AT175972T - Parathyroid hormone derivatives - Google Patents

Parathyroid hormone derivatives

Info

Publication number
AT175972T
AT175972T AT91116303T AT91116303T AT175972T AT 175972 T AT175972 T AT 175972T AT 91116303 T AT91116303 T AT 91116303T AT 91116303 T AT91116303 T AT 91116303T AT 175972 T AT175972 T AT 175972T
Authority
AT
Austria
Prior art keywords
parathyroid hormone
hormone derivatives
derivatives
parathyroid
Prior art date
Application number
AT91116303T
Other languages
German (de)
Inventor
Shizue Nakagawa
Tsunehiko Fukuda
Masahiro Kawase
Iwao Yamazaki
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP25749090 priority Critical
Priority to JP3227232A priority patent/JPH0532696A/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AT175972T publication Critical patent/AT175972T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
AT91116303T 1990-09-28 1991-09-25 Parathyroid hormone derivatives AT175972T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP25749090 1990-09-28
JP3227232A JPH0532696A (en) 1990-09-28 1991-09-06 Parathyroid hormone derivative

Publications (1)

Publication Number Publication Date
AT175972T true AT175972T (en) 1999-02-15

Family

ID=26527569

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91116303T AT175972T (en) 1990-09-28 1991-09-25 Parathyroid hormone derivatives

Country Status (6)

Country Link
US (1) US5393869A (en)
EP (1) EP0477885B1 (en)
JP (1) JPH0532696A (en)
AT (1) AT175972T (en)
CA (1) CA2052375C (en)
DE (2) DE69130790D1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3845000C2 (en) * 1987-07-10 1998-11-19 Novartis Ag Compsn. contg. somatostatin analogues for treating breast cancer
JPH05271279A (en) * 1991-08-07 1993-10-19 Takeda Chem Ind Ltd Human parathyroid hormone mutein and its production
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
DE4203040A1 (en) * 1992-02-04 1993-08-05 Boehringer Mannheim Gmbh New parathyroid hormone fragments, their preparation and containing the same drug
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
US5382658A (en) * 1992-04-03 1995-01-17 Allelix Biopharmaceuticals Inc. Stability-enhanced variants of parathyroid hormone
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
CA2098639A1 (en) * 1992-06-19 1993-12-20 K. Anne Kronis Bone stimulating, non-vasoactive parathyroid hormone variants
CN1070500C (en) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 Analogs of paratyroid hormone and parathyroid hormone related peptide; synthesis and use for treating osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995011697A1 (en) * 1993-10-27 1995-05-04 Chugai Seiyaku Kabushiki Kaisha Cure accelerator in chondroplasty
US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
CA2126299C (en) * 1994-06-20 2000-12-12 Gordon E. Willick Parathyroid hormone analogues for the treatment of osteoporosis
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US5747456A (en) * 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
EP0747092B1 (en) 1995-06-09 2003-12-03 Hisamitsu Pharmaceutical Co. Inc. Matrix for iontophoresis
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5908400A (en) * 1996-06-20 1999-06-01 Hisamitsu Pharmaceutical Co., Inc. Device structure for iontophoresis
AU740610B2 (en) * 1996-12-27 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Orthodontic remedies containing PTH
EP1016412A4 (en) * 1997-07-22 2001-05-02 Chugai Pharmaceutical Co Ltd Dental remedies containing pth
DE69938548T2 (en) * 1998-05-05 2009-06-18 Beth Israel Deaconess Medical Center, Inc., Boston Pth2 receptor selective compounds
US6495662B1 (en) * 1998-10-22 2002-12-17 The General Hospital Corporation Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
US7169567B1 (en) 1998-12-31 2007-01-30 The General Hospital Corporation Screening assay utilizing the PTH receptor
ES2316354T3 (en) * 1999-09-29 2009-04-16 The General Hospital Corporation Polypeptide derivatives of partiroid hormone (pth).
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR100491737B1 (en) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 Mosquito control apparatus with the effect of air cleaning
JP4837888B2 (en) * 2001-07-23 2011-12-14 ザ ジェネラル ホスピタル コーポレイション Conformationally restricted parathyroid hormone (PTH) analog
CA2472472A1 (en) 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US7906480B2 (en) * 2002-05-23 2011-03-15 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
CA2487712A1 (en) * 2002-06-28 2004-01-08 Nastech Pharmaceutical Company Inc. Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
US7795220B2 (en) * 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
US7910544B2 (en) 2003-07-17 2011-03-22 The General Hospital Corporation Conformationally constrained parthyroid hormone (PTH) analogs
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
JP5200027B2 (en) 2006-10-13 2013-05-15 イーライ リリー アンド カンパニー Pegylated PTH as PTH receptor modulator and use thereof
US8568737B2 (en) * 2007-08-01 2013-10-29 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
KR101792473B1 (en) * 2011-06-07 2017-10-31 아사히 가세이 파마 가부시키가이샤 Freeze-dried preparation containing high-purity pth and method for producing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5896052A (en) * 1981-11-30 1983-06-07 Toyo Jozo Co Ltd Preparation of highly active h-pth (1-34) amide
US4423037A (en) * 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
FR2550204B1 (en) * 1983-08-05 1987-11-13 Toyo Jozo Kk peptide derivatives of (nle8, nle1b, Tyr 34) -h-pth
EP0293158A3 (en) * 1987-05-26 1990-05-09 Merck & Co., Inc. Parathyroid hormone antagonists
US4771124A (en) * 1987-05-26 1988-09-13 Merck & Co., Inc. Parathyroid hormone antagonists with simplified synthetic methodology
EP0341963A3 (en) * 1988-05-09 1991-07-24 Merck & Co., Inc. Parathyroid hormone antagonists

Also Published As

Publication number Publication date
DE69130790D1 (en) 1999-03-04
EP0477885A2 (en) 1992-04-01
CA2052375A1 (en) 1992-03-29
EP0477885A3 (en) 1993-10-27
EP0477885B1 (en) 1999-01-20
CA2052375C (en) 2001-10-30
DE69130790T2 (en) 1999-07-22
JPH0532696A (en) 1993-02-09
US5393869A (en) 1995-02-28

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties