AT210189T - Phagemids which co-express a surface receptor and a heterologous surface protein - Google Patents

Phagemids which co-express a surface receptor and a heterologous surface protein

Info

Publication number
AT210189T
AT210189T AT93921370T AT93921370T AT210189T AT 210189 T AT210189 T AT 210189T AT 93921370 T AT93921370 T AT 93921370T AT 93921370 T AT93921370 T AT 93921370T AT 210189 T AT210189 T AT 210189T
Authority
AT
Austria
Prior art keywords
surface
phagemids
express
heterologous
receptor
Prior art date
Application number
AT93921370T
Other languages
German (de)
Inventor
James Paul Ii Light
Richard A Lerner
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US94136992A priority Critical
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Priority to PCT/US1993/008364 priority patent/WO1994005781A1/en
Publication of AT210189T publication Critical patent/AT210189T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
AT93921370T 1992-09-04 1993-09-03 Phagemids which co-express a surface receptor and a heterologous surface protein AT210189T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US94136992A true 1992-09-04 1992-09-04
PCT/US1993/008364 WO1994005781A1 (en) 1992-09-04 1993-09-03 Phagemids coexpressing a surface receptor and a surface heterologous protein

Publications (1)

Publication Number Publication Date
AT210189T true AT210189T (en) 2001-12-15

Family

ID=25476353

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93921370T AT210189T (en) 1992-09-04 1993-09-03 Phagemids which co-express a surface receptor and a heterologous surface protein

Country Status (11)

Country Link
US (1) US5770356A (en)
EP (2) EP0663953B1 (en)
JP (2) JPH08502645A (en)
AT (1) AT210189T (en)
AU (1) AU685753B2 (en)
CA (1) CA2143104C (en)
DE (2) DE69331278D1 (en)
DK (1) DK0663953T3 (en)
ES (1) ES2168277T3 (en)
PT (1) PT663953E (en)
WO (1) WO1994005781A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916605B1 (en) * 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
CA2095633C (en) * 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
PT100379B (en) * 1991-04-10 1999-01-29 Scripps Research Inst Libraries of heterodymeric receptors using fagomideos
DE69233745D1 (en) * 1991-12-02 2008-10-23 Cambridge Antibody Tech Production of autoantibodies on phage surfaces starting from antibody segment libraries
DK1231268T3 (en) 1994-01-31 2005-11-21 Univ Boston Polyclonal antibody libraries
US20060078561A1 (en) * 1994-01-31 2006-04-13 The Trustees Of Boston University Polyclonal antibody libraries
US6475806B1 (en) * 1995-06-07 2002-11-05 Praecis Pharmaceuticals, Inc. Anchor libraries and identification of peptide binding sequences
US5811381A (en) * 1996-10-10 1998-09-22 Mark A. Emalfarb Cellulase compositions and methods of use
US7883872B2 (en) * 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
AT447613T (en) * 1997-11-17 2009-11-15 Micromet Ag Method of identifying binding site domains that retain their epitopbindefähigkeit
US7244826B1 (en) 1998-04-24 2007-07-17 The Regents Of The University Of California Internalizing ERB2 antibodies
WO2000006717A2 (en) 1998-07-27 2000-02-10 Genentech, Inc. Improved transformation efficiency in phage display through modification of a coat protein
DK1117808T3 (en) * 1998-10-06 2005-04-25 Mark Aaron Emalfarb Transformaationssystem within jfjor area filamentous fungal hosts: In chrysoporium
ES2321568T3 (en) * 1999-05-18 2009-06-08 Dyax Corp. Libraries Fab fragments and procedures for use.
US20020102613A1 (en) 1999-05-18 2002-08-01 Hoogenboom Hendricus Renerus Jacobus Mattheus Novel Fab fragment libraries and methods for their use
JP2003516755A (en) * 1999-12-15 2003-05-20 ジェネンテック・インコーポレーテッド Shotgun scan, i.e. the combination method for mapping functional protein epitope
AU7919301A (en) * 2000-08-02 2002-02-13 Xencor Inc Methods and compositions for the construction and use of envelope viruses as display particles
WO2003004604A2 (en) * 2001-07-06 2003-01-16 Genentech, Inc. Phage displayed pdz domain ligands
US7112435B1 (en) * 2002-08-07 2006-09-26 Ambit Biosciences Corporation Uncoupling of DNA insert propagation and expression of protein for phage display
US7833741B2 (en) * 2002-08-07 2010-11-16 Ambit Biosciences Corporation Uncoupling of DNA insert propagation and expression of protein for phage display
US7897381B2 (en) * 2002-08-07 2011-03-01 Ambit Biosciences Corporation Uncoupling of DNA insert propagation and expression of protein for phage display
US20040235121A1 (en) * 2002-08-29 2004-11-25 Integrigen, Inc. High copy number plasmids and their derivatives
ES2301818T3 (en) * 2002-09-18 2008-07-01 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for detection of an antigen on a cell and a bilogica mixture.
EP2977470B1 (en) * 2002-10-16 2018-01-03 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
US7927840B2 (en) * 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
US7329725B1 (en) * 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
US20070224635A1 (en) * 2004-01-30 2007-09-27 Maxygen Holdings, Ltd. Regulated Stop Codon Readthrough
AU2005250369A1 (en) * 2004-05-18 2005-12-15 Genentech, Inc. M13 virus major coat protein variants for C-terminal and BI-terminal display of a heterologous protein
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
WO2008073914A2 (en) 2006-12-10 2008-06-19 Dyadic International Inc. Expression and high-throughput screening of complex expressed dna libraries in filamentous fungi
CA2736661A1 (en) * 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3852304T3 (en) * 1987-03-02 1999-07-01 Enzon Lab Inc Organism as a support for "Single Chain Antibody domain (SCAD)".
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5146568A (en) * 1988-09-06 1992-09-08 Digital Equipment Corporation Remote bootstrapping a node over communication link by initially requesting remote storage access program which emulates local disk to load other programs
US5142680A (en) * 1989-04-26 1992-08-25 Sun Microsystems, Inc. Method for loading an operating system through a network
CA2016841C (en) * 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
CA2025398A1 (en) * 1989-09-20 1992-03-15 Timothy Gerard Dinan Diagnosis and treatment of a disorder of the gastrointestinal tract
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
DK0600866T3 (en) * 1990-06-01 1998-03-09 Chiron Corp Compositions and methods for identifying biologically active molecules
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
IL99552D0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
GB9022190D0 (en) * 1990-10-12 1990-11-28 Perham Richard N Immunogenic material

