AT114242T - On crosslinked polymers and coated with polymer films coated therapeutic compositions with controlled release of drugs and their method of preparation. - Google Patents

On crosslinked polymers and coated with polymer films coated therapeutic compositions with controlled release of drugs and their method of preparation.

Info

Publication number
AT114242T
AT114242T AT91103224T AT91103224T AT114242T AT 114242 T AT114242 T AT 114242T AT 91103224 T AT91103224 T AT 91103224T AT 91103224 T AT91103224 T AT 91103224T AT 114242 T AT114242 T AT 114242T
Authority
AT
Austria
Prior art keywords
coated
drugs
preparation
method
controlled release
Prior art date
Application number
AT91103224T
Other languages
German (de)
Inventor
Fabio Carli
Italo Colombo
Leonardo Rabaglia
Original Assignee
Vectorpharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1957190A priority Critical patent/IT1241417B/en
Application filed by Vectorpharma Int filed Critical Vectorpharma Int
Publication of AT114242T publication Critical patent/AT114242T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
AT91103224T 1990-03-06 1991-03-04 On crosslinked polymers and coated with polymer films coated therapeutic compositions with controlled release of drugs and their method of preparation. AT114242T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT1957190A IT1241417B (en) 1990-03-06 1990-03-06 Therapeutic compositions with controlled release of drugs supportatisu crosslinked polymers and coated with polymer films, and their preparation processodi

Publications (1)

Publication Number Publication Date
AT114242T true AT114242T (en) 1994-12-15

Family

ID=11159155

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91103224T AT114242T (en) 1990-03-06 1991-03-04 On crosslinked polymers and coated with polymer films coated therapeutic compositions with controlled release of drugs and their method of preparation.

Country Status (13)

Country Link
US (1) US5275824A (en)
EP (1) EP0446753B1 (en)
JP (1) JP3240387B2 (en)
KR (1) KR0175935B1 (en)
AT (1) AT114242T (en)
CA (1) CA2037410C (en)
DE (1) DE69105222T2 (en)
ES (1) ES2067068T3 (en)
HU (1) HUT59588A (en)
IT (1) IT1241417B (en)
PL (1) PL289322A1 (en)
RU (1) RU2067859C1 (en)
YU (1) YU34491A (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2572673B2 (en) * 1990-07-25 1997-01-16 エスエス製薬株式会社 Sustained-release tablets
US5288505A (en) * 1991-06-26 1994-02-22 Galephar P.R., Inc., Ltd. Extended release form of diltiazem
US6764697B1 (en) * 1991-06-27 2004-07-20 Alza Corporation System for delaying drug delivery up to seven hours
GB2258613B (en) * 1991-08-12 1996-01-10 Euro Celtique Sa Pharmaceutical diltiazem formulation
KR100221695B1 (en) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 Pharmaceutical spheroid formulation
IT1252867B (en) * 1991-12-31 1995-06-28 Gentili Ist Spa Pharmaceutical compositions containing high progesterone bioavailability '
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
DE4236090C1 (en) * 1992-10-26 1994-01-05 Asta Medica Arzneimittel Pharmaceutical preparation for fluoride ion supply
AT201990T (en) * 1993-03-05 2001-06-15 Hexal Ag Crystalline cyclodextrin inclusion complex of ranitidinhxdrochlorid and procedural
GB9318880D0 (en) * 1993-09-11 1993-10-27 Smithkline Beecham Plc Pharmaceutical composition
US5484607A (en) * 1993-10-13 1996-01-16 Horacek; H. Joseph Extended release clonidine formulation
FR2711804B1 (en) * 1993-10-22 1996-01-19 Pf Medicament A method of controlling the dissolution of modified release dosage forms with a solid reactant and dose sachet containing such a reagent.
AT403988B (en) * 1994-05-18 1998-07-27 Lannacher Heilmittel Solid oral sustained-release
DE69510894T2 (en) * 1994-06-16 2000-02-03 Pharmacia & Upjohn Spa A process for producing starch mucoadhesiver
US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
EP0761209A3 (en) * 1995-09-01 1998-02-04 J.B. Chemicals & Pharmaceuticals Ltd. Controlled release formulations of ranitidine
WO1996026719A1 (en) * 1995-03-02 1996-09-06 Takeda Chemical Industries, Ltd. A prolonged release composition, use and production thereof
JP3471977B2 (en) * 1995-06-02 2003-12-02 信越化学工業株式会社 Enteric formulations coated without solvent enteric coating agents using a liquid plasticizer
US5773031A (en) * 1996-02-27 1998-06-30 L. Perrigo Company Acetaminophen sustained-release formulation
HU9600758A2 (en) * 1996-03-27 1998-03-02 Cyclolab Ciklodextrin Kutato F Diclofenac composition of diminished gastrointestinal irritation and enhanced biological resorption
IT1282381B1 (en) * 1996-04-29 1998-03-20 Trans Bussan S A New formulations of diacerein, obtained by inclusion of the active substance in the hydrogel polysaccharides
FR2757397B1 (en) * 1996-12-23 1999-03-05 Mazal Pharma pharmaceutical composition basis of rhein or diacerein has IMPROVED BIOAVAILABILITY
US5788987A (en) * 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
US5891474A (en) 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
AU6590598A (en) * 1997-04-04 1998-10-30 Monsanto Company Hydrolysable delivery system using cross-linked polymeric resins as vehicles
US6890524B1 (en) 1997-04-04 2005-05-10 Monsanto Company Hydrolyzable delivery system using cross-linked polymeric resins as vehicles
US6471955B1 (en) 1997-04-04 2002-10-29 Pharmacia Corporation Ph-selective delivery system using crosslinked polymeric resins as vehicles
FR2766709B1 (en) * 1997-07-31 2000-04-07 Dominique Cingotti A process for preparing an extract of active principles in the form of microgranules a base entirely soluble dietary fiber for different galenic forms
IT1298574B1 (en) * 1998-02-06 2000-01-12 Vectorpharma Int Pharmaceutical compositions in the form of microparticles in the polymer base obtained by extrusion and spheronization
ES2204109T3 (en) 1998-03-04 2004-04-16 Ortho-Mcneil Pharmaceutical, Inc. pharmaceutical composition of topiramate.
US6048736A (en) * 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US7091192B1 (en) 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
FR2785539B1 (en) * 1998-11-06 2004-04-09 Prographarm Laboratoires coated particles of crystalline ibuprofen granule
FR2792528A1 (en) * 1999-04-22 2000-10-27 Ethypharm Lab Prod Ethiques Prolonged release ketoprofen microgranules giving a more even liberation with a lower initial peak of concentration in the plasma
AU5152900A (en) * 1999-05-24 2000-12-12 Purepac Pharmaceutical Co. A pharmaceutical composition containing an active agent that is maintained in solid amorphous form and method of making the same
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
CA2393231A1 (en) 1999-12-06 2001-06-07 Edward Mendell Co., Inc. Pharmaceutical superdisintegrant
US20060153914A1 (en) * 1999-12-10 2006-07-13 Biovail Laboratories International S.R.L. Chronotherapeutic diltiazem formulations and the administration thereof
US7108866B1 (en) 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof
CA2440641A1 (en) * 2001-03-13 2002-09-19 Anand R. Baichwal Chronotherapeutic dosage forms containing glucocorticosteroid
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
WO2003002097A1 (en) * 2001-06-29 2003-01-09 Eurand Pharmaceuticals Ltd Process of thermodynamical activation of water-insoluble drugs loaded into cross-linked polymers
DE60205491T2 (en) * 2001-06-29 2006-06-01 Eurand Pharmaceuticals Ltd. A method for drug activation means of the vibrating mill
US7060498B1 (en) 2001-11-28 2006-06-13 Genta Salus Llc Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
JP3966459B2 (en) 2002-05-23 2007-08-29 株式会社日立製作所 Storage device management method, system, and program
KR101857900B1 (en) 2002-09-06 2018-05-14 인설트 테라페틱스, 인코퍼레이티드 Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
DE10247037A1 (en) 2002-10-09 2004-04-22 Abbott Gmbh & Co. Kg Solid, rapid release dosage form, especially for sparingly soluble drugs, obtained by forming and cooling softened, shapable mixture of crosslinked non-thermoplastic carrier, adjuvant and active agent
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
BRPI0408805A (en) * 2003-03-31 2006-03-28 Pliva Lachema As A pharmaceutical composition containing platinum complex and manufacturing method thereof
AU2004273958A1 (en) * 2003-09-19 2005-03-31 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
JP2007505921A (en) * 2003-09-19 2007-03-15 ペンウェスト ファーマシューティカルズ カンパニー Delayed release dosage form
US7387793B2 (en) 2003-11-14 2008-06-17 Eurand, Inc. Modified release dosage forms of skeletal muscle relaxants
CA2572928A1 (en) * 2004-07-22 2006-02-26 Amorepacific Corporation Sustained-release preparations containing topiramate and the producing method thereof
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
WO2007096902A2 (en) * 2006-02-23 2007-08-30 Lupin Limited Solid oral dosage forms of griseofulvin
JP5823093B2 (en) 2006-03-28 2015-11-25 ジャヴェリン ファーマシューティカルズ インコーポレイテッド Low doses of diclofenac and β- cyclodextrin formulation
US20080102128A1 (en) * 2006-07-28 2008-05-01 Flamel Technologies, Inc. Modified-release microparticles based on amphiphilic copolymer and on active principles(s) and pharmaceutical formulations comprising them
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
JP2010502590A (en) * 2006-09-01 2010-01-28 ユーエスヴィー リミテッド Sevelamer process for the preparation of hydrochloride salts and formulations
JP2010516625A (en) 2007-01-24 2010-05-20 インサート セラピューティクス, インコーポレイテッド Polymers having a tether group for controlled drug delivery - drug conjugates
US20100172991A1 (en) * 2007-06-08 2010-07-08 Henry Joseph Horacek Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
US20090087490A1 (en) * 2007-06-08 2009-04-02 Addrenex Pharmaceuticals, Inc. Extended release formulation and method of treating adrenergic dysregulation
KR20100032863A (en) * 2007-06-25 2010-03-26 엔싸이시브 파마슈티칼즈 인코퍼레이티드 Formulations of n-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide
US20090024570A1 (en) * 2007-07-20 2009-01-22 Oracle Internatonal Corporation User defined query rewrite mechanism
EP2471515A3 (en) 2007-09-14 2012-12-26 Wockhardt Limited Rhein or diacerein compositions
NZ599268A (en) * 2007-09-27 2012-11-30 Wockhardt Research Center Pharmaceutical compositions of rhein or diacerein made by wet granulation process
US20100285114A1 (en) * 2007-09-27 2010-11-11 Rahul Dabre Pharmaceutical compositions of rhein or diacerein
AU2013200968B2 (en) * 2007-09-27 2013-11-21 Wockhardt Limited Pharmaceutical compositions of rhein or diacerein
US8946277B2 (en) * 2008-04-18 2015-02-03 Warsaw Orthopedic, Inc. Clonidine formulations in a biodegradable polymer carrier
TWI473610B (en) * 2008-10-28 2015-02-21 Twi Biotechnology Inc Pharmaceutical compositions containing diacerein
RU2011134847A (en) * 2009-01-22 2013-02-27 Юсв Лимитед Pharmaceutical compositions containing the phosphate polymer
EA201200617A1 (en) * 2009-11-23 2012-11-30 Серулин Фарма Инк. Polymers on the basis of cyclodextrine for delivery of medicines
IE20100799A1 (en) 2010-12-22 2012-08-01 Eurand Pharmaceuticals Ltd Pharmaceutical composites of poorly water soluble drugs and polymers
RU2648353C2 (en) * 2011-06-01 2018-03-23 Нитто Денко Корпорейшн Particulate composition and process for obtaining it
US9452107B2 (en) * 2012-04-16 2016-09-27 New Jersey Institute Of Technology Systems and methods for superdisintegrant-based composite particles for dispersion and dissolution of agents
US8999393B1 (en) 2013-01-09 2015-04-07 Edgemont Pharmaceuticals Llc Sustained release formulations of lorazepam
CA2936748C (en) 2014-10-31 2017-08-08 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1218102A (en) 1968-03-15 1971-01-06 Philips Nv Improvements in medicaments comprising drug/ion-exchange resin compounds
DE2643004A1 (en) 1975-09-25 1977-06-16 Mitchell Beazley Encyclopedias Data reception and indexing equipment - has units containing graphic details illustrations and index with reproductions
US4221778A (en) 1979-01-08 1980-09-09 Pennwalt Corporation Prolonged release pharmaceutical preparations
HU189534B (en) 1981-09-09 1986-07-28 Chinoin Rt.,Hu Process for producing new tablets containing cyclodextrin polymer as desintegrator
EP0078430B2 (en) 1981-10-29 1993-02-10 Bayer Ag Process for preparing solid fast-releasing drug formulations of dihydropyridines
EP0147780A3 (en) 1984-01-03 1987-03-11 Merck & Co., Inc. Drug delivery device
GB8403359D0 (en) 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical compositions
CA1236023A (en) 1984-07-18 1988-05-03 Yegnaswami Raghunathan Controlled release pharmaceutical preparations
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
ES2022454B3 (en) * 1986-06-17 1991-12-01 Recordati Ind Chimica E Farm S P A therapeutic system for the controlled release of drugs.
JPH0819004B2 (en) 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical formulations
GB8705083D0 (en) * 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
US4894239A (en) 1987-06-02 1990-01-16 Takeda Chemical Industries, Ltd. Sustained-release preparation and production thereof
US4795644A (en) 1987-08-03 1989-01-03 Merck & Co., Inc. Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins
IE63242B1 (en) * 1988-06-24 1995-04-05 Abbott Lab Pharmaceutical granules and tablets made therefrom

Also Published As

Publication number Publication date
CA2037410A1 (en) 1991-09-07
EP0446753A1 (en) 1991-09-18
DE69105222T2 (en) 1995-04-06
RU2067859C1 (en) 1996-10-20
JPH0769927A (en) 1995-03-14
ES2067068T3 (en) 1995-03-16
JP3240387B2 (en) 2001-12-17
PL289322A1 (en) 1992-05-04
KR0175935B1 (en) 1999-03-20
DE69105222D1 (en) 1995-01-05
EP0446753B1 (en) 1994-11-23
IT9019571A1 (en) 1991-09-07
IT1241417B (en) 1994-01-14
YU34491A (en) 1994-06-10
CA2037410C (en) 2001-09-04
IT9019571D0 (en) 1990-03-06
HUT59588A (en) 1992-06-29
HU910707D0 (en) 1991-09-30
US5275824A (en) 1994-01-04

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Legal Events

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