AT214057T - Triazolic compounds and their use as dopamin-d 3-ligands - Google Patents

Triazolic compounds and their use as dopamin-d 3-ligands

Info

Publication number
AT214057T
AT214057T AT98938687T AT98938687T AT214057T AT 214057 T AT214057 T AT 214057T AT 98938687 T AT98938687 T AT 98938687T AT 98938687 T AT98938687 T AT 98938687T AT 214057 T AT214057 T AT 214057T
Authority
AT
Austria
Prior art keywords
dopamin
ligands
triazolic compounds
triazolic
compounds
Prior art date
Application number
AT98938687T
Other languages
German (de)
Inventor
Dorothea Starck
Stefan Blank
Hans-Joerg Treiber
Liliane Unger
Barbara Neumann-Schultz
Bris Theophile-Marie Le
Hans-Juergen Teschendorf
Karsten Wicke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19728996A priority Critical patent/DE19728996A1/en
Application filed filed Critical
Priority to PCT/EP1998/004138 priority patent/WO1999002503A1/en
Publication of AT214057T publication Critical patent/AT214057T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AT98938687T 1997-07-07 1998-07-03 Triazolic compounds and their use as dopamin-d 3-ligands AT214057T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19728996A DE19728996A1 (en) 1997-07-07 1997-07-07 Triazole compounds and their use
PCT/EP1998/004138 WO1999002503A1 (en) 1997-07-07 1998-07-03 Triazole compounds and the use thereof as dopamine-d3-ligands

Publications (1)

Publication Number Publication Date
AT214057T true AT214057T (en) 2002-03-15

Family

ID=7834914

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98938687T AT214057T (en) 1997-07-07 1998-07-03 Triazolic compounds and their use as dopamin-d 3-ligands

Country Status (30)

Country Link
US (1) US6472392B1 (en)
EP (1) EP0994865B1 (en)
JP (1) JP2002507999A (en)
KR (1) KR20010021538A (en)
CN (1) CN1144791C (en)
AR (1) AR015713A1 (en)
AT (1) AT214057T (en)
AU (1) AU748810B2 (en)
BG (1) BG65029B1 (en)
BR (1) BR9810984A (en)
CA (1) CA2296102A1 (en)
CO (1) CO4950565A1 (en)
CZ (1) CZ302359B6 (en)
DE (2) DE19728996A1 (en)
DK (1) DK0994865T3 (en)
ES (1) ES2174465T3 (en)
HR (1) HRP20000014A2 (en)
HU (1) HU0003332A3 (en)
ID (1) ID24839A (en)
IL (1) IL133603D0 (en)
NO (1) NO20000048D0 (en)
NZ (1) NZ502181A (en)
PL (1) PL193704B1 (en)
PT (1) PT994865E (en)
SI (1) SI0994865T1 (en)
SK (1) SK285342B6 (en)
TR (1) TR200000009T2 (en)
TW (1) TW538041B (en)
WO (1) WO1999002503A1 (en)
ZA (1) ZA9805867B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
CO5140073A1 (en) 1998-10-08 2002-03-22 Smithkline Beecham Plc Derivatives 2,3,4,5-tetrahydro-1H-3-benzapina
AR022230A1 (en) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Triazole compounds, pharmaceutical composition comprising them and use thereof for preparing said composition
ES2311012T3 (en) * 2000-03-27 2009-02-01 ABBOTT GMBH & CO. KG Dopamine d3 receiver links for the addiction treatment.
DE10109867A1 (en) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Use of triazole compounds for the prophylaxis and therapy of neurodegenerative diseases, brain trauma and cerebral ischemia
DE10109866A1 (en) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazole compounds and their use for the prophylaxis and therapy of neurodegenerative diseases, brain trauma and cerebral ischemia
HU0103986A2 (en) * 2001-09-28 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. New piperidinyl compound having carboxylic acid structures, process for their preparation and pharmaceutical compositions containing them
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
HU0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
JPWO2003048134A1 (en) * 2001-12-05 2005-04-14 日本たばこ産業株式会社 Triazole compounds and pharmaceutical use thereof
DE10304870A1 (en) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazole compounds and their therapeutic use
US20040204422A1 (en) 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
US7320979B2 (en) * 2003-04-14 2008-01-22 Abbott Gmbh & Co. Kg. N-[(piperazinyl)hetaryl]arylsulfonamide compounds
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
US6818631B1 (en) 2003-08-15 2004-11-16 Nippon Soda Co. Ltd. Fungicidal pyrimidine derivatives
DE10358004A1 (en) 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam compounds and their use
US20050137186A1 (en) 2003-12-18 2005-06-23 Abbott Gmbh & Co. Kg. Tetrahydrobenzazepines and their use
WO2005058328A1 (en) 2003-12-18 2005-06-30 Abbott Gmbh & Co. Kg Tetrahydrobenzazepines and their use in the modulation of the dopamine d3 receptor
DE102004027359A1 (en) * 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyridin-2-one compounds and their use
DE102004027358A1 (en) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidine compounds and their use
DE602005018366D1 (en) * 2004-08-09 2010-01-28 Abbott Gmbh & Co Kg For the treatment of 4-piperazinylpyrimidin compounds suitable for modulation of the dopamin d3 receptor
US8101754B2 (en) * 2004-12-02 2012-01-24 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
TWI417095B (en) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
KR20100065191A (en) 2007-09-14 2010-06-15 아덱스 파마 에스에이 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
CA2698929C (en) * 2007-09-14 2016-01-19 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones
CN101801951B (en) 2007-09-14 2013-11-13 杨森制药有限公司 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
PA8802101A1 (en) 2007-11-02 2009-08-26 Abbott Gmbh & Co Kg 1,2,4-3,5-dione compounds suitable for the treatment of disorders responsive to modulation of the dopamine D3 receptor
RU2492170C9 (en) 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Imidazo[1,2-a]pyridine derivatives and their application as positive allosteric modulators of mglur2 receptors
BRPI0918055A2 (en) 2008-09-02 2015-12-01 Addex Pharmaceuticals Sa 3-azabicyclo [3,1,0] hexyl derivatives as metabotropic glutamate receptor modulators.
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
WO2010130422A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EA020672B1 (en) 2009-05-12 2014-12-30 Янссен Фармасьютикалс, Инк. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
EP2536283B8 (en) 2010-02-18 2015-11-04 vTv Therapeutics LLC Phenyl-heteroaryl derivatives and methods of use thereof
CA2815002C (en) 2010-11-08 2019-10-22 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
WO2012062750A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
AU2011328195B2 (en) 2010-11-08 2015-04-02 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL3096790T3 (en) 2014-01-21 2020-01-31 Janssen Pharmaceutica, N.V. Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE258033C (en)
DE139082C (en)
DE139083C (en)
GB1053085A (en) 1964-03-26
US3362956A (en) 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
DE1620016C3 (en) 1966-07-02 1979-08-30 Merck Patent Gmbh, 6100 Darmstadt
BE756127A (en) 1969-09-12 1971-03-15 Hoechst Ag Heterocyclic ethers and their preparation
DE2110568A1 (en) 1971-03-05 1972-09-07 Merck Patent Gmbh New N-acyl (piperazinoalkyl) pyrazoles
US4404382A (en) 1980-09-17 1983-09-13 The Upjohn Company Piperazinyl-substituted imidazoles
US4408049A (en) 1980-09-17 1983-10-04 The Upjohn Company Substituted piperazinyl-1,2,4-triazoles
US4338453A (en) * 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
US4487773A (en) 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4575555A (en) 1983-06-29 1986-03-11 Mead Johnson & Company 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative
US4577020A (en) * 1983-01-25 1986-03-18 The Upjohn Company Aminoalkyl and aminoalkenyl triazoles as anti-psychotic agents
US4613600A (en) 1983-09-30 1986-09-23 Mead Johnson & Company Antidepressant 1,2,4-triazolone compounds
FR2580648B1 (en) 1985-04-17 1987-05-15 Adir Novel triazole derivatives, their preparation process and the pharmaceutical compositions containing them
FR2601952B1 (en) 1986-07-23 1988-11-25 Carpibem Novel amino alkyl thio derivatives of triazolopyridine or triazoloquinoline, processes for their preparation, medicaments containing them, useful in particular as antalgics
US4784998A (en) 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
SE8803429D0 (en) 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl and pyrimidyl derivatives
DE3923675A1 (en) 1989-07-18 1991-01-24 Basf Ag Amonoalkyl-substituted 2-aminothiazoles and therapeutical agents containing them
JP2814600B2 (en) 1989-08-31 1998-10-22 正幸 石川 Drugs for dysuria
FR2658514B1 (en) 1990-02-19 1992-06-19 Irceba Novel 4-methyl thiazole derivatives, processes for their preparation and pharmaceutical compositions containing the same.
GB9021535D0 (en) 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
US5273977A (en) 1990-11-05 1993-12-28 Warner-Lambert Company Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
FR2672052B1 (en) 1991-01-28 1995-05-24 Esteve Labor Dr Derivatives of aryl (or heteroaryl) -piperazinyl-alkyl-azoles, their preparation and their application as medicaments.
DE4119756A1 (en) 1991-06-15 1992-12-17 Basf Ag Aminoalkyl-substituted 5-mercaptothiazole, their production and use
DE4119758A1 (en) 1991-06-15 1992-12-17 Basf Ag Aminoalkyl-substituted 2-amino-5-mercaptothiadiazole, their production and use
DE4119757A1 (en) 1991-06-15 1992-12-17 Basf Ag Aminoalkyl-substituted thiazolin-2-one, their production and use
DE4119755A1 (en) 1991-06-15 1992-12-17 Basf Ag Aminoalkyl-substituted 2-amino-1,3,4-thiadiazoles, their production and use
US5256664A (en) 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
DE4425146A1 (en) 1994-07-15 1996-01-18 Basf Ag Use of heterocyclic compounds
DE4425145A1 (en) * 1994-07-15 1996-01-18 Basf Ag Use of thiazole and thiadiazole compounds
DE4425143A1 (en) 1994-07-15 1996-01-18 Basf Ag Substituted pyrimidine compounds and their use
DE4425144A1 (en) * 1994-07-15 1996-01-18 Basf Ag Triazole compounds and their use
US5688795A (en) 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
DE19600934A1 (en) * 1996-01-12 1997-07-17 Basf Ag Substituted aza and diazacycloheptane and cyclooctane compounds and their use

Also Published As

Publication number Publication date
AU8731698A (en) 1999-02-08
IL133603D0 (en) 2001-04-30
KR20010021538A (en) 2001-03-15
SI0994865T1 (en) 2002-04-30
AR015713A1 (en) 2001-05-16
HRP20000014A2 (en) 2001-04-30
SK285342B6 (en) 2006-11-03
NO20000048D0 (en) 2000-01-06
SK173799A3 (en) 2000-06-12
EP0994865A1 (en) 2000-04-26
PL193704B1 (en) 2007-03-30
JP2002507999A (en) 2002-03-12
TR200000009T2 (en) 2000-06-21
WO1999002503A1 (en) 1999-01-21
PT994865E (en) 2002-08-30
BG104056A (en) 2000-07-31
DE19728996A1 (en) 1999-01-14
EP0994865B1 (en) 2002-03-06
NO20000048L (en) 2000-01-06
HU0003332A3 (en) 2002-02-28
DE59803292D1 (en) 2002-04-11
CO4950565A1 (en) 2000-09-01
ID24839A (en) 2000-08-24
BR9810984A (en) 2000-08-15
CN1144791C (en) 2004-04-07
BG65029B1 (en) 2006-12-29
TW538041B (en) 2003-06-21
ES2174465T3 (en) 2002-11-01
CN1262678A (en) 2000-08-09
HU0003332A2 (en) 2001-06-28
NZ502181A (en) 2000-10-27
ZA9805867B (en) 2000-01-10
DK994865T3 (en)
AU748810B2 (en) 2002-06-13
DK0994865T3 (en) 2003-04-14
CA2296102A1 (en) 1999-01-21
US6472392B1 (en) 2002-10-29
CZ200036A3 (en) 2001-03-14
PL337904A1 (en) 2000-09-11
CZ302359B6 (en) 2011-04-06

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