AT242258T - Hypolipidemic 1,4-benzothiazepine-1,1-dioxide - Google Patents

Hypolipidemic 1,4-benzothiazepine-1,1-dioxide

Info

Publication number
AT242258T
AT242258T AT98103702T AT98103702T AT242258T AT 242258 T AT242258 T AT 242258T AT 98103702 T AT98103702 T AT 98103702T AT 98103702 T AT98103702 T AT 98103702T AT 242258 T AT242258 T AT 242258T
Authority
AT
Austria
Prior art keywords
benzothiazepine
hypolipidemic
dioxide
Prior art date
Application number
AT98103702T
Other languages
German (de)
Inventor
Eugen Falk
Alfons Enhsen
Siegfried Stengelin
Heiner Glombik
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP97104348 priority Critical
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of AT242258T publication Critical patent/AT242258T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/007Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
AT98103702T 1997-03-14 1998-03-03 Hypolipidemic 1,4-benzothiazepine-1,1-dioxide AT242258T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97104348 1997-03-14

Publications (1)

Publication Number Publication Date
AT242258T true AT242258T (en) 2003-06-15

Family

ID=8226598

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98103702T AT242258T (en) 1997-03-14 1998-03-03 Hypolipidemic 1,4-benzothiazepine-1,1-dioxide

Country Status (23)

Country Link
US (2) US6020330A (en)
EP (1) EP0864582B1 (en)
JP (1) JP3282998B2 (en)
KR (1) KR19980080223A (en)
CN (1) CN1070484C (en)
AR (1) AR011189A1 (en)
AT (1) AT242258T (en)
AU (1) AU731575B2 (en)
BR (1) BR9801126A (en)
CA (1) CA2231971C (en)
CZ (1) CZ75998A3 (en)
DE (1) DE69815180T2 (en)
DK (1) DK0864582T3 (en)
ES (1) ES2198613T3 (en)
HU (1) HU9800541A3 (en)
ID (1) ID20053A (en)
IL (1) IL123648A (en)
NZ (1) NZ329932A (en)
PL (1) PL325363A1 (en)
PT (1) PT864582E (en)
RU (1) RU2179977C2 (en)
TR (1) TR199800444A3 (en)
ZA (1) ZA9802140B (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
DE69815180T2 (en) * 1997-03-14 2004-04-29 Aventis Pharma Deutschland Gmbh Hypolipidemic 1,4-benzothiazepine-1,1-dioxide
AT242007T (en) * 1998-12-23 2003-06-15 Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
CN1338944A (en) 1998-12-23 2002-03-06 G.D.瑟尔有限公司 Cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
AT228012T (en) 1998-12-23 2002-12-15 Searle Llc Combinations of ileumgallensäuretransports inhibitors and bile acid sequestering agents for cardiovascular indications
BR9916564A (en) * 1998-12-23 2002-01-29 Searle Llc Combinations for cardiovascular indications
DK1140188T3 (en) 1998-12-23 2003-09-29 Searle Llc Combinations of ileal bile acid transport inhibitors, and cholesteryl esters tranferproteinhæmmere for cardiovascular indications
JP2002533409A (en) 1998-12-23 2002-10-08 ジー.ディー.サール エルエルシー Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestrants for application to the cardiovascular
CA2356607A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
DE19916108C1 (en) * 1999-04-09 2001-01-11 Aventis Pharma Gmbh With sugar residues substituted 1,4-benzothiazepine-1,1-dioxide derivatives, processes for their preparation and their use
GB9914745D0 (en) * 1999-06-24 1999-08-25 Knoll Ag Therapeutic agents
SE0000772D0 (en) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical Compounds
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
AU4733101A (en) * 2000-03-10 2001-09-24 Pharmacia Corp Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US20020183307A1 (en) * 2000-07-26 2002-12-05 Tremont Samuel J. Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
GB0121337D0 (en) * 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
HU227623B1 (en) 2001-09-08 2011-09-28 Astrazeneca Ab Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (ibat) inhibitory activity for the treatment of hyperlipidaemia, process for their preparation and pharmaceutical compositions containing them
JP2005518347A (en) * 2001-11-02 2005-06-23 ジー.ディー. サール エルエルシー Apical sodium co-dependent bile acid transport (ASBT) and novel mono- and di-fluorinated benzothiepine compounds as inhibitors of taurocholate uptake
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
GB0201850D0 (en) * 2002-01-26 2002-03-13 Astrazeneca Ab Therapeutic treatment
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
US7312208B2 (en) 2002-08-28 2007-12-25 Asahi Kasei Pharma Corporation Quaternary ammonium compounds
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
CA2557576C (en) 2004-02-27 2010-02-09 Asahi Kasei Pharma Corporation Novel benzothiazepine and benzothiepine compounds
DE102005033099A1 (en) 2005-07-15 2007-01-18 Sanofi-Aventis Deutschland Gmbh New 1,4-benzothiazepine-1,1-Dioxidderivat with improved properties, process for its preparation, pharmaceutical compositions containing this compound and its use
CA2744817A1 (en) * 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
ES2586956T3 (en) 2010-11-08 2016-10-19 Albireo Ab pharmaceutical combination comprising an IBAT inhibitor and the bile acid binder
PL2637668T3 (en) 2010-11-08 2017-01-31 Albireo Ab Ibat inhibitors for the treatment of liver diseases
US20140323412A1 (en) 2011-10-28 2014-10-30 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
CA2853285A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
CN105228615A (en) 2013-03-15 2016-01-06 鲁美纳医药公司 Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
MX2015013193A (en) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease.
JO3301B1 (en) 2013-04-26 2018-09-16 Albireo Ab Crystal modifications of elobixibat
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
JP2019504887A (en) 2016-02-09 2019-02-21 アルビレオ・アクチボラグ Oral cholestyramine preparation and use thereof
CA3011565A1 (en) 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
WO2019032026A1 (en) 2017-08-09 2019-02-14 Albireo Ab Cholestyramine granules, oral cholestyramine formulations and use thereof
WO2019032027A1 (en) 2017-08-09 2019-02-14 Albireo Ab Cholestyramine pellets, oral cholestyramine formulations and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
RU2115650C1 (en) * 1992-11-09 1998-07-20 Дзе Бутс Компани ПЛС 2,3,4,5-tetrahydro-1,4-benzothiazepines, stereoisomers thereof or pharmaceutically acceptable salts thereof, method of preparation thereof, pharmaceutical composition having anticonvulsive effect
IL108633A (en) * 1993-02-15 1998-07-15 Wellcome Found Hypolipidaemic benzothiazepine derivatives their preparation and pharmaceutical compositions containing them
IL108634D0 (en) * 1993-02-15 1994-05-30 Wellcome Found Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them
ZA9506647B (en) * 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
DE69815180T2 (en) * 1997-03-14 2004-04-29 Aventis Pharma Deutschland Gmbh Hypolipidemic 1,4-benzothiazepine-1,1-dioxide

Also Published As

Publication number Publication date
HU9800541D0 (en) 1998-05-28
US6114322A (en) 2000-09-05
BR9801126A (en) 2000-03-21
AR011189A1 (en) 2000-08-02
DE69815180D1 (en) 2003-07-10
NZ329932A (en) 1999-01-28
ZA9802140B (en) 1998-09-14
ES2198613T3 (en) 2004-02-01
KR19980080223A (en) 1998-11-25
TR199800444A3 (en) 1998-10-21
RU2179977C2 (en) 2002-02-27
EP0864582B1 (en) 2003-06-04
IL123648A (en) 2000-11-21
DK864582T3 (en)
HU9800541A2 (en) 1999-06-28
CN1194979A (en) 1998-10-07
HU9800541A3 (en) 2000-08-28
TR199800444A2 (en) 1998-10-21
CA2231971A1 (en) 1998-09-14
ID20053A (en) 1998-09-17
AU731575B2 (en) 2001-04-05
JPH10279568A (en) 1998-10-20
EP0864582A3 (en) 1998-10-21
CZ75998A3 (en) 1998-09-16
PT864582E (en) 2003-10-31
CN1070484C (en) 2001-09-05
JP3282998B2 (en) 2002-05-20
CA2231971C (en) 2008-05-20
IL123648D0 (en) 1998-10-30
US6020330A (en) 2000-02-01
AU5834998A (en) 1998-09-17
DK0864582T3 (en) 2003-09-29
DE69815180T2 (en) 2004-04-29
EP0864582A2 (en) 1998-09-16
PL325363A1 (en) 1998-09-28

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