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En el presente documento se proporcionan composiciones y métodos para desencadenar una respuesta inmunitaria en un sujeto. En particular, la presente divulgación se refiere a proteínas de fusión que comprenden una polipéptido de la variante III del receptor de factor de crecimiento epidérmico (EGFRvIII) y un polipéptido de mesotelina, y a métodos para desencadenar una respuesta inmunitaria usando células hospedadoras que comprenden moléculas de ácido nucleico que codifican dichas proteínas de fusión. En algunas realizaciones, las moléculas de ácido nucleico pueden codificar una proteína de fusión EGFRvIII-mesotelina que comprende una secuencia de aminoácidos que es al menos i) un 90% idéntica, ii) un 95% idéntica, o iii) un 99% idéntica a EGFRvIIIx5-mesotelina₃₅₋₆₂₂ tal como se expone en la SEQ ID Nº 8.Compositions and methods for triggering an immune response in a subject are provided herein. In particular, the present disclosure relates to fusion proteins comprising a polypeptide of variant III of the epidermal growth factor receptor (EGFRvIII) and a mesothelin polypeptide, and to methods for triggering an immune response using host cells comprising molecules of nucleic acid encoding said fusion proteins. In some embodiments, the nucleic acid molecules may encode an EGFRvIII-mesothelin fusion protein comprising an amino acid sequence that is at least i) 90% identical, ii) 95% identical, or iii) 99% identical to EGFRvIIIx5-mesothelin₃₅₋₆₂₂ as set forth in SEQ ID No. 8.
ARP160100978A2015-04-132016-04-12
VARIOUS FUSIONS III OF THE EPIDERMAL-MESOTHELINE GROWTH FACTOR RECEIVER AND METHODS TO USE THE SAME
AR105615A1
(en)
ISOLATED RECOMBINANT POLYPEPTIDE WITH PESTICIDAL ACTIVITY, PESTICIDAL COMPOSITION, NUCLEIC ACID MOLECULE, HOST CELL, DNA CONSTRUCTION, VECTOR, METHOD FOR PRODUCING SAID POLYPEPTIDE AND METHOD FOR PRODUCING A TRANSGENIC PLANT
IMMUNOGENIC POLYPROTEIN COMPLEX OF M. HYOPNEUMONIAE, SYNTHETIC GEN CODIFYING OF THE IMMUNOGENIC PROLIPROTEIN COMPLEX OF M. HYOPNEUMONIAE, ANTIGENIC COMPOSITION, PROCESS OF OBTAINING A COMPLEX COMPLETION COMPLEX IN A BASE HYDRAULIC COMPLEX. IMMUNOGENIC OF M. HYOPNEUMONIAE