AT135370T - Chemically modified granulocyte colony-causing factor - Google Patents

Chemically modified granulocyte colony-causing factor

Info

Publication number
AT135370T
AT135370T AT90900360T AT90900360T AT135370T AT 135370 T AT135370 T AT 135370T AT 90900360 T AT90900360 T AT 90900360T AT 90900360 T AT90900360 T AT 90900360T AT 135370 T AT135370 T AT 135370T
Authority
AT
Austria
Prior art keywords
chemically modified
granulocyte colony
causing factor
modified granulocyte
factor
Prior art date
Application number
AT90900360T
Other languages
German (de)
Inventor
Rika Ishikawa
Yuji Okada
Makoto Kakitani
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP32474788 priority Critical
Priority to JP19917689 priority
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Publication of AT135370T publication Critical patent/AT135370T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • C07K17/08Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/14Lymphokine; related peptides
    • Y10S930/145Colony stimulating factor
AT90900360T 1988-12-22 1989-12-22 Chemically modified granulocyte colony-causing factor AT135370T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP32474788 1988-12-22
JP19917689 1989-07-31

Publications (1)

Publication Number Publication Date
AT135370T true AT135370T (en) 1996-03-15

Family

ID=26511383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900360T AT135370T (en) 1988-12-22 1989-12-22 Chemically modified granulocyte colony-causing factor

Country Status (7)

Country Link
US (2) US5824778A (en)
EP (1) EP0401384B1 (en)
JP (1) JP2989002B2 (en)
AT (1) AT135370T (en)
CA (1) CA2006596C (en)
DE (2) DE68925966T2 (en)
WO (1) WO1990006952A1 (en)

Families Citing this family (625)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5718893A (en) * 1984-04-15 1998-02-17 Foster; Preston F. Use of G-CSF to reduce acute rejection
AT135370T (en) * 1988-12-22 1996-03-15 Kirin Amgen Inc Chemically modified granulocyte colony-causing factor
US20020177688A1 (en) * 1988-12-22 2002-11-28 Kirin-Amgen, Inc., Chemically-modified G-CSF
GB9107846D0 (en) * 1990-04-30 1991-05-29 Ici Plc Polypeptides
US8071737B2 (en) * 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
US6465188B1 (en) * 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
US20060084797A1 (en) * 1990-06-11 2006-04-20 Gilead Sciences, Inc. High affinity TGFbeta nucleic acid ligands and inhibitors
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5336782A (en) * 1991-04-24 1994-08-09 Kuraray Co., Ltd. Long chain carboxylic acid imide ester
FR2686900B1 (en) * 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa New polypeptides having an activity to stimulate granulocyte colony, their preparation and pharmaceutical compositions containing them.
FR2686899B1 (en) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa New biologically active polypeptides, their preparation and pharmaceutical compositions containing them.
WO1995021629A1 (en) * 1994-02-08 1995-08-17 Amgen Inc. Oral delivery of chemically modified proteins
HU217872B (en) 1994-02-23 2000-04-28 Kyowa Hakko Kogyo Co., Ltd. Use of the polypeptide of platelet production by facilitating preparation of a medicament
EP0675201A1 (en) * 1994-03-31 1995-10-04 Amgen Inc. Compositions and methods for stimulating megakaryocyte growth and differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5536495A (en) * 1994-04-15 1996-07-16 Foster; Preston F. Use of G-CSF to reduce acute rejection
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6124439A (en) * 1994-08-17 2000-09-26 The Rockefeller University OB polypeptide antibodies and method of making
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6001968A (en) * 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US20030053982A1 (en) * 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US7820798B2 (en) 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
JP3708151B2 (en) * 1994-12-15 2005-10-19 協和醗酵工業株式会社 Peg Determination of human granulocyte colony stimulating factor ized
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
AU6028396A (en) 1995-06-07 1996-12-30 Amgen, Inc. Ob protein compositions and method
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
AU1121997A (en) * 1995-11-29 1997-06-19 Amgen, Inc. Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US7632922B1 (en) 1995-12-22 2009-12-15 Amgen, Inc. Osteoprotegerin
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US5837681A (en) * 1996-02-23 1998-11-17 Amgen Inc. Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US6713061B1 (en) 1996-03-12 2004-03-30 Human Genome Sciences, Inc. Death domain containing receptors
US7357927B2 (en) 1996-03-12 2008-04-15 Human Genome Sciences, Inc. Death domain containing receptors
WO1997033904A1 (en) 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US6455277B1 (en) 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
US7138251B1 (en) 1996-04-22 2006-11-21 Amgen Inc. Polynucleotides encoding a neurotrophic factor receptor
US5766877A (en) * 1996-05-10 1998-06-16 Amgen Inc. Genes encoding art, an agouti-related transcript
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
US5919656A (en) * 1996-11-15 1999-07-06 Amgen Canada Inc. Genes encoding telomerase protein 1
WO1998024477A1 (en) 1996-12-06 1998-06-11 Amgen Inc. Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
US6455040B1 (en) 1997-01-14 2002-09-24 Human Genome Sciences, Inc. Tumor necrosis factor receptor 5
ES2275300T3 (en) 1997-01-15 2007-06-01 Phoenix Pharmacologics, Inc. Tumor necrosis factor modified.
US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
DK1012274T4 (en) 1997-01-28 2011-07-25 Human Genome Sciences Inc Death domain-containing receptor-4 (DR4: death receptor 4), a member of the TNF receptor superfamily and which binds to TRAIL (Apo-2L)
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US6433147B1 (en) 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
EP1881005B1 (en) * 1997-07-14 2013-04-03 Bolder Biotechnology, Inc. Derivatives of G-CSF and related proteins
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US6043221A (en) 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
AU3072799A (en) 1998-03-19 1999-10-11 Human Genome Sciences, Inc. Cytokine receptor common gamma chain like
US6858706B2 (en) 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
US6492138B1 (en) 1998-05-21 2002-12-10 Amgen Canada Inc. Polynucleotides encoding a novel SHC-binding protein
US5973119A (en) * 1998-06-05 1999-10-26 Amgen Inc. Cyclin E genes and proteins
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
US5962636A (en) * 1998-08-12 1999-10-05 Amgen Canada Inc. Peptides capable of modulating inflammatory heart disease
US6344541B1 (en) 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
ES2265693T3 (en) 1998-10-16 2007-02-16 Biogen Idec Ma Inc. Fusion proteins with interferon-beta and uses.
ES2653589T3 (en) 1998-10-16 2018-02-07 Biogen Ma Inc. Interferon beta-1a polymer conjugates and uses thereof
CA2346996C (en) 1998-10-23 2013-11-19 Amgen Inc. Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US6773911B1 (en) 1998-11-23 2004-08-10 Amgen Canada Inc. Apoptosis-inducing factor
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6753165B1 (en) * 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
SK286898B6 (en) * 1999-01-29 2009-07-06 Amgen, Inc. Physiologically active conjugate, a composition and preparing method
SI1157037T1 (en) * 1999-01-29 2003-12-31 F. Hoffmann-La Roche Ag Gcsf conjugates
US6303749B1 (en) 1999-01-29 2001-10-16 Amgen Inc. Agouti and agouti-related peptide analogs
US8624010B1 (en) 1999-02-03 2014-01-07 Steven K. Yoshinaga Nucleic acids encoding B7RP1
US7708993B2 (en) 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
PT2332976E (en) 1999-02-03 2014-05-23 Amgen Inc Novel polypeptides involved in immune response
US7435796B1 (en) 1999-02-03 2008-10-14 Amgen Inc. Antibodies which bind B7RP1
EP2357192A1 (en) 1999-02-26 2011-08-17 Human Genome Sciences, Inc. Human endokine alpha and methods of use
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US7408047B1 (en) 1999-09-07 2008-08-05 Amgen Inc. Fibroblast growth factor-like polypeptides
US6900043B1 (en) 1999-09-21 2005-05-31 Amgen Inc. Phosphatases which activate map kinase pathways
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
MXPA02006795A (en) * 2000-01-10 2005-04-19 Maxygen Holdings Ltd Gcsf conjugates.
AU2002325819B2 (en) 2001-07-11 2008-06-19 Maxygen, Inc. G-CSF Conjugates
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
WO2002064612A2 (en) 2001-02-09 2002-08-22 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
NZ521257A (en) 2000-02-11 2004-10-29 Maxygen Aps Factor VII or VIIa-like molecules
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
US7514239B2 (en) 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
ES2484966T3 (en) 2000-04-12 2014-08-12 Novozymes Biopharma Dk A/S Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
CA2413160A1 (en) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
CA2413673C (en) 2000-06-28 2018-01-09 Amgen Inc. Thymic stromal lymphopoietin receptor molecules and uses thereof
BR0112429A (en) * 2000-07-12 2003-12-30 Gryphon Therapeutics Inc chemokine receptor modulators, these modulators preparation and use
US20040077835A1 (en) * 2001-07-12 2004-04-22 Robin Offord Chemokine receptor modulators, production and use
US6716811B1 (en) * 2000-07-20 2004-04-06 Affymax, Inc. Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses
AT360640T (en) 2000-08-08 2007-05-15 St Jude Childrens Res Hospital Group B streptococcus polypeptide, nucleic acid, therapeutic compositions and vaccines thereof
AT451390T (en) 2000-08-18 2009-12-15 Dyax Corp Polypeptides for binding to the B lymphocyte stimulatory protein (BLyS)
US8435939B2 (en) 2000-09-05 2013-05-07 Biokine Therapeutics Ltd. Polypeptide anti-HIV agent containing the same
EP1319182A2 (en) * 2000-09-08 2003-06-18 Massachusetts Institute Of Technology G-csf analog compositions and methods
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
WO2002020033A1 (en) * 2000-09-08 2002-03-14 Gryphon Therapeutics, Inc. Polymer-modified synthetic proteins
US20020142964A1 (en) * 2000-11-02 2002-10-03 Nissen Torben Lauesgaard Single-chain polypeptides
CN1321134C (en) * 2000-11-23 2007-06-13 赵剑 Hetergeneous product of bio-active protein and its preparing process
JP4236925B2 (en) 2000-11-28 2009-03-11 アムジエン・インコーポレーテツド Novel polypeptides that are involved in the immune response
AU2002220720B2 (en) 2000-11-28 2006-09-14 Mondobiotech Ag Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
US6979556B2 (en) 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
EP2123293A3 (en) * 2000-12-14 2010-09-08 Amylin Pharmaceuticals, Inc. Peptide YY and petide YY agonists for treatment of metabolic disorders
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
ES2450115T3 (en) 2003-01-31 2014-03-24 Biogen Idec Ma Inc. Polymeric conjugates of mutated neublastin
EP1683865A3 (en) 2001-02-02 2006-10-25 Eli Lilly & Company Mammalian proteins and in particular CD200
BR0207576A (en) 2001-02-27 2004-04-27 Maxygen Aps glycosylated variant of an interferon beta polypeptide precursor (IFNB), processes of increasing in vivo glycosylation of a precursor IFNB molecule to produce a molecule glycosylated IFNB for preparing a conjugated variant and treating a mammal with sclerosis múltiplam pharmaceutical composition , variant iFNB molecule, nucleotide sequence, expression vector, host cell glycosylation conjugate, and use of a conjugate
DK1385864T3 (en) 2001-04-13 2010-08-16 Human Genome Sciences Inc Anti-VEGF-2 antibodies
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
ES2437992T3 (en) 2001-05-25 2014-01-15 Human Genome Sciences, Inc. Antibodies that bind immunospecifically to TRAIL receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US6867189B2 (en) 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
DE60224291T2 (en) 2001-08-27 2008-12-11 Genentech, Inc., South San Francisco System for antibody expression and-synthesis
KR100989647B1 (en) 2001-09-24 2010-10-26 오레곤 헬스 앤드 사이언스 유니버시티 Modification of feeding behavior
EP1474163A2 (en) 2002-01-10 2004-11-10 Imperial College Innovations Limited Modification of feeding behavior
US7084257B2 (en) 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US7173003B2 (en) * 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
AT517855T (en) 2001-11-30 2011-08-15 Biogen Idec Inc Antibodies against chemotoxic monocyte proteins
JP2005528082A (en) 2001-12-18 2005-09-22 モンドバイオテック・ラボラトリーズ・アンスタルト Novel pharmaceutical compositions of interferon γ or pirfenidone and molecular diagnostics for improving the treatment of interstitial lung disease
EP1463751B1 (en) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Albumin fusion proteins
US8058233B2 (en) 2002-01-10 2011-11-15 Oregon Health And Science University Modification of feeding behavior using PYY and GLP-1
US7662924B2 (en) 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
DE10209822A1 (en) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of low molecular weight substances to a modified polysaccharide
DE10209821A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of proteins to a modified polysaccharide
AU2003210052A1 (en) 2002-03-20 2003-09-29 Biopolymed Inc. Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue
JP2005535607A (en) 2002-06-10 2005-11-24 モンドバイオテック・ラボラトリーズ・アンスタルト Use of a compound having the biological activity of vasoactive intestinal peptide for the treatment of sarcoidosis
WO2003105763A2 (en) * 2002-06-14 2003-12-24 Amylin Pharmaceuticals, Inc. Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
JP4634145B2 (en) 2002-06-21 2011-02-23 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Pegylated Factor VII glycoform
DE60336555D1 (en) 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag Pegylated glyco forms of factor vii
CA2880296A1 (en) 2002-07-19 2004-01-29 Abbvie Biotechnology Ltd. Treatment of tnf.alpha. related disorders
ES2403932T3 (en) 2002-08-27 2013-05-22 Biokine Therapeutics Ltd. CXCR4 antagonist and use of it
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
WO2004024761A1 (en) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh Hasylated polypeptides, especially hasylated erythropoietin
US20080274948A1 (en) * 2003-08-08 2008-11-06 Fresenius Kabi Deutschland Gmbh Conjugates of Hydroxyalkyl Starch and G-Csf
TWI281864B (en) * 2002-11-20 2007-06-01 Pharmacia Corp N-terminally monopegylated human growth hormone conjugates and process for their preparation
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
EP2025345A1 (en) 2002-12-30 2009-02-18 Biogen Idec MA Inc. KIM-1 antagonists and use to modulate immune system
EP1616003A4 (en) * 2002-12-30 2007-06-20 Gryphon Therapeutics Inc Water-soluble thioester and selenoester compounds and methods for making and using the same
GB0300571D0 (en) 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
BRPI0408358A (en) 2003-03-14 2006-03-21 Neose Technologies Inc branched water-soluble polymers and their conjugates
WO2004085648A2 (en) 2003-03-19 2004-10-07 Biogen Idec Ma Inc. Nogo receptor binding protein
KR20040083268A (en) * 2003-03-21 2004-10-01 한미약품 주식회사 Human granulocyte-colony stimulating factor conjugate having enhanced stability in blood and process for the preparation thereof
US20050281778A1 (en) * 2003-03-28 2005-12-22 Myung-Ok Park Human growth hormone conjugated with biocompatible polymer
MXPA05010411A (en) * 2003-03-28 2006-05-31 Biopolymed Inc Biologically active material conjugated with biocompatible polymer with 1:1 complex, preparation method thereof and pharmaceutical composition comprising the same.
US20060134736A1 (en) * 2003-03-28 2006-06-22 Jacobs John W Human growth hormone conjugated with biocompatible polymer
JP2006523683A (en) * 2003-04-15 2006-10-19 オッパーバス・ホールディング・ビー・ブイ A pharmaceutical composition comprising a protein and / or polypeptide and colloidal particles
EP1618179B1 (en) 2003-04-18 2014-05-07 Biogen Idec MA Inc. Polymer-conjugated glycosylated neublastin
EP1624847B1 (en) 2003-05-09 2012-01-04 BioGeneriX AG Compositions and methods for the preparation of human growth hormone glycosylation mutants
EP1626983B8 (en) 2003-05-12 2010-12-22 Affymax, Inc. Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof
MXPA05012314A (en) 2003-05-12 2006-04-18 Affymax Inc Spacer moiety for poly(ethylene glycol) -modified peptides.
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
EP2263684A1 (en) 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 derivatives
EP2641611A3 (en) 2003-10-17 2013-12-18 Novo Nordisk A/S Combination therapy
US7220407B2 (en) * 2003-10-27 2007-05-22 Amgen Inc. G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7842661B2 (en) 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) * 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
WO2006074467A2 (en) 2005-01-10 2006-07-13 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
WO2005053730A1 (en) * 2003-12-05 2005-06-16 Kirin Beer Kabushiki Kaisha Therapeutic agent for terminal heart failure
SI1691837T1 (en) 2003-12-10 2012-11-30 Medarex Inc Ip-10 antibodies and their uses
WO2005059106A2 (en) 2003-12-10 2005-06-30 Medarex, Inc. Interferon alpha antibodies and their uses
US8361961B2 (en) 2004-01-08 2013-01-29 Biogenerix Ag O-linked glycosylation of peptides
AU2005319099B2 (en) 2004-02-02 2010-09-16 Ambrx, Inc. Modified human growth hormone
WO2005074524A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human interferon polypeptides and their uses
DK1729795T3 (en) 2004-02-09 2016-04-11 Human Genome Sciences Inc Albumin fusion proteins
EP2360180A3 (en) 2004-12-13 2012-02-08 Amylin Pharmaceuticals Inc. Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
BRPI0614649A2 (en) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc Hybrid polypeptides with selectable properties
CA2617649A1 (en) * 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
US8076288B2 (en) * 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
CA2555877C (en) 2004-02-11 2015-11-24 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
EP2335715A3 (en) 2004-02-11 2013-12-18 Amylin Pharmaceuticals, LLC Pancreatic polypeptide family motifs and polypeptides comprising the same
CN1929865B (en) * 2004-03-11 2011-11-16 费森尤斯卡比德国有限公司 Conjugates of hydroxyalkyl starch and a protein
EP2336192A1 (en) 2004-03-11 2011-06-22 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
WO2005090564A1 (en) 2004-03-19 2005-09-29 Genomidea Inc. Gene promoting vascular endothelial cell growth
EP2332992A1 (en) 2004-03-23 2011-06-15 Biogen Idec MA Inc. Receptor coupling agents and therapeutic uses thereof
TWI556829B (en) 2004-04-09 2016-11-11 Abbvie Biotechnology Ltd Multiple variable dose therapy for the treatment of TNFα-related disorders
BRPI0512235A (en) 2004-06-18 2008-02-19 Ambrx Inc linker polypeptide antigens and their uses
LT2662390T (en) 2004-06-21 2017-10-10 E. R. Squibb & Sons, L.L.C. Interferon alpha receptor 1 antibodies and their uses
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
ES2395094T3 (en) 2004-06-24 2013-02-08 Biogen Idec Ma Inc. Treatment of conditions that involve demyelination
EP1773400A2 (en) 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
EP1771066A2 (en) 2004-07-13 2007-04-11 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
US7638299B2 (en) 2004-07-21 2009-12-29 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
EP1778842B8 (en) 2004-07-22 2012-03-21 Five Prime Therapeutics, Inc. Compositions and methods of use for mgd-csf in disease treatment
US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
SI2586456T1 (en) 2004-10-29 2016-05-31 Ratiopharm Gmbh Remodeling and glycopegylation of fibroblast growth factor (FGF)
EP1817047B1 (en) * 2004-11-05 2012-02-08 Northwestern University Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders
AU2005319518B2 (en) * 2004-12-22 2010-09-09 Ambrx, Inc. Compositions of aminoacyl-tRNA synthetase and uses thereof
EP1833993A4 (en) 2004-12-22 2009-07-22 Ambrx Inc Formulations of human growth hormone comprising a non-naturally encoded amino acid
NZ555206A (en) * 2004-12-22 2010-09-30 Ambrx Inc Methods for expression and purification of recombinant human growth hormone
US8168588B2 (en) 2005-01-25 2012-05-01 Five Prime Therapeutics, Inc. Compositions comprising FGF-9 and betacellulin and methods for treating cardiac conditions
US7402730B1 (en) 2005-02-03 2008-07-22 Lexicon Pharmaceuticals, Inc. Knockout animals manifesting hyperlipidemia
US8263545B2 (en) * 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
EA011653B1 (en) * 2005-02-11 2009-04-28 Амилин Фармасьютикалз, Инк. Analogs and fusion polypeptides with elected properties gip
US7629315B2 (en) 2005-03-09 2009-12-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compositions for blocking the inhibitory effect of human CRP on human leptin
JP2008532966A (en) * 2005-03-11 2008-08-21 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングFRESENIUS KABI DEUTSCHLAND GmbH Generation of bioactive glycoproteins from inert starting materials
EA013121B1 (en) 2005-03-31 2010-02-26 Амилин Фармасьютикалз, Инк. Amylin and amylin agonists for the treatment of psychiatric diseases and disorders
EP1868652A2 (en) 2005-04-05 2007-12-26 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Method for shielding functional sites or epitopes on proteins
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
SI2439273T1 (en) 2005-05-09 2019-05-31 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
US8715664B2 (en) 2005-05-16 2014-05-06 Abbvie Biotechnology Ltd. Use of human TNFα antibodies for treatment of erosive polyarthritis
JP5216580B2 (en) * 2005-05-25 2013-06-19 ノヴォ ノルディスク アー/エス Glycopegylated factor IX
AT500847T (en) 2005-06-01 2011-03-15 Maxygen Inc Pegylated g-csf polypeptides and method of manufacturing thereof
US20070015701A1 (en) * 2005-06-01 2007-01-18 Samuel Zalipsky Macromolecular conjugates of bone morphogenetic protein-7
MX2007015058A (en) * 2005-06-03 2008-01-28 Ambrx Inc Improved human interferon molecules and their uses.
KR100694994B1 (en) 2005-06-13 2007-03-14 씨제이 주식회사 Human Granulocyte-Colony Stimulating Factor Isoforms
WO2006134173A2 (en) 2005-06-17 2006-12-21 Novo Nordisk Health Care Ag Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
KR101888321B1 (en) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. Human monoclonal antibodies to programmed death ligand 1(pd-l1)
US7482124B2 (en) 2005-07-08 2009-01-27 Bristol-Myers Squibb Company Method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema
PT1904104E (en) 2005-07-08 2013-11-21 Biogen Idec Inc Sp35 antibodies and uses thereof
AU2006272759B2 (en) 2005-07-22 2012-01-12 Five Prime Therapeutics, Inc. Compositions and methods of treating disease with FGFR fusion proteins
US7632823B2 (en) 2005-08-18 2009-12-15 Ambrx, Inc. Compositions of tRNA and uses thereof
US20070041905A1 (en) 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
AU2006283517B2 (en) 2005-08-19 2010-12-02 Amylin Pharmaceuticals, Llc Exendin for treating diabetes and reducing body weight
EP1762250A1 (en) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
NZ597082A (en) 2005-10-13 2013-11-29 Human Genome Sciences Inc Methods and Compositions for Use in Treatment of Patients with Autoantibody Positive Diseases
JP5006330B2 (en) 2005-10-21 2012-08-22 ノバルティス アーゲー Human antibodies against IL13 and therapeutic uses
EP1978993B1 (en) 2005-10-31 2016-12-14 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating cancer based on human fzd receptors
KR20140012160A (en) 2005-11-01 2014-01-29 애브비 바이오테크놀로지 리미티드 Methods and compositions for diagnosing ankylosing spondylitis using biomarkers
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
NZ568705A (en) 2005-11-04 2012-07-27 Biogen Idec Inc Methods for promoting neurite outgrowth and survival of dopaminergic neurons
JP5508716B2 (en) * 2005-11-08 2014-06-04 アンブルックス,インコーポレイテッドAmbrx,Inc. Accelerators for modifying unnatural amino acids and unnatural amino acid polypeptides
EP1951890A4 (en) * 2005-11-16 2009-06-24 Ambrx Inc Methods and compositions comprising non-natural amino acids
EP2543384A3 (en) 2005-12-02 2013-04-10 Biogen Idec MA Inc. Treatment of conditions involving demyelination
NZ568551A (en) 2005-12-08 2012-03-30 Medarex Inc Human monoclonal antibodies to Fucosyl-GM1 and methods using anti-Fucosyl-GM1
KR101423898B1 (en) * 2005-12-14 2014-07-28 암브룩스, 인코포레이티드 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
US8669345B2 (en) 2006-01-27 2014-03-11 Biogen Idec Ma Inc. Nogo receptor antagonists
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
US7566565B2 (en) 2006-03-24 2009-07-28 Syntonix Pharmaceuticals, Inc. PC5 as a factor IX propeptide processing enzyme
EP2738178A1 (en) 2006-04-05 2014-06-04 AbbVie Biotechnology Ltd Antibody purification
CA2564435A1 (en) 2006-04-10 2007-10-10 Abbott Biotechnology Ltd. Methods for monitoring and treating intestinal disorders
EP2703010A3 (en) 2006-04-10 2014-08-06 AbbVie Biotechnology Ltd Uses and compositions for treatment of rheumatoid arthritis
EP2007426A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd Uses and compositions for treatment of psoriatic arthritis
JP2009534423A (en) 2006-04-20 2009-09-24 アムジェン インコーポレイテッド Glp-1 compound
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
EP2029160A2 (en) * 2006-05-12 2009-03-04 Amylin Pharmaceuticals, Inc. Methods to restore glycemic control
WO2007136752A2 (en) 2006-05-19 2007-11-29 Glycofi, Inc. Erythropoietin compositions
BRPI0712008A2 (en) 2006-05-24 2012-01-10 Novo Nordisk Healthcare Ag extended fix derivatives and analogs
WO2007140599A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
EP1872790A1 (en) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft New formulation for increasing bioavailability of neurturin
KR101396797B1 (en) 2006-06-30 2014-05-26 애브비 바이오테크놀로지 리미티드 Automatic injection device
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
US9187532B2 (en) 2006-07-21 2015-11-17 Novo Nordisk A/S Glycosylation of peptides via O-linked glycosylation sequences
US7666423B2 (en) 2006-07-28 2010-02-23 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
WO2008019368A2 (en) 2006-08-07 2008-02-14 Teva Biopharmaceuticals Usa, Inc. Albumin-insulin fusion proteins
TW200817437A (en) 2006-08-11 2008-04-16 Medarex Inc Monoclonal antibodies against stromal cell derived factor-1 (SDF-1)
ITMI20061624A1 (en) 2006-08-11 2008-02-12 Bioker Srl Mono-conjugated site-specific g-csf
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
WO2008030611A2 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
AU2007292893B2 (en) * 2006-09-08 2012-03-01 Ambrx, Inc. Suppressor tRNA transcription in vertebrate cells
CA2663083A1 (en) 2006-09-08 2008-03-13 Ambrx, Inc. Modified human plasma polypeptide or fc scaffolds and their uses
DK2061878T3 (en) * 2006-09-08 2014-04-07 Ambrx Inc Hybrid suppressor trna for animal cells
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
EP2486941B1 (en) 2006-10-02 2017-03-15 E. R. Squibb & Sons, L.L.C. Human antibodies that bind CXCR4 and uses thereof
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As Methods for the purification of polypeptide conjugates
PL2068922T3 (en) 2006-10-19 2012-11-30 Anti-il-13r alpha 1 antibodies and their uses thereof
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
JP2010509920A (en) 2006-11-15 2010-04-02 メダレックス インコーポレーティッド Human monoclonal antibodies and methods of use for Btla
KR101552735B1 (en) 2006-12-01 2015-09-14 메다렉스, 엘.엘.시. 22 human antibodies that bind cd22 and uses thereof
DK2121751T3 (en) 2006-12-08 2017-04-24 Lexicon Pharmaceuticals Inc Monoclonal antibodies to ANGPTL3
TWI428346B (en) 2006-12-13 2014-03-01 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
WO2009054863A2 (en) 2006-12-13 2009-04-30 Medarex, Inc. Human antibodies that bind cd19 and uses thereof
CA2672468A1 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
US8455450B2 (en) 2006-12-21 2013-06-04 Biokine Therapeutics Ltd. Methods for obtaining a therapeutically effective amount of hematopoietic precursor cells and long term engraftment thereof
US8128926B2 (en) 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
US8389482B2 (en) 2007-01-30 2013-03-05 New York University Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
JP2010520855A (en) 2007-01-31 2010-06-17 アフィーマックス・インコーポレイテッドAffymax, Inc. Nitrogen-based linker for attaching modifying groups to the polypeptides and other macromolecules
UA99452C2 (en) 2007-02-02 2012-08-27 Байоджэн Айдэк Ма Инк. Use of semaphorin 6a for promoting myelination and oligodendrocyte differentiation
AU2008222563A1 (en) 2007-03-05 2008-09-12 Cancer Care Ontario Assessment of risk for colorectal cancer
ES2385114T3 (en) 2007-03-30 2012-07-18 Ambrx, Inc. Modified FGF-21 polypeptides and their uses
EP2144923B1 (en) 2007-04-03 2013-02-13 BioGeneriX AG Methods of treatment using glycopegylated g-csf
MX2009011870A (en) 2007-05-02 2009-11-12 Ambrx Inc Modified interferon beta polypeptides and their uses.
EP2679995A1 (en) 2007-05-31 2014-01-01 AbbVie Inc. Biomarkers predictive of the responsiveness to TNF-alfa inhibitors in autoimmune disorders
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
MX2009013259A (en) 2007-06-12 2010-01-25 Novo Nordisk As Improved process for the production of nucleotide sugars.
AU2008287063B2 (en) 2007-08-09 2013-10-24 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
JP2010535788A (en) 2007-08-09 2010-11-25 シントニックス・ファーマシューティカルズ・インコーポレーテッド Immunomodulatory peptide
DK2197919T3 (en) 2007-08-27 2014-07-07 Ratiopharm Gmbh Liquid formulation of g-csf conjugate
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US8415455B2 (en) 2007-09-04 2013-04-09 Compugen Ltd Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
US8758761B2 (en) 2007-09-30 2014-06-24 University Of Florida Research Foundation, Inc. Combination therapies for treating type 1 diabetes
AR068767A1 (en) 2007-10-12 2009-12-02 Novartis Ag Sclerostin antibodies, compositions and methods of using these antibodies for treating a disease mediated disorder sclerostin
EA201000718A1 (en) 2007-11-02 2011-06-30 Новартис Аг Molecules and methods designed to modulate the related lipoproteides receptor of low density protein 6 (lrp6)
MX2010005317A (en) 2007-11-20 2010-06-02 Ambrx Inc Modified insulin polypeptides and their uses.
EP2070951A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Method for producing a hydroxyalkyl starch derivatives with two linkers
EP2070950A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
CN105001333B (en) 2007-12-14 2019-05-17 诺沃—诺迪斯克有限公司 Anti-human NKG2D antibody and application thereof
AU2009212442C1 (en) 2008-02-05 2014-07-17 Bristol-Myers Squibb Company Alpha 5 - beta 1 antibodies and their uses
DK2250279T3 (en) 2008-02-08 2016-08-01 Medimmune Llc ANTI-IFNAR1 antibodies with reduced Fc ligand affinity-
NZ602170A (en) 2008-02-08 2014-03-28 Ambrx Inc Modified leptin polypeptides and their uses
JP5225393B2 (en) 2008-02-18 2013-07-03 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. Water-soluble polymer modified G-CSF complex
ES2476690T3 (en) 2008-02-27 2014-07-15 Novo Nordisk A/S Factor VIII conjugated molecules
EP2271772B1 (en) 2008-03-11 2014-07-16 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
CA2712511A1 (en) 2008-03-17 2009-09-24 Universitaetsklinikum Muenster Yopm as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
WO2009118300A1 (en) 2008-03-25 2009-10-01 Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Treating cancer by down-regulating frizzled-4 and/or frizzled-1
ES2620285T3 (en) 2008-05-02 2017-06-28 Novartis Ag Binding molecules based on improved fibronectin and their uses
WO2009143285A2 (en) 2008-05-21 2009-11-26 Amylin Pharmaceuticals, Inc. Exendins to lower cholestrol and triglycerides
AU2009256232B2 (en) 2008-06-04 2011-12-22 Amgen Inc. FGF21 mutants and uses thereof
AU2009269099B2 (en) 2008-07-09 2016-03-10 Biogen Ma Inc. Compositions comprising antibodies to LINGO or fragments thereof
CN106928339A (en) 2008-07-23 2017-07-07 Ambrx 公司 Modified bovine G-CSF polypeptides and their uses
DK2328616T3 (en) 2008-08-05 2015-07-20 Novartis Ag Compositions and Methods for Antibodies to Complement Protein C5
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc human antibodies that bind to the gene 3 of lymphocyte activation (LAG-3) and uses these
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2010037062A1 (en) 2008-09-26 2010-04-01 Ambrx, Inc. Non-natural amino acid replication-dependent microorganisms and vaccines
CN102232085A (en) 2008-09-26 2011-11-02 Ambrx公司 Modified animal erythropoietin polypeptides and their uses
MX341149B (en) 2008-10-10 2016-08-09 Amgen Inc Fgf21 mutants and uses thereof.
ITRM20080551A1 (en) * 2008-10-15 2010-04-16 Univ Catania Amphiphilic derivatives of polyoxyethylene glycol (peg), method of preparation and their uses in the preparation of pharmaceutical systems.
CA2738498A1 (en) 2008-10-20 2010-12-09 Abbott Laboratories Isolation and purification of antibodies using protein a affinity chromatography
MX2011004195A (en) * 2008-10-20 2011-09-27 Usv Ltd An improved process for pegylation of proteins.
WO2010052288A1 (en) 2008-11-07 2010-05-14 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Teneurin and cancer
CA3053156A1 (en) 2008-12-03 2010-06-10 Genmab A/S Antibody variants having modifications in the constant region
EP2865689A1 (en) 2008-12-08 2015-04-29 Compugen Ltd. FAM26F polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
WO2010085590A1 (en) 2009-01-23 2010-07-29 Biosynexus Incorporated Opsonic and protective antibodies specific for lipoteichoic acid gram positive bacteria
JP2013502458A (en) 2009-08-24 2013-01-24 アムニクス オペレーティング インコーポレイテッド Coagulation factor VII composition and methods of making and using the same
EP2396023A2 (en) 2009-02-11 2011-12-21 Yeda Research and Development Co. Ltd. Short beta-defensin-derived peptides
HUE034196T2 (en) 2009-03-05 2018-02-28 Squibb & Sons Llc Fully human antibodies specific to cadm1
WO2010100247A1 (en) 2009-03-06 2010-09-10 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Novel therapy for anxiety
CA2757114C (en) 2009-03-30 2019-05-21 Universite De Lausanne Preparation of isolated agonist anti-edar monoclonal antibodies
WO2010112458A1 (en) 2009-03-31 2010-10-07 Novartis Ag Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit
US8580732B2 (en) 2009-04-07 2013-11-12 Duke University Peptide therapy for hyperglycemia
EP2241323A1 (en) 2009-04-14 2010-10-20 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Tenascin-W and brain cancers
EP2419121B1 (en) 2009-04-17 2018-07-18 New York University Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof
CA2759538C (en) 2009-04-20 2018-07-24 Oxford Biotherapeutics Ltd Antibodies specific to cadherin-17
BRPI1014522A2 (en) 2009-04-27 2016-04-05 Novartis Ag compositions and methods to increase muscle growth
CA2760237C (en) 2009-04-29 2017-11-14 Abbott Biotechnology Ltd. Automatic injection device and plunger for same
US8188040B2 (en) 2009-05-05 2012-05-29 Amgen Inc. FGF21 mutants and uses thereof
EP2427207B1 (en) 2009-05-05 2017-08-16 Amgen, Inc Fgf21 mutants and uses thereof
JP5715622B2 (en) 2009-06-14 2015-05-07 バイオカイン セラピューティックス リミテッド Peptide therapy to increase platelet levels
US8324160B2 (en) 2009-06-17 2012-12-04 Amgen Inc. Chimeric polypeptides and uses thereof
EP3431501A1 (en) 2009-06-18 2019-01-23 Pfizer Inc Anti notch-1 antibodies
SG177689A1 (en) 2009-07-31 2012-02-28 Organon Nv Fully human antibodies to btla
WO2011021146A1 (en) 2009-08-20 2011-02-24 Pfizer Inc. Osteopontin antibodies
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
US20120244170A1 (en) 2009-09-22 2012-09-27 Rafal Ciosk Treating cancer by modulating mex-3
EP2470569A1 (en) 2009-10-13 2012-07-04 Oxford Biotherapeutics Ltd. Antibodies against epha10
WO2011045352A2 (en) 2009-10-15 2011-04-21 Novartis Forschungsstiftung Spleen tyrosine kinase and brain cancers
MX341136B (en) 2009-10-20 2016-08-09 Abbvie Inc Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography.
US20110098862A1 (en) 2009-10-27 2011-04-28 ExxonMobil Research Engineering Company Law Department Multi-stage processes and control thereof
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
US20120213801A1 (en) 2009-10-30 2012-08-23 Ekaterina Gresko Phosphorylated Twist1 and cancer
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
EP2496707A4 (en) 2009-11-04 2013-06-26 Merck Sharp & Dohme Engineered anti-tslp antibody
EP2504021A4 (en) 2009-11-23 2013-05-15 Amylin Pharmaceuticals Llc Polypeptide conjugate
WO2011067711A2 (en) 2009-12-01 2011-06-09 Compugen Ltd Novel heparanase splice variant
MX360487B (en) 2009-12-07 2018-10-24 Amgen Inc Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof.
NZ600069A (en) 2009-12-15 2015-02-27 Abbvie Biotechnology Ltd Improved firing button for automatic injection device
WO2011075578A1 (en) 2009-12-16 2011-06-23 Philip Bosch Methods of treating interstitial cystitis
MX2012006980A (en) 2009-12-21 2012-07-17 Ambrx Inc Modified porcine somatotropin polypeptides and their uses.
NZ600361A (en) 2009-12-21 2014-06-27 Ambrx Inc Modified bovine somatotropin polypeptides and their uses
EP3088532A1 (en) 2009-12-22 2016-11-02 Sequenom, Inc. Processes and kits for identifying aneuploidy
KR20120107122A (en) 2009-12-22 2012-09-28 노파르티스 아게 Tetravalent cd47-antibody constant region fusion protein for use in therapy
TWI535445B (en) 2010-01-12 2016-06-01 Oncomed Pharm Inc Wnt antagonists and treatment and screening methods
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
CN102959088A (en) 2010-02-02 2013-03-06 艾博特生物技术有限公司 Methods and compositions for predicting responsiveness to treatment with TNF-a inhibitor
CA2789125A1 (en) 2010-02-10 2011-08-18 Novartis Ag Methods and compounds for muscle growth
CN102985441B (en) 2010-02-19 2015-04-22 俄克拉何马大学董事会 Monoclonal antibodies that inhibit the Wnt signaling pathway and methods of production and use thereof
ES2639398T3 (en) 2010-03-04 2017-10-26 Pfenex Inc. Method for producing soluble recombinant interferon protein without denaturation
EP2542578A1 (en) 2010-03-05 2013-01-09 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Smoc1, tenascin-c and brain cancers
AU2011222883B2 (en) 2010-03-05 2016-05-26 Omeros Corporation Chimeric inhibitor molecules of complement activation
US8455218B2 (en) 2010-04-01 2013-06-04 Pfenex, Inc. Methods for G-CSF production in a Pseudomonas host cell
CA2796055A1 (en) 2010-04-15 2011-10-20 Amgen Inc. Human fgf receptor and .beta.-klotho binding proteins
WO2011131611A1 (en) 2010-04-19 2011-10-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Modulating xrn1
SG10201503080XA (en) 2010-04-27 2015-06-29 Agency Science Tech & Res Eif4e binding peptides
KR20130066632A (en) 2010-05-06 2013-06-20 노파르티스 아게 Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies
US9290573B2 (en) 2010-05-06 2016-03-22 Novartis Ag Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
WO2011143274A1 (en) 2010-05-10 2011-11-17 Perseid Therapeutics Polypeptide inhibitors of vla4
US20130137628A1 (en) 2010-05-11 2013-05-30 Esperion Therapeutics, Inc. Dimeric Oxidation-Resistant Apolipoprotein A1 Variants
CN103108652B (en) 2010-05-14 2016-05-11 巴克斯特国际公司 OspA chimeric genes, proteins and methods of use thereof
WO2011146727A1 (en) 2010-05-19 2011-11-24 Philip Bosch Methods of treating interstitial cystitis
WO2011145085A2 (en) 2010-05-21 2011-11-24 Procognia (Israel) Ltd Novel antibodies and methods of use for the treatment and diagnosis of cancer
CN105056232A (en) 2010-06-03 2015-11-18 阿布维生物技术有限公司 Uses and compositions for treatment of hidradenitis suppurativa
EP2580239A1 (en) 2010-06-10 2013-04-17 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Treating cancer by modulating mammalian sterile 20-like kinase 3
WO2012006027A1 (en) 2010-06-28 2012-01-12 Five Prime Therapeutics, Inc. Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules and treatments using same
EP2591101B1 (en) 2010-07-09 2018-11-07 Bioverativ Therapeutics Inc. Systems for factor viii processing and methods thereof
RU2446173C1 (en) * 2010-08-13 2012-03-27 Зао "Биокад" New functional, high-purity stable conjugate of granulocyte colony-stimulating factor (g-csf) and polyethylene glycol with prolonged biological action, applicable for medical purposes, and based immunobiological agent
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
CN108285482A (en) 2010-08-17 2018-07-17 阿姆布埃克斯股份有限公司 Through modifying relaxain polypeptide and application thereof
GEP201706605B (en) 2010-08-20 2017-01-25 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
EP2614080A1 (en) 2010-09-10 2013-07-17 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Phosphorylated twist1 and metastasis
WO2012035518A1 (en) 2010-09-17 2012-03-22 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
CA2813038A1 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Llc Highly soluble leptins
EP2625203A1 (en) 2010-10-05 2013-08-14 Novartis AG Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders
US20140093506A1 (en) 2010-11-15 2014-04-03 Marc Buehler Anti-fungal-agents
NZ610487A (en) 2010-11-15 2015-03-27 Five Prime Therapeutics Inc Treatment of cancer with elevated dosages of soluble fgfr1 fusion proteins
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
DK2643019T3 (en) 2010-11-24 2019-04-15 Lexicon Pharmaceuticals Inc Antibodies against note pectinacetyl esterase
EP3434691A1 (en) 2010-12-01 2019-01-30 AlderBio Holdings LLC Anti-ngf compositions and use thereof
WO2012076670A2 (en) 2010-12-10 2012-06-14 Novartis Ag Antibody formulation
CN103547594B (en) 2010-12-15 2016-05-11 惠氏有限责任公司 Anti-Notch 1 antibody
EP2663578A2 (en) 2011-01-14 2013-11-20 Five Prime Therapeutics, Inc. Il-27 antagonists for treating inflammatory diseases
NZ722287A (en) 2011-01-24 2018-03-23 Abbvie Biotechnology Ltd Automatic injection devices having overmolded gripping surfaces
GB201105584D0 (en) 2011-04-01 2011-05-18 Imp Innovations Ltd Cancer methods
BR112013026199A2 (en) 2011-04-15 2017-11-07 Compugen Ltd isolated polypeptide, fusion protein, nucleic acid sequence, expression vector or a virus, recombinant cell, method of producing a soluble ectodomain polypeptide or fusion protein or fragment thereof, pharmaceutical composition, use of a monoclonal antibody or polyclonal or antigen-binding fragment thereof, use of antibody or antigen-binding fragment, use of any of an isolated polypeptide, method of regulating cytokines, induction of t-cell expansion, promotion of cell immunity antigen specific t and promotion of cd4 + and / or cd8 + t cell activation in a subject, method for enhancing an immune response secondary to an antigen in a patient, method of using at least one of: an isolated polypeptide, method for treatment or prevention of an immune system related condition, method for treating or preventing an infectious disease a, method for diagnosing a disease in a subject, method of producing a soluble ectodomain polypeptide tmem25, vsig10, ly6g6f, or fusion protein or fragment thereof, monoclonal or polyclonal antibody or antigen-binding fragment thereof, immunotherapy in a patient and method for combining therapeutic vaccination with an antigen in conjunction with administration of either of a polypeptide
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
EP2683817B1 (en) 2011-05-10 2017-07-26 Danisco US Inc. Thermostable carbonic anhydrases and methods of use thereof
NO2707391T3 (en) 2011-05-13 2018-04-07
CN103748111B (en) 2011-05-20 2018-04-27 奥尔德生物控股有限责任公司 Compositions and the use of anti-cgrp
SG194973A1 (en) 2011-05-20 2013-12-30 Alderbio Holdings Llc Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
SG194974A1 (en) 2011-05-20 2013-12-30 Alderbio Holdings Llc Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
WO2012168259A1 (en) 2011-06-06 2012-12-13 Novartis Forschungsstiftung, Zweigniederlassung Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
AU2012269929A1 (en) 2011-06-16 2013-12-12 Novartis Ag Soluble proteins for use as therapeutics
WO2012175692A1 (en) 2011-06-22 2012-12-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl antibodies and uses thereof
AU2012273954A1 (en) 2011-06-22 2014-01-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-Axl antibodies and uses thereof
PL2726508T3 (en) 2011-06-28 2017-12-29 Oxford Biotherapeutics Ltd Antibodies to adp-ribosyl cyclase 2
EP2726503B1 (en) 2011-06-30 2019-09-04 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
WO2013006437A1 (en) 2011-07-01 2013-01-10 Novartis Ag Method for treating metabolic disorders
EP2726502A1 (en) 2011-07-01 2014-05-07 Bayer Intellectual Property GmbH Relaxin fusion polypeptides and uses thereof
EP3088005B1 (en) 2011-07-05 2019-01-02 biOasis Technologies Inc P97-antibody conjugates
MX350581B (en) 2011-07-08 2017-09-11 Biogen Hemophilia Inc Factor viii chimeric and hybrid polypeptides, and methods of use thereof.
CN103957926B (en) 2011-07-08 2018-07-03 安米林药品有限责任公司 The engineered polypeptide of acting duration and the immunogenicity reduced with enhancing
EP2734552A1 (en) 2011-07-22 2014-05-28 CSL Behring GmbH Inhibitory anti -factor xii/xiia monoclonal antibodies and their uses
AU2012301769B2 (en) 2011-08-31 2016-05-19 Amgen Inc. FGF21 for use in treating type 1 diabetes
US9458214B2 (en) 2011-09-26 2016-10-04 Novartis Ag Dual function fibroblast growth factor 21 proteins
MX2014005411A (en) 2011-11-04 2015-02-12 Novartis Ag Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs.
US20140314787A1 (en) 2011-11-08 2014-10-23 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute Treatment for neurodegenerative diseases
WO2013068432A1 (en) 2011-11-08 2013-05-16 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Early diagnostic of neurodegenerative diseases
CN104093414A (en) 2011-11-29 2014-10-08 神经噬菌体制药股份有限公司 Use of P3 of bacteriophage as amyloid binding agents
US20140017174A1 (en) 2011-11-30 2014-01-16 Raja Atreya Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
JP2015500829A (en) 2011-12-05 2015-01-08 ノバルティス アーゲー HER3 antibody against domain II of epidermal growth factor receptor 3 (HER3)
MX362521B (en) 2011-12-05 2019-01-22 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3).
AP201407761A0 (en) 2011-12-21 2014-07-31 Novartis Ag Compositions and methods for antibodies targeting factor P
US20140363448A1 (en) 2012-01-02 2014-12-11 Novartis Ag Cdcp1 and breast cancer
EP2623110A1 (en) 2012-01-31 2013-08-07 CSL Behring GmbH Factor XII inhibitors for the treatment of neurological inflammatory disorders
WO2013114367A2 (en) 2012-02-01 2013-08-08 Compugen Ltd. C10rf32 antibodies, and uses thereof for treatment of cancer
KR20190094480A (en) 2012-02-15 2019-08-13 바이오버라티브 테라퓨틱스 인크. Recombinant factor viii proteins
EP2814840A4 (en) 2012-02-15 2016-03-02 Amunix Operating Inc Factor viii compositions and methods of making and using same
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
HU1200171A2 (en) 2012-03-19 2013-09-30 Richter Gedeon Nyrt Methods for the production of polypeptides
US20150266961A1 (en) 2012-03-29 2015-09-24 Novartis Forschungsstiftung, Zweigniederlassung, Fridrich Miescher Institute Inhibition of interleukin-8 and/or its receptor cxcr1 in the treatment of her2/her3-overexpressing breast cancer
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9439942B2 (en) 2012-04-24 2016-09-13 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
US9783610B2 (en) 2012-04-27 2017-10-10 The Trustees Of The University Of Pennsylvania Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof
US20140004131A1 (en) 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
AU2013262934B2 (en) 2012-05-14 2018-02-01 Biogen Ma Inc. LINGO-2 antagonists for treatment of conditions involving motor neurons
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
TW201348247A (en) 2012-05-21 2013-12-01 Abbvie Inc Novel purification of non-human antibodies using protein a affinity chromatography
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9738724B2 (en) 2012-06-08 2017-08-22 Sutro Biopharma, Inc. Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
US9216219B2 (en) 2012-06-12 2015-12-22 Novartis Ag Anti-BAFFR antibody formulation
EP3135690A1 (en) 2012-06-26 2017-03-01 Sutro Biopharma, Inc. Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
US20150218238A1 (en) 2012-06-29 2015-08-06 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear Treating diseases by modulating a specific isoform of mkl1
AR091649A1 (en) 2012-07-02 2015-02-18 Squibb Bristol Myers Co Optimization of antibodies which bind to lymphocyte activation gene 3 (LAG-3) and their uses
WO2014006114A1 (en) 2012-07-05 2014-01-09 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research New treatment for neurodegenerative diseases
EP3404105A1 (en) 2012-07-06 2018-11-21 Bioverativ Therapeutics Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
RU2015106742A (en) 2012-07-27 2016-09-20 Бакстер Интернэшнл Инк. Compositions containing ospa chimeric molecules and ways of their application
EP2880156B1 (en) 2012-07-31 2017-08-23 biOasis Technologies Inc Dephosphorylated lysosomal storage disease proteins and methods of use thereof
CN104981254B (en) 2012-08-31 2018-05-22 苏特罗生物制药公司 Comprising a modified amino acid of the azido
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
EP2906235B1 (en) 2012-10-02 2017-07-19 Proclara Biosciences, Inc. Use of p3 of bacteriophage fusion proteins as amyloid binding agents
AU2013331000B2 (en) 2012-10-18 2018-04-19 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
EP2914293A4 (en) 2012-10-30 2016-04-20 Biogen Ma Inc Methods of using fviii polypeptide
KR20150083121A (en) 2012-11-12 2015-07-16 레드우드 바이오사이언스 인코포레이티드 Compounds and methods for producing a conjugate
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Medicale) Methods for the preparation of immunoconjugates and uses thereof
WO2014078733A1 (en) 2012-11-16 2014-05-22 The Regents Of The University Of California Pictet-spengler ligation for protein chemical modification
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
EA201591010A1 (en) 2012-12-05 2015-10-30 Новартис Аг Compositions and methods for taring antibodies on epo
US9383357B2 (en) 2012-12-07 2016-07-05 Northwestern University Biomarker for replicative senescence
TW201829452A (en) 2012-12-11 2018-08-16 英商梅迪繆思有限公司 Glucagon and glp-1 co-agonists for the treatment of obesity
EP2953969B1 (en) 2013-02-08 2019-08-28 Novartis AG Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders
EP3161001A2 (en) 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
US10286047B2 (en) 2013-03-08 2019-05-14 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
EP3456344A1 (en) 2013-03-13 2019-03-20 Amgen, Inc Proteins specific for baff and b7rp1 and uses thereof
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
EP2970433B1 (en) 2013-03-13 2019-09-18 Bioasis Technologies Inc. Fragments of p97 and uses thereof
JP2016512213A (en) 2013-03-14 2016-04-25 メディミューン リミテッド Pegylated glucagon and GLP-1 co-agonist for the treatment of obesity
JP2016514130A (en) 2013-03-14 2016-05-19 ノバルティス アーゲー Antibody against Notch3
WO2014142882A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Protein purification using displacement chromatography
US9623088B2 (en) 2013-03-15 2017-04-18 Bioverativ Therapeutics Inc. Factor VIII polypeptide formulations
CA2907249A1 (en) 2013-03-15 2014-09-18 Danafarber Cancer Institute, Inc. Therapeutic peptides
RU2015150233A (en) 2013-05-01 2017-06-02 Файв Прайм Терапьютикс, Инк. Methods for treating a malignant tumor
RU2015154985A (en) 2013-05-23 2017-06-29 Файв Прайм Терапьютикс, Инк. Cancer treatment methods
WO2014186877A1 (en) 2013-05-24 2014-11-27 Uger Marni Diane FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
EP3003349B1 (en) 2013-05-28 2018-12-12 Proclara Biosciences, Inc. Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity
US10227390B2 (en) 2013-06-14 2019-03-12 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
AR096601A1 (en) 2013-06-21 2016-01-20 Novartis Ag 1 receptor antibodies lectin-like oxidized LDL and methods of use
US9562101B2 (en) 2013-06-21 2017-02-07 Novartis Ag Lectin-like oxidized LDL receptor 1 antibodies and methods of use
CA2916399A1 (en) 2013-06-28 2014-12-31 Marc Nolte Combination therapy using a factor xii inhibitor and a c1-inhibitor
EP3019522B1 (en) 2013-07-10 2017-12-13 Sutro Biopharma, Inc. Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
MX2016001485A (en) 2013-08-02 2016-06-02 Pfizer Anti-cxcr4 antibodies and antibody-drug conjugates.
US20160178610A1 (en) 2013-08-07 2016-06-23 Friedrich Miescher Institute For Biomedical Research New screening method for the treatment Friedreich's ataxia
SG11201600212VA (en) 2013-08-14 2016-02-26 Novartis Ag Methods of treating sporadic inclusion body myositis
WO2015031673A2 (en) 2013-08-28 2015-03-05 Bioasis Technologies Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
WO2015040215A1 (en) 2013-09-20 2015-03-26 Westfaelische Wilhelms-Universitaet Muenster Cell-penetrating bacterial e3-ubiqitin-ligases for use in immunotherapy
EP3055298A1 (en) 2013-10-11 2016-08-17 Sutro Biopharma, Inc. Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
US10117908B2 (en) 2013-10-17 2018-11-06 Grant Labs, Inc. Suppression of cellular transformation and dysplasia by topical application of lefty
WO2015057908A1 (en) 2013-10-18 2015-04-23 Novartis Ag Methods of treating diabetes and related disorders
EP3066124A1 (en) 2013-11-07 2016-09-14 INSERM - Institut National de la Santé et de la Recherche Médicale Neuregulin allosteric anti-her3 antibody
EP3066123A1 (en) 2013-11-07 2016-09-14 AbbVie Inc. Isolation and purification of antibodies
TW201609099A (en) 2014-08-11 2016-03-16 艾森塔製藥公司 Use Bruton (Bruton's)'s tyrosine kinase (BTK) inhibitor for the treatment of chronic lymphocytic leukemia and small lymphocytic leukemias of
WO2015085276A1 (en) 2013-12-06 2015-06-11 Biogen Idec Ma Inc. Population pharmacokinetics tools and uses thereof
US10106611B2 (en) 2013-12-06 2018-10-23 Dana-Farber Cancer Institute, Inc. Antibodies that bind to MHC class I polypeptide-related sequence A
WO2015110923A2 (en) 2014-01-21 2015-07-30 Acerta Pharma B.V. Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia usng a btk inhibitor
WO2015139020A2 (en) 2014-03-14 2015-09-17 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
TW201622746A (en) 2014-04-24 2016-07-01 Novartis Ag Improve or accelerate hip fracture surgery method of Rehab
KR101923326B1 (en) 2014-06-06 2018-11-29 브리스톨-마이어스 스큅 컴퍼니 Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
EP3154579A1 (en) 2014-06-13 2017-04-19 Friedrich Miescher Institute for Biomedical Research New treatment against influenza virus
EP3157548A1 (en) 2014-06-18 2017-04-26 CSL Behring GmbH Therapy using a factor xii inhibitor in a neurotraumatic disorder
US10308935B2 (en) 2014-06-23 2019-06-04 Friedrich Miescher Institute For Biomedical Research Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small RNAS
WO2016020880A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
WO2016128912A1 (en) 2015-02-12 2016-08-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor, and/or a pd-l1 inhibitor
TW201618775A (en) 2014-08-11 2016-06-01 艾森塔製藥公司 Btk inhibitor treatment, PI3K inhibitor, jak-2 inhibitors, pd-1 inhibitors and / or inhibitors of pd-l1 composition
CA2957722A1 (en) 2014-08-19 2016-02-25 Merck Sharp & Dohme Corp. Anti-tigit antibodies
SG11201701090VA (en) 2014-08-19 2017-03-30 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
EP3197557A1 (en) 2014-09-24 2017-08-02 Friedrich Miescher Institute for Biomedical Research Lats and breast cancer
CN107001476A (en) 2014-10-08 2017-08-01 诺华股份有限公司 Compositions and methods of use for augmented immune response and cancer therapy
WO2016065301A1 (en) 2014-10-23 2016-04-28 Biogen Ma Inc. Anti-gpiib/iiia antibodies and uses thereof
TW201625667A (en) 2014-10-24 2016-07-16 Squibb Bristol Myers Co Fgf-21 by the use of modified polypeptides and the
WO2016070050A1 (en) 2014-10-31 2016-05-06 Biogen Ma Inc. ANTI-GLYCOPROTEIN IIb/IIIa ANTIBODIES
EP3221363A2 (en) 2014-11-21 2017-09-27 Bristol-Myers Squibb Company Antibodies against cd73 and uses thereof
EP3226900A4 (en) 2014-12-05 2018-09-19 Immunext, Inc. Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
US10398774B2 (en) 2014-12-09 2019-09-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies against AXL
UY36449A (en) 2014-12-19 2016-07-29 Novartis Ag Compositions and methods for antibodies directed to BMP6
KR20170099963A (en) 2014-12-19 2017-09-01 레제네상스 비.브이. Antibodies that bind human c6 and uses thereof
WO2016131893A1 (en) 2015-02-18 2016-08-25 Medimmune Limited Incretin fusion polypeptides
WO2016134333A1 (en) 2015-02-19 2016-08-25 Compugen Ltd. Anti-pvrig antibodies and methods of use
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
US20180127510A1 (en) 2015-05-22 2018-05-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies fragments inhibiting both the cath-d catalytic activity and its binding to the lrp1 receptor
US20180237534A1 (en) 2015-05-29 2018-08-23 Bristol-Myers Squibb Company Antibodies against ox40 and uses thereof
PE00412018A1 (en) 2015-06-05 2018-01-09 Novartis Ag Antibodies directed to the bone morphogenetic protein (BMP9) and methods from these
TW201710287A (en) 2015-06-10 2017-03-16 Medimmune Ltd The lipidated peptide protease-resistant
UY36751A (en) 2015-06-26 2017-01-31 Novartis Ag Xi factor antibodies and methods of use
WO2017004016A1 (en) 2015-06-29 2017-01-05 The Rockefeller University Antibodies to cd40 with enhanced agonist activity
JP2018525029A (en) 2015-07-07 2018-09-06 インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) Antibody having specificity for myosin 18A and use thereof
CA2991980A1 (en) 2015-07-13 2017-01-19 Compugen Ltd. Hide1 compositions and methods
CA2994516A1 (en) 2015-08-03 2017-02-09 Novartis Ag Methods of treating fgf21-associated disorders
US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
US10000561B2 (en) 2015-09-09 2018-06-19 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding molecules and methods of using the molecules
WO2017046746A1 (en) 2015-09-15 2017-03-23 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
US20180317602A1 (en) 2015-09-15 2018-11-08 Nike, Inc. Therapeutic Combinations of a CD19 Inhibitor and a BTK Inhibitor
MX2018004041A (en) 2015-10-01 2018-11-09 Amgen Inc Treatment of bile acid disorders.
WO2017066714A1 (en) 2015-10-16 2017-04-20 Compugen Ltd. Anti-vsig1 antibodies and drug conjugates
EP3368566A1 (en) 2015-10-28 2018-09-05 Friedrich Miescher Institute for Biomedical Research Tenascin-w and biliary tract cancers
EA201891048A1 (en) 2015-10-29 2018-10-31 Мерк Шарп И Доум Корп. Antibody, neutralizing respiratory-synctial human virus
KR20180082563A (en) 2015-11-19 2018-07-18 브리스톨-마이어스 스큅 컴퍼니 Antibodies to glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
WO2017095875A1 (en) 2015-11-30 2017-06-08 Bristol-Myers Squibb Company Anti human ip-10 antibodies and their uses
TW201731872A (en) 2015-12-18 2017-09-16 Novartis Ag Target CD32b antibodies and methods of use of
MX2018008592A (en) 2016-01-11 2018-12-10 Novartis Ag Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof.
EP3402503A1 (en) 2016-01-13 2018-11-21 Acerta Pharma B.V. Therapeutic combinations of an antifolate and a btk inhibitor
WO2017144668A1 (en) 2016-02-26 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity for btla and uses thereof
EP3423489A1 (en) 2016-03-04 2019-01-09 The Rockefeller University Antibodies to cd40 with enhanced agonist activity
BR112018067368A2 (en) 2016-03-04 2019-01-15 Squibb Bristol Myers Co anti-cd73 antibody combination therapy
WO2017153575A1 (en) 2016-03-10 2017-09-14 Medimmune Limited Glucagon and glp-1 co-agonists for the treatment of obesity
WO2017162678A1 (en) 2016-03-22 2017-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Humanized anti-claudin-1 antibodies and uses thereof
MX2018012178A (en) 2016-04-04 2019-02-07 Shire Human Genetic Therapies Conjugated c1 esterase inhibitor and uses thereof.
WO2017187319A1 (en) 2016-04-25 2017-11-02 Glaxosmithkline Intellectual Property Development Limited Nope for treatment of pathological muscle loss and weakness
CN109071647A (en) 2016-04-27 2018-12-21 诺华股份有限公司 The antibody and application thereof of anti-growth and differentiation factor 15
AU2017283787A1 (en) 2016-06-15 2019-01-24 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)
SG11201900026TA (en) 2016-07-14 2019-01-30 Squibb Bristol Myers Co Antibodies against tim3 and uses thereof
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
EP3491022A1 (en) 2016-07-29 2019-06-05 Institut National de la Sante et de la Recherche Medicale (INSERM) Antibodies targeting tumor associated macrophages and uses thereof
NL2017270B1 (en) 2016-08-02 2018-02-09 Aduro Biotech Holdings Europe B V New anti-hCTLA-4 antibodies
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
KR20190053949A (en) 2016-09-26 2019-05-20 머크 샤프 앤드 돔 코포레이션 Anti-CD27 antibody
US20180105583A1 (en) 2016-10-13 2018-04-19 Massachusetts Institute Of Technology Antibodies that bind zika virus envelope protein and uses thereof
TW201831690A (en) 2016-10-31 2018-09-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
AU2017362418A1 (en) 2016-11-17 2019-06-06 Iovance Biotherapeutics, Inc. Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
CA3044574A1 (en) 2016-11-23 2018-05-31 Bioverativ Therapeutics Inc. Bispecific antibodies binding to coagulation factor ix and coagulation factor x
EP3548063A1 (en) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
CA3045660A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
CA3048156A1 (en) 2016-12-23 2018-06-28 Novartis Ag Factor xi antibodies and methods of use
WO2018116267A2 (en) 2016-12-23 2018-06-28 Novartis Ag Methods of treatment with anti-factor xi/xia antibodies
WO2018129092A1 (en) 2017-01-04 2018-07-12 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
CA3049105A1 (en) 2017-01-04 2018-07-12 Research Institute Of Nationwide Children's Hospital Dnabii vaccines and antibodies with enhanced activity
CA3049165A1 (en) 2017-01-06 2018-07-12 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
AU2018205234A1 (en) 2017-01-06 2019-07-04 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists
WO2018138267A1 (en) 2017-01-27 2018-08-02 Cinfa Biotech S.L. Method for determining the efficacy of a g-csf containing composition
TW201831521A (en) 2017-01-31 2018-09-01 美商生物化學醫療公司 Factor IX fusion proteins and methods of making and using same
CA3052911A1 (en) 2017-02-08 2018-08-16 Novartis Ag Fgf21 mimetic antibodies and uses thereof
WO2018148419A1 (en) 2017-02-08 2018-08-16 Bristol-Myers Squibb Company Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
SG11201906947SA (en) 2017-02-17 2019-08-27 Squibb Bristol Myers Co Antibodies to alpha-synuclein and uses thereof
WO2018158398A1 (en) 2017-03-02 2018-09-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
AU2018236271A1 (en) 2017-03-15 2019-10-03 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation
CA3054837A1 (en) 2017-03-24 2018-09-27 Novartis Ag Methods for preventing and treating heart disease
TW201843173A (en) 2017-04-07 2018-12-16 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
WO2018190719A2 (en) 2017-04-13 2018-10-18 Aduro Biotech Holdings, Europe B.V. Anti-sirp alpha antibodies
US10294264B2 (en) 2017-04-21 2019-05-21 Warsaw Orthopedic, Inc. Oxysterol-therapeutic agent derivative for bone healing
WO2019103857A1 (en) 2017-11-22 2019-05-31 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
TW201904578A (en) 2017-05-10 2019-02-01 美商艾歐凡斯生物治療公司 Liquid tumors derived from the tumor infiltrating lymphocytes and amplification of the amplified therapeutic use of tumor infiltrating lymphocytes
WO2018213097A1 (en) 2017-05-15 2018-11-22 University Of Rochester Broadly neutralizing anti-influenza monoclonal antibody and uses thereof
WO2018218056A1 (en) 2017-05-25 2018-11-29 Birstol-Myers Squibb Company Antibodies comprising modified heavy constant regions
US20190010246A1 (en) 2017-06-01 2019-01-10 Compugen Ltd. Triple combination antibody therapies
UY37758A (en) 2017-06-12 2019-01-31 Novartis Ag Method for making bispecific antibodies, bispecific antibodies and therapeutic use of such antibodies
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
WO2019030692A1 (en) 2017-08-10 2019-02-14 Friedrich Miescher Institute For Biomedical Research Hdac6 and protein aggregation
WO2019057933A1 (en) 2017-09-21 2019-03-28 Imcheck Therapeutics Sas Antibodies having specificity for btn2 and uses thereof
WO2019075090A1 (en) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag Antibodies targeting cd32b and methods of use thereof
WO2019118873A2 (en) 2017-12-15 2019-06-20 Iovance Biotherapeutics, Inc. Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof
WO2019133747A1 (en) 2017-12-27 2019-07-04 Bristol-Myers Squibb Company Anti-cd40 antibodies and uses thereof
WO2019140229A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Antibodies against tim3 and uses thereof
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
WO2019160829A1 (en) 2018-02-13 2019-08-22 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists
NL2020520B1 (en) 2018-03-02 2019-09-12 Labo Bio Medical Invest B V Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
WO2019183040A1 (en) 2018-03-21 2019-09-26 Five Prime Therapeutics, Inc. ANTIBODIES BINDING TO VISTA AT ACIDIC pH

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1609546A (en) * 1925-11-19 1926-12-07 Petroleum Rectifying Co Process of separating water from emulsions
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
JPS57192435A (en) * 1981-05-20 1982-11-26 Toyobo Co Ltd Modified polypeptide
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3380726D1 (en) * 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
EP0154316B1 (en) * 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
JPH0144200B2 (en) * 1984-07-25 1989-09-26 Chugai Pharmaceutical Co Ltd
JPS6142558A (en) * 1984-08-06 1986-03-01 Matsushita Electric Works Ltd Amino resin molding material
WO1986004605A1 (en) * 1985-02-08 1986-08-14 Chugai Seiyaku Kabushiki Kaisha Human granulocyte colony stimulating factor
US5532341A (en) * 1985-03-28 1996-07-02 Sloan-Kettering Institute For Cancer Research Human pluripotent hematopoietic colony stimulating factor
WO1987000056A1 (en) * 1985-06-26 1987-01-15 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
ES8800982A1 (en) * 1985-07-05 1987-12-01 Takeda Chemical Industries Ltd A method for producing superoxide dismutase enzyme modified with polyethylene glycol derivatives and triazine.
JPH0531598B2 (en) * 1985-08-11 1993-05-12 Handotai Energy Kenkyusho
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPH0331437B2 (en) * 1985-08-23 1991-05-07 Kirin Amgen Inc
JPH0657152B2 (en) * 1985-09-17 1994-08-03 中外製薬株式会社 Csf genes
JPS62129298A (en) * 1985-12-02 1987-06-11 Chugai Pharmaceut Co Ltd Novel polypeptide
JP2514950B2 (en) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー Chemically modified proteins, their production and intermediates
CA1283046C (en) * 1986-05-29 1991-04-16 Nandini Katre Tumor necrosis factor formulation
US4791192A (en) * 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
JPS63126900A (en) * 1986-06-26 1988-05-30 Takeda Chem Ind Ltd Chemically modified protein
JPS6360938A (en) * 1986-09-02 1988-03-17 Meiji Milk Prod Co Ltd Plasminogen activator of modified tissue type and production thereof
US4894226A (en) * 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
US5362853A (en) * 1986-12-23 1994-11-08 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
US5194592A (en) * 1986-12-23 1993-03-16 Kyowa Hakko Kogyo Co. Ltd. Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor
US5214132A (en) * 1986-12-23 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
JPH086063B2 (en) * 1987-07-22 1996-01-24 日本ペイント株式会社 Hydrophilic surface treatment agent and treatment method
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
JPH0796558B2 (en) * 1988-03-31 1995-10-18 協和醗酵工業株式会社 Modified polypeptide
CA1340810C (en) * 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
US5349052A (en) * 1988-10-20 1994-09-20 Royal Free Hospital School Of Medicine Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
AT135370T (en) * 1988-12-22 1996-03-15 Kirin Amgen Inc Chemically modified granulocyte colony-causing factor
US6166183A (en) * 1992-11-30 2000-12-26 Kirin-Amgen, Inc. Chemically-modified G-CSF
EP0460101A4 (en) * 1989-02-24 1992-04-15 Immunotherapeutics, Inc. Immobilized cytokines
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
JP2966686B2 (en) * 1993-04-20 1999-10-25 三洋電機株式会社 A method of manufacturing a semiconductor laser
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications

Also Published As

Publication number Publication date
JP2989002B2 (en) 1999-12-13
US20070219357A1 (en) 2007-09-20
WO1990006952A1 (en) 1990-06-28
DE68925966T2 (en) 1996-08-29
US5824778A (en) 1998-10-20
EP0401384A1 (en) 1990-12-12
EP0401384A4 (en) 1991-09-25
EP0401384B1 (en) 1996-03-13
CA2006596C (en) 2000-09-05
CA2006596A1 (en) 1990-06-22
DE68925966D1 (en) 1996-04-18

Similar Documents

Publication Publication Date Title
DE69031750T2 (en) Osteoprotheseimplantat
DE19675051I2 (en) Aminosaeurederivate
DE69032621T2 (en) Zweiwellenlängenlaserabtastmikroskop
DE69025673D1 (en) Epiduralsauerstoffsensor
DE69131866D1 (en) Spreizspektrumkorrelator
DE69025197T2 (en) Fötalsonde
DE10075018I1 (en) Imidazoalkensaeure
DE69031509D1 (en) Personal organizer
DE69033697T2 (en) Mykonematizide
DE69029542T2 (en) Viterbidekodierer
DE69034258D1 (en) Stamzellfaktor
DE69133296D1 (en) speech
DE69031367D1 (en) Blockübertragungs- and Koprozessorschnittstellenbefehl
NO170326B (en) Dihydroksydifenylcykloalkaner
NO178264C (en) 11-
NO922122D0 (en) Batteriovervaakingssystem
DE68925691D1 (en) telephone
NO179500B (en) Skjöthylster
DE69033803T2 (en) Positionsauswerteschaltung
DE69031490T2 (en) Kantenendbearbeitungssystem
DE69031649D1 (en) Oxoindolderivate
DE69029775T2 (en) Tintenstrahlaufzeichungsgerät
IT1232356B (en) Dialogenobenzol-derivatives
DE68928754D1 (en) Collagen-polymer-conjugates
DE68928345T2 (en) Confokales scan-endoscope

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties