AT191470T - Enzymhemmer - Google Patents

Enzymhemmer

Info

Publication number
AT191470T
AT191470T AT95924405T AT95924405T AT191470T AT 191470 T AT191470 T AT 191470T AT 95924405 T AT95924405 T AT 95924405T AT 95924405 T AT95924405 T AT 95924405T AT 191470 T AT191470 T AT 191470T
Authority
AT
Austria
Prior art keywords
enzymhemmer
Prior art date
Application number
AT95924405T
Other languages
English (en)
Inventor
Harold Francis Dson
Richard M J Palmer
David Alan Sawyer
Richard Graham Knowles
Karl Witold Franzmann
Martin James Drysdale
Steven Smith
Patricia Ifeyinwa Davies
Helen Alice Rebecca Clark
Barry George Shearer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP94304314 priority Critical
Priority to GBGB9509774.7A priority patent/GB9509774D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Priority to PCT/GB1995/001378 priority patent/WO1995034534A1/en
Publication of AT191470T publication Critical patent/AT191470T/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT95924405T 1994-06-15 1995-06-14 Enzymhemmer AT191470T (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94304314 1994-06-15
GBGB9509774.7A GB9509774D0 (en) 1995-05-15 1995-05-15 Enzyme inhibitors
PCT/GB1995/001378 WO1995034534A1 (en) 1994-06-15 1995-06-14 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
AT191470T true AT191470T (de) 2000-04-15

Family

ID=26137155

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95924405T AT191470T (de) 1994-06-15 1995-06-14 Enzymhemmer
AT99116304T AT229001T (de) 1994-06-15 1995-06-14 Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99116304T AT229001T (de) 1994-06-15 1995-06-14 Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren

Country Status (29)

Country Link
US (1) USRE39576E1 (de)
EP (2) EP0957087B1 (de)
JP (2) JP2989010B2 (de)
KR (1) KR100430207B1 (de)
CN (1) CN1070849C (de)
AT (2) AT191470T (de)
AU (1) AU692892B2 (de)
BR (1) BR9507995A (de)
CA (1) CA2192668A1 (de)
CY (2) CY2238B1 (de)
DE (2) DE69529101T2 (de)
DK (2) DK0765308T3 (de)
ES (2) ES2189322T3 (de)
FI (1) FI965019A (de)
GR (1) GR3033746T3 (de)
HK (1) HK1003935A1 (de)
HU (1) HUT77407A (de)
IL (2) IL114142A (de)
IS (1) IS4384A (de)
MX (1) MX9606136A (de)
MY (1) MY115437A (de)
NO (1) NO308655B1 (de)
NZ (1) NZ289157A (de)
PT (2) PT957087E (de)
RU (1) RU2162841C2 (de)
SI (2) SI0957087T1 (de)
TW (1) TW442453B (de)
WO (1) WO1995034534A1 (de)
ZA (1) ZA9504940B (de)

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DE10111052A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
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GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
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US7943651B2 (en) 2006-04-20 2011-05-17 Glaxo Group Limited Compounds
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BRPI0912267A2 (pt) 2008-05-23 2015-10-13 Amira Pharmaceuticals Inc sal farmaceuticamente aceitável, composição farmacêutica, artigo de fabricação, métodos para tratar asma, rinite alérgica, doença, lesões gástricas e dor, métodos para prevenir broncoconstrição e rinite alérgica, uso de um sal farmaceuticamente aceitável, e, processo para a preparação de um sal farmaceuticamente aceitável.
JP5502858B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッドGlaxo Group Limited Pi3キナーゼの阻害剤として有用な4−カルボキサミドインダゾール誘導体
JP5502077B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッドGlaxo Group Limited 新規な化合物
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria
EP2406255B1 (de) 2009-03-09 2015-04-29 Glaxo Group Limited 4-oxadiazol-2-ylindazole als inhibitoren von pi3-kinasen
EP2406249A1 (de) 2009-03-10 2012-01-18 Glaxo Group Limited Indolderivate als ikk2-inhibitoren
WO2010106016A1 (en) 2009-03-17 2010-09-23 Glaxo Group Limited Pyrimidine derivatives used as itk inhibitors
WO2010107957A2 (en) 2009-03-19 2010-09-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20120035247A1 (en) 2009-03-19 2012-02-09 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA)
EP2408917A2 (de) 2009-03-19 2012-01-25 Merck Sharp&Dohme Corp. Rna-interferenz-vermittelte hemmung der genexpression von bach1 (btb and cnc homology 1, basic leucine zipper transcription factor 1) unter verwendung von sina (short interfering nucleic acid)
US20120016011A1 (en) 2009-03-19 2012-01-19 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
WO2010111490A2 (en) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE THYMIC STROMAL LYMPHOPOIETIN (TSLP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2411018A2 (de) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. Rna-interferenz-vermittelte hemmung der nervenwachstumsfaktor-betaketten (ngf9-gen-expression mittels sina (short interfering nucleic acid)
CN102439152A (zh) 2009-03-27 2012-05-02 默沙东公司 使用短干扰核酸(siNA)的RNA干扰介导的细胞间粘附分子1(ICAM-1)基因表达的抑制
US20120022142A1 (en) 2009-03-27 2012-01-26 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
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WO2010122088A1 (en) 2009-04-24 2010-10-28 Glaxo Group Limited Pyrazole and triazole carboxamides as crac channel inhibitors
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Family Cites Families (4)

