
DE69720811D1 (en) L-ribavirin and its use
DE69535315D1 (en) 1-aminoindanderivate and compositions herevon
DE69528706T2 (en) Coupled ampflication and ligation procedure
DE69528912D1 (en) Inhaler

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties