AT163540T - Retinoid-containing, aqueous, gel-like dosage form - Google Patents

Retinoid-containing, aqueous, gel-like dosage form

Info

Publication number
AT163540T
AT163540T AT93302926T AT93302926T AT163540T AT 163540 T AT163540 T AT 163540T AT 93302926 T AT93302926 T AT 93302926T AT 93302926 T AT93302926 T AT 93302926T AT 163540 T AT163540 T AT 163540T
Authority
AT
Austria
Prior art keywords
retinoid
gel
aqueous
containing
dosage form
Prior art date
Application number
AT93302926T
Other languages
German (de)
Inventor
Richard K Farng
Shirley M Ng
Gerard J Gendimenico
Stanley B Wrobel Jr
James A Mezick
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US86968492A priority Critical
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of AT163540T publication Critical patent/AT163540T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/412Microsized, i.e. having sizes between 0.1 and 100 microns
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/75Anti-irritant
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/857Dermatitis
    • Y10S514/859Acne
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/944Gel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/946Penetrant or absorbent, increases or enhances penetration into subject treated
    • Y10S514/947Topical application
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/975Characterized by the designated surfactant used
AT93302926T 1992-04-16 1993-04-15 Retinoid-containing, aqueous, gel-like dosage form AT163540T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US86968492A true 1992-04-16 1992-04-16

Publications (1)

Publication Number Publication Date
AT163540T true AT163540T (en) 1998-03-15

Family

ID=25354073

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93302926T AT163540T (en) 1992-04-16 1993-04-15 Retinoid-containing, aqueous, gel-like dosage form

Country Status (20)

Country Link
US (1) US5643584A (en)
EP (1) EP0566405B1 (en)
JP (1) JP2779303B2 (en)
KR (1) KR970007901B1 (en)
AT (1) AT163540T (en)
AU (1) AU670777B2 (en)
CA (1) CA2094084C (en)
DE (2) DE69317139D1 (en)
DK (1) DK0566405T3 (en)
ES (1) ES2114588T3 (en)
FI (1) FI931717A (en)
GR (1) GR3026597T3 (en)
HU (1) HUT64468A (en)
IL (1) IL105413A (en)
MX (1) MX9302244A (en)
NO (1) NO303816B1 (en)
NZ (1) NZ247387A (en)
SG (1) SG52276A1 (en)
TW (1) TW429152B (en)
ZA (1) ZA9302653B (en)

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WO1990014833A1 (en) * 1989-06-07 1990-12-13 Bazzano Gail S Slow release vehicles for minimizing skin irritancy of topical compositions
AU688757B2 (en) * 1993-05-27 1998-03-19 Johnson & Johnson Consumer Products, Inc. Retinoid composition
FR2718021B1 (en) * 1994-04-05 1996-06-28 Fabre Pierre Cosmetique topical composition based on retinal.
US5646186A (en) * 1994-05-17 1997-07-08 Johnson & Johnson Consumer Products, Inc. Retinoid composition
ZA9504599B (en) * 1994-06-07 1996-01-26 Allergan Inc Stable gel formulation for topical treatment of skin conditions
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
JP3940209B2 (en) 1996-11-14 2007-07-04 株式会社資生堂 Solubilized cosmetics
US6008254A (en) * 1997-05-09 1999-12-28 Kligman; Douglas E. Method of treating skin disorders with high-strength tretinoin
SE9801647D0 (en) * 1998-05-12 1998-05-12 Interhealth Ab Therapeutic Composition
FR2781371B1 (en) 1998-07-21 2001-04-27 Oreal transparent aqueous cosmetic composition is a single phase
US20020006418A1 (en) * 1998-10-13 2002-01-17 John Kung Composition to enhance permeation of topical skin agents
US6656456B2 (en) * 1998-11-23 2003-12-02 The Procter & Gamble Company Skin deodorizing compositions
EP1131044A1 (en) * 1998-11-23 2001-09-12 THE PROCTER & GAMBLE COMPANY Skin deodorizing and sanitizing compositions
US6262117B1 (en) * 1999-02-18 2001-07-17 Allergan Sales, Inc. Method and composition for treating acne
US6114348A (en) * 1999-03-10 2000-09-05 Weber; Paul J. Method of treating warts using tazarotene
US20030206958A1 (en) * 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
CA2565236A1 (en) * 2004-05-06 2005-11-17 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
US20060141046A1 (en) * 2004-05-06 2006-06-29 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
FR2807662A1 (en) * 2000-04-12 2001-10-19 Cll Pharma Method for stabilizing the granulometry of an active ingredient disperse in a liquid and its applications
US7029694B2 (en) * 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
JP2003531157A (en) * 2000-04-26 2003-10-21 ワトソン ファーマシューティカルズ, インコーポレイテッド Minimization of adverse experiences associated with oxybutynin therapy
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
US20040087520A1 (en) * 2002-10-25 2004-05-06 Chowdhury Dipak K. Compositions and methods for delivery of therapeutic agents
BR0315953A (en) * 2002-12-12 2005-09-13 Galderma Res & Dev depigmentation composition, process for preparing a composition, the composition uses and cosmetic process non - therapeutic for the beautification of the skin
MXPA05012632A (en) * 2003-05-20 2006-02-22 Ranbaxy Lab Ltd Pharmaceutical compositions of acitretin.
WO2005048929A2 (en) * 2003-11-13 2005-06-02 Galileo Pharmaceuticals, Inc. Plant-derived protein extract compositions and methods
US7662855B2 (en) 2004-05-11 2010-02-16 Imaginative Research Associates, Inc. Retinoid solutions and formulations made therefrom
US20080132580A1 (en) * 2004-12-17 2008-06-05 Mandavilli Sarveswara Rao Srir Dispersion For Delivering Active Agents
CN102343092A (en) 2004-12-22 2012-02-08 日东电工株式会社 Drug carrier and drug carrier kit for inhibiting fibrosis
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
FR2879459B1 (en) * 2004-12-22 2007-02-16 Galderma Res & Dev Composition comprising adapalene solubilized with cyclodextrins
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US7803357B2 (en) * 2006-10-30 2010-09-28 John V Cappello Topical and transdermal treatments using urea formulation
US20090098191A1 (en) * 2007-10-16 2009-04-16 Anderson Christopher G Use of bases to stabilize transdermal formulations
JP2011500687A (en) * 2007-10-18 2011-01-06 メディシス・ファーマシューティカル・コーポレーション Aqueous retinoids and benzoyl peroxide gel
JP2009221164A (en) 2008-03-17 2009-10-01 Nitto Denko Corp Drug for treating pulmonary fibrosis
US20100029765A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Labortories Limited Topical aqueous composition comprising tretinoin
JP5342834B2 (en) * 2008-09-05 2013-11-13 日東電工株式会社 Bone marrow fibrosis treatment agent
EP2432453A2 (en) 2009-05-20 2012-03-28 Ranbaxy Laboratories Limited Topical retinoid solutions
US10022348B2 (en) 2009-05-20 2018-07-17 Sun Pharmaceutical Industries Limited Topical solution of isotretinoin
US20110117182A1 (en) * 2009-07-30 2011-05-19 Allergan, Inc. Combination of dapsone with other anti-acne agents
JP5950428B2 (en) 2010-08-05 2016-07-13 日東電工株式会社 Composition for regenerating normal tissue from fibrotic tissue
JP6340162B2 (en) 2012-12-20 2018-06-06 日東電工株式会社 Apoptosis-inducing agents
EP3065702A1 (en) 2013-10-31 2016-09-14 Sun Pharmaceutical Industries Ltd Topical pharmaceutical composition of acitretin
CA2944417A1 (en) 2014-04-02 2015-10-08 Nitto Denko Corporation A targeting molecule and a use thereof
AU2014390729B2 (en) 2014-04-07 2018-11-29 Nitto Denko Corporation Novel polymer-based hydrotropes for hydrophobic drug delivery

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US3729568A (en) * 1969-09-23 1973-04-24 Johnson & Johnson Acne treatment
US3906108A (en) * 1973-10-12 1975-09-16 Johnson & Johnson Stabilized tretinoin cream emulsion
IN142640B (en) * 1975-01-17 1977-08-06 Johnson & Johnson A process for preparing a gel formulation of tretinoin for topical application
US4247547A (en) * 1979-03-19 1981-01-27 Johnson & Johnson Tretinoin in a gel vehicle for acne treatment
DE3119383A1 (en) * 1981-05-15 1982-12-02 Basf Ag A process for producing finely divided pulverfoermigen carotinodpraeparaten
US4826871A (en) * 1985-03-13 1989-05-02 Gressel Philip D Topical ophthalmic compositions containing one or more retinoids
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
IL93928D0 (en) * 1989-04-17 1990-12-23 Maxam Inc Moisturizing composition containing a retinoic acid derivative and methods for the preparation thereof
US5476852A (en) * 1989-05-03 1995-12-19 Janssen Pharmaceutica N.V. Method of topically treating acne vulgaris, hyperkeratotic dermatoses, and photo-aging of the skin
FR2647015B1 (en) * 1989-05-17 1994-05-06 Cird aqueous gel base of retinoic acid and its use in human medicine and in cosmetics
WO1990014833A1 (en) * 1989-06-07 1990-12-13 Bazzano Gail S Slow release vehicles for minimizing skin irritancy of topical compositions

Also Published As

Publication number Publication date
JPH06100443A (en) 1994-04-12
EP0566405A2 (en) 1993-10-20
EP0566405B1 (en) 1998-03-04
FI931717D0 (en)
NO931390L (en) 1993-10-18
TW429152B (en) 2001-04-11
DE69317139T2 (en) 1998-08-20
AU3685893A (en) 1993-10-21
IL105413A (en) 1999-09-22
FI931717A0 (en) 1993-04-15
NO931390D0 (en) 1993-04-15
EP0566405A3 (en) 1993-12-15
US5643584A (en) 1997-07-01
CA2094084C (en) 1998-06-30
IL105413D0 (en) 1993-08-18
HUT64468A (en) 1994-01-28
DK0566405T3 (en) 1998-09-28
ES2114588T3 (en) 1998-06-01
SG52276A1 (en) 1998-09-28
FI931717A (en) 1993-10-17
JP2779303B2 (en) 1998-07-23
DE69317139D1 (en) 1998-04-09
MX9302244A (en) 1994-05-31
KR970007901B1 (en) 1997-05-17
GR3026597T3 (en) 1998-07-31
AU670777B2 (en) 1996-08-01
HU9301114D0 (en) 1993-07-28
ZA9302653B (en) 1994-10-15
NO303816B1 (en) 1998-09-07
NZ247387A (en) 1996-02-27
CA2094084A1 (en) 1993-10-17

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Legal Events

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UEP Publication of translation of european patent specification