AT111443T - COLLAGENAS INHIBITORS BASED ON HYDROXAMIC ACID. - Google Patents

COLLAGENAS INHIBITORS BASED ON HYDROXAMIC ACID.

Info

Publication number
AT111443T
AT111443T AT90911398T AT90911398T AT111443T AT 111443 T AT111443 T AT 111443T AT 90911398 T AT90911398 T AT 90911398T AT 90911398 T AT90911398 T AT 90911398T AT 111443 T AT111443 T AT 111443T
Authority
AT
Austria
Prior art keywords
collagenas
inhibitors
hydroxamic acid
hydroxamic
acid
Prior art date
Application number
AT90911398T
Other languages
English (en)
Inventor
Colin Campion
Alan Hornsby Davidson
Jonathan Philip Dickens
Michael John Crimmin
Original Assignee
British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB898919251A priority Critical patent/GB8919251D0/en
Application filed by British Bio Technology filed Critical British Bio Technology
Publication of AT111443T publication Critical patent/AT111443T/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/382-Pyrrolones
AT90911398T 1989-08-24 1990-07-20 COLLAGENAS INHIBITORS BASED ON HYDROXAMIC ACID. AT111443T (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB898919251A GB8919251D0 (en) 1989-08-24 1989-08-24 Compounds

Publications (1)

Publication Number Publication Date
AT111443T true AT111443T (de) 1994-09-15

Family

ID=10662057

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90911398T AT111443T (de) 1989-08-24 1990-07-20 COLLAGENAS INHIBITORS BASED ON HYDROXAMIC ACID.

Country Status (16)

Country Link
US (2) US5453438A (de)
EP (1) EP0489032B1 (de)
JP (1) JP2871849B2 (de)
KR (1) KR927003624A (de)
AT (1) AT111443T (de)
AU (1) AU639706B2 (de)
CA (1) CA2064786A1 (de)
DE (1) DE69012575T2 (de)
DK (1) DK0489032T3 (de)
ES (1) ES2063975T3 (de)
FI (1) FI920771A0 (de)
GB (1) GB8919251D0 (de)
NO (1) NO920702L (de)
NZ (1) NZ235050A (de)
TW (1) TW202456B (de)
WO (1) WO1991002716A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
EP0520573A1 (de) * 1991-06-27 1992-12-30 Glaxo Inc. Derivate von cyclischen Imiden
US5525629A (en) * 1992-04-07 1996-06-11 British Bio-Technology Limited Inhibition of cytokine production
GB9211706D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
NZ262447A (en) * 1993-03-16 1996-07-26 British Biotech Pharm Hydroxamic acid derivatives and their use as pharmaceutical agents
GB9308695D0 (en) * 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
ES2134939T3 (es) * 1993-04-27 1999-10-16 Celltech Therapeutics Ltd Derivados de peptidilo como inhibidores de metaloproteinas.
ES2075798B1 (es) * 1993-08-18 1996-03-01 British Bio Technology Derivados de aminoacidos naturales como inhibidores de metaloproteinasas, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina.
ES2075797B1 (es) * 1993-08-18 1996-05-16 British Bio Technology Derivados de acidos hidroxamicos terapeuticamente activos, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina.
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
CZ290145B6 (cs) * 1994-01-20 2002-06-12 British Biotech Pharmaceuticals Limited Inhibitory metaloproteinázy
US5919940A (en) * 1995-01-20 1999-07-06 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
US5831004A (en) 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
ES2164264T3 (es) 1995-11-23 2002-02-16 British Biotech Pharm Inhibidores de metaloproteinasas.
AT226590T (de) * 1996-08-28 2002-11-15 Procter & Gamble Phosphinsäureamide als matrix metalloprotease inhibitoren
CZ62699A3 (cs) 1996-08-28 1999-07-14 The Procter & Gamble Company Heterocyklické inhibitory metaloproteinas
CZ63799A3 (cs) * 1996-08-28 1999-08-11 The Procter & Gamble Company Spirocyklické metalloproteázové inhibitory
NZ334251A (en) * 1996-08-28 2000-11-24 Procter & Gamble 1,3-diheterocyclic metalloprotease inhibitors
BR9712086A (pt) * 1996-08-28 2000-10-24 Procter & Gamble Inibidores1,4-heterocìclicos de metaloproteinases
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
WO1998011063A1 (en) * 1996-09-10 1998-03-19 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives
US5840974A (en) * 1996-12-04 1998-11-24 Britisch Biotech Pharmaceuticals, Ltd. Metalloproteinase inhibitors
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
EP1009737A2 (de) 1997-07-31 2000-06-21 The Procter & Gamble Company Sulfonylamino-substituierte hydroxamsäure-derivate als metalloprotease-hemmer
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
TR200102523T2 (tr) 1999-03-03 2002-02-21 The Procter & Gamble Company Alkenil ve alkinil içeren metaloproteaz inhibitörleri
PL353745A1 (en) 1999-08-10 2003-12-01 British Biotech Pharmaceuticals Limitedbritish Biotech Pharmaceuticals Limited Antibacterial agents
GB9929527D0 (en) * 1999-12-14 2000-02-09 Smithkline Beecham Plc Novel compounds
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
CA2446931A1 (en) 2001-06-15 2002-12-27 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4496540A (en) * 1982-12-30 1985-01-29 Biomeasure, Inc. Therapeutic compounds
JPS6115840A (en) * 1984-07-03 1986-01-23 Microbial Chem Res Found Immuno-activating agent
US4599361A (en) * 1985-09-10 1986-07-08 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
FR2609289B1 (fr) * 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes

Also Published As

Publication number Publication date
TW202456B (de) 1993-03-21
US5910609A (en) 1999-06-08
EP0489032A1 (de) 1992-06-10
DE69012575T2 (de) 1995-03-30
CA2064786A1 (en) 1991-02-25
AU639706B2 (en) 1993-08-05
AU6045490A (en) 1991-04-03
NZ235050A (en) 1991-12-23
GB8919251D0 (en) 1989-10-04
WO1991002716A2 (en) 1991-03-07
ES2063975T3 (es) 1995-01-16
FI920771D0 (de)
DE69012575D1 (de) 1994-10-20
JPH05501864A (de) 1993-04-08
EP0489032B1 (de) 1994-09-14
WO1991002716A3 (en) 1991-06-27
FI920771A0 (fi) 1992-02-21
US5453438A (en) 1995-09-26
JP2871849B2 (ja) 1999-03-17
NO920702L (no) 1992-04-23
NO920702D0 (no) 1992-02-21
DK0489032T3 (da) 1995-01-30
KR927003624A (ko) 1992-12-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee