AT134624T - acyl compounds - Google Patents

acyl compounds

Info

Publication number
AT134624T
AT134624T AT91810098T AT91810098T AT134624T AT 134624 T AT134624 T AT 134624T AT 91810098 T AT91810098 T AT 91810098T AT 91810098 T AT91810098 T AT 91810098T AT 134624 T AT134624 T AT 134624T
Authority
AT
Austria
Prior art keywords
acyl compounds
acyl
compounds
Prior art date
Application number
AT91810098T
Other languages
German (de)
Inventor
Peter Dr Buehlmayer
Franz Dr Ostermayer
Tibur Dr Schmidlin
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to CH51890 priority Critical
Priority to CH223490 priority
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of AT134624T publication Critical patent/AT134624T/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25684817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT134624(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
AT91810098T 1990-02-19 1991-02-12 acyl compounds AT134624T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH51890 1990-02-19
CH223490 1990-07-05

Publications (1)

Publication Number Publication Date
AT134624T true AT134624T (en) 1996-03-15

Family

ID=25684817

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91810098T AT134624T (en) 1990-02-19 1991-02-12 acyl compounds

Country Status (25)

Country Link
US (2) US5399578A (en)
EP (1) EP0443983B1 (en)
JP (1) JP2749458B2 (en)
KR (1) KR0171409B1 (en)
AT (1) AT134624T (en)
AU (1) AU644844B2 (en)
CA (2) CA2232775C (en)
CY (1) CY1978A (en)
DE (4) DE122007000050I1 (en)
DK (1) DK0443983T3 (en)
ES (1) ES2084801T3 (en)
FI (2) FI107921B (en)
GR (1) GR3019155T3 (en)
HK (1) HK219996A (en)
HU (2) HU220073B (en)
IE (1) IE71155B1 (en)
IL (1) IL97219A (en)
LU (4) LU90100I2 (en)
LV (1) LV5773B4 (en)
NL (3) NL970001I2 (en)
NO (4) NO2007009I2 (en)
NZ (1) NZ237126A (en)
PH (1) PH30484A (en)
PT (1) PT96799B (en)
SA (1) SA93140130A (en)

Families Citing this family (263)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU657498B2 (en) * 1990-12-14 1995-03-16 Novartis Ag Biphenylyl compounds
ES2101824T3 (en) * 1991-08-15 1997-07-16 Ciba Geigy Ag N-acyl-n-heterocyclyl-alkyl-amino-onaftalenil as angiotensin II antagonists.
US5260325A (en) * 1991-08-19 1993-11-09 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking tertiary amides
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
EP0549352B1 (en) * 1991-12-27 2000-03-01 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds as angiotensin II antagonists
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
ZA9301063B (en) * 1992-02-17 1993-09-23 Ciba Geigy Treatment of glaucoma.
US5378715A (en) * 1992-02-24 1995-01-03 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
US5312820A (en) * 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
US5420123A (en) * 1992-12-21 1995-05-30 Bristol-Myers Squibb Company Dibenzodiazepine endothelin antagonists
US5256658A (en) * 1993-01-15 1993-10-26 Ortho Pharmaceutical Corporation Angiotensin II inhibitors
US5965732A (en) * 1993-08-30 1999-10-12 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
FR2711367B1 (en) * 1993-10-19 1995-12-01 Roussel Uclaf New sulfur derivatives process for preparing imidazole and new intermediates obtained.
MX9603999A (en) * 1994-03-17 1997-12-31 Novartis Ag Tambien Denominada Treatment of diabetic nephropathy with valsartan.
JPH0853424A (en) * 1994-08-11 1996-02-27 Kureha Chem Ind Co Ltd Benzimidazolesulfonic acid amide derivative
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH11513395A (en) * 1995-10-06 1999-11-16 ノバルティス・アクチエンゲゼルシャフト at1- receptor antagonists for the prevention of post-ischemic renal failure and treatment as well as protection of the ischemic kidney
JPH09124620A (en) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co Substituted biphenylsulfonamide endothelin antagonist
WO1997030036A1 (en) * 1996-02-15 1997-08-21 Novartis Ag Aryl derivatives
JP2001523218A (en) 1996-02-20 2001-11-20 ブリストル―マイヤーズ・スクイブ・カンパニー Preparation of biphenyl isoxazole sulfonamides
EP0883401B1 (en) 1996-02-29 2003-01-02 Novartis AG At1 receptor antagonist for the stimulation of apoptosis
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
TW536540B (en) * 1997-01-30 2003-06-11 Squibb Bristol Myers Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
AU6187898A (en) * 1997-01-30 1998-08-25 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US5945441A (en) * 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
JP2002516846A (en) * 1998-06-03 2002-06-11 ジーピーアイ ニル ホールディングス インコーポレイテッド Small molecule sulfonamide onset hair compositions and uses
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
EA200001247A1 (en) 1998-06-03 2001-08-27 Джи Пи Ай Нил Холдингс, Инк. N-bonded sulphonamides of n-heterocyclic carbonic acids or isateres of carbonic acids
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
CZ200172A3 (en) * 1998-07-06 2001-08-15 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual antagonists of angiotensin receptor and endothelin receptor
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US6395728B2 (en) 1999-07-08 2002-05-28 Novartis Ag Method of treatment and pharmaceutical composition
PT1096932E (en) * 1998-07-10 2007-09-21 Novartis Pharma Ag Antihypertensive combination of valsartan and calcium channel blocker
US6204281B1 (en) 1998-07-10 2001-03-20 Novartis Ag Method of treatment and pharmaceutical composition
EP1013273A1 (en) * 1998-12-23 2000-06-28 Novartis AG Use of AT-1 receptor antagonist or AT-2 receptor modulator for treating diseases associated with an increase of AT-1 or AT-2 receptors
SI1588706T1 (en) 1998-12-23 2012-01-31 Novartis Ag Valsartan tablet
US6465502B1 (en) * 1998-12-23 2002-10-15 Novartis Ag Additional therapeutic use
CN101011390A (en) * 1999-01-26 2007-08-08 诺瓦提斯公司 Use of angiotensin II receptor antagonists for treating acute myocardial infarction
PE14562000A1 (en) 1999-02-02 2001-01-28 Smithkline Beecham Corp calcilytic compounds
KR20040088519A (en) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. Active Agent Delivery Systems and Methods for Protecting and Administering Active Agents
HU0201320A2 (en) 1999-03-19 2002-08-28 Bristol Myers Squibb Co Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof
SE9903028D0 (en) 1999-08-27 1999-08-27 Astra Ab New use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
DE60030764T2 (en) * 1999-12-15 2007-09-13 Bristol-Myers Squibb Co. Biphenyl - sulfonamides as dual angiotensin - endothelin - receptor - antagonists
AU1464101A (en) 1999-12-21 2001-07-03 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
PL358290A1 (en) * 2000-06-22 2004-08-09 Novartis Ag Pharmaceutical compositions
US20020132839A1 (en) * 2000-06-22 2002-09-19 Ganter Sabina Maria Tablet formulations comprising valsartan
PL205715B1 (en) * 2000-07-19 2010-05-31 Novartis Ag Valsartan salts
US20060089389A1 (en) * 2000-08-22 2006-04-27 Malcolm Allison Combination
AR033390A1 (en) 2000-08-22 2003-12-17 Novartis Ag A pharmaceutical composition comprising an AT1 receptor antagonist and an enhancer of insulin secretion, the use of said composition for the manufacture of a medicament and a kit of parts
US6639082B2 (en) 2000-10-17 2003-10-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
DE10059418A1 (en) * 2000-11-30 2002-06-20 Aventis Pharma Gmbh Ortho, meta-substituted Bisarylverbindungen, processes for their preparation, their use as a medicine as well as pharmaceutical compositions containing them
AT386716T (en) * 2000-12-26 2008-03-15 Pola Pharma Inc biphenyl
PT1757606E (en) * 2001-02-24 2009-05-26 Boehringer Ingelheim Pharma Xanthinderivatives for use as medical agents and the preparation thereof
AU2002328569B9 (en) * 2001-08-28 2005-10-27 Sankyo Company, Limited Medicinal compositions containing angiotensin II receptor antagonist
US7468390B2 (en) 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
US20040072886A1 (en) * 2002-04-15 2004-04-15 Dr. Reddy's Laboratories Limited Novel crystalline forms of (S)-N- (1-Carboxy-2-methyl-prop-1-yl) -N-pentanoyl-N- [2' -(1H-tetrazol-5-yl)- biphenyl-4-yl methyl] amine (Valsartan)
AU2003223637A1 (en) * 2002-04-15 2003-11-03 Dr. Reddy's Laboratories Limited Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- (2'-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl) amine (valsartan)
EG24716A (en) * 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
BR0313593A (en) 2002-08-19 2005-07-12 Pfizer Prod Inc combination therapy for hyperproliferative diseases
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
GB0222056D0 (en) * 2002-09-23 2002-10-30 Novartis Ag Process for the manufacture of organic compounds
TW200408393A (en) 2002-10-03 2004-06-01 Ono Pharmaceutical Co Antagonist of lysophosphatidine acid receptor
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
EP1556363A2 (en) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Process for the preparation of valsartan and intermediates thereof
AT393764T (en) 2003-03-17 2008-05-15 Teva Pharma Polymorphic forms of valsartan
US20050165075A1 (en) * 2003-03-31 2005-07-28 Hetero Drugs Limited Novel amorphous form of valsartan
US7010633B2 (en) * 2003-04-10 2006-03-07 International Business Machines Corporation Apparatus, system and method for controlling access to facilities based on usage classes
US7378531B2 (en) 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
NZ579310A (en) 2007-03-01 2012-03-30 Probiodrug Ag Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
CZ298685B6 (en) * 2003-05-15 2007-12-19 Zentiva, A.S. Process for preparing N-(1-oxopentyl)-N-[[2?-(1H-tetrazol-5-yl)[1,1?-biphenyl]-4-yl]methyl]-L-valine (valsartan)
EP1658283A2 (en) * 2003-05-30 2006-05-24 Ranbaxy Laboratories, Ltd. Substituted pyrrole derivatives and their use as hmg-co inhibitors
WO2004111018A1 (en) * 2003-06-16 2004-12-23 Hetero Drugs Limited A novel process for preparation of valsartan
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
DE10335027A1 (en) 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of telmisartan and simvastatin for treatment or prophylaxis of cardiovascular, cardiopulmonary and renal diseases e.g. hypertension combined with hyperlipidemia or atherosclerosis
RS20060125A (en) * 2003-08-27 2008-06-05 Zentiva A.S., A method of removing the triphenylmethane protecting group
US20070238740A1 (en) * 2003-08-28 2007-10-11 Nitromed, Inc. Nitrosated And Nitrosylated Cardiovascular Compounds, Compositions And Methods Of Use
JP4537678B2 (en) * 2003-09-04 2010-09-01 住友化学株式会社 2 '- (1H-tetrazol-5-yl) biphenyl-4-carbaldehyde crystal and manufacturing method thereof
EP1673107B1 (en) * 2003-10-10 2008-03-26 Solvay Pharmaceuticals GmbH Pharmaceutical composition comprising a selective i1 imidazoline receptor agonist and an angiotensin ii receptor blocker
CN1882327A (en) 2003-11-19 2006-12-20 症变治疗公司 Novel phosphorus-containing thyromimetics
ITMI20032267A1 (en) * 2003-11-21 2005-05-22 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procdimento for preparzione of valsartan and intermediates
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
HRP20030965A2 (en) * 2003-11-24 2005-08-31 Belupo - Lijekovi I Kozmetika D.D. Process for production of (s)-n-pentanoyl-n-[[2'-(
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
US7501426B2 (en) * 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
JP2007529459A (en) 2004-03-17 2007-10-25 ノバルティス アクチエンゲゼルシャフト The use of put to treat renin inhibitors
ES2251292B1 (en) * 2004-04-20 2007-07-01 Inke, S.A. Method for obtaining a pharmaceutically active compound and its synthesis intermediates.
EP2172222A3 (en) * 2004-04-26 2010-06-23 Ono Pharmaceutical Co., Ltd. Novel BLT2-mediated disease, BLT2-binding agent and compound
CZ298471B6 (en) * 2004-05-19 2007-10-10 Zentiva, A.S. N-[(2?-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester salts and their use for preparing valsartan
TW200606157A (en) * 2004-07-02 2006-02-16 Sankyo Co Suppressant of production of tissue factor
KR20070101843A (en) 2004-10-08 2007-10-17 노파르티스 아게 Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
TW200619191A (en) 2004-10-27 2006-06-16 Sankyo Co Phenyl compounds with more than 2 substitutes
DE102004054054A1 (en) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg A process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines
US20090124577A1 (en) 2004-12-22 2009-05-14 Enantia Si Intermediate Compounds for the Preparation of an Angiotensin II Receptor Antagonist
DK2033629T3 (en) * 2004-12-24 2013-02-04 Krka Solid pharmaceutical composition comprising valsartan
US7659406B2 (en) * 2005-01-03 2010-02-09 Dr. Reddy's Laboratories Limited Process for preparing valsartan
JP2007527924A (en) * 2005-01-11 2007-10-04 テバ ファーマシューティカル インダストリーズ リミティド Method of manufacturing an amorphous valsartan
EP1714963A1 (en) * 2005-04-19 2006-10-25 IPCA Laboratories Limited Process for the Preparation of Valsartan and its Intermediates
EP1896433A4 (en) * 2005-05-25 2010-06-02 Ipca Lab Ltd Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)bi-phenyl-4-ylmethyl]-amine
US20070117987A1 (en) * 2005-07-05 2007-05-24 Viviana Braude Process for preparing valsartan
DE102005035891A1 (en) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as medicaments
AT502219B1 (en) * 2005-08-04 2007-04-15 Sanochemia Pharmazeutika Ag tetrazoles process for the preparation of pure 5-substituted
WO2007019448A2 (en) * 2005-08-08 2007-02-15 Nitromed, Inc. Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use
ES2333169T3 (en) * 2005-08-22 2010-02-17 Alembic Limited Process for the preparation of valsartan.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007057919A2 (en) * 2005-10-25 2007-05-24 Alembic Limited An improved process for preparation of (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine
WO2007052307A2 (en) * 2005-10-31 2007-05-10 Lupin Limited Stable solid oral dosage forms of valsartan
US8026377B2 (en) * 2005-11-08 2011-09-27 Ranbaxy Laboratories, Limited Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
AR057882A1 (en) 2005-11-09 2007-12-26 Novartis Ag Compounds double action of angiotensin receptor blockers and neutral endopeptidase inhibitors
RU2459809C2 (en) * 2005-11-09 2012-08-27 Новартис Аг Pharmaceutical combinations of angiotensine receptor antagonist and nep inhibitor
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US20070141533A1 (en) * 2005-12-20 2007-06-21 Ford Christopher W Polymeric dental implant assembly
US20070166372A1 (en) * 2006-01-19 2007-07-19 Mai De Ltd. Preparation of solid coprecipitates of amorphous valsartan
WO2007088558A2 (en) * 2006-02-02 2007-08-09 Alembic Limited A process for purification of valsartan
AR059838A1 (en) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulations for stabilizing statin dose
PE02512008A1 (en) * 2006-05-04 2008-04-25 Boehringer Ingelheim Int Uses DPP IV inhibitors
EP1852108A1 (en) * 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN109503584A (en) 2006-05-04 2019-03-22 勃林格殷格翰国际有限公司 Polymorphic
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2021338A1 (en) 2006-05-09 2009-02-11 Pfizer Products Inc. Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
CZ300801B6 (en) * 2006-06-07 2009-08-12 Helvetia Pharma A.S. Valsartan-containing composition in solid drug forms
WO2008035364A2 (en) * 2006-06-23 2008-03-27 Usv Limited Process for the preparation of micronized valsartan
US20080004313A1 (en) * 2006-06-28 2008-01-03 Mai De Ltd. Preparation of crystalline polymorphs of rimonabant hydrochloride
US7880015B2 (en) * 2006-07-03 2011-02-01 Aurobindo Pharma Ltd. Process for the preparation of angiotensin II antagonist
AR063469A1 (en) * 2006-07-14 2009-01-28 Ranbaxy Lab Ltd polymorphic forms of (3R, 5R) -7- [2- (4-fluorophenyl) -5-isopropyl-3-phenyl-4 - [(4-hydroxymethyl-phenylamino) carbonyl] pyrrole-1-yl] -3, 5 dihydroxy-heptanoic acid, hemicalcium salt, methods of preparation thereof, a pharmaceutical composition comprising them and their use in the treatment of diseases
NZ574905A (en) 2006-08-22 2011-12-22 Ranbaxy Lab Ltd Matrix metalloproteinase inhibitors
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
ES2382009T3 (en) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company N - ((3-Benzyl) -2,2- (bis-phenyl -) - propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2008071400A1 (en) * 2006-12-14 2008-06-19 Ratiopharm Gmbh Process for the preparation of valsartan and intermediate products
SG185318A1 (en) 2007-01-12 2012-11-29 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
CA2681708A1 (en) * 2007-03-29 2008-10-09 Alembic Limited Valsartan tablet formulations
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
TWI448284B (en) 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
AU2008247136B2 (en) * 2007-05-07 2012-12-13 Cipla Limited Process for preparing valsartan
US20080299218A1 (en) * 2007-06-01 2008-12-04 Protia, Llc Deuterium-enriched valsartan
CA2688161A1 (en) 2007-06-04 2008-12-11 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
TWI406850B (en) 2007-06-05 2013-09-01 Theravance Inc Dual-acting benzoimidazole antihypertensive agents
EP1849777B1 (en) * 2007-06-07 2008-10-29 Inke, S.A. Process for obtaining a valsartan salt useful for obtaining valsartan
US8258312B2 (en) 2007-06-27 2012-09-04 Mylan Laboratories Ltd Process for preparing pure valsartan
GB0715628D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Solid valsartan composition
CA2735562C (en) * 2008-08-15 2017-10-17 Boehringer Ingelheim International Gmbh Dpp-4 inhibitors for wound healing
MX2010001821A (en) * 2007-08-17 2010-03-10 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases.
JP2010538071A (en) 2007-09-07 2010-12-09 セラヴァンス, インコーポレーテッド Double-acting antihypertensive agents
CN104119336B (en) * 2007-10-05 2016-08-24 维拉斯通股份有限公司 Pyrimidine-disubstituted purine derivatives
AU2008311053B2 (en) 2007-10-09 2012-08-30 Novartis Ag Pharmaceutical formulation of valsartan
CN101854913A (en) 2007-11-12 2010-10-06 诺瓦提斯公司 Pharmaceutical compositions
JP2011506459A (en) 2007-12-11 2011-03-03 セラヴァンス, インコーポレーテッド Double-acting benzimidazole derivatives and their use as antihypertensive agents
WO2009084003A1 (en) * 2007-12-31 2009-07-09 Lupin Limited Pharmaceutical compositions of amlodipine and valsartan
EP2090567A3 (en) 2008-02-13 2011-06-01 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
US20090226515A1 (en) * 2008-03-04 2009-09-10 Pharma Pass Ii Llc Statin compositions
US20090226516A1 (en) * 2008-03-04 2009-09-10 Pharma Pass Ii Llc Sartan compositions
PE17302009A1 (en) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulations comprising a DPP4 inhibitor
WO2009125416A2 (en) 2008-04-07 2009-10-15 Hetero Research Foundation Process for preparation of valsartan intermediate
EP2297113A1 (en) 2008-04-29 2011-03-23 Theravance, Inc. Dual-acting antihypertensive agents
KR100995734B1 (en) 2008-05-28 2010-11-19 일동제약주식회사 An improved process for the preparation of valsartan
PE01562010A1 (en) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Treatment of NAFLD
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010011821A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
KR20190016601A (en) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 Treatment for diabetes in patients inappropriate for metformin therapy
UY32030A (en) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "Treatment for diabetes in patients unsuitable for therapy with metformin"
CN101362728B (en) 2008-08-22 2011-07-20 北京赛科药业有限责任公司 Valsartan synthesis method
AU2009290911A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
MX2011003780A (en) * 2008-10-10 2011-05-03 Janssen Pharmaceutica Nv Combination therapy comprising angiotensin receptor blockers and vasopressin receptor antagonists.
EP2194048A1 (en) 2008-12-02 2010-06-09 Dirk Sartor Nitrate esters for the treatment of vascular and metabolic diseases
KR101012135B1 (en) 2008-12-18 2011-02-07 주식회사 대희화학 Process for preparing Valsartan methyl ester
WO2010075347A2 (en) 2008-12-23 2010-07-01 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin ii receptor blocker and chlorthalidone
JP2012512848A (en) 2008-12-23 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Salt forms of organic compounds
CN101768128B (en) 2009-01-05 2012-10-10 浙江华海药业股份有限公司 Method for refining Valsartan containing more than 10% of isomer
AR074990A1 (en) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Treatment of diabetes in patients with inadequate glycemic control despite metformin therapy
CN101475540B (en) 2009-01-22 2011-05-11 江苏德峰药业有限公司 Preparation of Valsartan
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
US7956054B2 (en) 2009-07-07 2011-06-07 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
US8372984B2 (en) 2009-07-22 2013-02-12 Theravance, Inc. Dual-acting oxazole antihypertensive agents
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
EP2316821A1 (en) * 2009-10-27 2011-05-04 Novartis AG Process for the manufacture of organic compounds
JP2013512229A (en) 2009-11-27 2013-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Treatment of diabetic patients whose genotype has been identified with DDP-IV inhibitors such as linagliptin
JP2013517295A (en) 2010-01-19 2013-05-16 セラヴァンス, インコーポレーテッド Dual acting thiophene, pyrrole, thiazole and furan antihypertensive drugs
KR101152144B1 (en) * 2010-02-01 2012-06-15 경동제약 주식회사 Process for the preparation of valsartan and novel intermediates used in the process
WO2011102702A2 (en) 2010-02-16 2011-08-25 Krka, D. D., Novo Mesto Process for the preparation of oral solid dosage forms comprising valsartan
EP2542549B1 (en) 2010-03-03 2016-05-11 Probiodrug AG Inhibitors of glutaminyl cyclase
AU2011226074B2 (en) 2010-03-10 2015-01-22 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
CN102822151B (en) * 2010-04-07 2015-03-18 新梅斯托克公司 Improved process for preparing valsartan
TW201138768A (en) 2010-04-19 2011-11-16 Cardiolynx Ag Valsartan derivatives carrying NO donors for the treatment of vascular and metabolic diseases
JP5945532B2 (en) 2010-04-21 2016-07-05 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
NZ602921A (en) 2010-05-05 2016-01-29 Boehringer Ingelheim Int Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor
AU2011268940B2 (en) 2010-06-24 2015-05-21 Boehringer Ingelheim International Gmbh Diabetes therapy
US8981109B2 (en) 2010-07-02 2015-03-17 Aurobindo Pharma Ltd Process for the preparation of valsartan
TR201005419A2 (en) 2010-07-05 2012-01-23 Bilgiç Mahmut pharmaceutical composition comprising valsartan.
AU2011287616A1 (en) 2010-08-03 2013-02-28 Novartis Ag Highly crystalline valsartan
MX2013002150A (en) 2010-08-23 2013-04-03 Novartis Ag Process for the preparation of intermediates for the manufacture of nep inhibitors.
US20130158088A1 (en) 2010-08-24 2013-06-20 Novartis Ag Treatment of hypertension and/or prevention or treatment of heart failure in a mammal receiving anti-coagulant therapy
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
AR083878A1 (en) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Vasoprotectives and cardioprotective anti-diabetic therapy, linagliptin, treatment method
JP5959066B2 (en) * 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー Substituted aminobutyric acid derivatives as neprilysin inhibitors
JP6050264B2 (en) 2011-03-16 2016-12-21 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
FR2977253B1 (en) 2011-06-30 2013-08-09 Centre Nat Rech Scient Alcoxylic organostannic reagent supported, prepared and used for the synthesis of heterogeneous phase tetrazoles
ES2713566T3 (en) 2011-07-15 2019-05-22 Boehringer Ingelheim Int Derivative of substituted dinamic quinazoline, its preparation and its use in pharmaceutical compositions for the treatment of type I and II diabetes
WO2013022243A2 (en) * 2011-08-05 2013-02-14 동국대학교 산학협력단 Novel biphenyl derivative or a pharmaceutically acceptable salt thereof, and pharmaceutical composition for preventing or treating inflammatory diseases or autoimmune diseases comprising same as an active ingredient
RU2570752C2 (en) 2011-08-26 2015-12-10 Вокхардт Лимитед Method of treating cardiovascular diseases
WO2013090196A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Combinations of azilsartan and chlorthalidone for treating hypertension black patients
KR20140108652A (en) 2011-12-26 2014-09-12 노파르티스 아게 Tablets and dry-coated agents
WO2013098578A1 (en) 2011-12-31 2013-07-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Immediate release pharmaceutical composition of valsartan hydrochlorothiazide
WO2013098576A1 (en) 2011-12-31 2013-07-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Immediate release pharmaceutical composition of valsartan
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP2015523546A (en) 2012-05-01 2015-08-13 トランスレイタム メディカス インコーポレイテッド Methods for treating and diagnosing blindness diseases
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
RU2018126749A (en) 2012-08-24 2019-03-12 Новартис Аг Nep inhibitors for the treatment of diseases characterized by increasing or simulating atrial
WO2014118721A1 (en) 2013-01-30 2014-08-07 Ranbaxy Laboratories Limited Pharmaceutical oral solid dosage forms comprising valsartan and nebivolol
AU2014230304B2 (en) 2013-03-12 2018-07-05 Lg Chem, Ltd. Complex preparation including valsartan and rosuvastatin calcium and manufacturing method therefor
JP2016514670A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists in combination with other drugs
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
KR101695582B1 (en) 2013-04-17 2017-01-13 화이자 인코포레이티드 N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
JP2016530282A (en) 2013-08-26 2016-09-29 ノバルティス アーゲー New use
JP6097888B2 (en) 2013-08-26 2017-03-15 ノバルティス アーゲー New use
WO2015056219A1 (en) 2013-10-18 2015-04-23 Ranbaxy Laboratories Limited Process for simultaneous drying and micronization of valsartan
JP2017507956A (en) 2014-02-28 2017-03-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Medical use of DPP-4 inhibitors
CN103923028B (en) * 2014-05-04 2017-05-24 青岛雪洁助剂有限公司 A method for the preparation of valsartan methyl ester
CN104072386A (en) * 2014-06-28 2014-10-01 浙江华海药业股份有限公司 Improvement method of valsartan intermediate
WO2016037552A1 (en) * 2014-09-09 2016-03-17 上海翰森生物医药科技有限公司 Crystalline arb-nepi compound and preparation method therefor and application thereof
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
JP6382736B2 (en) * 2015-02-02 2018-08-29 株式会社トクヤマ Method for producing valsartan
JP6576469B2 (en) 2015-05-11 2019-09-18 ノバルティス アーゲー Sacvitril-valsartan dose regimen for the treatment of heart failure
EP3302460A1 (en) 2015-05-29 2018-04-11 Novartis AG Sacubitril and valsartan for treating metabolic disease
KR20180011783A (en) 2015-06-12 2018-02-02 테바 파마슈티컬스 인터내셔널 게엠베하 Trisodium valsartan: solid form of sacbitol
WO2017006254A1 (en) 2015-07-08 2017-01-12 Novartis Ag Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist
WO2017013010A1 (en) 2015-07-23 2017-01-26 Bayer Pharma Aktiengesellschaft Stimulators and/or activators of soluble guanylate cyclase (sgc) in combination with an inhibitor of neutral endopeptidase (nep inhibitor) and/or an angiotensin aii antagonist and the use thereof
US20190022063A1 (en) 2015-08-28 2019-01-24 Novartis Ag New use
JP2019504096A (en) 2016-02-03 2019-02-14 ノバルティス アーゲー New use of combination of sacbitril and valsartan
BR112018072401A2 (en) 2016-06-10 2019-02-19 Boehringer Ingelheim Int linagliptin and metformin combination
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
CN109641856A (en) * 2016-09-02 2019-04-16 诺瑞特国际药业股份有限公司 The crystal form of Valsartan disodium salt
CN107056720A (en) * 2016-12-30 2017-08-18 湖南千金湘江药业股份有限公司 Preparation and purification method of valsartan
EP3342400A1 (en) 2016-12-31 2018-07-04 Abdi Ibrahim Ilac Sanayi ve Ticaret A.S. A pharmaceutical composition comprising valsartan and chlorthalidone
WO2018153895A1 (en) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selective partial adenosine a1 receptor agonists in combination with a neutral endopeptidase inhibitor and/or an angiotensin ii receptor antagonist
WO2019008077A1 (en) 2017-07-07 2019-01-10 Boehringer Ingelheim Vetmedica Gmbh Angiotensin ii receptor antagonist for the prevention or treatment of systemic diseases in cats
EP3461819A1 (en) 2017-09-29 2019-04-03 Probiodrug AG Inhibitors of glutaminyl cyclase
EP3498698A1 (en) 2017-12-15 2019-06-19 Mankind Pharma Ltd Solid forms of valsartan disodium and process of preparation thereof

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973975A (en) * 1962-05-23 1964-11-04 Painton & Co Ltd Improvements in or relating to electric switches
SE307365B (en) * 1966-05-28 1969-01-07 Yoshitomi Pharmaceutical
GB2044754B (en) * 1978-11-14 1983-05-05 Eisai Co Ltd Imidazoles
JPS6364428B2 (en) * 1979-11-12 1988-12-12
US4333943A (en) * 1980-04-24 1982-06-08 Miles Laboratories, Inc. Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
JPH034074B2 (en) * 1983-01-13 1991-01-22 Tanabe Seiyaku Co
EP0142754A2 (en) * 1983-11-04 1985-05-29 Ferrer Internacional, S.A. 2-Substituted-benzoic acid imidazoles, process for preparing them and pharmaceutical compositions containing them
US4551279A (en) * 1984-01-09 1985-11-05 G. D. Searle & Co. Protease inhibitors
US4578386A (en) * 1984-02-10 1986-03-25 Usv Pharmaceutical Corp. 7,8-Dihydroimidazo[1,5-a]pyrazin-8-ones
US4755518A (en) * 1985-12-20 1988-07-05 Warner-Lambert Company Imidazolyl or tetrazolyl substituted benzoic acid derivatives and pharmaceutical compositions thereof
US4748245A (en) * 1986-03-20 1988-05-31 Stauffer Chemical Company Process for making phenylthiopyrimidines
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
ZA8705052B (en) * 1986-07-11 1989-03-29 Du Pont Angiotensin ii receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4874867A (en) * 1987-05-22 1989-10-17 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4921632A (en) * 1987-08-26 1990-05-01 Nec Corporation Liquid crystal compounds and compositions
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US5189048A (en) * 1988-01-07 1993-02-23 E. I. Du Pont De Nemours And Company Substituted 1,2,3 triazole angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
DE3928177A1 (en) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, medicaments containing these compounds and method for the production thereof
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
DE69033469T2 (en) * 1989-06-14 2000-09-07 Smithkline Beecham Corp Imidazoalkensäure
EP0403158A3 (en) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
AU645022B2 (en) * 1989-06-30 1994-01-06 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
CA2060656A1 (en) * 1989-06-30 1990-12-31 Robert John Ardecky Substituted imidazoles
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
EP0409332A3 (en) * 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists
EP0412594B1 (en) * 1989-07-28 1996-01-03 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
EP0411507B1 (en) * 1989-08-02 1994-10-26 Takeda Chemical Industries, Ltd. Pyrazole derivatives, their production and use
PL286445A1 (en) * 1989-08-11 1991-04-22 Ici Plc Method of obtaining novel quinoline derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
US5298518A (en) * 1989-09-29 1994-03-29 Eisai Co., Ltd. Biphenylmethane derivative and pharmacological use
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
AU640417B2 (en) * 1989-10-25 1993-08-26 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles
IL96019D0 (en) * 1989-10-31 1991-07-18 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CA2028925A1 (en) * 1989-11-06 1991-05-07 Gerald R. Girard Substituted n-(imidazolyl)alkyl alanine derivatives
PT95899A (en) * 1989-11-17 1991-09-13 Glaxo Group Ltd Process for the preparation of indole derivatives
IE903911A1 (en) * 1989-11-20 1991-05-22 Ici Plc Diazine derivatives
EP0430709A3 (en) * 1989-12-01 1992-02-12 Glaxo Group Limited Benzthiophen derivatives
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
EP0430300A3 (en) * 1989-12-01 1992-03-25 Takeda Chemical Industries, Ltd. Xanthine derivatives, their production and use
US5104891A (en) * 1989-12-11 1992-04-14 G. D. Searle & Co. Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
IE910913A1 (en) * 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
JPH05505609A (en) * 1990-03-30 1993-08-19
US5260325A (en) * 1991-08-19 1993-11-09 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking tertiary amides

Also Published As

Publication number Publication date
DE122010000024I1 (en) 2010-07-08
SA93140130A (en) 2005-12-03
KR910021387A (en) 1991-12-20
LU91676I2 (en) 2010-06-07
LU90362I2 (en) 1999-05-10
HU9100537D0 (en) 1991-09-30
IE71155B1 (en) 1997-01-29
FI107921B (en) 2001-10-31
GR3019155T3 (en) 1996-05-31
LV5773A4 (en) 1996-12-20
HK219996A (en) 1997-01-03
LV5773B4 (en) 1997-04-20
PH30484A (en) 1997-05-28
SA459B1 (en) 2005-10-16
NO2007009I1 (en) 2007-07-23
IE910548A1 (en) 1991-08-28
NO2010008I1 (en) 2010-05-03
FI910747A (en) 1991-08-20
EP0443983B1 (en) 1996-02-28
FI107921B1 (en)
DK0443983T3 (en) 1996-03-18
CA2232775A1 (en) 1991-08-20
IL97219D0 (en) 1992-05-25
NO2007009I2 (en) 2010-09-13
NL300285I1 (en) 2007-10-01
NL980036I2 (en) 2001-02-01
JP2749458B2 (en) 1998-05-13
FI910747A0 (en) 1991-02-15
NZ237126A (en) 1994-11-25
AU644844B2 (en) 1993-12-23
CY1978A (en) 1997-09-05
FI980787A0 (en) 1998-04-06
HU219343B (en) 2001-03-28
NL970001I1 (en) 1997-03-03
NL970001I2 (en) 1997-06-02
CA2232775C (en) 2003-06-10
PT96799B (en) 1998-09-30
DE122007000050I1 (en) 2007-11-08
LU90100A9 (en)
LU90100I2 (en) 1997-09-25
HU220073B (en) 2001-10-28
US5965592A (en) 1999-10-12
DE59107440D1 (en) 1996-04-04
EP0443983A1 (en) 1991-08-28
HUT61271A (en) 1992-12-28
LU91347A9 (en)
PT96799A (en) 1991-10-31
US5399578A (en) 1995-03-21
IL97219A (en) 1995-12-08
HU9802895D0 (en) 1999-02-01
JPH04235149A (en) 1992-08-24
DE19675036I2 (en) 2004-10-21
AU7115191A (en) 1991-08-22
FI910747D0 (en)
NL980036I1 (en) 1999-02-01
FI980787A (en) 1998-04-06
FI980787D0 (en)
NO910630L (en) 1991-08-20
NO304023B1 (en) 1998-10-12
ES2084801T3 (en) 1996-05-16
CA2036427A1 (en) 1991-08-20
LU91347I2 (en) 2009-01-14
LU90362A9 (en)
CA2036427C (en) 1998-12-29
KR0171409B1 (en) 1999-02-01
NO910630D0 (en) 1991-02-18
LU91676A9 (en)
NO1999001I2 (en) 2007-04-23

Similar Documents

Publication Publication Date Title
NO305379B1 (en) OvervÕkningssystem
DE69122092D1 (en) contrast agents
NL970001I2 (en) Acyl compounds.
DE69118889T2 (en) R (+) - terazosin
NO173261B (en) Intravenoeskanyle
DE69119378D1 (en) Fasciaclip
DE69125378D1 (en) Suboberflächebeschriftung
DE69130944T2 (en) Endocurietherapie
DE69128529T2 (en) Haarfrisurshampo0
DE69127193T2 (en) Chrominanzverarbeitungssystem
DE69133426D1 (en) Fliessbettchromatographieverfahren
DE69123806D1 (en) Spreizbandkommunikationssystem
DE69123357D1 (en) Einmalinhalator
DE69123124D1 (en) Dihydro-Isoquinolinderivate
DE69029586D1 (en) Photolackentferner
DE69119046D1 (en) Plug-breaker
DE69120420D1 (en) Much-surface bausystem
DE69221327T2 (en) Schmierhölherstellungsverfahren
DE69122296D1 (en) Raumfeldleistungsaddierer
DE69127474T2 (en) Matrizenwechseleinrichtung
NO179545B (en) Konstruksjonsleketöysystem
DE69131839T2 (en) Duplexadsorptionsprozess
DE59108400D1 (en) Sicherheitsschliessvorrichtung
DE69312901T2 (en) Naphtensäurekorrosionsschutzmittel
DE69127196T2 (en) Antioxidanttest

Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
ESZA Application filed for a certificate of protection (e-series)

Free format text: SZ 23/1997, 19970620

EEZF Grant for a certificate of protection (e-series)

Free format text: SZ 23/1997, 19970620, EXPIRES:20110513

ESZA Application filed for a certificate of protection (e-series)

Free format text: SZ 16/2010, 20100415

Spc suppl protection certif: SZ 16/2010

Filing date: 20100415

ESZP Application for prolongation of spc

Free format text: PRODUCT NAME: ALSARTAN ODER EIN PHARMAZEUTISCH VERWENDBARES SALZ ODER EIN ESTER DAVON; NAT REGISTRATION NO/DATE: 1-21751, 1-21752 19961220; FIST REG.: DE 36983.00.00, 36983.01.00 19960513

Spc suppl protection certif: SZ 23/97

Filing date: 19970620

SZV Spc prolonged

Free format text: PRODUCT NAME: VALSARTAN ODER EIN PHARMAZEUTISCH VERWENDBARES SALZ ODER EIN ESTER DAVON; NAT. REG.NO/DATE: 1-21751, 1-21752 19961220; FIRST REG: DE 36983.00.00 36983.01.00 19960513

Spc suppl protection certif: SZ 23/97

Filing date: 19970620

Expiry date: 20110213

Extension date: 20111113

Effective date: 20101210

EELA Cancelled due to lapse of time