AT250598T - 5- (2-imidazolinylamino) benzimidazole derivatives, their production and their use as alpha-2-adrenoceptor agonists - Google Patents

5- (2-imidazolinylamino) benzimidazole derivatives, their production and their use as alpha-2-adrenoceptor agonists

Info

Publication number
AT250598T
AT250598T AT95904327T AT95904327T AT250598T AT 250598 T AT250598 T AT 250598T AT 95904327 T AT95904327 T AT 95904327T AT 95904327 T AT95904327 T AT 95904327T AT 250598 T AT250598 T AT 250598T
Authority
AT
Austria
Prior art keywords
imidazolinylamino
alpha
production
use
benzimidazole derivatives
Prior art date
Application number
AT95904327T
Other languages
German (de)
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US16986893A priority Critical
Priority to US08/349,558 priority patent/US5478858A/en
Application filed by Procter & Gamble filed Critical Procter & Gamble
Priority to PCT/US1994/014292 priority patent/WO1995016685A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT250598(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of AT250598T publication Critical patent/AT250598T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
AT95904327T 1993-12-17 1994-12-15 5- (2-imidazolinylamino) benzimidazole derivatives, their production and their use as alpha-2-adrenoceptor agonists AT250598T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US16986893A true 1993-12-17 1993-12-17
US08/349,558 US5478858A (en) 1993-12-17 1994-12-08 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
PCT/US1994/014292 WO1995016685A1 (en) 1993-12-17 1994-12-15 5-(2-imidazolinylamino)benzimidazole derivatives, their preparation and their use as alpha-2 adrenoceptor agonists

Publications (1)

Publication Number Publication Date
AT250598T true AT250598T (en) 2003-10-15

Family

ID=26865464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95904327T AT250598T (en) 1993-12-17 1994-12-15 5- (2-imidazolinylamino) benzimidazole derivatives, their production and their use as alpha-2-adrenoceptor agonists

Country Status (23)

Country Link
US (3) US5478858A (en)
EP (1) EP0736022B1 (en)
JP (1) JPH09507216A (en)
KR (1) KR100385195B1 (en)
CN (1) CN1076352C (en)
AT (1) AT250598T (en)
AU (1) AU699631B2 (en)
BR (1) BR9408343A (en)
CA (1) CA2179008C (en)
CZ (1) CZ286816B6 (en)
DE (2) DE69433181T2 (en)
ES (1) ES2202352T3 (en)
FI (1) FI962494A (en)
HU (1) HU224016B1 (en)
MY (1) MY131696A (en)
NO (1) NO309325B1 (en)
NZ (1) NZ333371A (en)
PL (1) PL180903B1 (en)
RU (1) RU2143430C1 (en)
SG (1) SG49049A1 (en)
SK (1) SK282566B6 (en)
TW (1) TW393469B (en)
WO (1) WO1995016685A1 (en)

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ID24081A (en) * 1997-04-15 2000-07-06 Procter & Gamble The compounds 5- (2-imidazolinilamino) benzimidazole useful as agonists of alpha-2-adrenoceptor
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US7919119B2 (en) * 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US8889112B2 (en) * 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US20070059367A1 (en) * 2000-06-06 2007-03-15 Cherukuri S R Drug Delivery System and Associated Methods
US20100196466A1 (en) * 2000-06-06 2010-08-05 Capricorn Pharma Inc. Drug delivery system
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AU2024802A (en) * 2000-11-06 2002-05-15 Andrx Pharmaceuticals Inc Once a day antihistamine and decongestant formulation
JP2006516964A (en) * 2002-10-31 2006-07-13 ザ ジーアイ カンパニー インコーポレーティッド Trefoil type domain-containing polypeptide and use thereof
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030148949A1 (en) * 2001-10-05 2003-08-07 Podolsky Daniel K. Methods and compositions for treating dermal lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
AU2002351181B2 (en) * 2001-11-28 2008-08-07 The General Hospital Corporation Methods and compositions for treating lesions of the respiratory epithelium
MXPA04009363A (en) * 2002-03-26 2005-01-25 Gen Hospital Corp Combination therapy using trefoil peptides.
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US20040167194A1 (en) * 2003-02-20 2004-08-26 Randall Jared Lynn Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
US7777051B2 (en) * 2003-05-13 2010-08-17 Icagen, Inc. Asymmetric benzimidazoles and related compounds as potassium channel modulators
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
US20070053868A1 (en) 2005-03-08 2007-03-08 Banner Pharmacaps, Inc. Solvent system for enhancing the solubility of pharmaceutical agents
AR054045A1 (en) 2005-05-18 2007-05-30 Neuraxon Inc benzimidazole-substituted compounds inhibitory activity twofold and mu opioid agonist
EP1896022B1 (en) * 2005-06-17 2012-10-31 AFT Pharmaceuticals Limited Novel pharmaceutical composition and its use in a method for treatment of patients with upper respiratory mucosal congestion
CA2628570A1 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
US20130210876A1 (en) * 2010-01-21 2013-08-15 Allergan, Inc Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect
AU2011207301A1 (en) * 2010-01-21 2012-08-09 Allergan, Inc. Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect
CN103781785A (en) 2011-07-25 2014-05-07 阿勒根公司 N-(imidazolidin-2-ylidene)-heterocyclopenta[b]pyridine derivatives as modulators of alpha2 adrenergic receptors
US9629847B2 (en) 2011-11-23 2017-04-25 Michael Leighton Compositions and methods for treating symptoms of inflammatory related conditions using a combination of an antihistamine and a stimulant
US9149474B2 (en) * 2011-11-23 2015-10-06 Michael Leighton Compositions and methods for treating symptoms of inflammatory related conditions using a combination of an antihistamine and a stimulant
WO2015073736A1 (en) 2013-11-13 2015-05-21 Arbor Pharmaceuticals, Llc Methods and compositions for treating adhd

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Also Published As

Publication number Publication date
CZ286816B6 (en) 2000-07-12
PL315059A1 (en) 1996-09-30
HU224016B1 (en) 2005-04-28
SK282566B6 (en) 2002-10-08
US5541210A (en) 1996-07-30
NO962539L (en) 1996-08-13
US5691370A (en) 1997-11-25
KR100385195B1 (en) 2003-08-21
FI962494D0 (en)
FI962494A0 (en) 1996-06-14
CA2179008C (en) 1999-08-17
TW393469B (en) 2000-06-11
SG49049A1 (en) 1998-05-18
DE69433181D1 (en) 2003-10-30
JPH09507216A (en) 1997-07-22
NO309325B1 (en) 2001-01-15
WO1995016685A1 (en) 1995-06-22
HU9601663D0 (en) 1996-08-28
NZ333371A (en) 2001-12-21
ES2202352T3 (en) 2004-04-01
RU2143430C1 (en) 1999-12-27
AU1306295A (en) 1995-07-03
MY131696A (en) 2007-08-30
HUT76473A (en) 1997-09-29
FI962494A (en) 1996-06-14
EP0736022A1 (en) 1996-10-09
PL180903B1 (en) 2001-04-30
CN1137794A (en) 1996-12-11
AU699631B2 (en) 1998-12-10
CZ175196A3 (en) 1996-11-13
BR9408343A (en) 1997-08-19
US5478858A (en) 1995-12-26
CN1076352C (en) 2001-12-19
NO962539D0 (en) 1996-06-14
CA2179008A1 (en) 1995-06-22
EP0736022B1 (en) 2003-09-24
DE69433181T2 (en) 2004-07-01
SK77196A3 (en) 1997-03-05

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