AT104348T - O-glycosylated IFN-alpha. - Google Patents

O-glycosylated IFN-alpha.


Publication number
AT104348T AT91912306T AT91912306T AT104348T AT 104348 T AT104348 T AT 104348T AT 91912306 T AT91912306 T AT 91912306T AT 91912306 T AT91912306 T AT 91912306T AT 104348 T AT104348 T AT 104348T
Prior art keywords
glycosylated ifn
Prior art date
Application number
Other languages
German (de)
Guenther Adolf
Adolf Himmler
Horst Johann Ahorn
Inge Kalsner
Ingrid Maurer-Fogy
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19904021917 priority Critical patent/DE4021917A1/en
Priority to DE19904035877 priority patent/DE4035877A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Priority to PCT/EP1991/001266 priority patent/WO1992001055A1/en
Publication of AT104348T publication Critical patent/AT104348T/en



    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • A61K38/00Medicinal preparations containing peptides
AT91912306T 1990-07-10 1991-07-06 O-glycosylated IFN-alpha. AT104348T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19904021917 DE4021917A1 (en) 1990-07-10 1990-07-10 O-glycosylated alpha-interferon, used as medicament - isolated following secretion into conditioned medium of mammalian cells contg. a suitable expression plasmid
DE19904035877 DE4035877A1 (en) 1990-11-12 1990-11-12 O-glycosylated alpha interferon
PCT/EP1991/001266 WO1992001055A1 (en) 1990-07-10 1991-07-06 O-glycosylated ifn-alpha

Publications (1)

Publication Number Publication Date
AT104348T true AT104348T (en) 1994-04-15



Family Applications (1)

Application Number Title Priority Date Filing Date
AT91912306T AT104348T (en) 1990-07-10 1991-07-06 O-glycosylated IFN-alpha.

Country Status (16)

Country Link
EP (1) EP0538300B1 (en)
JP (1) JPH06502987A (en)
KR (1) KR930701601A (en)
AT (1) AT104348T (en)
AU (1) AU650893B2 (en)
CA (1) CA2084514A1 (en)
CZ (1) CZ386392A3 (en)
DE (1) DE59101397D1 (en)
DK (1) DK0538300T3 (en)
ES (1) ES2063515T3 (en)
FI (1) FI930058A (en)
HU (1) HUT65846A (en)
NO (1) NO930059L (en)
PL (1) PL297610A1 (en)
SK (1) SK386392A3 (en)
WO (1) WO1992001055A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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US5541071A (en) * 1992-02-07 1996-07-30 New England Medical Center Hospitals, Inc. Assay for identifying antagonists of gastrin and CCK-B receptors
NZ245771A (en) * 1992-02-07 1994-08-26 New England Medical Center Inc Mammalian gastrin/cholecystokinin b (cck-b) receptor and antagonists
EP0626448A3 (en) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Process for preparing and purifying alpha-interferon
US6221582B1 (en) 1994-10-28 2001-04-24 Innogenetics N.V. Polynucleic acid sequences for use in the detection and differentiation of prokaryotic organisms
DE69725857T2 (en) * 1996-08-14 2004-07-29 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer Vector for polynukleotidimpfstoffe
GB9904695D0 (en) * 1999-03-01 1999-04-21 Imp Cancer Res Tech Peptide
JP2003530847A (en) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド Albumin fusion protein
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
DK2279755T3 (en) * 2001-10-10 2014-05-26 Ratiopharm Gmbh Glycokonjugering of remodeling and fibroblast growth factor (FGF)
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
ES2420581T3 (en) 2003-03-14 2013-08-26 Biogenerix Gmbh water soluble polymers branched and their conjugates
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
NZ556436A (en) 2005-01-10 2010-11-26 Biogenerix Ag Glycopegylated granulocyte colony stimulating factor
ES2560657T3 (en) 2004-01-08 2016-02-22 Ratiopharm Gmbh O-linked glycosylation of peptides G-CSF
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
JP5948627B2 (en) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー Remodeling and carbohydrate pegylated of fibroblast growth factor (fgf)
EP1871795A4 (en) 2005-04-08 2010-03-31 Biogenerix Ag Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
AR078117A1 (en) 2006-06-20 2011-10-19 Protech Pharma S A A recombinant mutein of human alpha interferon glycosylated, a gene coding for said mutein, a method of producing said gene, a method for obtaining a eukaryotic cell producing such a mutein, a method for producing such a mutein, a process for purifying said mutein
US20080280818A1 (en) 2006-07-21 2008-11-13 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As Methods for the purification of polypeptide conjugates
US9050304B2 (en) 2007-04-03 2015-06-09 Ratiopharm Gmbh Methods of treatment using glycopegylated G-CSF
ES2551123T3 (en) 2007-06-12 2015-11-16 Ratiopharm Gmbh Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
RU2573587C2 (en) 2008-02-27 2016-01-20 Ново Нордиск А/С Conjugated factor viii molecules
EP2938726B1 (en) 2012-12-31 2017-09-27 Boehringer Ingelheim International GmbH Heterologous intron within a signal peptide
WO2014102101A1 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Novel intron sequences
RU2610173C1 (en) * 2016-03-30 2017-02-08 Илья Александрович Марков Recombinant plasmid pfm-ifn-17 providing expression of interferon alpha-2b of human, recombinant plasmid pfm-ap, providing expression of enzyme methionine-aminopeptidase e coli, biplasmid strain escherichia coli fm-ifn-ap (pfm-ifn-17, pfm-ap) - producer (met-) of recombinant interferon alpha -2b of human

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (en) * 1978-11-24 1982-12-04 Hoffmann La Roche A process for purifying chromatographically interferon to homogeneity
JPS58501543A (en) * 1981-08-14 1983-09-16
DE3306060A1 (en) * 1983-02-22 1984-08-23 Boehringer Ingelheim Int New immunoglobulin-producing hybrid cell lines whose use and process for their preparation
FR2560212B1 (en) * 1984-02-24 1989-12-29 Unicet monoclonal antibodies against the interferon a2 and hybridomas producing such antibodies

Also Published As

Publication number Publication date
HUT65846A (en) 1994-07-28
AU650893B2 (en) 1994-07-07
HU9300036D0 (en) 1993-04-28
PL297610A1 (en) 1992-07-13
SK386392A3 (en) 1994-08-10
DE59101397D1 (en) 1994-05-19
EP0538300B1 (en) 1994-04-13
FI930058A (en) 1993-01-08
WO1992001055A1 (en) 1992-01-23
NO930059L (en) 1993-01-08
NO930059D0 (en) 1993-01-08
ES2063515T3 (en) 1995-01-01
CZ386392A3 (en) 1993-08-11
FI930058D0 (en)
CA2084514A1 (en) 1992-01-11
KR930701601A (en) 1993-06-12
FI930058A0 (en) 1993-01-08
DK0538300T3 (en) 1994-10-10
JPH06502987A (en) 1994-04-07
AU8208291A (en) 1992-02-04
EP0538300A1 (en) 1993-04-28

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee