AT189458T - Dipeptide p-amidinobenzylamide with n-terminal sulfonyl or aminosulfonylresten - Google Patents

Dipeptide p-amidinobenzylamide with n-terminal sulfonyl or aminosulfonylresten

Info

Publication number
AT189458T
AT189458T AT95941015T AT95941015T AT189458T AT 189458 T AT189458 T AT 189458T AT 95941015 T AT95941015 T AT 95941015T AT 95941015 T AT95941015 T AT 95941015T AT 189458 T AT189458 T AT 189458T
Authority
AT
Austria
Prior art keywords
aminosulfonylresten
amidinobenzylamide
dipeptide
terminal sulfonyl
sulfonyl
Prior art date
Application number
AT95941015T
Other languages
German (de)
Inventor
Hans Joachim Boehm
Stefan Koser
Helmut Mack
Thomas Pfeiffer
Werner Seitz
Hans Wolfgang Hoeffken
Wilfried Hornberger
Thomas Zierke
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE4443390A priority Critical patent/DE4443390A1/en
Application filed by Basf Ag filed Critical Basf Ag
Priority to PCT/EP1995/004646 priority patent/WO1996017860A1/en
Publication of AT189458T publication Critical patent/AT189458T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043Leu-amino acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
AT95941015T 1994-12-06 1995-11-25 Dipeptide p-amidinobenzylamide with n-terminal sulfonyl or aminosulfonylresten AT189458T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE4443390A DE4443390A1 (en) 1994-12-06 1994-12-06 New dipeptide p-Amidinobenzylamide with N-terminal sulfonyl or Aminosulfonylresten
PCT/EP1995/004646 WO1996017860A1 (en) 1994-12-06 1995-11-25 New dipeptide p-amidinobenzylamides with n-terminal sulfonyl or aminosulfonyl radicals

Publications (1)

Publication Number Publication Date
AT189458T true AT189458T (en) 2000-02-15

Family

ID=6535046

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95941015T AT189458T (en) 1994-12-06 1995-11-25 Dipeptide p-amidinobenzylamide with n-terminal sulfonyl or aminosulfonylresten

Country Status (20)

Country Link
US (1) US5852051A (en)
EP (1) EP0796271B1 (en)
JP (1) JPH10509727A (en)
CN (1) CN1168673A (en)
AT (1) AT189458T (en)
AU (1) AU699579B2 (en)
BR (1) BR9509970A (en)
CA (1) CA2207874A1 (en)
CZ (1) CZ153797A3 (en)
DE (1) DE4443390A1 (en)
ES (1) ES2143666T3 (en)
FI (1) FI972384A0 (en)
HU (1) HU222353B1 (en)
IL (1) IL116231A (en)
MX (1) MX9704050A (en)
NO (1) NO972559L (en)
RU (1) RU2152953C1 (en)
TW (1) TW336222B (en)
WO (1) WO1996017860A1 (en)
ZA (1) ZA9510295B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SE9602263D0 (en) * 1996-06-07 1996-06-07 Astra Ab New Amino Acid Derivatives
CA2258915A1 (en) * 1996-06-25 1997-12-31 Michael Robert Wiley Anticoagulant agents
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
AR013084A1 (en) 1997-06-19 2000-12-13 Astrazeneca Ab Amidino derivatives useful as inhibitors of thrombin, pharmaceutical composition, use of said compounds for the preparation demedicamentos and process for preparing said compounds
SE9704543D0 (en) 1997-12-05 1997-12-05 Astra Ab New compounds
SE9900043D0 (en) * 1999-01-11 1999-01-11 Astra Ab New use
HU0203167A3 (en) * 1999-04-09 2003-09-29 Basf Ag Peptidic substances, their preparations and their use as complement protease inhibitors
US6586405B2 (en) 2000-08-11 2003-07-01 Corvas International, Inc. Non-covalent inhibitors of urokinase and blood vessel formation
IL149042D0 (en) * 2000-08-11 2002-11-10 Corvas Int Inc Non-covalent inhibitors of urokinase and blood vessel formation
DE10049937A1 (en) * 2000-10-06 2002-04-11 Knoll Ag New sugar-modified amidine and guanidine compounds, useful as competitive inhibitors of serine protease, e.g. for treating thrombosis
CH695999A5 (en) 2002-02-28 2006-11-15 Wilex Ag A process for preparing 3-amidinophenylalanine derivatives.
DE102004029812A1 (en) * 2004-06-19 2006-05-24 Clariant Gmbh Process for the preparation of nitriles from aldehyde oximes by reaction with alkylphosphonic anhydrides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (en) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (en) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
CA2140598C (en) * 1994-01-27 2010-03-09 Masahiro Ohshima Prolineamide derivatives
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN1168673A (en) 1997-12-24
IL116231A (en) 2001-01-28
DE4443390A1 (en) 1996-06-13
HU222353B1 (en) 2003-06-28
FI972384A0 (en) 1997-06-05
FI972384A (en) 1997-06-05
US5852051A (en) 1998-12-22
HUT77289A (en) 1998-03-30
NO972559D0 (en) 1997-06-05
JPH10509727A (en) 1998-09-22
TW336222B (en) 1998-07-11
CZ153797A3 (en) 1998-02-18
MX9704050A (en) 1997-08-30
EP0796271B1 (en) 2000-02-02
FI972384D0 (en)
ZA9510295B (en) 1997-06-05
IL116231D0 (en) 1996-03-31
NO972559L (en) 1997-08-05
EP0796271A1 (en) 1997-09-24
BR9509970A (en) 1997-11-25
WO1996017860A1 (en) 1996-06-13
AU4255996A (en) 1996-06-26
CA2207874A1 (en) 1996-06-13
RU2152953C1 (en) 2000-07-20
AU699579B2 (en) 1998-12-10
ES2143666T3 (en) 2000-05-16

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee