AT168992T - 7-substituted-9-substituted glycylamido-6-demethyl-6-deoxytetracyclines - Google Patents

7-substituted-9-substituted glycylamido-6-demethyl-6-deoxytetracyclines

Info

Publication number
AT168992T
AT168992T AT93107717T AT93107717T AT168992T AT 168992 T AT168992 T AT 168992T AT 93107717 T AT93107717 T AT 93107717T AT 93107717 T AT93107717 T AT 93107717T AT 168992 T AT168992 T AT 168992T
Authority
AT
Austria
Prior art keywords
substituted
glycylamido
deoxytetracyclines
demethyl
Prior art date
Application number
AT93107717T
Other languages
German (de)
Inventor
Phaik-Eng Sum
Ving J Lee
Raymond T Testa
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/928,589 priority Critical patent/US5328902A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AT168992T publication Critical patent/AT168992T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28Nitrogen atoms
    • C07D295/30Nitrogen atoms non-acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen, hydrocarbon radicals attached to the substituent nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/461,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
AT93107717T 1992-08-13 1993-05-12 7-substituted-9-substituted glycylamido-6-demethyl-6-deoxytetracyclines AT168992T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/928,589 US5328902A (en) 1992-08-13 1992-08-13 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines

Publications (1)

Publication Number Publication Date
AT168992T true AT168992T (en) 1998-08-15

Family

ID=25456485

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93107717T AT168992T (en) 1992-08-13 1993-05-12 7-substituted-9-substituted glycylamido-6-demethyl-6-deoxytetracyclines

Country Status (25)

Country Link
US (5) US5328902A (en)
EP (1) EP0582788B1 (en)
JP (1) JP3583449B2 (en)
CN (1) CN1034216C (en)
AT (1) AT168992T (en)
AU (1) AU674690B2 (en)
CA (1) CA2103836C (en)
CZ (1) CZ288152B6 (en)
DE (2) DE69319976T2 (en)
DK (1) DK0582788T3 (en)
ES (1) ES2119831T3 (en)
FI (1) FI115523B (en)
HK (1) HK1009598A1 (en)
HU (2) HUT64943A (en)
IL (3) IL119118A (en)
LV (1) LV12358B (en)
MX (1) MX9304647A (en)
NO (1) NO302359B1 (en)
NZ (1) NZ248357A (en)
PH (1) PH30007A (en)
PL (3) PL174115B1 (en)
RU (1) RU2125986C1 (en)
SG (1) SG47559A1 (en)
SK (1) SK281705B6 (en)
ZA (1) ZA9305894B (en)

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US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
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Also Published As

Publication number Publication date
NZ248357A (en) 1996-04-26
CA2103836A1 (en) 1994-02-14
CZ288152B6 (en) 2001-05-16
IL106673D0 (en) 1993-12-08
EP0582788A1 (en) 1994-02-16
AU674690B2 (en) 1997-01-09
LV12358A (en) 1999-10-20
CN1034216C (en) 1997-03-12
NO932869L (en) 1994-02-14
CA2103836C (en) 2004-10-05
PH30007A (en) 1996-10-29
NO302359B1 (en) 1998-02-23
HU9302330D0 (en) 1993-10-28
IL106673A (en) 1997-11-20
FI933565A0 (en) 1993-08-12
JP3583449B2 (en) 2004-11-04
ES2119831T3 (en) 1998-10-16
MX9304647A (en) 1994-02-28
US5495031A (en) 1996-02-27
NO932869D0 (en) 1993-08-12
DK0582788T3 (en) 1999-02-01
FI933565D0 (en)
PL174116B1 (en) 1998-06-30
HU211946A9 (en) 1996-01-29
DE69319976D1 (en) 1998-09-03
SK281705B6 (en) 2001-07-10
DK582788T3 (en)
US5466684A (en) 1995-11-14
US5401729A (en) 1995-03-28
PL174115B1 (en) 1998-06-30
CZ159993A3 (en) 1994-03-16
AU4461293A (en) 1994-02-17
CN1083805A (en) 1994-03-16
HK1009598A1 (en) 2000-04-20
FI115523B1 (en)
FI933565A (en) 1994-02-14
FI115523B (en) 2005-05-31
KR940003924A (en) 1994-03-14
IL119118D0 (en) 1996-11-14
EP0582788B1 (en) 1998-07-29
PL300063A1 (en) 1994-02-21
IL119118A (en) 1998-02-08
LV12358B (en) 2000-01-20
DE69319976T2 (en) 1999-03-25
PL173904B1 (en) 1998-05-29
SG47559A1 (en) 1998-04-17
RU2125986C1 (en) 1999-02-10
HUT64943A (en) 1994-03-28
US5328902A (en) 1994-07-12
US5380888A (en) 1995-01-10
JPH06206855A (en) 1994-07-26
ZA9305894B (en) 1994-03-09
SK85693A3 (en) 1994-06-08

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