AT238986T - 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs - Google Patents

1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs


Publication number
AT238986T AT98952587T AT98952587T AT238986T AT 238986 T AT238986 T AT 238986T AT 98952587 T AT98952587 T AT 98952587T AT 98952587 T AT98952587 T AT 98952587T AT 238986 T AT238986 T AT 238986T
Prior art keywords
vitamin d3
d3 analogs
Prior art date
Application number
Other languages
German (de)
Percy Sarwood Manchand
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US5813297P priority Critical
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to PCT/EP1998/005571 priority patent/WO1999012894A1/en
Publication of AT238986T publication Critical patent/AT238986T/en



    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
AT98952587T 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs AT238986T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US5813297P true 1997-09-08 1997-09-08
PCT/EP1998/005571 WO1999012894A1 (en) 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs

Publications (1)

Publication Number Publication Date
AT238986T true AT238986T (en) 2003-05-15



Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952587T AT238986T (en) 1997-09-08 1998-09-02 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs

Country Status (9)

Country Link
US (3) US6492353B1 (en)
EP (1) EP1015423B1 (en)
JP (1) JP4219553B2 (en)
AT (1) AT238986T (en)
AU (1) AU1022999A (en)
CA (1) CA2303248A1 (en)
DE (1) DE69814109T2 (en)
ES (1) ES2196614T3 (en)
WO (1) WO1999012894A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19916419B4 (en) * 1999-04-08 2005-06-16 Schering Ag Combination preparation of vitamin D metabolite or vitamin D analogues and a Östrogenpartialagonisten for treating osteoporosis
JP2003528833A (en) * 2000-03-27 2003-09-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン Vitamin d compounds for renal transplant stabilization
CN101596191B (en) * 2001-01-26 2011-06-15 中外制药株式会社 Method for treatment of disease using malonyl-coa decarboxylase inhibitor
AT410172T (en) * 2001-05-22 2008-10-15 Bioxell Spa Using an analog of vitamins d3 for the treatment of autoimmune diabetes
AU2002338672B2 (en) * 2001-09-21 2006-03-09 F. Hoffmann-La Roche Ag 3-desoxy-vitamin D3 analog esters
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
AU2004275815A1 (en) * 2003-09-24 2005-04-07 Bioxell S.P.A. 1,3-diaclyated,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof
CN101106985A (en) * 2004-09-24 2008-01-16 拜奥艾克塞尔股份公司 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
WO2006093291A1 (en) * 2005-03-04 2006-09-08 Tokyo Medical And Dental University 19-norvitamin d derivative
WO2007039322A1 (en) * 2005-09-19 2007-04-12 Bioxell Spa Use of vitamin d3 compounds for the treatment of uveitis
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
JP2013538830A (en) * 2010-09-27 2013-10-17 マイクロドース セラピューテクス,インコーポレイテッド Methods and compositions for treatment of diseases using inhalation
WO2012118154A1 (en) * 2011-03-02 2012-09-07 学校法人日本大学 Novel vitamin d receptor modulator with partial agonist activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
KR0144358B1 (en) * 1988-04-21 1998-07-15 피. 라이달 크리스텐슨 Novel vitamin d analogues
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
EP0521550B1 (en) 1991-07-05 1996-09-18 Duphar International Research B.V Vitamin D compound, method of preparing this compound and intermediate therefor
DE4141746A1 (en) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituted vitamin D derivatives
DK0580968T3 (en) * 1992-05-20 1996-10-14 Hoffmann La Roche Fluorinated analogs of Vitamin D3
DE4220757A1 (en) * 1992-06-24 1994-01-05 Schering Ag Derivatives in the vitamin D series with modifications in the 20-position, processes for their preparation, intermediates for this process, pharmaceutical compositions containing these derivatives and their use for the preparation of medicaments
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
EP0972762B1 (en) * 1993-07-09 2003-10-01 Laboratoire Theramex Novel structural analogues of vitamin D
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
ES2144239T3 (en) * 1995-06-14 2000-06-01 Schering Ag Vitamin D derivatives with substituents at C-25, process for their preparation, intermediates and the use for preparing medicines.
NO971934L (en) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 analogues
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF

Also Published As

Publication number Publication date
US20040167105A1 (en) 2004-08-26
EP1015423A1 (en) 2000-07-05
US20030083319A1 (en) 2003-05-01
WO1999012894A1 (en) 1999-03-18
JP4219553B2 (en) 2009-02-04
US6492353B1 (en) 2002-12-10
DE69814109T2 (en) 2004-02-26
EP1015423B1 (en) 2003-05-02
JP2001515881A (en) 2001-09-25
ES2196614T3 (en) 2003-12-16
CA2303248A1 (en) 1999-03-18
AU1022999A (en) 1999-03-29
DE69814109D1 (en) 2003-06-05

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Legal Events

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