Also Published As

Publication number Publication date
ES2168277T3 (en) 2002-06-16
DE69331278T2 (en) 2002-07-18
DK663953T3 (en)
CA2143104A1 (en) 1994-03-17
AU4848593A (en) 1994-03-29
EP0663953A1 (en) 1995-07-26
EP0663953B1 (en) 2001-12-05
EP1162270A2 (en) 2001-12-12
DE69331278D1 (en) 2002-01-17
PT663953E (en) 2002-05-31
EP0663953A4 (en) 1997-05-02
JPH08502645A (en) 1996-03-26
CA2143104C (en) 2008-04-08
AU685753B2 (en) 1998-01-29
DK0663953T3 (en) 2002-04-02
US5770356A (en) 1998-06-23
WO1994005781A1 (en) 1994-03-17
JP2004000238A (en) 2004-01-08
EP1162270A3 (en) 2003-04-09

Similar Documents

Publication Publication Date Title
DE69323773D1 (en) Anticonvulsant sulfamate sorbopyranose
DE69317183T2 (en) The health-serving drink
DE69325213T2 (en) Digital micromirror
IT1298691B1 (en) Pesticides
DE69328973T2 (en) intraocular prosthesis
DE69132984T2 (en) Programmable interconnect architecture
DK0598255T3 (en) Bag-in-carton and the pouring spout thereof
LU91556I2 (en) reconstituted human antibodies directed against a receptor for the human interleukin 6 - tocilizumab
DE69316999D1 (en) dispenser
DE69317301D1 (en) dispenser
NO930193D0 (en) Biarylsubstituerte 4 aminosmoersyreamider
DE69211793T2 (en) Adjusted and frequency controlled by the ejection fraction pacemakers
DE69427472T2 (en) Drug controlled release
AT169495T (en) shampoo
DE69331539T2 (en) Multilayer material
AT184470T (en) Conical hip pan
EE9700191A (en) The herbicidal ylbenzoyl
DK165090D0 (en) conglomerated particles
DE69308180T2 (en) Nickel-cobalt alloy
DE69219415D1 (en) programmable transponder
DE69425258D1 (en) Liquid-conveyable material
DE19680996D2 (en) modular endoprosthesis
DE69317329T3 (en) pigment material
NO954491D0 (en) vibrating sieve
DK0776608T3 (en) chocolate Molding

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification