AT123306T - Alpha-glycosyl-L-ascorbic acid and uses its production and. - Google Patents

Alpha-glycosyl-L-ascorbic acid and uses its production and.

Info

Publication number
AT123306T
AT123306T AT90303484T AT90303484T AT123306T AT 123306 T AT123306 T AT 123306T AT 90303484 T AT90303484 T AT 90303484T AT 90303484 T AT90303484 T AT 90303484T AT 123306 T AT123306 T AT 123306T
Authority
AT
Austria
Prior art keywords
glycosyl
alpha
uses
production
ascorbic acid
Prior art date
Application number
AT90303484T
Other languages
German (de)
Inventor
Itaru Yamamoto
Norio Muto
Toshio Miyake
Original Assignee
Hayashibara Biochem Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP12707289 priority Critical
Priority to JP1274518A priority patent/JP2926412B2/en
Application filed by Hayashibara Biochem Lab filed Critical Hayashibara Biochem Lab
Publication of AT123306T publication Critical patent/AT123306T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/82Acid flavourants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/16Preparation of compounds containing saccharide radicals produced by the action of an alpha-1, 6-glucosidase, e.g. amylose, debranched amylopectin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/58Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
AT90303484T 1989-05-19 1990-03-30 Alpha-glycosyl-L-ascorbic acid and uses its production and. AT123306T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP12707289 1989-05-19
JP1274518A JP2926412B2 (en) 1989-05-19 1989-10-20 Its preparation and uses the α- glycosyl -L- ascorbate

Publications (1)

Publication Number Publication Date
AT123306T true AT123306T (en) 1995-06-15

Family

ID=26463107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90303484T AT123306T (en) 1989-05-19 1990-03-30 Alpha-glycosyl-L-ascorbic acid and uses its production and.

Country Status (7)

Country Link
US (3) US5137723A (en)
EP (1) EP0398484B1 (en)
AT (1) AT123306T (en)
DE (2) DE69019779T2 (en)
DK (1) DK0398484T3 (en)
ES (1) ES2075148T3 (en)
HK (1) HK111196A (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137723A (en) * 1989-05-19 1992-08-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo α-Glycosyl-L-ascorbic acid, and its preparation and uses
JP2832848B2 (en) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 Crystalline 2-O-α-D- glucopyranosyl -L- ascorbate and its preparation and uses
JP2926432B2 (en) * 1990-06-11 1999-07-28 株式会社林原生物化学研究所 Tonic
TW197375B (en) * 1990-11-19 1993-01-01 Hayashibara Biochem Lab
US5215767A (en) * 1991-03-16 1993-06-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Additive for aquaculture feed for fish and shellfish and aquaculture feed for fish and shellfish which contains same
US5272136A (en) * 1991-10-12 1993-12-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo 5-0-α-D-Glucopyranosyl-L-ascorbic acid, and its preparation and uses
JP3072535B2 (en) * 1991-10-21 2000-07-31 株式会社林原生物化学研究所 5-O-α-D- glucopyranosyl -L- ascorbate and its preparation and uses
JP3134235B2 (en) * 1991-10-23 2001-02-13 株式会社林原生物化学研究所 Method for producing 2-O-α-D- glucopyranosyl -L- ascorbate-rich product
US5314678A (en) * 1992-01-28 1994-05-24 Mallinckrodt Medical, Inc. Sodium iodide 131 I capsules
JP3134236B2 (en) * 1992-01-30 2001-02-13 株式会社林原生物化学研究所 Separation system for the production method and the production of α- glycosyl -L- ascorbate-rich product
NZ247157A (en) * 1992-03-17 1994-04-27 Ueno Seiyaku Oyo Kenkyujo Kk Production of powdery or granular crystalline maltitol from a highly concentrated aqueous solution using seed crystals
EP0649648B1 (en) * 1993-10-26 2001-09-19 Shiseido Company Limited Skin whitening agents containing glycosides
US5935584A (en) * 1994-01-13 1999-08-10 Elizabeth Arden Company Vitamin C delivery system
US5455035A (en) * 1994-01-13 1995-10-03 Elizabeth Arden Company, Division Of Conopco, Inc. Clear two-phase cosmetic composition
GB9403855D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US6224376B1 (en) 1994-06-10 2001-05-01 Richard A. Cloonan Dental cleaning liquid and gel
US5837222A (en) * 1994-06-10 1998-11-17 Cloonan; Richard A. Liquid dental cleaning solution
US5573398A (en) * 1994-06-10 1996-11-12 Towle; Lawrence E. Dental hygiene device and cleaning solution
FR2733148B1 (en) * 1995-04-20 1997-05-30 Oreal Composition fight against stains and / or aging of the skin, its uses
US5853741A (en) * 1996-06-28 1998-12-29 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Vitamin C delivery system
JP4981198B2 (en) 1998-03-31 2012-07-18 格 山本 Acylated derivatives of glycosyl-L-ascorbic acid
US6656920B2 (en) 2000-04-04 2003-12-02 Amarillo Biosciences, Inc. Composition and method for promoting oral health
FR2807320B1 (en) * 2000-04-10 2002-05-24 Oreal Use of ascorbic acid derivatives to increase the synthesis of epidermal creramides
FR2807322B1 (en) 2000-04-10 2004-02-20 Oreal Composition, in particular cosmetic, comprising ascorbic acid in combination with an ascorbic acid derivative
JP2002326924A (en) * 2001-05-07 2002-11-15 Asaba Keshohin Kk Face cleansing cosmetic
FR2834641B1 (en) * 2002-01-14 2005-04-22 Ct Regional De Lutte Contre Le Protecting the neurotoxicity of oxaliplatin administration of calcium and magnesium
JP4043312B2 (en) * 2002-08-06 2008-02-06 株式会社林原生物化学研究所 Method for producing 2-O-α-D- glucopyranosyl -L- ascorbate
FR2861734B1 (en) 2003-04-10 2006-04-14 Corneal Ind Crosslinking polysaccharides low and high molecular weight; preparation of hydrogels injectable monophase; polysaccharides and hydrogels obtained
KR100511419B1 (en) * 2003-09-15 2005-08-30 한국생명공학연구원 beta-fructosyl-L-ascorbic acid and the preparation method thereof
WO2006079212A1 (en) 2005-01-26 2006-08-03 Diamedica Inc. Use of s-adenosylmethionme, vitamin e, and vitamin c for the treatment of oxidative liver injury or insulin resistance
JP4766653B2 (en) * 2005-01-28 2011-09-07 国立大学法人 岡山大学 Ophthalmic pharmaceutical composition
WO2006090939A1 (en) * 2005-02-23 2006-08-31 Bioland Ltd. Cosmetic composition comprising beta-fructosyl-l-ascorbic acid for skin whitening
AT527985T (en) * 2005-03-23 2011-10-15 Mary Kay Inc Compositions for skin lightening
WO2006137129A1 (en) * 2005-06-21 2006-12-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Skin preparation for external use
KR100691540B1 (en) * 2006-06-22 2007-02-28 주식회사 펩트론 Stabilized vitamin c derivatives with a peptide molecule, preparation method thereof, and composition containing the same
EP2129231A4 (en) * 2007-02-01 2015-01-21 Nat Res Council Canada Formulations of lipophilic bioactive molecules
BRPI0811784A2 (en) * 2007-05-23 2011-05-10 Allergan Inc Collagen and crosslinked using the same
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
KR101206288B1 (en) * 2007-09-14 2012-11-29 난징 후아쉬 케미칼 컴퍼니 리미티드 Ascorbic acid derivates, their preparation methods, intermediates and uses in cosmetics
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
JP5670196B2 (en) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク. Compositions and methods for treating purpura
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394784B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20110118206A1 (en) * 2008-08-04 2011-05-19 Allergan Industrie, Sas Hyaluronic acid based formulations
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
JP5722217B2 (en) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエAllergan Holdings France S.A.S. Yarn of hyaluronic acid and / or its derivative, method for its preparation and use thereof
JP4885245B2 (en) * 2009-01-15 2012-02-29 日本航空電子工業株式会社 RD converter and angle detection device
RU2532671C2 (en) * 2009-09-03 2014-11-10 Хаясибара Ко.,Лтд. PREPARATION IN FORM OF SOLID PARTICLE OF DISPERSE PHASE, WHICH CONTAINS WATER-FREE CRYSTALLINE 2-O-α-D-GLUCOSYL-L-ASCORBIC ACID, METHOD OF PRODUCTION AND APPLICATION THEREOF
CN102480950B (en) * 2009-09-14 2014-07-23 国立大学法人北海道大学 Anti-plant-virus agent
CN102695413A (en) * 2009-11-10 2012-09-26 麦赛尔控股有限公司 Stabilized formulations of fatty acids
US20110171310A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US8586562B2 (en) * 2010-03-12 2013-11-19 Allergan Industrie, Sas Fluid compositions for improving skin conditions
EP3520827A1 (en) 2010-03-22 2019-08-07 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
EP2653475B1 (en) 2011-03-07 2018-11-14 Hayashibara Co., Ltd. Method for producing 2-o-alpha-d-glucosyl-l-ascorbic acid anhydrous crystal-containing powder
AU2012298791B2 (en) 2011-08-25 2015-09-24 Allergan Industrie, Sas Dermal filler compositions including antioxidants
CN107412002A (en) 2011-06-03 2017-12-01 阿勒根公司 Dermal filler compositions including antioxidants
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
CA2896646A1 (en) 2012-12-27 2014-07-03 Hayashibara Co., Ltd. Skin-exterior anti-ageing composition and production method therefor
CN103755756B (en) * 2014-02-11 2015-07-08 江苏诚信药业有限公司 Process system and process method for preparation of vitamin C ascorbyl glucoside

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD33788A (en) *
JPS4838158B1 (en) * 1970-10-05 1973-11-15
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
DD141832A1 (en) * 1978-10-31 1980-05-21 Joachim Schmidt Method and device for preparing l-ascorbin acid
WO1984000107A1 (en) * 1982-06-30 1984-01-19 Massachusetts Gen Hospital Vitamin d glycosides
JPH0358345B2 (en) * 1983-12-19 1991-09-05 Takeda Chemical Industries Ltd
US4822816A (en) * 1987-04-10 1989-04-18 Oxycal Laboratories, Inc. Compositions and methods for administering vitamin C
US5137723A (en) * 1989-05-19 1992-08-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo α-Glycosyl-L-ascorbic acid, and its preparation and uses
JP2832848B2 (en) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 Crystalline 2-O-α-D- glucopyranosyl -L- ascorbate and its preparation and uses

Also Published As

Publication number Publication date
HK111196A (en) 1996-07-05
EP0398484A2 (en) 1990-11-22
US5767149A (en) 1998-06-16
EP0398484A3 (en) 1991-02-27
ES2075148T3 (en) 1995-10-01
DK0398484T3 (en) 1995-07-24
US5616611A (en) 1997-04-01
DE69019779D1 (en) 1995-07-06
EP0398484B1 (en) 1995-05-31
US5137723A (en) 1992-08-11
DE69019779T2 (en) 1995-12-14

Similar Documents

Publication Publication Date Title
DE69227467T2 (en) Intrabuccally disintegrating preparation and their production
DE3872495T2 (en) Manufacture of 3,3,3-trifluoropropen.
NL970033I1 (en) Substituted pyridyl-dihydroxy-heptenoic acid, and dezouten thereof.
DE3434946A1 (en) Diarylacetylenes, their production and use
DE69017703D1 (en) Labels and their verfertigung.
DE3687646T2 (en) Biosensor and its production.
DE69333731D1 (en) Glialmitogene factors, their production and use
FI905531A0 (en) Transdermalisk anvaendning of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobensotiazol.
ES2021049B3 (en) Sustained release formulation and production thereof.
DE3780329T2 (en) Quinolone carboxylic acid derivatives and their production.
DE69019609T2 (en) Proteins and their production.
DE3762421D1 (en) Polyester production.
DE3685061D1 (en) Zer-iv-oxydenthaltende composition, their manufacture and uses her.
DE3781126T3 (en) Geschwefelt Erdalkalimetallalkylphenolate, their preparation and their use.
DE3772721D1 (en) Profilstueck and manufacturing processes.
DE3782492T2 (en) Liposome-anthraquinone-drug-composition and production.
DE59003587D1 (en) Diarylacetylenes, their preparation and use.
AT307825T (en) Aspartic acid derivatives, their manufacture and use
DE68924026D1 (en) Biosensor and its production.
DE3853159D1 (en) Labels and manufacturing processes.
DE3865988D1 (en) Benzoxazole derivatives and their production.
DE3861774D1 (en) Solid friction-reducing schmiermittelueberzuege, their manufacture and use.
AT144513T (en) Pyrrolopyrimidinderivate, their production and use
AT120168T (en) Production of isopropanol.
DE3881087D1 (en) Klebverbaende, their production and application.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee