AT141646T - Genetically transformed animals that secrete a desired protein in milk - Google Patents

Genetically transformed animals that secrete a desired protein in milk

Info

Publication number
AT141646T
AT141646T AT87303112T AT87303112T AT141646T AT 141646 T AT141646 T AT 141646T AT 87303112 T AT87303112 T AT 87303112T AT 87303112 T AT87303112 T AT 87303112T AT 141646 T AT141646 T AT 141646T
Authority
AT
Austria
Prior art keywords
secrete
milk
desired protein
genetically transformed
transformed animals
Prior art date
Application number
AT87303112T
Other languages
German (de)
Inventor
Katherine Gordon
Suzanne Groet
Lothar Hennighausen
Of Heiner Westphal
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US84981586A priority Critical
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of AT141646T publication Critical patent/AT141646T/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25306586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT141646(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse Transcribing DNA Viruses
    • C12N2730/00011Reverse Transcribing DNA Viruses
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian
AT87303112T 1986-04-09 1987-04-09 Genetically transformed animals that secrete a desired protein in milk AT141646T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US84981586A true 1986-04-09 1986-04-09

Publications (1)

Publication Number Publication Date
AT141646T true AT141646T (en) 1996-09-15

Family

ID=25306586

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87303112T AT141646T (en) 1986-04-09 1987-04-09 Genetically transformed animals that secrete a desired protein in milk

Country Status (7)

Country Link
US (2) US7939317B1 (en)
EP (1) EP0264166B1 (en)
JP (2) JP2874751B2 (en)
AT (1) AT141646T (en)
DE (4) DE3751873D1 (en)
LU (1) LU91304I2 (en)
NL (1) NL300257I2 (en)

Families Citing this family (310)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT141646T (en) 1986-04-09 1996-09-15 Genzyme Corp Genetically transformed animals that secrete a desired protein in milk
US5322775A (en) * 1986-06-30 1994-06-21 Pharmaceutical Proteins Ltd. Peptide production
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
EP0832981A1 (en) * 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
JP2707466B2 (en) * 1988-07-06 1998-01-28 第一製薬株式会社 Transgenic non-human animal
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5650503A (en) * 1988-11-11 1997-07-22 Ppl Therapeutics (Scotland) Limited Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals
GB8826446D0 (en) * 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6689610B1 (en) 1989-08-22 2004-02-10 University Of Utah Research Foundation Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
RU2095414C1 (en) * 1989-12-01 1997-11-10 Джен Фарминг Ойроп БВ Transgene for preparing the recombinant polypeptide in transgenic cow milk, a method of obtaining the transgenic cow (variants), milk from transgenic cow, food composition
EP1465248A1 (en) 1990-03-08 2004-10-06 Fujitsu Limited Layer structure having contact hole and method of producing the same
JPH04365487A (en) * 1990-04-11 1992-12-17 Consortium Elektrochem Ind Gmbh Recombinant dna-structruct recombinant vector, collection of protein from milk of transgenic animal, production of transgenic animal and milk of transgenic animal
US5831141A (en) * 1991-01-11 1998-11-03 United States Of America As Represented By The Department Of Health And Human Services Expression of a heterologous polypeptide in mammary tissue of transgenic non-human mammals using a long whey acidic protein promoter
US5965789A (en) * 1991-01-11 1999-10-12 American Red Cross Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals
US6262336B1 (en) 1991-01-11 2001-07-17 American Red Cross Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter
CA2099562C (en) * 1991-01-11 2010-04-20 William N. Drohan Expression of active human protein c in mammary tissue of transgenic animals
US5965788A (en) * 1992-06-12 1999-10-12 Institut National De La Recherche Agronomique Transgenic non-human mammal comprising a rabbit WAP promoter
US6268545B1 (en) 1991-06-12 2001-07-31 Institut National De La Recherche Agronomique Transgenic non-human mammal comprising a rabbit WAP promoter, uses thereof, and a DNA construct comprising the rabbit WAP promoter
FR2677652B1 (en) * 1991-06-12 2005-05-27 Agronomique Inst Nat Rech Method of preparing a protein of interest in milk of a transgenic animal, the product obtained and used eukaryotic cell.
WO1993004171A1 (en) * 1991-08-19 1993-03-04 Symbicom Aktiebolag Human beta-casein, process for producing it and use thereof
GB9119338D0 (en) 1991-09-10 1991-10-23 Inst Of Animal Physiology And Control of gene expression
US6448469B1 (en) 1991-10-02 2002-09-10 Genzyme Corporation Production of membrane proteins in the milk of transgenic nonhuman mammals
DK8892D0 (en) * 1992-01-23 1992-01-23 Symbicom Ab human protein gene
JP3670003B2 (en) * 1992-06-15 2005-07-13 ファーミング ビー.ブイ. Manufacture and transgenic methods of recombinant polypeptides by bovine species
US5667839A (en) * 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
US6984772B1 (en) 1994-02-18 2006-01-10 Virginia Tech Intellectual Properties, Inc. Transgenic non-human mammals producing fibrinogen in their milk
US20030033617A1 (en) 1996-04-10 2003-02-13 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
JP2001505405A (en) * 1996-07-24 2001-04-24 ユニバーシティ・オブ・メリーランド Butyrophilin gene promoter and its use
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
AU7137398A (en) 1997-04-16 1998-11-11 Millennium Pharmaceuticals, Inc. Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
US6087166A (en) 1997-07-03 2000-07-11 Basf Aktiengesellschaft Transcriptional activators with graded transactivation potential
EP1025244A2 (en) 1997-10-20 2000-08-09 Genzyme Transgenics Corporation NOVEL MODIFIED MSP-1 NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS
US6733991B1 (en) 1998-05-08 2004-05-11 Osi Pharmaceuticals, Inc. AGS proteins and nucleic acid molecules and uses therefor
US6746852B1 (en) 1998-05-08 2004-06-08 Osi Pharmaceuticals, Inc. AGS proteins and nucleic acid molecules and uses thereof
US20030005468A1 (en) * 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
WO2000040693A2 (en) * 1999-01-06 2000-07-13 Atlantic Biopharmaceuticals, Inc. Expression of secreted human alpha-fetoprotein in transgenic animals
EP1179000A4 (en) 1999-02-26 2005-10-12 Millennium Pharm Inc Secreted proteins and uses thereof
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
ES2178979T1 (en) 1999-06-25 2003-01-16 Basf Ag Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production.
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
DE1246922T1 (en) 1999-07-01 2003-03-20 Basf Ag For proteins of the phosphoenolpyruvate: sugar phosphotransferase system coding gene from corynebacterium glutamicum
PT1210428E (en) 1999-08-23 2015-07-21 Genetics Inst Llc Pd-1, a receptor for b7-4, and uses therefor
AT361934T (en) 1999-12-30 2007-06-15 Harvard College A method for modulating the activity of Th2 cells by modulating the activity of XBP-1
US7544859B2 (en) 2000-02-09 2009-06-09 Basf Aktiengesellschaft Elongase gene and method for producing multiple-unsaturated fatty acids
WO2001064882A2 (en) 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
EP1267839B1 (en) 2000-03-24 2007-10-03 Biosphere Medical, Inc. Microspheres for active embolization
ES2340879T3 (en) 2000-04-07 2010-06-10 Basf Plant Science Gmbh phosphatases realacionadas stress and methods of use in plants.
EP1714661A3 (en) 2000-05-19 2012-03-14 The Center for Blood Research, INC. Methods for diagnosing and treating hemostatic disorders by modulating p-selectin activity
AU7173101A (en) 2000-06-28 2002-01-08 Genetics Inst Pd-l2 molecules: novel pd-1 ligands and uses therefor
EP1335981B1 (en) 2000-07-18 2010-06-09 Millennium Pharmaceuticals, Inc. 18480 human protein kinase molecules and uses therefor
WO2002014473A2 (en) 2000-08-15 2002-02-21 Board Of Trustees Of The University Of Illinois Animals expressing exogenous igf-i in their milk
DE60140457D1 (en) 2000-09-01 2009-12-24 Blood Res Center Modified, stabilized in the desired conformation polypeptides and methods for their preparation
AU2001288858B2 (en) 2000-09-18 2007-11-01 Biogen Ma Inc. Receptor nucleic acids and polypeptides
US20040226053A1 (en) * 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
AT452910T (en) 2000-10-18 2010-01-15 Brigham & Womens Hospital E-selectin / L-selectin-ligand polypeptides hematopoietic cells and methods of use thereof
EP2316976A1 (en) 2000-11-28 2011-05-04 Wyeth LLC Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
IL155951D0 (en) 2000-11-28 2003-12-23 Wyeth Corp Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
CA2431861A1 (en) 2000-12-08 2002-06-13 Curagen Corporation Method of detecting and treating tuberous sclerosis complex associated disorders
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US8231878B2 (en) 2001-03-20 2012-07-31 Cosmo Research & Development S.P.A. Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
EP1379125A4 (en) 2001-03-22 2004-12-08 Abbott Gmbh & Co Kg Transgenic animals expressing antibodies specific for genes of interest and uses thereof
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
MXPA03008959A (en) 2001-04-02 2004-10-15 Wyeth Corp Pd-1, a receptor for b7-4, and uses therefor.
EP2258842A1 (en) 2001-04-16 2010-12-08 Wyeth Holdings Corporation Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
JP2005511012A (en) 2001-08-10 2005-04-28 セローノ ジェネティクス インスティテュート ソシエテ アノニム Human cDNA and protein and uses thereof
AT541920T (en) 2001-09-05 2012-02-15 Basf Plant Science Gmbh With stress-related proteinphosphatase- polypeptides and methods for use in plant
WO2003045304A2 (en) 2001-09-26 2003-06-05 Mayo Foundation For Medical Education And Research Mutable vaccines
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
DE10154180A1 (en) 2001-11-05 2003-05-15 Basf Ag genes which encode genetic stability, gene expression and folding proteins
DE10154270A1 (en) 2001-11-05 2003-05-15 Basf Ag Genes encoding proteins Kohlenstoffmetabolismus- and energy production
WO2003042362A2 (en) 2001-11-09 2003-05-22 Dana-Farber Cancer Institute, Inc. PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
US7220585B2 (en) 2001-11-09 2007-05-22 Basf Plant Science Gmbh Transcription factor stress-related polypeptides and methods of use in plants
EP1455815A4 (en) 2001-12-19 2006-11-02 Millennium Pharm Inc Human diacylglycerol acyltransferase 2 (dgat2)family members and uses therefor
US7781396B2 (en) 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
AU2003227303A1 (en) 2002-03-18 2003-09-29 Yeda Research And Development Co. Ltd. Methods of identifying gene expression products resultant from alternative splicing and methods of diagnosing and treating disorders associated therewith
AU2003224950B2 (en) 2002-04-09 2006-09-14 Biogen Ma Inc. Methods for treating tweak-related conditions
EP1572950B1 (en) 2002-06-17 2012-10-10 Thrasos, Inc. Single domain tdf-related compounds and analogs thereof
US7250551B2 (en) 2002-07-24 2007-07-31 President And Fellows Of Harvard College Transgenic mice expressing inducible human p25
EP1565581B1 (en) 2002-08-20 2011-08-10 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US20060009378A1 (en) 2002-11-14 2006-01-12 Itshak Golan Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
EP1583713B1 (en) 2003-01-07 2009-03-25 Ramot at Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
EP1599598A4 (en) 2003-03-04 2007-08-08 Yeda Res & Dev Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
EP2330132B1 (en) 2003-04-04 2013-08-14 Yeda Research and Development Co. Ltd. Antibodies against MMP2 or MMP9 and pharmaceutical compositions containing same useful for inhibiting activity of said metalloproteins
FR2853551B1 (en) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement stabilizing formulation to immunoglobulin compositions g in liquid form and lyophilized form
US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
CA2530927A1 (en) 2003-06-30 2005-01-06 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
EP2520654B8 (en) 2003-08-26 2017-04-19 The Regents of the University of Colorado, a body corporate Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
WO2005031362A2 (en) 2003-10-02 2005-04-07 Ramot At Tel Aviv University Ltd. Novel antibacterial agents and methods of identifying and utilizing same
EP2261667A3 (en) 2003-10-07 2011-05-25 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and their therapy of ovarian cancer
AU2004284220B2 (en) 2003-10-24 2010-10-14 Selexis S.A. High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences
IL158868D0 (en) 2003-11-13 2004-05-12 Yeda Res & Dev Methods of generating and using stem cells enriched with immature primitive progenitor
DE10359661A1 (en) 2003-12-18 2005-07-28 Basf Ag Gene variants that code for proteins from the pathway of fine chemicals
US8007847B2 (en) 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
US20050245444A1 (en) * 2004-04-30 2005-11-03 Yann Echelard Method of using recombinant human antithrombin for neurocognitive disorders
CA2571218C (en) 2004-06-17 2015-11-03 William D. Carlson Tdf-related compounds and analogs thereof
US7288385B2 (en) 2004-06-25 2007-10-30 The Salk Institute For Biological Studies Increasing life span by modulation of Smek
AT539745T (en) 2004-08-19 2012-01-15 Univ Tel Aviv Future Tech Dev Compositions for the treatment of amyloid-associated diseases
US7893197B2 (en) 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
EP2340848A3 (en) 2004-10-21 2011-09-14 Wyeth LLC Immunogenic compositions of Staphylococcus epidermidis polypeptide and polynucleotide antigens
US8013116B2 (en) 2004-11-29 2011-09-06 Universite Henri-Poincare-Nancy I Therapeutic peptides and method
US20060121004A1 (en) * 2004-12-07 2006-06-08 Yann Echelard Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin
CN1274829C (en) 2004-12-10 2006-09-13 四川大学华西医院 Anti EB virus resulted tumour polypeptide, and its use and preparing method
WO2007080559A2 (en) 2006-01-16 2007-07-19 Zlango Ltd. Iconic communication
EP1982450A2 (en) 2006-01-16 2008-10-22 Zlango Ltd. Communications network system and methods for using same
JP2008527563A (en) 2005-01-16 2008-07-24 ズランゴー リミテッド Iconic communication
CA2794483A1 (en) 2010-03-26 2011-09-29 Trustees Of Dartmouth College Vista regulatory t cell mediator protein, vista binding agents and use thereof
JP2008540478A (en) 2005-05-09 2008-11-20 ビオスフェレ メディカル エス.エー. Compositions and methods using microspheres and non-ionic contrast agent
EP1899364A4 (en) 2005-05-17 2009-05-20 Univ Connecticut Compositions and methods for immunomodulation in an organism
EP1896575B1 (en) 2005-06-17 2012-07-18 BASF Plant Science GmbH Lecitin-like protein kinase stress-related polypeptides and methods of use in plants
US8067573B2 (en) 2005-07-07 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating H19 and methods of using same
WO2007035213A2 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
ES2537527T3 (en) 2005-09-20 2015-06-09 Thrasos Innovation, Inc. TDF related compounds and analogs thereof
CA2624662A1 (en) 2005-09-30 2007-04-12 The Government Of The United States Of America, As Represented By The Se Cretary Of Health And Human Services Methods and compositions for modulating immune tolerance
IL172297A (en) 2005-10-03 2016-03-31 Compugen Ltd Soluble vegfr-1 variants for diagnosis of preeclamsia
DK2357226T3 (en) 2005-10-18 2012-06-25 Prec Biosciences Rationally Designed meganucleases with altered sequence specificity and DNA binding affinity
US7767420B2 (en) 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
EP1973945A4 (en) 2006-01-16 2009-11-18 Compugen Ltd Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
EA028578B1 (en) 2012-02-14 2017-12-29 Опко Байолоджикс Лтд. Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US7553941B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
WO2007133797A2 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
FR2901707B1 (en) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement recombinant factor vii composition or transgenic, each factor VII molecule having two N-glycosylation sites was defined glycan motifs
CA2654165A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
JP5248494B2 (en) 2006-07-11 2013-07-31 ユニバーシティ・オブ・メディシン・アンド・デンティストリー・オブ・ニュージャージーUniversity Of Medicine And Dentistry Of New Jersey Protein, a method using the nucleic acid and associated encoding it
FR2904558B1 (en) * 2006-08-01 2008-10-17 Lab Francais Du Fractionnement "Factor composition vii recombinant or transgenic, mostly biantennary glycan having shapes, bisialylated and non fucosylated"
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
US9505821B2 (en) 2006-10-03 2016-11-29 Rutgers, The State University Of New Jersey ATAP peptides, nucleic acids encoding the same and associated methods of use
FR2910786B1 (en) 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "A method of extracting a protein present in milk"
FR2910969B1 (en) * 2006-12-29 2009-02-27 Lab Francais Du Fractionnement Method for measuring the concentration of factor VIIa (FVIIa) in a sample
AT548454T (en) 2007-01-16 2012-03-15 Yissum Res Dev Co Nucleic acid drugs for decommissioning of h19 for the purpose of treating rheumatoid arthritis
AU2008206936B2 (en) 2007-01-19 2013-03-14 Probiodrug Ag In vivo screening models for treatment of Alzheimer's disease and other Qpct-related disorders
FR2912310B1 (en) 2007-02-13 2009-08-07 Kasan Sarl New cosmetic and / or pharmaceutical compositions and their applications.
US20110189663A1 (en) 2007-03-05 2011-08-04 Cancer Care Ontario Assessment of risk for colorectal cancer
WO2008116032A1 (en) 2007-03-21 2008-09-25 Effat Emamian Compositions and methods for inhibiting tumor cell growth
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
PT2144633E (en) 2007-04-23 2014-10-27 Deliversir Ltd A system for delivering therapeutic agents into living cells and cells nuclei
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
EP2908864A4 (en) 2012-10-22 2016-06-08 Deliversir Ltd A system for delivering therapeutic agents into living cells and cells nuclei
FR2917414B1 (en) * 2007-06-15 2012-07-13 Lab Francais Du Fractionnement Factor VII / VIIa human modifies and pharmaceutical composition containing the same
ES2614735T3 (en) 2007-07-23 2017-06-01 Janssen Biotech, Inc. Methods and compositions for treating disorders related to fibrosis using antagonists of IL-17
FR2920024B1 (en) 2007-08-14 2012-12-14 Lfb Biotechnologies Process for purification or detection of a target protein
HUE042982T2 (en) 2007-09-04 2019-07-29 Compugen Ltd Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
US8283517B2 (en) 2007-09-12 2012-10-09 Probiodrug Ag Transgenic mouse models of Aβ overexpression
US8663980B2 (en) 2007-10-26 2014-03-04 Janssen Biotech, Inc. Vectors, host cells, and methods of production and uses
CA2704383A1 (en) 2007-10-31 2009-05-07 James Jefferson Smith Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
US8501449B2 (en) 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
NZ586665A (en) 2008-01-14 2011-12-22 Probiodrug Ag MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct)
CN102316894A (en) 2008-06-20 2012-01-11 惠氏有限责任公司 Compositions and methods of use of ORF1358 from beta-hemolytic streptococcal strains
FR2933496B1 (en) * 2008-07-02 2012-10-05 Lfb Biotechnologies A method of measuring factor VIIa levels in a sample
CN102105594A (en) 2008-07-30 2011-06-22 达纳-法伯癌症研究所有限公司 Compositions for detecting cell death and methods of use thereof
US20110237496A1 (en) 2008-09-10 2011-09-29 Ilana Nathan Antinecrotic activity of alpha 1-antitrypsin
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
MX2011003195A (en) 2008-09-26 2011-08-12 Dana Farber Cancer Inst Inc Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor.
LT2340038T (en) 2008-10-10 2018-04-10 Children`S Medical Center Corporation Biochemically stabilized hiv-1 env trimer vaccine
WO2010061393A1 (en) 2008-11-30 2010-06-03 Compugen Ltd. He4 variant nucleotide and amino acid sequences, and methods of use thereof
WO2010064231A1 (en) 2008-12-02 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of analyzing a-i rna editing and nucleic acid constructs capable of same
EP2373301B1 (en) 2008-12-05 2013-11-06 Yeda Research and Development Co. Ltd. Methods of diagnosing motor neuron diseases
FR2940655B1 (en) 2008-12-31 2011-02-18 Lfb Biotechnologies Peptides isolated rabbit vii factor.
US9181315B2 (en) 2009-01-08 2015-11-10 Dana-Farber Cancer Institute, Inc. Compositions and methods for induced brown fat differentiation
US8530629B2 (en) 2009-01-30 2013-09-10 Ab Biosciences, Inc. Lowered affinity antibodies and uses therefor
FR2942232B1 (en) 2009-02-19 2015-03-13 Lfb Biotechnologies Means for purifying a protein of coagulation and processes for its implementation
FR2942231B1 (en) 2009-02-19 2015-03-20 Lfb Biotechnologies nucleic acids specifically binding to factor vii / human viia and uses
US9023767B2 (en) 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
FR2947181B1 (en) 2009-06-26 2012-05-04 Lfb Biotechnologies factor composition vii
FR2948664B1 (en) 2009-07-31 2013-11-01 Lfb Biotechnologies Method for purification of protein coagulation has gla domain
FR2948665B1 (en) 2009-07-31 2011-09-23 Lfb Biotechnologies Method for purification of protein coagulation has active field gla
EP2470164B1 (en) 2009-08-27 2017-05-31 Technion Research & Development Foundation Ltd. Liposomal compositions and uses of same
WO2011060272A2 (en) 2009-11-13 2011-05-19 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
CA2785020A1 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
US9745589B2 (en) 2010-01-14 2017-08-29 Cornell University Methods for modulating skeletal remodeling and patterning by modulating SHN2 activity, SHN3 activity, or SHN2 and SHN3 activity in combination
AU2011207210A1 (en) 2010-01-22 2012-08-16 Dana-Farber Cancer Institute, Inc. Compositions,kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders
CN102822202B (en) 2010-01-27 2015-07-22 耶达研究及发展有限公司 Antibodies that inhibit metalloproteins
WO2011094593A2 (en) 2010-01-28 2011-08-04 Ab Biosciences, Inc. Novel lowered affinity antibodies and methods of marking the same
TWI518325B (en) 2010-02-04 2016-01-21 Univ Jichi Medical Identification, assessment, and therapy of cancers with innate or acquired resistance to alk inhibitors
WO2011104708A2 (en) 2010-02-24 2011-09-01 Ben Gurion University Of The Negev Research And Development Authority Methods for inhibiting necrosis
US8861162B2 (en) * 2010-03-09 2014-10-14 Honeywell International Inc. High power solid state power controller (SSPC) solution for primary power distribution applications
WO2011133288A1 (en) 2010-04-19 2011-10-27 The Trustees Of The University Of Pennsylvania Microrna induction of pluripotential stem cells and uses thereof
EP2585110A4 (en) 2010-06-22 2014-01-22 Univ Colorado Regents Antibodies to the c3d fragment of complement component 3
CA2805024A1 (en) 2010-06-30 2012-01-05 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of multiples sclerosis, rheumatoid arthritis and other autoimmune disorders
WO2012028706A1 (en) 2010-09-02 2012-03-08 Probiodrug Ag IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS
WO2012033831A2 (en) 2010-09-07 2012-03-15 Memorial Sloan-Kettering Cancer Center Methods and compositions for gamma-secretase assay
WO2012046238A2 (en) 2010-10-06 2012-04-12 Ramot At Tel-Aviv University Ltd. Erythropoietin receptor antagonists
WO2012051301A1 (en) 2010-10-12 2012-04-19 President And Fellows Of Harvard College Methods for identifying modulators of triglyceride metabolism, for modulating triglyceride metabolism and for identifying subjects at risk for abnormal triglyceride metabolism
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells
WO2012064743A2 (en) 2010-11-08 2012-05-18 The Johns Hopkins University Methods for improving heart function
FR2967071A1 (en) 2010-11-10 2012-05-11 Lab Francais Du Fractionnement H Factor for the treatment of autoimmune diseases of the nervous system
AU2011330768A1 (en) 2010-11-15 2013-05-30 Merz Pharma Gmbh & Co. Kgaa Dipeptide analogs for treating conditions associated with amyloid fibril formation
RU2623161C2 (en) 2011-04-15 2017-06-22 Компуджен Лтд. Polypeptides and polynucleotides and their use for treatment of immune disorders and cancer
WO2012156976A1 (en) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of producing artemisinin in non-host plants and vectors for use in same
US9822379B2 (en) 2011-05-19 2017-11-21 Fundación Pública Andaluza Progreso Y Salud Highly inducible dual-promoter lentiviral TET-ON system
EA201391755A1 (en) 2011-05-25 2014-08-29 Иннейт Фарма, С.А. Anti-kir antibodies for the treatment of inflammatory diseases
CA2836855A1 (en) 2011-06-30 2013-01-03 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
WO2013017555A1 (en) 2011-08-01 2013-02-07 Lfb-Biotechnologies Factor vii compositions with specific glycosylation for controlled half-life
EP2742062A2 (en) 2011-08-12 2014-06-18 Probiodrug AG In vivo screening models for treatment of qc-related disorders
CA2846197A1 (en) 2011-08-23 2013-02-28 Foundation Medicine, Inc. Kif5b-ret fusion molecules and uses thereof
WO2013039996A1 (en) 2011-09-13 2013-03-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using fndc5
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
FR2983212A1 (en) 2011-11-28 2013-05-31 Lfb Biotechnologies Anti-fh aptamers, process for their preparation and uses
WO2013114363A2 (en) 2012-01-30 2013-08-08 Yeda Research And Development Co.Ltd. Antimicrobial agents
KR20140126357A (en) 2012-02-01 2014-10-30 컴퓨젠 엘티디. C1orf32 antibodies, and uses thereof for treatment of cancer
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
EP3456742A1 (en) 2012-02-15 2019-03-20 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
US9000127B2 (en) 2012-02-15 2015-04-07 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
WO2013131021A1 (en) 2012-03-02 2013-09-06 Sequenom Inc. Methods and processes for non-invasive assessment of genetic variations
TW201400499A (en) 2012-03-12 2014-01-01 Revo Biolog Inc The use of antithrombin in the treatment of pre-eclampsia
US9494597B2 (en) 2012-04-02 2016-11-15 Ab Biosciences, Inc. Human control antibodies and uses therefor
PE24052014A1 (en) 2012-04-19 2015-01-25 Opko Biolog Ltd Oxyntomodulin variants long acting and production methods thereof
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2013174003A1 (en) 2012-05-24 2013-11-28 Mountgate Group Limited Compositions and methods related to prevention and treatment of rabies infection
JP6285923B2 (en) 2012-06-22 2018-02-28 トラスティーズ・オブ・ダートマス・カレッジ New VISTA-Ig constructs and autoimmunity, use of VISTA-Ig for the treatment of allergic and inflammatory disorders
AU2013312211B2 (en) 2012-09-07 2018-03-29 King's College London VISTA modulators for diagnosis and treatment of cancer
CA2879763A1 (en) 2012-08-03 2014-02-06 Simon LOWRY The use of antithrombin in extracorporeal membrane oxygenation
AU2013337277B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel NTRK1 fusion molecules and uses thereof
MX363326B (en) 2012-11-20 2019-03-20 Opko Biologics Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides.
ES2701749T3 (en) 2012-12-12 2019-02-25 Broad Inst Inc Methods, models, systems and apparatus to identify target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and transmit results thereof
AU2014281031A1 (en) 2013-06-17 2016-01-21 Massachusetts Institute Of Technology Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components
CN105658796A (en) 2012-12-12 2016-06-08 布罗德研究所有限公司 CRISPR/CAS component systems, methods and compositions for sequence manipulation
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
KR20150105633A (en) 2012-12-12 2015-09-17 더 브로드 인스티튜트, 인코퍼레이티드 Engineering of systems, methods and optimized guide compositions for sequence manipulation
JP2016501531A (en) 2012-12-12 2016-01-21 ザ・ブロード・インスティテュート・インコーポレイテッド Delivery of array operations and systems for therapeutic applications, the methods and compositions, Engineering and Optimization
EP2931899A1 (en) 2012-12-12 2015-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
WO2014093655A2 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
WO2014093635A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
EP2784162B1 (en) 2012-12-12 2015-04-08 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions for sequence manipulation
WO2014204728A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
WO2014113729A2 (en) 2013-01-18 2014-07-24 Foundation Mecicine, Inc. Methods of treating cholangiocarcinoma
CN105263319A (en) 2013-02-13 2016-01-20 法国化学与生物科技实验室 Proteins with modified glycosylation and methods of production thereof
KR20160002713A (en) 2013-02-13 2016-01-08 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 Highly galactosylated anti-tnf-alpha antibodies and uses thereof
FR3005576B1 (en) 2013-05-15 2015-06-19 Lab Francais Du Fractionnement Method for inactivating prion protein
WO2014207578A2 (en) 2013-06-13 2014-12-31 Orgenesis Ltd. Cell populations, methods of transdifferention and methods of use thereof
FR3011250A1 (en) 2013-09-30 2015-04-03 Lab Francais Du Fractionnement nucleic acids specifically binding to factor ix / human ixa and uses
WO2015065964A1 (en) 2013-10-28 2015-05-07 The Broad Institute Inc. Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
FR3012453B1 (en) 2013-10-31 2015-11-13 Lab Francais Du Fractionnement Chimerical protein in the treatment of amyloidosis
EP2876114A1 (en) 2013-11-25 2015-05-27 Consejo Superior De Investigaciones Científicas Antibodies against CCR9 and applications thereof
KR20160097331A (en) 2013-12-12 2016-08-17 더 브로드 인스티튜트, 인코퍼레이티드 Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
JP2017532001A (en) 2013-12-12 2017-11-02 ザ・ブロード・インスティテュート・インコーポレイテッド Systems for sequence manipulation by optimization CRISPR-Cas system, the methods and compositions
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
AU2014361826A1 (en) 2013-12-12 2016-06-23 Massachusetts Institute Of Technology Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using particle delivery components
RU2016128077A3 (en) 2013-12-12 2018-12-06
FR3022462B1 (en) 2014-06-18 2018-04-27 Lab Francais Du Fractionnement oral composition of anti-TNFalpha antibody
EP3172232A1 (en) 2014-07-17 2017-05-31 Novo Nordisk A/S Site directed mutagenesis of trem-1 antibodies for decreasing viscosity
WO2016049251A1 (en) 2014-09-24 2016-03-31 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
WO2016049163A2 (en) 2014-09-24 2016-03-31 The Broad Institute Inc. Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
MX2017007136A (en) 2014-12-05 2017-12-04 Immunext Inc Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators.
