AT210682T - Destruction of contaminating tumor cells in stem cell transplants with bispecific antibodies - Google Patents

Destruction of contaminating tumor cells in stem cell transplants with bispecific antibodies

Info

Publication number
AT210682T
AT210682T AT97115188T AT97115188T AT210682T AT 210682 T AT210682 T AT 210682T AT 97115188 T AT97115188 T AT 97115188T AT 97115188 T AT97115188 T AT 97115188T AT 210682 T AT210682 T AT 210682T
Authority
AT
Austria
Prior art keywords
destruction
tumor cells
stem cell
bispecific antibodies
cell transplants
Prior art date
Application number
AT97115188T
Other languages
German (de)
Inventor
Horst Dr Lindhofer
Helge Dr Menzel
Hans-Jochem Prof Dr Kolb
Stefan Prof Dr Thierfelder
Original Assignee
Gsf Forschungszentrum Umwelt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19635743 priority Critical
Priority to DE1996149223 priority patent/DE19649223C2/en
Application filed by Gsf Forschungszentrum Umwelt filed Critical Gsf Forschungszentrum Umwelt
Publication of AT210682T publication Critical patent/AT210682T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
AT97115188T 1996-09-03 1997-09-02 Destruction of contaminating tumor cells in stem cell transplants with bispecific antibodies AT210682T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19635743 1996-09-03
DE1996149223 DE19649223C2 (en) 1996-09-03 1996-11-27 Destroying contaminating tumor cells in stem cell transplants with bispecific antibodies

Publications (1)

Publication Number Publication Date
AT210682T true AT210682T (en) 2001-12-15

Family

ID=26028996

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97115188T AT210682T (en) 1996-09-03 1997-09-02 Destruction of contaminating tumor cells in stem cell transplants with bispecific antibodies

Country Status (6)

Country Link
US (2) US5985276A (en)
EP (1) EP0826695B1 (en)
JP (1) JP3257970B2 (en)
AT (1) AT210682T (en)
DK (1) DK0826695T3 (en)
ES (1) ES2169299T3 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT210682T (en) * 1996-09-03 2001-12-15 Gsf Forschungszentrum Umwelt Destruction of contaminating tumor cells in stem cell transplants with bispecific antibodies
DE19725586C2 (en) 1997-06-17 1999-06-24 Gsf Forschungszentrum Umwelt A process for the preparation of cell preparations for the immunization by means of heterologous intact bispecific and / or trispecific antibodies
US6994853B1 (en) 1998-09-25 2006-02-07 Trion Pharma Gmbh Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
US6319675B1 (en) 1999-11-24 2001-11-20 Millennium Pharmaceuticals, Inc. Methods for detecting and/or identifying agents which bind and/or modulate function of “bonzo” chemokine receptor
US7208152B2 (en) * 1999-11-24 2007-04-24 Millennium Pharmaceuticals, Inc. Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof
CA2409991A1 (en) * 2000-05-24 2001-11-29 Imclone Systems Incorporated Bispecific immunoglobulin-like antigen binding proteins and method of production
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
NZ562811A (en) 2000-08-07 2009-05-31 Centocor Inc Anti-TNF antibodies, compositions, methods and uses
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
DE10043437A1 (en) * 2000-09-04 2002-03-28 Horst Lindhofer Use of trifunctional bispecific and trispecific antibodies for the treatment of malignant ascites
JP4214249B2 (en) 2001-07-30 2009-01-28 学校法人慶應義塾 Pharmaceutical compositions containing the Fc receptor γ-chain activator
JP2007528691A (en) 2001-11-14 2007-10-18 セントカー・インコーポレーテツド Anti il-6 antibody, composition, methods and uses
US7332580B2 (en) * 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
US7332585B2 (en) * 2002-04-05 2008-02-19 The Regents Of The California University Bispecific single chain Fv antibody molecules and methods of use thereof
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
WO2005077065A2 (en) * 2004-02-09 2005-08-25 The Regents Of The University Of California Selective high-affinity polydentate ligands and methods of making such
US8066989B2 (en) * 2004-11-30 2011-11-29 Trion Pharma Gmbh Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
WO2006114115A1 (en) 2005-04-26 2006-11-02 Trion Pharma Gmbh Combination of antibodies and glucocorticoids for treating cancer
JO3058B1 (en) 2005-04-29 2017-03-15 Applied Molecular Evolution Inc Anti-IL-6 Antibodies,Compositions,Methods and uses
EP2452694B1 (en) 2005-06-30 2018-11-14 Janssen Biotech, Inc. Anti-IL-23 antibodies, compositions, methods and uses
US8623356B2 (en) 2005-11-29 2014-01-07 The University Of Sydney Demibodies: dimerization-activated therapeutic agents
MY162559A (en) 2005-12-29 2017-06-15 Centocor Inc Human anti-il-23 antibodies, compositions, methods and uses
EP1820513A1 (en) 2006-02-15 2007-08-22 Trion Pharma Gmbh Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
WO2007134274A2 (en) * 2006-05-12 2007-11-22 Attenuon, Llc Antibodies to urokinase- type plasminogen activator receptor(upar)bind cancer stem cells: use in diagnosis and therapy
US8580263B2 (en) * 2006-11-21 2013-11-12 The Regents Of The University Of California Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof
CA2721980C (en) 2008-04-21 2017-01-03 The Regents Of The University Of California Selective high-affinity poly dentate ligands and methods of making such
KR101835648B1 (en) 2009-06-26 2018-03-07 리제너론 파마슈티칼스 인코포레이티드 Readily isolated bispecific antibodies with native immunoglobulin format
CN102933231B (en) 2010-02-10 2015-07-29 伊缪诺金公司 Cd20 antibody and uses thereof
MX2012011479A (en) 2010-03-30 2012-12-17 Janssen Biotech Inc Humanized il-25 antibodies.
AU2011268110B2 (en) 2010-06-19 2016-05-19 Memorial Sloan-Kettering Cancer Center Anti-GD2 antibodies
EP2578230A1 (en) 2011-10-04 2013-04-10 Trion Pharma Gmbh Removal of Tumor Cells from Intraoperative Autologous Blood Salvage
RU2680267C2 (en) 2013-03-15 2019-02-19 Мемориал Слоан Кеттеринг Кэнсер Сентер High-affinity anti-gd2 antibodies
WO2015097536A2 (en) 2013-12-24 2015-07-02 Janssen Pharmaceutical Nv Anti-vista antibodies and fragments
EP3447075A3 (en) 2015-05-15 2019-05-29 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
CN107922497A (en) 2015-06-24 2018-04-17 詹森药业有限公司 Anti-VISTA antibodies and fragments
CN109069626A (en) 2016-02-12 2018-12-21 詹森药业有限公司 Anti- VISTA (B7H5) antibody
EP3436477A2 (en) 2016-03-29 2019-02-06 Janssen Biotech, Inc. Method of treating psoriasis with increased interval dosing of anti-il12 and/or -23 antibody
WO2017175058A1 (en) 2016-04-07 2017-10-12 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3507305A1 (en) 2016-09-02 2019-07-10 Dana-Farber Cancer Institute, Inc. Composition and methods of treating b cell disorders
TW201825515A (en) 2017-01-04 2018-07-16 美商伊繆諾金公司 Met antibody and immune conjugate and uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8626412D0 (en) 1986-11-05 1986-12-03 Clark M R Antibodies
US5320942A (en) * 1987-02-19 1994-06-14 Vito Quaranta Method of diagnosing the presence of abnormal epithelial tissue using monoclonal antibodies to the A6 B4 cell surface protein
ES2156587T3 (en) 1993-08-02 2001-07-01 Merck Patent Gmbh Bispecific molecules that recognize antigen starter lymphocytic CD2 and tumor antigens.
AT210682T (en) * 1996-09-03 2001-12-15 Gsf Forschungszentrum Umwelt Destruction of contaminating tumor cells in stem cell transplants with bispecific antibodies

Also Published As

Publication number Publication date
ES2169299T3 (en) 2002-07-01
DK0826695T3 (en) 2002-04-15
EP0826695B1 (en) 2001-12-12
EP0826695A1 (en) 1998-03-04
US6210668B1 (en) 2001-04-03
JP3257970B2 (en) 2002-02-18
DK826695T3 (en)
US5985276A (en) 1999-11-16
JPH10179151A (en) 1998-07-07

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