AT114474T - Methods and compounds for administration of AICA ribosides and for lowering the blood glucose content. - Google Patents

Methods and compounds for administration of AICA ribosides and for lowering the blood glucose content.

Info

Publication number
AT114474T
AT114474T AT90903063T AT90903063T AT114474T AT 114474 T AT114474 T AT 114474T AT 90903063 T AT90903063 T AT 90903063T AT 90903063 T AT90903063 T AT 90903063T AT 114474 T AT114474 T AT 114474T
Authority
AT
Austria
Prior art keywords
ribosides
aica
administration
lowering
compounds
Prior art date
Application number
AT90903063T
Other languages
German (de)
Inventor
Harry E Gruber
Ronald E Tuttle
Clinton E Browne
Bheemarao G Ugarkar
Jack W Reich
Ernest Kurt Metzner
Paul J Marangos
Original Assignee
Gensia Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/301,453 priority Critical patent/US5200525A/en
Priority to US07/301,222 priority patent/US5082829A/en
Priority to US40810789A priority
Application filed by Gensia Pharma filed Critical Gensia Pharma
Publication of AT114474T publication Critical patent/AT114474T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052Imidazole radicals
AT90903063T 1989-01-24 1990-01-24 Methods and compounds for administration of AICA ribosides and for lowering the blood glucose content. AT114474T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US07/301,453 US5200525A (en) 1989-01-24 1989-01-24 Anti-seizure compounds
US07/301,222 US5082829A (en) 1989-01-24 1989-01-24 AICA riboside prodrugs
US40810789A true 1989-09-15 1989-09-15

Publications (1)

Publication Number Publication Date
AT114474T true AT114474T (en) 1994-12-15

Family

ID=27404800

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90903063T AT114474T (en) 1989-01-24 1990-01-24 Methods and compounds for administration of AICA ribosides and for lowering the blood glucose content.

Country Status (13)

Country Link
EP (1) EP0427799B1 (en)
JP (1) JPH03504728A (en)
KR (1) KR917000057A (en)
AT (1) AT114474T (en)
AU (2) AU5086190A (en)
CA (1) CA2008325A1 (en)
DE (2) DE69014562D1 (en)
DK (1) DK0427799T3 (en)
FI (1) FI904694A0 (en)
IE (1) IE75372B1 (en)
IL (1) IL93164D0 (en)
NO (1) NO904149L (en)
WO (1) WO1990009163A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5202459A (en) * 1989-11-07 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for producing cyclobutane derivative
JPH0615556B2 (en) * 1989-11-10 1994-03-02 旭化成工業株式会社 4-carbamoyl -1-beta-D-ribofuranosyl - imidazolium-5 Oreito anhydrous crystalline
US5324730A (en) * 1990-05-24 1994-06-28 Nippon Kayaku Kabushiki Kaisha Phenoxyphosphoryloxymethyl cyclobutyl purines
IL99124A (en) * 1990-08-10 1998-02-22 Gensia Pharma Substituted imidazole analogs of aica riboside
US5236908A (en) * 1991-06-07 1993-08-17 Gensia Pharmaceuticals, Inc. Methods of treating injury to the central nervous system
IL103294D0 (en) * 1991-09-30 1993-05-13 Gensia Pharma Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow
IL108523D0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
EP1402895A1 (en) * 1997-03-07 2004-03-31 Metabasis Therapeutics Inc. Benzimidazole inhibitors of fructose 1,6-biphosphatase
AU6691498A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase
WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
AU2003242500B2 (en) * 1998-09-09 2006-11-02 Metabasis Therapeutics, Inc. Novel Heteroaromatic Inhibitors of Fructose 1,6-bisphosphatase
US6489476B1 (en) 1998-09-09 2002-12-03 Metabasis Therapeutics, Inc. Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
KR20070046210A (en) * 1998-12-24 2007-05-02 메타베이시스 테라퓨틱스, 인크. A combination of fbpase inhibitors and insulin sensitizers for the treatment of diabetes
AT350385T (en) 2000-03-08 2007-01-15 Metabasis Therapeutics Inc New aryl fructose-1,6-bisphosphatase inhibitors
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
CN101301294A (en) * 2000-07-06 2008-11-12 症变治疗公司 Combinated inhibitors of FBP-ase and antidiabetic agents for diabetes treatment
ES2192495B1 (en) 2002-03-21 2005-02-16 Universidad De Barcelona New therapeutic use of 5-aminoimidazole riboside-4-carboxamide (acadesine).
EP1752450A1 (en) 2005-08-01 2007-02-14 Merck Sante Imidazole derivatives as fructose-1,6-bisphosphatase inhibitors and pharmaceutical compositions containing them
WO2008086341A1 (en) * 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
EP2058308A1 (en) 2007-11-12 2009-05-13 Merck Sante Benzimidazoledihydrothiadiazinone derivatives used as fructose-1,6-biphosphatase inhibitors and pharmaceutical compositions containing same.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1535561A (en) * 1966-06-18 1968-08-09 Ajinomoto Kk Method for the preparation of adenine, its derivatives and intermediates
US4575498A (en) * 1983-07-21 1986-03-11 Duke University Method for restoring depleted purine nucleotide pools
DE3650505D1 (en) * 1986-03-27 1996-05-02 Gensia Inc AICA riboside for the prophylactic treatment of diseases with reduced blood flow.
US4912092A (en) * 1986-03-27 1990-03-27 The Regents Of The University Of California Methods for increasing extracellular adenosine and for stabilizing mast cells

Also Published As

Publication number Publication date
AU5236093A (en) 1994-02-24
AU5086190A (en) 1990-09-05
NO904149D0 (en) 1990-09-24
DE69014562D1 (en) 1995-01-12
JPH03504728A (en) 1991-10-17
NO904149L (en) 1990-11-26
IE75372B1 (en) 1997-09-10
IE900274L (en) 1990-07-24
WO1990009163A2 (en) 1990-08-23
DK0427799T3 (en) 1995-05-08
DE69014562T2 (en) 1995-06-22
IL93164D0 (en) 1990-11-05
FI904694D0 (en)
CA2008325A1 (en) 1990-07-24
EP0427799B1 (en) 1994-11-30
FI904694A0 (en) 1990-09-24
WO1990009163A3 (en) 1991-01-24
KR917000057A (en) 1991-03-13
EP0427799A4 (en) 1991-07-24
EP0427799A1 (en) 1991-05-22

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