PE13802017A1 (en) 2014-12-10 2017-09-15 Opko Biologics Ltd Methods of producing polypeptides modified growth hormone long acting ctp
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
WO2016094880A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
WO2016094867A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Protected guide rnas (pgrnas)
EP3230452A1 (en) 2014-12-12 2017-10-18 The Broad Institute Inc. Dead guides for crispr transcription factors
EP3234192A1 (en) 2014-12-19 2017-10-25 The Broad Institute Inc. Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
WO2016106236A1 (en) 2014-12-23 2016-06-30 The Broad Institute Inc. Rna-targeting system
AU2015369725A1 (en) 2014-12-24 2017-06-29 Massachusetts Institute Of Technology CRISPR having or associated with destabilization domains
WO2016108926A1 (en) 2014-12-30 2016-07-07 The Broad Institute Inc. Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
KR20170102308A (en) 2014-12-30 2017-09-08 오르제네시스 엘티디. How to differentiate conversion method and use thereof
FR3034669A1 (en) 2015-04-07 2016-10-14 Lab Francais Du Fractionnement New use of von Willebrand factor
WO2016181393A1 (en) 2015-05-11 2016-11-17 Yeda Research And Development Co. Ltd. Citrin inhibitors for the treatment of cancer
WO2016185457A1 (en) 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Methods of promoting lymphangiogenesis
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
US20180169297A1 (en) 2015-06-12 2018-06-21 Laboratoire Français Du Fractionnement Et Des Biotechnologies Injectable composition of factor vii and fillers
WO2016205728A1 (en) 2015-06-17 2016-12-22 Massachusetts Institute Of Technology Crispr mediated recording of cellular events
CA3012607A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
WO2016205764A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2016205745A2 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Cell sorting
WO2017024317A2 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
KR20180133374A (en) 2015-10-22 2018-12-14 더 브로드 인스티튜트, 인코퍼레이티드 Type VI-B CRISPR Enzymes and Systems
WO2017106657A1 (en) 2015-12-18 2017-06-22 The Broad Institute Inc. Novel crispr enzymes and systems
US20190046497A1 (en) 2016-02-14 2019-02-14 Yeda Research And Development Co., Ltd. Methods of modulating protein exocytosis and uses of same in therapy
WO2017168428A1 (en) 2016-03-30 2017-10-05 Regentis Biomaterials Ltd. Treatments utilizing a polymer-protein conjugate
EP3445848A1 (en) 2016-04-19 2019-02-27 The Broad Institute, Inc. Novel crispr enzymes and systems
WO2017184786A1 (en) 2016-04-19 2017-10-26 The Broad Institute Inc. Cpf1 complexes with reduced indel activity
CA3026110A1 (en) 2016-04-19 2017-11-02 The Broad Institute, Inc. Novel crispr enzymes and systems
WO2017219027A1 (en) 2016-06-17 2017-12-21 The Broad Institute Inc. Type vi crispr orthologs and systems
WO2018005873A1 (en) 2016-06-29 2018-01-04 The Broad Institute Inc. Crispr-cas systems having destabilization domain
AU2017296352A1 (en) 2016-07-11 2019-02-21 Opko Biologics Ltd. Long-acting coagulation factor VII and methods of producing same
FR3054444A1 (en) 2016-07-29 2018-02-02 Lab Francais Du Fractionnement oral composition of anti-TNF alpha antibody
WO2018047154A1 (en) 2016-09-07 2018-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-nkp46 antibodies and therapeutic use of same
WO2018096547A1 (en) 2016-11-28 2018-05-31 Yeda Research And Development Co. Ltd. Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest
WO2018208910A1 (en) 2017-05-09 2018-11-15 The Broad Institute Inc. Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases
WO2018229521A1 (en) 2017-06-16 2018-12-20 Oslo Universitetssykehus Hf Improved gene editing
WO2019023680A1 (en) 2017-07-28 2019-01-31 President And Fellows Of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
EP3466975A1 (en) 2017-10-05 2019-04-10 Laboratoire Français du Fractionnement et des Biotechnologies A specific binding molecule directed against galectin-3 protein
EP3488858A1 (en) 2017-11-27 2019-05-29 Laboratoire Français du Fractionnement et des Biotechnologies A von willebrand factor composition for use in treating a pathology mediated by angiogenesis
FR3075200A1 (en) 2017-12-15 2019-06-21 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Variants with fc fragment having increased affinity for fcrn and increased affinity for at least one fragment fc receptor
FR3075603A1 (en) 2017-12-21 2019-06-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Pharmaceutical composition for oral administration of antibodies for the treatment of gastrointestinal tract diseases

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497796A (en) 1980-03-26 1985-02-05 The Regents Of The University Of California Gene transfer in intact mammals
US4495280A (en) * 1981-05-20 1985-01-22 The Board Of Trustees Of The Leland Stanford Jr. University Cloned high signal strength promoters
EP0081570A4 (en) 1981-06-12 1985-09-02 Univ Ohio Genetic transformation of zygotes.
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
EP0105141A3 (en) 1982-09-09 1985-12-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Recombinant dna molecules, process for their production, their use for production of hepatitis b surface antigen (hbsag) and pharmaceutical compositions containing this hbsag
US4512922A (en) 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0116718B2 (en) 1983-01-13 1996-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Process for the introduction of expressible genes into plant cell genomes and agrobacterium strains carrying hybrid Ti plasmid vectors useful for this process
WO1984002913A1 (en) 1983-01-17 1984-08-02 Monsanto Co Chimeric genes suitable for expression in plant cells
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
NZ207765A (en) 1983-04-15 1987-03-06 Lubrizol Genetics Inc Plant expression of transferred dna(t-dna)from plasmids associated with agrobacterium sp
US4696898A (en) 1984-01-16 1987-09-29 Integrated Genetics, Inc. Vector encoding hepatitis B surface antigen
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
ES8702945A1 (en) 1984-10-01 1987-01-16 Integrated Genetics Inc A method of producing plasminogen activator human uterine tissue
EP0263166A4 (en) 1986-03-19 1991-07-31 Purdue, John C. Air conditioning apparatus
US6727405B1 (en) * 1986-04-09 2004-04-27 Genzyme Corporation Transgenic animals secreting desired proteins into milk
AT141646T (en) * 1986-04-09 1996-09-15 Genzyme Corp Genetically transformed animals that secrete a desired protein in milk
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
US5322775A (en) * 1986-06-30 1994-06-21 Pharmaceutical Proteins Ltd. Peptide production
AU7879987A (en) 1986-08-28 1988-03-24 Immunex Corp. Expression of heterologous proteins by transgenic lactating mammals
EP0832981A1 (en) 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US6448469B1 (en) 1991-10-02 2002-09-10 Genzyme Corporation Production of membrane proteins in the milk of transgenic nonhuman mammals
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5843705A (en) 1995-02-21 1998-12-01 Genzyme Transgenic Corporation Transgenically produced antithrombin III
US6268487B1 (en) 1996-05-13 2001-07-31 Genzyme Transgenics Corporation Purification of biologically active peptides from milk
CA2281949A1 (en) 1997-02-25 1998-08-27 Genzyme Transgenics Corporation Transgenically produced non-secreted proteins
US6210736B1 (en) 1997-06-17 2001-04-03 Genzyme Transgenics Corporation Transgenically produced prolactin
US20030005468A1 (en) 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
US20040117863A1 (en) 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
US6580017B1 (en) 1998-11-02 2003-06-17 Genzyme Transgenics Corporation Methods of reconstructed goat embryo transfer
EP1818397A1 (en) 1998-11-02 2007-08-15 Trustees Of Tufts College Methods for cloning animals
US20030177513A1 (en) 1998-11-02 2003-09-18 Yann Echelard Transgenic and cloned mammals
AU5946501A (en) 2000-05-05 2001-11-20 Genzyme Transgenics Corp Transgenically produced decorin
IL153507D0 (en) 2000-06-19 2003-07-06 Genzyme Transgenics Corp Transgenically produced platelet derived growth factor
US20040226053A1 (en) 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
WO2003064633A1 (en) 2002-01-11 2003-08-07 Gtc Biotherapeutics, Inc. Method and system for fusion and activation following nuclear transfer in reconstructed embryos
CA2480802A1 (en) 2002-04-01 2003-10-16 Gtc Biotherapeutics, Inc. A method for selecting cell lines to be used for nuclear transfer in mammalian species
WO2004012499A2 (en) 2002-08-01 2004-02-12 Gtc Biotherapeutics, Inc. Method of selecting cells for somatic cell nuclear transfer
WO2004050847A2 (en) 2002-11-27 2004-06-17 Gtc Biotherapeutics, Inc. Modified antibodies stably produced in milk and methods of producing same
WO2004053090A2 (en) 2002-12-10 2004-06-24 Gtc Biotherapeutics, Inc. Method and system for utilizing somatic cell nuclear transfer embryos as cell donors for additional nuclear transfer
US20040133931A1 (en) 2003-01-08 2004-07-08 Gavin William G. Method and system for fusion and activation following nuclear transfer in reconstructed embryos
EP1678298A2 (en) 2003-09-15 2006-07-12 GTC Biotherapeutics, Inc. Expression of dominant negative transmembrane receptors in the milk of transgenic animals
US20050186608A1 (en) 2004-02-19 2005-08-25 Olsen Byron V. Method for the production of transgenic proteins useful in the treatment of obesity and diabetes
US20060123500A1 (en) 2004-12-07 2006-06-08 Gtc Biotherapeutics, Inc. Methods of prescreening cells for nuclear transfer procedures
US20060168671A1 (en) 2005-01-21 2006-07-27 Gavin William G Injection of caprine sperm factor (cSF), phospholipase C zeta (PLCzeta) and adenophostin A as alternative methods of activation during nuclear transfer in the caprine species

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US7939317B1 (en) 2011-05-10
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DE3751873D1 (en) 1996-09-26
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JPS63291A (en) 1988-01-05
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EP0264166A1 (en) 1988-04-20
US7045676B1 (en) 2006-05-16
DE122007000007I2 (en) 2010-12-30
JPH09294586A (en) 1997-11-18
DE122007000007I1 (en) 2007-05-16
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NL300257I1 (en) 2007-04-02
EP0264166B1 (en) 1996-08-21

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