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DE3514450A1 (de) * 1985-04-22 1986-10-23 Hoechst Ag Verfahren zur herstellung von imidaten sowie neue arylsubstituierte imidate
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
DE4310202A1 (de) 1992-03-30 1993-10-07 Ciba Geigy µ-Ketoimidoester als Stabilisatoren für chlorhaltige Polymerisate
FR2727111B1 (fr) * 1994-11-21 1997-01-17 Hoechst Lab Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments

Also Published As

Publication number Publication date
AU2891795A (en) 1996-01-05
IL114142D0 (en) 1995-10-31
AT229001T (de) 2002-12-15
RU2162841C2 (ru) 2001-02-10
FI965019D0 (de)
DE69516141D1 (de) 2000-05-11
DE69529101T2 (de) 2003-11-13
CN1070849C (zh) 2001-09-12
NO308655B1 (no) 2000-10-09
MY115437A (en) 2003-06-30
EP0957087A3 (de) 2000-12-20
SI0765308T1 (en) 2000-08-31
PT957087E (pt) 2003-04-30
USRE39576E1 (en) 2007-04-17
GR3033746T3 (en) 2000-10-31
NZ289157A (en) 1998-03-25
DK0765308T3 (da) 2000-09-11
DK765308T3 (de)
EP0765308A1 (de) 1997-04-02
CA2192668A1 (en) 1995-12-21
ES2145282T3 (es) 2000-07-01
US5889056A (en) 1999-03-30
CY2238B1 (en) 2003-07-04
HU9603454D0 (en) 1997-02-28
JP2989010B2 (ja) 1999-12-13
IS4384A (is) 1996-11-13
JP3614711B2 (ja) 2005-01-26
CY2455B1 (en) 2005-06-03
MX9606136A (es) 1998-06-30
FI965019A0 (fi) 1996-12-13
NO965379L (no) 1996-12-13
TW442453B (en) 2001-06-23
ZA9504940B (en) 1996-12-17
IL128717D0 (en) 2000-01-31
EP0957087A2 (de) 1999-11-17
IL114142A (en) 2000-02-17
NO965379D0 (no) 1996-12-13
ES2189322T3 (es) 2003-07-01
AU692892B2 (en) 1998-06-18
KR100430207B1 (ko) 2004-07-19
EP0957087B1 (de) 2002-12-04
BR9507995A (pt) 1997-08-05
EP0765308B1 (de) 2000-04-05
HK1003935A1 (en) 1998-11-13
DE69516141T2 (de) 2000-10-19
JPH10506371A (ja) 1998-06-23
DK0957087T3 (da) 2003-03-24
JP2000026402A (ja) 2000-01-25
CN1155276A (zh) 1997-07-23
SI0957087T1 (sl) 2003-04-30
WO1995034534A1 (en) 1995-12-21
FI965019A (fi) 1996-12-13
PT765308E (pt) 2000-09-29
DE69529101D1 (de) 2003-01-16
HUT77407A (hu) 1998-04-28

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Legal Events

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