AT144522T - Polyazamacrocyclic connections for complexation metal ions - Google Patents

Polyazamacrocyclic connections for complexation metal ions

Info

Publication number
AT144522T
AT144522T AT92901960T AT92901960T AT144522T AT 144522 T AT144522 T AT 144522T AT 92901960 T AT92901960 T AT 92901960T AT 92901960 T AT92901960 T AT 92901960T AT 144522 T AT144522 T AT 144522T
Authority
AT
Austria
Prior art keywords
polyazamacrocyclic
complexation
connections
metal ions
ions
Prior art date
Application number
AT92901960T
Other languages
German (de)
Inventor
A Dean Sherry
Istvan Lazar
Erno Brucher
Ravichandran Ramasamy
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US06/662,075 priority Critical patent/US4639365A/en
Priority to US07/615,619 priority patent/US5342606A/en
Application filed by Univ Texas filed Critical Univ Texas
Publication of AT144522T publication Critical patent/AT144522T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0489Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D255/00Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2123/00Preparations for testing in vivo
AT92901960T 1984-10-18 1991-11-12 Polyazamacrocyclic connections for complexation metal ions AT144522T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US06/662,075 US4639365A (en) 1984-10-18 1984-10-18 Gadolinium chelates as NMR contrast agents
US07/615,619 US5342606A (en) 1984-10-18 1990-11-19 Polyazamacrocyclic compounds for complexation of metal ions

Publications (1)

Publication Number Publication Date
AT144522T true AT144522T (en) 1996-11-15

Family

ID=34922814

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92901960T AT144522T (en) 1984-10-18 1991-11-12 Polyazamacrocyclic connections for complexation metal ions

Country Status (20)

Country Link
US (1) US5342606A (en)
JP (1) JP3334717B2 (en)
CN (2) CN1036717C (en)
AT (1) AT144522T (en)
AU (1) AU654987B2 (en)
CA (1) CA2095615C (en)
DE (2) DE69122881T2 (en)
ES (1) ES2093816T3 (en)
FI (1) FI932231A (en)
HK (1) HK88897A (en)
HU (1) HUT64768A (en)
IE (1) IE914001A1 (en)
IL (1) IL100073A (en)
MX (1) MX9102116A (en)
NO (1) NO307380B1 (en)
NZ (1) NZ240626A (en)
PT (1) PT99556B (en)
SG (1) SG48154A1 (en)
WO (1) WO1992008725A1 (en)
ZA (1) ZA9109127B (en)

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US5532006A (en) * 1993-04-23 1996-07-02 The Board Of Trustees Of The University Of Illinois Magnetic gels which change volume in response to voltage changes for MRI
US5554749A (en) * 1994-01-14 1996-09-10 Mallinckrodt Medical, Inc. Functionalized macrocyclic ligands for imaging applications
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US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
ES2094101B1 (en) * 1995-06-13 1997-08-01 Univ Madrid Nac Educacion Nature complexones acid n-2- (azole-1 (2) -yl) etiliminodiaceticos, synthesis, and biological analytical study applications.
CN1203899C (en) * 1995-06-26 2005-06-01 螯合剂有限公司 Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6776977B2 (en) * 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US20050112066A1 (en) * 2003-11-26 2005-05-26 Concat Lp, A California Limited Partnership Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
SI1791565T1 (en) 2004-09-23 2016-08-31 Genentech, Inc. Cysteine engineered antibodies and conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
SG172656A1 (en) 2006-05-30 2011-07-28 Genentech Inc Antibodies and immunoconjugates and uses therefor
KR20140116546A (en) 2006-10-27 2014-10-02 제넨테크, 인크. Antibodies and immunoconjugates and uses therefor
WO2008100805A2 (en) 2007-02-09 2008-08-21 Genentech, Inc. Anti-robo4 antibodies and uses therefor
UA103004C2 (en) 2007-07-16 2013-09-10 Дженентек, Інк. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
AU2008276140C1 (en) 2007-07-16 2012-10-25 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
EP2657253B1 (en) 2008-01-31 2017-07-19 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
NZ595574A (en) 2009-04-01 2013-11-29 Genentech Inc Anti-fcrh5 antibodies and immunoconjugates and methods of use
AU2010256410B2 (en) 2009-06-04 2016-10-20 Massachusetts Institute Of Technology Methods for identification of sites for IgG conjugation
JP5690733B2 (en) * 2009-08-20 2015-03-25 富士フイルムRiファーマ株式会社 Bisphosphonic acid derivatives and radioactive metal nuclide labels
AU2011261362B2 (en) 2010-06-03 2016-06-09 Genentech, Inc. Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
AU2011265054B2 (en) 2010-06-08 2016-09-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
DK2869848T3 (en) 2012-07-04 2016-11-21 F Hoffmann-La Roche Ag Covalent BOUND ANTIGEN-ANTIBODY CONJUGATES
EP3339328A1 (en) 2012-07-04 2018-06-27 F. Hoffmann-La Roche AG Anti-biotin antibodies and methods of use
PL2869837T3 (en) 2012-07-04 2017-03-31 F.Hoffmann-La Roche Ag Anti-theophylline antibodies and methods of use
KR20160105880A (en) 2014-01-03 2016-09-07 에프. 호프만-라 로슈 아게 Covalently linked polypeptide toxin-antibody conjugates
BR112016013849A2 (en) 2014-01-03 2017-10-10 Hoffmann La Roche Bispecific conjugates of anti-hapten / antibody antirreceptores the blood brain barrier, their uses and pharmaceutical formulation
RU2016129894A3 (en) 2014-01-03 2018-07-23
JP2017531620A (en) 2014-09-12 2017-10-26 ジェネンテック, インコーポレイテッド Cysteine ​​engineered antibodies and conjugates
SG11201704625UA (en) 2014-12-17 2017-07-28 F Hoffmann-La Roche Ag Novel methods for enzyme mediated polypeptide conjugation using sortase
EP3353291A1 (en) 2015-09-25 2018-08-01 Hoffmann-La Roche AG Novel soluble sortase a
EP3353310A1 (en) 2015-09-25 2018-08-01 H. Hoffnabb-La Roche Ag Process for producing thioesters employing a sortase a
EP3353314A1 (en) 2015-09-25 2018-08-01 H. Hoffnabb-La Roche Ag Transamidation employing sortase a in deep eutectic solvents
KR20180053751A (en) 2015-09-25 2018-05-23 에프. 호프만-라 로슈 아게 Recombinant immunoglobulin heavy chain comprising a sirtase conjugation loop and conjugate thereof
WO2017167712A1 (en) 2016-03-30 2017-10-05 F. Hoffmann-La Roche Ag Improved sortase
WO2018191389A1 (en) 2017-04-12 2018-10-18 Roche Sequencing Solutions, Inc. A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction
WO2019012019A1 (en) 2017-07-13 2019-01-17 F. Hoffmann-La Roche Ag New binding agent and assay for pivka
WO2019077113A1 (en) 2017-10-20 2019-04-25 F. Hoffmann-La Roche Ag Copy protection for antibodies
WO2019108755A1 (en) 2017-11-30 2019-06-06 Genentech, Inc. Anti-pd-l1 antibodies and methods of using the same for detection of pd-l1

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US3996276A (en) * 1975-08-22 1976-12-07 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic phosphorous triamides
US3987128A (en) * 1975-08-22 1976-10-19 E. I. Du Pont De Nemours And Company Tetracyclic tetraamino phosphoranes and method of preparation
US4038312A (en) * 1975-08-22 1977-07-26 E. I. Du Pont De Nemours And Company Tricyclic phosphorous triamides
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US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4421671A (en) * 1982-06-18 1983-12-20 General Electric Company Rare-earth-doped yttria-gadolinia ceramic scintillators
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CA1317937C (en) * 1984-10-18 1993-05-18 A. Dean Sherry Gadolinium chelates with carboxymethyl derivatives of polyazamacrocycles as nmr contrast agents
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CA2057868A1 (en) * 1990-04-18 1991-10-19 David Parker Tetra-aza macrocycles processes for their preparation and their use in magnetic resonance imaging

Also Published As

Publication number Publication date
US5342606A (en) 1994-08-30
ES2093816T3 (en) 1997-01-01
IE914001A1 (en) 1992-05-20
JPH06502645A (en) 1994-03-24
CN1036717C (en) 1997-12-17
FI932231A (en) 1993-05-17
AU9077091A (en) 1992-06-11
DE69122881T2 (en) 1997-04-03
PT99556B (en) 1999-04-30
ZA9109127B (en) 1993-05-18
CA2095615C (en) 2003-07-08
NO307380B1 (en) 2000-03-27
IL100073A (en) 1997-11-20
IL100073D0 (en) 1992-08-18
SG48154A1 (en) 1998-04-17
CN1066073A (en) 1992-11-11
PT99556A (en) 1992-10-30
FI932231D0 (en)
NO931793D0 (en) 1993-05-18
NZ240626A (en) 1994-11-25
HU9301431D0 (en) 1993-12-28
HUT64768A (en) 1994-02-28
MX9102116A (en) 1992-06-01
DE69122881D1 (en) 1996-11-28
HK88897A (en) 1997-06-27
WO1992008725A1 (en) 1992-05-29
FI932231A0 (en) 1993-05-17
JP3334717B2 (en) 2002-10-15
CA2095615A1 (en) 1992-05-20
CN1193625A (en) 1998-09-23
AU654987B2 (en) 1994-12-01
NO931793L (en) 1993-05-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties