AT205534T - Pneumolysin mutant and pneumococcal vaccines it - Google Patents

Pneumolysin mutant and pneumococcal vaccines it


Publication number
AT205534T AT90900035T AT90900035T AT205534T AT 205534 T AT205534 T AT 205534T AT 90900035 T AT90900035 T AT 90900035T AT 90900035 T AT90900035 T AT 90900035T AT 205534 T AT205534 T AT 205534T
Prior art keywords
pneumococcal vaccines
pneumolysin mutant
Prior art date
Application number
Other languages
German (de)
James Cleland Paton
Graham John Boulnois
Peter William Andrew
Timothy John Mitchell
John Arthur Walker
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AUPJ198988 priority Critical
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Priority to PCT/AU1989/000539 priority patent/WO1990006951A1/en
Publication of AT205534T publication Critical patent/AT205534T/en



    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A61K39/00Medicinal preparations containing antigens or antibodies
AT90900035T 1988-12-16 1989-12-15 Pneumolysin mutant and pneumococcal vaccines it AT205534T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AUPJ198988 1988-12-16
PCT/AU1989/000539 WO1990006951A1 (en) 1988-12-16 1989-12-15 Pneumolysin mutants and pneumococcal vaccines made therefrom

Publications (1)

Publication Number Publication Date
AT205534T true AT205534T (en) 2001-09-15



Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900035T AT205534T (en) 1988-12-16 1989-12-15 Pneumolysin mutant and pneumococcal vaccines it

Country Status (15)

Country Link
EP (1) EP0449856B1 (en)
JP (1) JP3237842B2 (en)
AT (1) AT205534T (en)
AU (1) AU626961B2 (en)
BG (1) BG51358A3 (en)
CA (1) CA2005704C (en)
DE (2) DE68929323D1 (en)
DK (1) DK173629B1 (en)
ES (1) ES2160570T3 (en)
FI (1) FI103122B1 (en)
HU (1) HUT58804A (en)
MC (1) MC2178A1 (en)
NO (1) NO304317B1 (en)
RU (1) RU2121481C1 (en)
WO (1) WO1990006951A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716432B1 (en) * 1988-12-16 2004-04-06 James Cleland Paton Pneumolysin mutants and pneumococcal vaccines made therefrom
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
US5391712A (en) * 1991-08-30 1995-02-21 Beckman Instruments, Inc. Non-hemolytic streptolysin O variants
US5928900A (en) * 1993-09-01 1999-07-27 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
EP0687688A1 (en) * 1993-12-17 1995-12-20 Universidad De Oviedo Antibodies against pneumolysine and their applications
US8791237B2 (en) 1994-11-08 2014-07-29 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of non-hodgkins lymphoma
HU0002475A3 (en) * 1997-07-21 2002-01-28 Baxter Healthcare S A Wallisel Modified immunogenic pneumolysin compositions as vaccines
PT1163000E (en) * 1999-03-19 2008-03-20 Glaxosmithkline Biolog Sa Vaccine against antigens from bacteriae
GB9906437D0 (en) 1999-03-19 1999-05-12 Smithkline Beecham Biolog Vaccine
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
JP4254931B1 (en) 2000-10-27 2009-04-15 カイロン ソチエタ ア レスポンサビリタ リミタータ Nucleic acids and proteins from Group A Streptococcus and Group B Streptococcus
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
DE20321889U1 (en) 2002-08-02 2012-03-12 Glaxosmithkline Biologicals S.A. vaccine composition
US8945589B2 (en) 2003-09-15 2015-02-03 Novartis Vaccines And Diagnostics, Srl Immunogenic compositions for Streptococcus agalactiae
WO2004039417A2 (en) 2002-11-01 2004-05-13 Glaxosmithkline Biologicals S.A. Drying process
US7217791B2 (en) 2002-11-07 2007-05-15 Synergy America, Inc. Compositions and methods for treating or preventing pneumococcal infection
MXPA05009579A (en) 2003-03-13 2005-11-17 Glaxosmithkline Biolog Sa Purification process for bacterial cytolysin.
JP4875490B2 (en) 2003-07-31 2012-02-15 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド Immunogenic composition for Streptococcus pyogenes
CA2539715C (en) 2003-10-02 2015-02-24 Glaxosmithkline Biologicals S.A. Pertussis antigens and use thereof in vaccination
US20060257421A1 (en) * 2004-02-13 2006-11-16 Martina Ochs Pneumolysin derivatives
WO2005108419A1 (en) * 2004-05-07 2005-11-17 Lea-Ann Kirkham Mutant cholesterol-binding cytolysin proteins
GB0410220D0 (en) * 2004-05-07 2004-06-09 Kirkham Lea Ann Mutant pneumolysin proteins
EP2612679A1 (en) 2004-07-29 2013-07-10 Novartis Vaccines and Diagnostics, Inc. Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
GB0421083D0 (en) * 2004-09-22 2004-10-27 Glaxosmithkline Biolog Sa Purification process
JP2008544949A (en) 2004-10-08 2008-12-11 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド Immunostimulatory and therapeutic compositions for pyogenic streptococci
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
TW201350129A (en) 2005-12-22 2013-12-16 Glaxosmithkline Biolog Sa Streptococcus pneumoniae immunogenic composition comprising capsular saccharide conjugates, vaccine and kit comprising the same and uses thereof
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
KR101151202B1 (en) 2006-10-12 2012-06-11 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccine comprising an oil in water emulsion adjuvant
EP2433648A3 (en) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
CN101374859B (en) 2006-01-17 2014-11-26 阿恩·福斯格伦 A novel surface exposed haemophilus influenzae protein (protein e; pE)
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
HUE037808T2 (en) 2006-09-26 2018-09-28 Infectious Disease Res Institute Vaccine composition containing synthetic adjuvant
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US9717788B2 (en) 2007-03-02 2017-08-01 Glaxosmithkline Biologicals Sa Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant
WO2008107370A1 (en) 2007-03-02 2008-09-12 Glaxosmithkline Biologicals S.A. Novel method and compositions
BRPI0810211A2 (en) * 2007-04-13 2014-10-21 Univ Oklahoma Dependent cholesterol dependent cytolisin, composition, vaccine, method for vaccinating a patient, monoclonal antibody, nucleic acid, and, host cell.
EA201391788A1 (en) 2007-06-26 2014-08-29 Глаксосмитклайн Байолоджикалс С.А. Vaccine containing conjugates of capsular polysaccharides streptococcus pneumoniae
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
JP5653215B2 (en) 2007-09-12 2015-01-14 ノバルティス アーゲー GAS57 mutant antigen and GAS57 antibody
JP5656642B2 (en) 2007-12-21 2015-01-21 ノバルティス アーゲー A mutant form of streptolysin O
EP2271360B1 (en) 2008-04-16 2015-09-23 GlaxoSmithKline Biologicals S.A. Vaccine
GB0815872D0 (en) 2008-09-01 2008-10-08 Pasteur Institut Novel method and compositions
US8758766B2 (en) * 2008-12-24 2014-06-24 The Kingdom of The Netherlands, Represented by The Mininster of Health, Welfare and Sport, on Behalf of The Minster The National Institute of Public Health and The Environment Modified Streptococcus pneumoniae pneumolysin (PLY) polypeptides
EP2411045A1 (en) 2009-03-24 2012-02-01 Novartis AG Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
MX360448B (en) 2009-06-05 2018-11-01 Infectious Disease Res Institute Synthetic glucopyranosyl lipid adjuvants.
CN102695523A (en) 2009-09-10 2012-09-26 诺华有限公司 Combination vaccines against respiratory tract diseases
CN102802664B (en) * 2009-12-22 2017-04-05 赛诺菲巴斯德有限公司 The immunogenic composition
EP2515940A4 (en) 2009-12-22 2013-10-09 Sanofi Pasteur Ltd Immunogenic compositions and related methods
WO2011112717A1 (en) 2010-03-09 2011-09-15 Biomedical Research Models, Inc. A novel mucosal vaccination approach for herpes simplex virus type-2
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
EP2544714A1 (en) 2010-03-10 2013-01-16 GlaxoSmithKline Biologicals S.A. Vaccine composition
JP6002659B2 (en) 2010-04-13 2016-10-05 セルデックス・セラピューティクス・インコーポレイテッド Antibodies that bind to human CD27 and uses thereof
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
GB201022007D0 (en) 2010-12-24 2011-02-02 Imp Innovations Ltd DNA-sensor
WO2012134975A1 (en) 2011-03-28 2012-10-04 St. Jude Children's Research Hospital Methods and compositions employing immunogenic fusion proteins
CN103596586A (en) 2011-04-08 2014-02-19 免疫设计公司 Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
AR086405A1 (en) 2011-05-17 2013-12-11 Glaxosmithkline Biolog Sa Streptococcus pneumoniae vaccine
LT2811981T (en) 2012-02-07 2019-06-10 Infectious Disease Research Institute Improved adjuvant formulations comprising tlr4 agonists and methods of using the same
WO2013131983A1 (en) 2012-03-07 2013-09-12 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
WO2013173590A1 (en) 2012-05-16 2013-11-21 Immune Design Corp. Vaccines for hsv-2
AU2014203873A1 (en) 2013-01-07 2015-07-30 Biomedical Research Models, Inc. Therapeutic vaccines for treating herpes simplex virus type 2 infections
CA2903716C (en) 2013-03-08 2019-04-09 Pfizer Inc. Immunogenic fusion polypeptides
MX2015014431A (en) 2013-04-18 2016-06-02 Immune Design Corp Gla monotherapy for use in cancer treatment.
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US20180044429A1 (en) 2015-03-09 2018-02-15 Celldex Therapeutics, Inc. Cd27 agonists
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
WO2017184619A2 (en) 2016-04-18 2017-10-26 Celldex Therapeutics, Inc. Agonistic antibodies that bind human cd40 and uses thereof
CN109562057A (en) 2016-05-16 2019-04-02 传染病研究所 Pegylated liposomal and application method
WO2017200852A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Formulation containing tlr agonist and methods of use
KR20190015255A (en) 2016-06-01 2019-02-13 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) Nanomaterials containing a sizing agent
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
WO2018232257A1 (en) 2017-06-15 2018-12-20 Infectious Disease Research Institute Nanostructured lipid carriers and stable emulsions and uses thereof
WO2019051149A1 (en) 2017-09-08 2019-03-14 Infectious Disease Research Institute Liposomal formulations comprising saponin and methods of use
WO2019204462A2 (en) 2018-04-17 2019-10-24 Celldex Therapeutics, Inc. Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs

Also Published As

Publication number Publication date
NO304317B1 (en) 1998-11-30
MC2178A1 (en) 1992-05-22
EP0449856A1 (en) 1991-10-09
FI103122B1 (en) 1999-04-30
CA2005704A1 (en) 1990-06-16
FI103122B (en) 1999-04-30
FI912878A0 (en) 1991-06-14
JPH04503948A (en) 1992-07-16
AU4756490A (en) 1990-07-10
DE68929323D1 (en) 2001-10-18
WO1990006951A1 (en) 1990-06-28
BG51358A3 (en) 1993-04-15
AU626961B2 (en) 1992-08-13
RU2121481C1 (en) 1998-11-10
CA2005704C (en) 2003-02-11
EP0449856A4 (en) 1992-05-20
HUT58804A (en) 1992-03-30
DE68929323T2 (en) 2002-04-18
ES2160570T3 (en) 2001-11-16
NO912226D0 (en) 1991-06-11
FI912878D0 (en)
EP0449856B1 (en) 2001-09-12
DK115591A (en) 1991-08-14
JP3237842B2 (en) 2001-12-10
DK173629B1 (en) 2001-05-14
DK115591D0 (en) 1991-06-14
NO912226L (en) 1991-07-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time