AT214595T - A process for preparing solvent-free noncrystalline bioactive substances - Google Patents

A process for preparing solvent-free noncrystalline bioactive substances

Info

Publication number
AT214595T
AT214595T AT98965661T AT98965661T AT214595T AT 214595 T AT214595 T AT 214595T AT 98965661 T AT98965661 T AT 98965661T AT 98965661 T AT98965661 T AT 98965661T AT 214595 T AT214595 T AT 214595T
Authority
AT
Austria
Prior art keywords
noncrystalline
free
process
bioactive substances
preparing solvent
Prior art date
Application number
AT98965661T
Other languages
German (de)
Inventor
Joerg Breitenbach
Ulrich Reinhold
Juergen Zeidler
Joerg Rosenberg
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19752895 priority Critical
Application filed by Knoll Ag filed Critical Knoll Ag
Priority to PCT/EP1998/007141 priority patent/WO1999027891A2/en
Publication of AT214595T publication Critical patent/AT214595T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
AT98965661T 1997-11-28 1998-11-09 A process for preparing solvent-free noncrystalline bioactive substances AT214595T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19752895 1997-11-28
PCT/EP1998/007141 WO1999027891A2 (en) 1997-11-28 1998-11-09 Method for producing solvent-free non-crystalline biologically active substances

Publications (1)

Publication Number Publication Date
AT214595T true AT214595T (en) 2002-04-15

Family

ID=7850166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98965661T AT214595T (en) 1997-11-28 1998-11-09 A process for preparing solvent-free noncrystalline bioactive substances

Country Status (10)

Country Link
US (1) US6547997B1 (en)
EP (1) EP1033975B1 (en)
JP (1) JP2001524503A (en)
CN (1) CN1150891C (en)
AT (1) AT214595T (en)
CA (1) CA2310847C (en)
DK (1) DK1033975T3 (en)
ES (1) ES2174538T3 (en)
PT (1) PT1033975E (en)
WO (1) WO1999027891A2 (en)

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AT329579T (en) * 1999-11-12 2006-07-15 Abbott Lab Solid dispersion with ritonavir, fenofibrate or griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
DE10026698A1 (en) * 2000-05-30 2001-12-06 Basf Ag Self-emulsifying drug formulation and use of this formulation
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
SI1842533T1 (en) * 2003-08-06 2013-06-28 Grunenthal Gmbh Dosage form that is secured against misuse
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) * 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
DE10361596A1 (en) * 2003-12-24 2005-09-29 Grünenthal GmbH A process for preparing a secured against misuse dosage form
DE102004020220A1 (en) * 2004-04-22 2005-11-10 Grünenthal GmbH A process for preparing a secured against misuse, solid dosage form
DE102004032103A1 (en) * 2004-07-01 2006-01-19 Grünenthal GmbH Abuse-proofed, oral dosage form
DE102004032051A1 (en) * 2004-07-01 2006-01-19 Grünenthal GmbH A process for preparing a secured against misuse, solid dosage form
DE102004032049A1 (en) * 2004-07-01 2006-01-19 Grünenthal GmbH Abuse-proofed, oral dosage form
DE102005005449A1 (en) * 2005-02-04 2006-08-10 Grünenthal GmbH A process for preparing a secured against misuse dosage form
DE102005005446A1 (en) * 2005-02-04 2006-08-10 Grünenthal GmbH Unbreakable dosage forms with delayed release
SA2709B1 (en) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
DE102007011485A1 (en) 2007-03-07 2008-09-11 Grünenthal GmbH Dosage form with impeded abuse
WO2009085828A2 (en) * 2007-12-20 2009-07-09 Mutual Pharmaceutical Company, Inc. Quinine sulfate polymorphs, processes of preparing, compositions and uses thereof
TWI454288B (en) * 2008-01-25 2014-10-01 Gruenenthal Chemie Pharmaceutical dosage form
CA2723438C (en) 2008-05-09 2016-10-11 Gruenenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
EP2456424B1 (en) 2009-07-22 2013-08-28 Grünenthal GmbH Oxidation-stabilized tamper-resistant dosage form
PE10672012A1 (en) 2009-07-22 2012-09-05 Gruenenthal Chemie Form of controlled release dosage extruded by hot melt
CN102821757B (en) * 2010-02-03 2016-01-20 格吕伦塔尔有限公司 Preparation of a powdered pharmaceutical composition by an extruder
JP5933553B2 (en) 2010-09-02 2016-06-15 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Abuse-resistant dosage form comprising an anionic polymer
KR20130097202A (en) 2010-09-02 2013-09-02 그뤼넨탈 게엠베하 Tamper resistant dosage form comprising inorganic salt
HUE034711T2 (en) 2011-07-29 2018-02-28 Gruenenthal Gmbh Tamper-resistant tablet providing immediate drug release
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
DK2838512T3 (en) 2012-04-18 2018-11-19 Gruenenthal Gmbh Tamper-proof and dose dumping secured pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6445537B2 (en) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Modified anti containing one or more particles (tamper-resistant) dosage forms
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
JP2017518980A (en) 2014-05-12 2017-07-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Containing tapentadol, modified prevent immediate release capsule formulation
MX2016015417A (en) 2014-05-26 2017-02-22 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping.
KR20170139158A (en) 2015-04-24 2017-12-18 그뤼넨탈 게엠베하 Immediately released and prevent the tamper-resistant dosage form extraction solvent

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3310676A1 (en) 1983-03-24 1984-09-27 Basf Ag A method and apparatus for removing volatile components from polymer melt or paste
US5811547A (en) 1992-10-14 1998-09-22 Nippon Shinyaju Co., Ltd. Method for inducing crystalline state transition in medicinal substance
WO1994008561A1 (en) 1992-10-14 1994-04-28 Nippon Shinyaku Co., Ltd. Crystalline condition dislocating method
US5466865A (en) 1993-07-02 1995-11-14 Ibah, Inc. Neomorphic ibuprofen and methods of using same
DE69525763T2 (en) * 1994-04-11 2002-10-02 Chugai Pharmaceutical Co Ltd 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE WHICH INHIBIT LDL OXIDATION
DE4418837A1 (en) * 1994-05-30 1995-12-07 Bayer Ag thermal granulation
NZ322907A (en) * 1995-11-23 1998-12-23 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
DE19624607A1 (en) 1996-06-20 1998-01-02 Basf Ag A process for the preparation of salts of acid group-containing pharmaceutical active substances
DE19801073A1 (en) * 1998-01-14 1999-07-15 Bayer Ag mixing device

Also Published As

Publication number Publication date
PT1033975E (en) 2002-07-31
EP1033975B1 (en) 2002-03-20
DK1033975T3 (en) 2002-05-27
US6547997B1 (en) 2003-04-15
CA2310847A1 (en) 1999-06-10
CN1280491A (en) 2001-01-17
WO1999027891A2 (en) 1999-06-10
CA2310847C (en) 2007-03-13
EP1033975A2 (en) 2000-09-13
ES2174538T3 (en) 2002-11-01
JP2001524503A (en) 2001-12-04
CN1150891C (en) 2004-05-26
WO1999027891A3 (en) 1999-08-12

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Legal Events

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REN Ceased due to non-payment of the annual fee