AT18910T - Succinimid-derivate und verfahren zu ihrer herstellung. - Google Patents

Succinimid-derivate und verfahren zu ihrer herstellung.

Info

Publication number
AT18910T
AT18910T AT82111295T AT82111295T AT18910T AT 18910 T AT18910 T AT 18910T AT 82111295 T AT82111295 T AT 82111295T AT 82111295 T AT82111295 T AT 82111295T AT 18910 T AT18910 T AT 18910T
Authority
AT
Austria
Prior art keywords
succinimid
derivatives
production
Prior art date
Application number
AT82111295T
Other languages
English (en)
Inventor
Kikuo Ishizumi
Fuji Antoku
Yukio Asami
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP20837981A priority Critical patent/JPH0128756B2/ja
Priority to JP9576382A priority patent/JPH0235749B2/ja
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of AT18910T publication Critical patent/AT18910T/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/724,7-Endo-alkylene-iso-indoles
    • C07D209/764,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
AT82111295T 1981-12-22 1982-12-06 Succinimid-derivate und verfahren zu ihrer herstellung. AT18910T (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP20837981A JPH0128756B2 (de) 1981-12-22 1981-12-22
JP9576382A JPH0235749B2 (ja) 1982-06-03 1982-06-03 Kanjoimidojudotaioyobisonosanfukaen

Publications (1)

Publication Number Publication Date
AT18910T true AT18910T (de) 1986-04-15

Family

ID=26436953

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82111295T AT18910T (de) 1981-12-22 1982-12-06 Succinimid-derivate und verfahren zu ihrer herstellung.

Country Status (6)

Country Link
US (2) US4507303A (de)
EP (1) EP0082402B1 (de)
AT (1) AT18910T (de)
CA (1) CA1184915A (de)
DE (1) DE3270307D1 (de)
MX (2) MX154758A (de)

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JPH034069B2 (de) * 1982-10-21 1991-01-22 Sumitomo Pharma
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke Gmbh & Co Kg 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JPH0566952B2 (de) * 1985-04-17 1993-09-22 Sumitomo Pharma
US4812567A (en) * 1985-10-16 1989-03-14 American Home Products Corporation Polycyclic spiroimides with psychotropic activity
CA1286672C (en) * 1985-10-16 1991-07-23 Magid A. Abou-Gharbia Fused bicyclic imides with psychotropic activity
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
US4777254A (en) * 1986-12-02 1988-10-11 American Home Products Corp. Cyclic imides as H1 -antagonists
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
US5242911A (en) * 1988-06-17 1993-09-07 Pfizer Inc. Bridged bicyclic imides as anxiolytics and antidepressants
HUT61760A (en) * 1988-09-16 1993-03-01 Pfizer Process for producing bridged, bicyclic imides comprising 4-/4-(3-benzisothiazolyl)-1-piperazinyl/-butyl group and pharmaceutical compositions comprising such compounds
US5011841B1 (en) * 1989-11-14 1994-09-06 Pfizer Treatment of depression
FR2654934B1 (fr) * 1989-11-29 1994-09-30 Midy Spa Utilisation de derive [4-(2-pyrimidinyl)-1-piperazinyl] butyliques pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale.
US5258379A (en) * 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
ZA918221B (en) * 1990-10-23 1992-06-24 Akzo Nv 4-(4-or 6-(trifluoromethyl-2-pyridinyl))-1-piperazinyl-alkyl substituted lactams
WO1992010200A1 (en) * 1990-12-14 1992-06-25 New York University Functional interactions between glial s-100b and central nervous system serotonergic neurons
US5858407A (en) * 1992-02-27 1999-01-12 Alza Corporation Method for administering tandospirone
US5688518A (en) * 1992-02-27 1997-11-18 Alza Corporation Antidepressive therapy
US5185158A (en) * 1992-02-27 1993-02-09 Alza Corporation Dosage form comprising succinimide drug for treating depressive disorders and composition comprising same
US5246710A (en) * 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating cyclothymia
US5246711A (en) * 1992-02-27 1993-09-21 Alza Corporation Dosage form for treating dysthymia
US5330762A (en) * 1992-02-27 1994-07-19 Alza Corporation Tandospiaine antidepressive therapy
US5521313A (en) * 1994-05-05 1996-05-28 Bristol-Myers Squibb Company Process for preparing certain azapirones
ES2094690B1 (es) * 1994-11-22 1997-08-01 Univ Madrid Complutense Nuevos derivados de imida-piperazinas.
US6312717B1 (en) 1998-07-07 2001-11-06 Bristol-Myers Squibb Company Method for treatment of anxiety and depression
AU4683499A (en) * 1998-07-30 2000-02-21 Bristol-Myers Squibb Company Improved method for treatment of sleep-related respiratory disorders
US6566361B2 (en) 1999-06-30 2003-05-20 Laboratories, Upsa Azapirone pain treatment
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
EP1854798A3 (de) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
CN1115389C (zh) * 2000-10-08 2003-07-23 南京化工大学 石油加氢过程催化活性促进剂
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1467979B1 (de) * 2001-12-19 2008-08-13 Bristol-Myers Squibb Company Kondensierte heterocyclische verbindungen und deren analoga; modulatoren der funktion von nukleären hormonrezeptoren
AU2002253429A1 (en) * 2002-04-08 2003-10-20 Ranbaxy Laboratories Limited ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE Alpha1Alpha ADRENOCEPTOR BLOCKERS
US20040002500A1 (en) * 2002-06-28 2004-01-01 Fabre Kramer Pharmaceutical, Inc. Methods for treating attention deficit disorder
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
CN101880274A (zh) * 2010-06-28 2010-11-10 北大国际医院集团西南合成制药股份有限公司 一种坦度螺酮及其类似物的制备方法
WO2012016569A1 (en) 2010-08-05 2012-02-09 Conrig Pharma Aps Deuterated tandospirone derivatives as 5-ht1a receptor agonists
CN103641818B (zh) * 2011-08-04 2015-08-12 四川科瑞德制药有限公司 一种枸橼酸坦度螺酮化合物及其制备方法和用途
CZ304027B6 (cs) * 2011-08-18 2013-08-28 Farmak, A. S. Zpusob prípravy polymorfu (1R,2S,3R,4S)-N-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl]-1-cyklohexylmethyl]-2,3-bicyklo[2.2.1]heptandikarboximidu hydrochloridu
CN103755687B (zh) * 2013-12-25 2015-10-21 四川科瑞德制药有限公司 盐酸坦度螺酮晶型ⅰ及其制备方法
CN105218528A (zh) * 2014-06-06 2016-01-06 四川科瑞德制药有限公司 一种l-酒石酸坦度螺酮化合物
CN106349225A (zh) * 2014-06-06 2017-01-25 四川科瑞德制药股份有限公司 一种草酸坦度螺酮化合物
US10758535B1 (en) 2019-04-26 2020-09-01 Sumitomo Dainippon Pharma Co., Ltd. Therapeutic drug for dyskinesia

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US2928846A (en) * 1957-01-15 1960-03-15 Pfizer & Co C Imides of bicycloheptene adducts
US3184456A (en) * 1960-09-12 1965-05-18 Sterling Drug Inc Reduced maleimide adducts of alpha-phellandrene
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3850921A (en) * 1972-09-20 1974-11-26 I Matuo Derivatives of 2,3-norbornanedicarboxamide
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
DE2907070A1 (de) * 1979-02-23 1980-09-04 Hoechst Ag Heterocyclische spiroverknuepfte amidine und verfahren zu ihrer herstellung
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
JPH0229671B2 (de) * 1981-05-29 1990-07-02 Eisai Co Ltd

Also Published As

Publication number Publication date
DE3270307D1 (en) 1986-05-07
EP0082402A2 (de) 1983-06-29
EP0082402A3 (en) 1983-11-23
MX9203165A (es) 1992-07-01
US4543355A (en) 1985-09-24
CA1184915A1 (de)
US4507303A (en) 1985-03-26
EP0082402B1 (de) 1986-04-02
MX154758A (es) 1987-12-10
CA1184915A (en) 1985-04-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time