AT208773T - Chinoxalindione - Google Patents

Chinoxalindione

Info

Publication number
AT208773T
AT208773T AT97908156T AT97908156T AT208773T AT 208773 T AT208773 T AT 208773T AT 97908156 T AT97908156 T AT 97908156T AT 97908156 T AT97908156 T AT 97908156T AT 208773 T AT208773 T AT 208773T
Authority
AT
Austria
Prior art keywords
chinoxalindione
Prior art date
Application number
AT97908156T
Other languages
English (en)
Inventor
David John Bull
Christopher Lee Carr
Michael Jonathan Fray
Elisabeth Colette Loui Gautier
Charles Eric Mowbray
Alan Stobie
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB9605027.3A priority Critical patent/GB9605027D0/en
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Priority to PCT/EP1997/000995 priority patent/WO1997032873A1/en
Publication of AT208773T publication Critical patent/AT208773T/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AT97908156T 1996-03-09 1997-02-27 Chinoxalindione AT208773T (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB9605027.3A GB9605027D0 (en) 1996-03-09 1996-03-09 Quinoxalinediones
PCT/EP1997/000995 WO1997032873A1 (en) 1996-03-09 1997-02-27 Quinoxalinediones

Publications (1)

Publication Number Publication Date
AT208773T true AT208773T (de) 2001-11-15

Family

ID=10790134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97908156T AT208773T (de) 1996-03-09 1997-02-27 Chinoxalindione

Country Status (42)

Country Link
US (1) US6376490B1 (de)
EP (1) EP0885212B1 (de)
JP (1) JP3110467B2 (de)
KR (1) KR100288099B1 (de)
CN (1) CN1103770C (de)
AP (1) AP767A (de)
AR (1) AR006119A1 (de)
AT (1) AT208773T (de)
AU (1) AU717972B2 (de)
BG (1) BG63340B1 (de)
BR (1) BR9707851A (de)
CA (1) CA2248366C (de)
CO (1) CO4770976A1 (de)
CZ (1) CZ292792B6 (de)
DE (1) DE69708269T2 (de)
DK (1) DK0885212T3 (de)
DZ (1) DZ2188A1 (de)
EA (1) EA001730B1 (de)
ES (1) ES2163742T3 (de)
GB (1) GB9605027D0 (de)
HN (1) HN1998000034A (de)
HR (1) HRP970132A2 (de)
HU (1) HU9900975A3 (de)
ID (1) ID18112A (de)
IL (1) IL125491A (de)
IS (1) IS4811A (de)
MA (1) MA26422A1 (de)
NO (1) NO984058L (de)
NZ (1) NZ331060A (de)
OA (1) OA10850A (de)
PE (2) PE43398A1 (de)
PL (1) PL329032A1 (de)
PT (1) PT885212E (de)
SI (1) SI0885212T1 (de)
SK (1) SK283467B6 (de)
TN (1) TNSN97044A1 (de)
TR (1) TR199801782T2 (de)
TW (1) TW454004B (de)
UY (1) UY24482A1 (de)
WO (1) WO1997032873A1 (de)
YU (2) YU39698A (de)
ZA (2) ZA971987B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP982A (en) * 1997-02-27 2001-07-16 Pfizer Quinoxalinediones.
CN1121403C (zh) * 1997-02-27 2003-09-17 辉瑞大药厂 喹喔啉二酮
US6340758B1 (en) * 1997-05-16 2002-01-22 Warner-Lambert Company Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
DE10005150A1 (de) * 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden
AU5676901A (en) * 2000-05-19 2001-11-26 Yamanouchi Pharma Co Ltd Triazole derivatives
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2005006945A2 (en) * 2003-07-03 2005-01-27 The Salk Institute For Biological Studies Methods for treating neural disorders and compounds useful therefor
MY145368A (en) * 2004-01-13 2012-01-31 Nissan Chemical Ind Ltd Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
EP1713101B1 (de) 2004-02-06 2012-10-31 Yamaguchi University Elektrode für eine energiespeichereinrichtung und herstellungsprozess dafür
JP2007223901A (ja) * 2004-03-24 2007-09-06 Takeda Chem Ind Ltd 複素環化合物およびその用途
US20060211739A1 (en) * 2005-02-08 2006-09-21 Arturo Perez-Medrano Use of selective P2X7 receptor antagonists
WO2007112347A1 (en) * 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP2089383B1 (de) 2006-11-09 2015-09-16 Probiodrug AG 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
WO2008088820A2 (en) 2007-01-16 2008-07-24 The Johns Hopkins University Glutamate receptor antagonists and methods of use
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101679383B (zh) 2007-05-17 2014-10-29 株式会社半导体能源研究所 三唑衍生物,和使用三唑衍生物的发光元件、发光器件和电子器件
KR101755737B1 (ko) 2009-09-11 2017-07-07 프로비오드룩 아게 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
KR101790806B1 (ko) 2010-03-10 2017-11-20 프로비오드룩 아게 글루타미닐 사이클라제(qc, ec 2.3.2.5)의 헤테로사이클릭 억제제
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
CN104955809B (zh) * 2013-02-07 2018-12-11 普雷斯特威克化学公司 取代的乙炔衍生物及其作为mGluR4的正变构调节剂的用途
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283244A (en) * 1990-11-06 1994-02-01 Yamanouchi Pharmaceutical Co., Ltd. Fused pyrazine derivatives
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
CN1121403C (zh) * 1997-02-27 2003-09-17 辉瑞大药厂 喹喔啉二酮

Also Published As

Publication number Publication date
SI0885212T1 (en) 2002-02-28
HRP970132A2 (en) 1998-06-30
DK885212T3 (de)
CN1213369A (zh) 1999-04-07
EA199800702A1 (ru) 1999-04-29
KR100288099B1 (ko) 2001-05-02
PE43398A1 (es) 1998-08-29
PT885212E (pt) 2002-02-28
AP9700947A0 (en) 1997-04-30
DZ2188A1 (fr) 2002-12-02
AU2023197A (en) 1997-09-22
IL125491D0 (en) 1999-03-12
HU9900975A3 (en) 2001-12-28
NO984058D0 (no) 1998-09-03
CA2248366C (en) 2002-06-04
YU39698A (sh) 1999-03-04
US6376490B1 (en) 2002-04-23
IS4811A (is) 1998-07-27
TW454004B (en) 2001-09-11
ID18112A (id) 1998-03-05
DE69708269D1 (de) 2001-12-20
CA2248366A1 (en) 1997-09-12
EP0885212B1 (de) 2001-11-14
CZ292792B6 (cs) 2003-12-17
JP3110467B2 (ja) 2000-11-20
HU9900975A2 (hu) 1999-07-28
CO4770976A1 (es) 1999-04-30
SK283467B6 (sk) 2003-08-05
MA26422A1 (fr) 2004-12-20
OA10850A (en) 2001-08-16
YU41199A (sh) 2001-09-28
ZA971987B (en) 1998-09-07
HN1998000034A (es) 1999-02-09
BG63340B1 (bg) 2001-10-31
ZA9701987B (en) 1998-09-07
WO1997032873A1 (en) 1997-09-12
KR19990087614A (ko) 1999-12-27
TR199801782T2 (xx) 1998-12-21
PE58199A1 (es) 1999-06-11
BG102760A (en) 1999-09-30
PL329032A1 (en) 1999-03-01
DE69708269T2 (de) 2002-07-25
EA001730B1 (ru) 2001-08-27
JPH11506123A (ja) 1999-06-02
CN1103770C (zh) 2003-03-26
UY24482A1 (es) 2000-09-29
IL125491A (en) 2003-07-06
AR006119A1 (es) 1999-08-11
GB9605027D0 (en) 1996-05-08
EP0885212A1 (de) 1998-12-23
TNSN97044A1 (fr) 2005-03-15
CZ286498A3 (cs) 1999-07-14
AU717972B2 (en) 2000-04-06
SK121498A3 (en) 2000-10-09
AP767A (en) 1999-09-29
BR9707851A (pt) 1999-07-27
ES2163742T3 (es) 2002-02-01
NZ331060A (en) 2000-01-28
DK0885212T3 (da) 2002-03-25
NO984058L (no) 1998-11-06

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee