AT124405T - 1,4,7,10-tetraazacyclododecane-butyltriole, processes for their preparation and pharmaceutical compositions containing them. - Google Patents

1,4,7,10-tetraazacyclododecane-butyltriole, processes for their preparation and pharmaceutical compositions containing them.

Info

Publication number
AT124405T
AT124405T AT91250081T AT91250081T AT124405T AT 124405 T AT124405 T AT 124405T AT 91250081 T AT91250081 T AT 91250081T AT 91250081 T AT91250081 T AT 91250081T AT 124405 T AT124405 T AT 124405T
Authority
AT
Austria
Prior art keywords
butyltriole
tetraazacyclododecane
processes
preparation
pharmaceutical compositions
Prior art date
Application number
AT91250081T
Other languages
German (de)
Inventor
Johannes Dr Platzek
Heinz Dr Gries
Hanns-Joachim Dr Weinmann
Gabriele D Schuhmann-Giampieri
Wolf-Ruediger Press
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19904009119 priority Critical patent/DE4009119A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of AT124405T publication Critical patent/AT124405T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/101Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/836Chelate
AT91250081T 1990-03-19 1991-03-18 1,4,7,10-tetraazacyclododecane-butyltriole, processes for their preparation and pharmaceutical compositions containing them. AT124405T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19904009119 DE4009119A1 (en) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecane-butyltriole, processes for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AT124405T true AT124405T (en) 1995-07-15

Family

ID=6402765

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91250081T AT124405T (en) 1990-03-19 1991-03-18 1,4,7,10-tetraazacyclododecane-butyltriole, processes for their preparation and pharmaceutical compositions containing them.

Country Status (17)

Country Link
US (4) US5980864A (en)
EP (1) EP0448191B1 (en)
JP (1) JP2968367B2 (en)
AT (1) AT124405T (en)
AU (1) AU647091B2 (en)
CA (1) CA2038493C (en)
DE (3) DE4009119A1 (en)
DK (1) DK0448191T3 (en)
ES (1) ES2074219T3 (en)
FI (1) FI109695B (en)
HK (1) HK1002811A1 (en)
HU (1) HU215964B (en)
IE (1) IE67643B1 (en)
IL (1) IL97592A (en)
NO (1) NO179610C (en)
NZ (1) NZ237461A (en)
PT (1) PT97065B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
DE4035760A1 (en) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, processes for their preparation and pharmaceutical compositions containing them
DE4140779A1 (en) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De A process for preparing mono-N-substituted tetraazamacrocycles
DE4218744C2 (en) * 1992-06-04 1997-11-06 Schering Ag A process for the preparation of N-ß-Hxdroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives and their metal complexes
DE4237943C2 (en) * 1992-11-06 1997-10-23 Schering Ag A process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives
DE4317588C2 (en) * 1993-05-24 1998-04-16 Schering Ag Fluorine-containing macrocyclic metal complexes, to processes for their preparation, and their use
DE4318369C1 (en) * 1993-05-28 1995-02-09 Schering Ag Use of macrocyclic metal complexes as temperature probes
DE19646762B4 (en) * 1996-11-04 2004-05-13 Schering Ag Use of metal compounds for the preparation of agents for radiotherapy of tumors
DE19652387A1 (en) * 1996-12-04 1998-06-10 Schering Ag Macrocyclic metal complex carboxylic acids, their use and processes for their preparation
MA24594A1 (en) 1997-03-07 1999-04-01 Procter & Gamble Bleaching compositions
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
ZA9801883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
US20050192195A1 (en) * 2002-08-27 2005-09-01 Busch Daryle H. Catalysts and methods for catalytic oxidation
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
DE19724186C2 (en) * 1997-06-02 2002-07-18 Schering Ag A process for mono- and 1,7-bis-N-ß-hydroxyalkylation of cycles and the corresponding N-.beta.-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li-salt complexes
IT1297035B1 (en) 1997-12-30 1999-08-03 Bracco Spa Derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid
DE19816370B4 (en) * 1998-04-03 2004-09-09 Schering Ag Substituted D02A manganese complexes containing them and their use in diagnostic agents
EP1088559A3 (en) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenic formulations
DE10064467C2 (en) * 2000-12-15 2002-10-31 Schering Ag Lithium complexes of N- (1-hydroxymethyl-2,3-dihydroxypropyl) -1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their production and use
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
AU2003249999A1 (en) * 2002-07-10 2004-02-02 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecanes as modulators of the guanine-binding protein for treating tumours
WO2004112840A2 (en) * 2003-06-25 2004-12-29 Guerbet Peptide conjugate for magnetic resonance imaging
FR2867473B1 (en) 2004-03-12 2006-06-23 Guerbet Sa Consists of porphyrins and use a high field MRI
JP5106107B2 (en) * 2004-07-02 2012-12-26 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. Magnetic resonance imaging comprising a chelating moiety having a polyhydroxylated substituent (mri) for high relaxivity contrast agent
US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
DE102009053171B4 (en) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 A process for the preparation of the calcium complex of dihydroxy-hydroxy-methylpropyl-tetraazacyclododecane-triacetic acid (Calcobutrol)
WO2011054480A1 (en) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrol production by means of a ceramic membrane
EP2327395A1 (en) * 2009-11-23 2011-06-01 Bracco Imaging S.p.A Process for the preparation of gadobenate dimeglumine complex in a solid form
DE102009057274B4 (en) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung means Trioxobicyclo-octane
DE102010013833A1 (en) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Producing gadolinium complex of N-(hydroxymethyl-dihydroxypropyl)-triscarboxymethyl-tetraazacyclododecane useful as magnetic resonance imaging contrast agent, comprises e.g. reacting cyclic compound with dimethylformamide dimethylacetal
DE102010023105A1 (en) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung one-pot process using DMF-acetal and N-methylimidazole
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
SG194511A1 (en) 2011-04-21 2013-12-30 Bayer Ip Gmbh Preparation of high-purity gadobutrol
WO2018108780A1 (en) 2016-12-12 2018-06-21 Bracco Imaging Spa Dimeric contrast agents
EP3442949A1 (en) 2016-04-13 2019-02-20 Bracco Imaging S.p.A Contrast agents
WO2018059914A1 (en) 2016-09-27 2018-04-05 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
US4284620A (en) * 1979-03-23 1981-08-18 Mallinckrodt, Inc. N-(2-Hydroxyethyl)-2,4,6-triiodo-3,5-bis-(2-keto-L-gulonamido)benzamide and radiological compositions containing same
NO161560C (en) * 1980-04-17 1989-09-06 Univ California Symmetrical trijodisoftaldiamid derivatives and roentgenkontrastmidler containing them.
DE3150916C2 (en) * 1981-12-18 1990-11-22 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
MX174467B (en) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboxymethyl-1,4,7,10-decane substituted tetraazaciclodo 1 and analogous compounds
DE3625417C2 (en) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
IT1224416B (en) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Macrocyclic chelators and their chelates
US5312617A (en) * 1991-05-23 1994-05-17 Unger Evan C Liposoluble compounds useful as magnetic resonance imaging agents
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Also Published As

Publication number Publication date
NO911063D0 (en) 1991-03-18
US5980864A (en) 1999-11-09
CA2038493C (en) 2002-07-02
HU215964B (en) 1999-03-29
IE67643B1 (en) 1996-04-17
EP0448191B1 (en) 1995-06-28
IE910902A1 (en) 1991-09-25
HK1002811A1 (en) 1998-09-18
DE10075007I2 (en) 2003-06-12
FI109695B1 (en)
US6399043B1 (en) 2002-06-04
DE4009119A1 (en) 1991-09-26
PT97065B (en) 1998-07-31
HUT60478A (en) 1992-09-28
DE59105815D1 (en) 1995-08-03
EP0448191A1 (en) 1991-09-25
HU910874D0 (en) 1991-09-30
US6951639B2 (en) 2005-10-04
JPH05320146A (en) 1993-12-03
US20060078503A1 (en) 2006-04-13
AU647091B2 (en) 1994-03-17
DK0448191T3 (en) 1995-11-20
NO911063A (en) 1991-09-20
CA2038493A1 (en) 1991-09-20
NO179610B (en) 1996-08-05
FI109695B (en) 2002-09-30
JP2968367B2 (en) 1999-10-25
PT97065A (en) 1991-10-31
ES2074219T3 (en) 1995-09-01
FI911330A (en) 1991-09-20
IL97592D0 (en) 1992-06-21
AU7361091A (en) 1991-09-19
FI911330A0 (en) 1991-03-19
US20020176823A1 (en) 2002-11-28
FI911330D0 (en)
NO179610C (en) 1996-11-13
NZ237461A (en) 1993-12-23
IL97592A (en) 1995-10-31

Similar Documents

Publication Publication Date Title
DE69017479T2 (en) Azabicycloheptenderivate and their salts, processes for their preparation, their use as medicaments and compositions containing them.
DE69216150D1 (en) Tachykininderivate, their preparation and pharmaceutical compositions containing them
DE54951T1 (en) Dibenzo (b, f) (1,4) oxazepine derivatives, processes for their preparation and compositions containing them pharmaceutical.
DE69205327T2 (en) Urea derivatives, processes for their preparation and medicines containing.
DE69308395D1 (en) Pyrazole derivatives, processes for their preparation and pharmaceutical compositions containing them
DE69100079D1 (en) Naphthalene derivatives, to processes for their preparation and pharmaceutical compositions containing them.
DE69007429D1 (en) Isoindolonderivate, their preparation and pharmaceutical compositions containing them.
DE69210029T2 (en) Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
DE69021472D1 (en) Pyrazole derivatives, processes for their preparation and containing pharmaceutical composition.
DE69123697T2 (en) Peptide compounds, processes for their preparation and pharmaceutical compositions containing them
DE69015244T2 (en) Peptide compounds, processes for their preparation and pharmaceutical compositions containing them.
AT130604T (en) New arylethylaminderivate, methods for their manufacture and pharmaceutical compositions containing them.
DE69110625T2 (en) Oxazolopyridinderivate, processes for their preparation and pharmaceutical compositions containing them.
DE59609487D1 (en) Cascade polymer complexes, process for their preparation and pharmaceutical compositions containing them
DE69032414T2 (en) Diphenylmethane derivatives, processes for their preparation and pharmaceutical compositions containing them
AT46900T (en) Phenylethanolaminotetraline, processes for their preparation and pharmaceutical compositions containing them.
DE69104723D1 (en) Coughing breastfeeding and mucus-regulating agents, process for its manufacture and pharmaceutical compositions containing it.
AT214709T (en) 14,15-cyclopropanosteroide the row 19 norandrostan-, to processes for their preparation and pharmaceutical compositions containing them
AT175201T (en) Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, processes for their preparation and pharmaceutical compositions containing them
DE69609371T2 (en) Pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
DE69023934D1 (en) PF 1022 substance, processes for their preparation and anthelmintic substance composition.
AT47840T (en) Chinolinamidderivate, methods for their manufacture and pharmaceutical compositions containing them.
DE69011628T2 (en) 1,2-Benzisoxazolderivate, processes for their preparation, and pharmaceutical compositions containing them.
DE3850321T2 (en) Cephalosporins, processes for their preparation and pharmaceutical compositions containing them.
DE59102092D1 (en) DTPA-monoamides, containing these compounds, pharmaceutical compositions, their use and processes for their preparation.

Legal Events

Date Code Title Description
EEFA Change of the company name
EELA Cancelled due to lapse of time