AT150464T - Synthesis of dimer-blocks and their use in the composition of oligonucleotides - Google Patents

Synthesis of dimer-blocks and their use in the composition of oligonucleotides


Publication number
AT150464T AT94906568T AT94906568T AT150464T AT 150464 T AT150464 T AT 150464T AT 94906568 T AT94906568 T AT 94906568T AT 94906568 T AT94906568 T AT 94906568T AT 150464 T AT150464 T AT 150464T
Prior art keywords
Prior art date
Application number
Other languages
German (de)
Jin-Yan Tang
Patricia L Iadarola
Sudhir Agrawal
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US282393A priority Critical
Application filed by Hybridon Inc filed Critical Hybridon Inc
Priority to PCT/US1994/000296 priority patent/WO1994015946A1/en
Publication of AT150464T publication Critical patent/AT150464T/en



    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
AT94906568T 1993-01-08 1994-01-07 Synthesis of dimer-blocks and their use in the composition of oligonucleotides AT150464T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US282393A true 1993-01-08 1993-01-08
PCT/US1994/000296 WO1994015946A1 (en) 1993-01-08 1994-01-07 Synthesis of dimmer blocks and their use in assembling oligonucleotides

Publications (1)

Publication Number Publication Date
AT150464T true AT150464T (en) 1997-04-15



Family Applications (1)

Application Number Title Priority Date Filing Date
AT94906568T AT150464T (en) 1993-01-08 1994-01-07 Synthesis of dimer-blocks and their use in the composition of oligonucleotides

Country Status (13)

Country Link
EP (1) EP0678096B1 (en)
JP (1) JPH08507752A (en)
KR (1) KR960700262A (en)
CN (1) CN1122137A (en)
AT (1) AT150464T (en)
CA (1) CA2153505A1 (en)
DE (2) DE69402177D1 (en)
DK (1) DK0678096T3 (en)
ES (1) ES2100051T3 (en)
FI (1) FI953363A0 (en)
GR (1) GR3023123T3 (en)
NZ (1) NZ261480A (en)
WO (1) WO1994015946A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
AU5319396A (en) * 1995-03-23 1996-10-08 Hybridon, Inc. Thiono triester modified antisense oligodeoxynucleotide phosphorothioates
US5856464A (en) * 1995-06-07 1999-01-05 Lajolla Pharmaceutical Company Selective capping solution phase oligonucleotide synthesis
US6172217B1 (en) 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US5902881A (en) 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US6380378B1 (en) 1998-12-24 2002-04-30 Toagosei Company, Ltd. Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
US6207819B1 (en) * 1999-02-12 2001-03-27 Isis Pharmaceuticals, Inc. Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
DE60024628T2 (en) 1999-06-25 2006-09-21 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Pharmaceutical and cosmetic preparations containing urocaninsäurederivate as an antioxidant or radikalenabfaengermittel
CN102344477B (en) * 2010-07-27 2015-04-08 苏州瑞博生物技术有限公司 Nucleotide and / or oligonucleotide and preparation method thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
DE3332068A1 (en) * 1983-09-06 1985-03-21 Hoechst Ag A process for preparing nukleosidalkyl-, aralkyl and arylphosphoniten and phosphonates
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
FR2596761B1 (en) * 1986-04-08 1988-05-20 Commissariat Energie Atomique Nucleoside derivatives and their use for the synthesis of oligonucleotides
US5194428A (en) * 1986-05-23 1993-03-16 Worcester Foundation For Experimental Biology Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5003097A (en) * 1989-10-02 1991-03-26 The United States Of America As Represented By The Department Of Health And Human Services Method for the sulfurization of phosphorous groups in compounds
CA2071510C (en) * 1989-10-24 2004-07-06 Chris A. Buhr 2' modified oligonucleotides
AU642673B2 (en) * 1990-09-04 1993-10-28 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
WO1992020967A1 (en) * 1991-05-10 1992-11-26 Scholer Incineration Co Pty Ltd Incinerator
IL104461A (en) * 1992-01-22 2001-05-20 Hoechst Ag Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them
DE69316369D1 (en) * 1992-07-27 1998-02-19 Hybridon Inc Oligonukleotid alkylphosphonothiate

Also Published As

Publication number Publication date
FI953363A0 (en) 1995-07-07
AU673051B2 (en) 1996-10-24
DK0678096T3 (en) 1997-08-18
ES2100051T3 (en) 1997-06-01
DK678096T3 (en)
NZ261480A (en) 1997-05-26
KR960700262A (en) 1996-01-19
FI953363D0 (en)
AU6024394A (en) 1994-08-15
DE69402177D1 (en) 1997-04-24
EP0678096A1 (en) 1995-10-25
FI953363A (en) 1995-07-07
EP0678096B1 (en) 1997-03-19
JPH08507752A (en) 1996-08-20
DE69402177T2 (en) 1997-06-26
WO1994015946A1 (en) 1994-07-21
GR3023123T3 (en) 1997-07-30
CN1122137A (en) 1996-05-08
CA2153505A1 (en) 1994-07-21

Similar Documents

Publication Publication Date Title
DE69602286D1 (en) Polymer compositions and their use in tires
DE69409525D1 (en) Acetamide derivatives and their use as medium modification of the behavior of the digestive
DE69333731D1 (en) Glialmitogene factors, their production and use
AT298572T (en) Purinhemmer of cyclin-dependent kinase 2 and IkappaB-alpha
DE59309352D1 (en) Multicistronic expression units and their use
AT174382T (en) Retrovirus from the HIV-group and its use
DE69313644T2 (en) Chipboard and their use
DE69407322D1 (en) Elucidation and synthesis of selected pentapeptides
DE69232616D1 (en) Saponin-antigen conjugates and their use
DE69210941D1 (en) Borehole Zementierungszusammensetzungen and their use
DE69434314D1 (en) Polymorphism of mononucleotides and their use in gene analysis
AT275723T (en) Electrodes and their use in assays
AT292641T (en) Mucin-mannan-conjugates and their immunotherapeutic application
DE69303383T2 (en) Fine Alphaaluminiumoxydteilchen, their preparation and use
FI945959A0 (en) Metallocenes and their use as catalysts
DE69534265D1 (en) cytokine chimera and their use
DE59310220D1 (en) pyrimidine substituted and their use as pesticides
DE69418305T2 (en) Compositions and uses thereof
AT118796T (en) Polyisocyanate mixtures and their use.
DE69429717D1 (en) Heterocyclic compounds and their production and use
DE59408887D1 (en) Infrared dye-labeled nucleotide and their use in nucleic-detection
DE69322765D1 (en) Carbonated hydroxyapatite-compositions and their uses
DE69418914T2 (en) Aluminoxane containing product and its use
DE69310926T2 (en) 2-propylheptanol-derivatives and their use
DE69638333D1 (en) Protect curing composition and its use

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee