AR104610A1 - Determinación de pureza de proteínas multiméricas - Google Patents
Determinación de pureza de proteínas multiméricasInfo
- Publication number
- AR104610A1 AR104610A1 ARP160101379A ARP160101379A AR104610A1 AR 104610 A1 AR104610 A1 AR 104610A1 AR P160101379 A ARP160101379 A AR P160101379A AR P160101379 A ARP160101379 A AR P160101379A AR 104610 A1 AR104610 A1 AR 104610A1
- Authority
- AR
- Argentina
- Prior art keywords
- ace
- mixture
- quantification
- homodimer
- bispecific
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44795—Isoelectric focusing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Optics & Photonics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160341P | 2015-05-12 | 2015-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104610A1 true AR104610A1 (es) | 2017-08-02 |
Family
ID=56072452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101379A AR104610A1 (es) | 2015-05-12 | 2016-05-12 | Determinación de pureza de proteínas multiméricas |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10520511B2 (https=) |
| EP (2) | EP3885368A1 (https=) |
| JP (3) | JP7240812B2 (https=) |
| AR (1) | AR104610A1 (https=) |
| AU (2) | AU2016261854B2 (https=) |
| CA (1) | CA2984010A1 (https=) |
| ES (1) | ES2881359T3 (https=) |
| MA (2) | MA56416A (https=) |
| PL (1) | PL3294775T3 (https=) |
| WO (1) | WO2016183222A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4434629A3 (en) | 2015-11-30 | 2024-12-25 | Intabio, Llc | Methods for sample characterization |
| CN109937034B (zh) | 2016-11-21 | 2022-09-16 | 济世-伊沃泰克生物制品有限公司 | 阿柏西普制剂及其用途 |
| DK3668985T3 (da) | 2017-08-17 | 2021-09-20 | Just Evotec Biologics Inc | Fremgangsmåde til rensning af glycosyleret protein fra værtscellegalectiner og andre urenheder |
| CA3081094A1 (en) | 2017-11-20 | 2019-05-23 | Alison J. GILLESPIE | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
| WO2019148198A1 (en) | 2018-01-29 | 2019-08-01 | Intabio, Inc. | Devices, methods and kits for sample characterization |
| EP3811397B1 (en) | 2018-05-31 | 2024-09-18 | Intabio, Llc | Methods for interfacing microfluidic systems with mass spectrometry |
| PL3837282T3 (pl) * | 2018-09-10 | 2026-02-16 | Genentech, Inc. | Układy i sposoby elektroforezy kapilarnej powinowactwa |
| US11573226B2 (en) | 2018-09-10 | 2023-02-07 | Genentech, Inc. | Systems and methods for affinity capillary electrophoresis |
| US11782023B2 (en) * | 2018-12-19 | 2023-10-10 | Regeneron Pharmaceuticals, Inc. | Ce-western applications for antibody development |
| CA3126712A1 (en) * | 2019-01-31 | 2020-08-06 | Regeneron Pharmaceuticals, Inc. | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
| US11285484B2 (en) | 2019-08-12 | 2022-03-29 | Intabio, Llc | Multichannel isoelectric focusing devices and high voltage power supplies |
| US12594557B2 (en) | 2019-08-12 | 2026-04-07 | Intabio, Llc | Isoelectric focusing devices and fixtures |
| EP4323761A1 (en) * | 2021-04-14 | 2024-02-21 | DH Technologies Development Pte. Ltd. | Native fluorescence detection for protein analysis in capillary electrophoresis |
| JP2024544607A (ja) * | 2021-11-25 | 2024-12-03 | エフ． ホフマン－ラ ロシュ アーゲー | 少量の抗体副産物の定量 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP385598A0 (en) * | 1998-06-02 | 1998-06-25 | Life Therapeutics Limited | Purification of antibodies |
| US6472179B2 (en) * | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| JP4723725B2 (ja) * | 1999-04-20 | 2011-07-13 | ターゲット ディスカバリー， インコーポレイテッド | 代謝経路を分析するための方法 |
| US6818112B2 (en) * | 1999-04-20 | 2004-11-16 | Target Discovery, Inc. | Protein separation via multidimensional electrophoresis |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| AUPQ743300A0 (en) * | 2000-05-11 | 2000-06-01 | Life Therapeutics Limited | Separation of avian antibodies |
| SG106672A1 (en) | 2002-03-08 | 2004-10-29 | Asml Netherlands Bv | Mask for use in lithography, method of making a mask, lithographic apparatus, and device manufacturing method |
| US20090134028A1 (en) * | 2005-09-22 | 2009-05-28 | Chemicals Evaluation And Research Institute | Method of Estimating Effect of Test Chemical on Living Organisms |
| EP1803814A1 (en) * | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Method of improving the antibody selection capacity in phage-display library |
| US9670269B2 (en) * | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| WO2008151219A1 (en) | 2007-06-04 | 2008-12-11 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| CN101874042B9 (zh) * | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| JP4977588B2 (ja) * | 2007-12-07 | 2012-07-18 | 富士フイルム株式会社 | イムノクロマトグラフ方法 |
| JP5816170B2 (ja) | 2009-06-26 | 2015-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体 |
| CA2836873C (en) * | 2011-05-21 | 2019-10-22 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
| GB2504139B (en) | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| EP2604624A1 (en) * | 2011-12-13 | 2013-06-19 | University College Dublin National University Of Ireland, Dublin | Bowman-Birk protease Inhibitor (BBI) binding peptides, and uses thereof in the separation, detection or purification of BBI. |
| PT2825559T (pt) * | 2012-03-13 | 2019-06-07 | Novimmune Sa | Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo |
| RU2014153674A (ru) | 2012-06-05 | 2016-07-27 | Регенерон Фармасьютикалз, Инк. | Способ получения полностью человеческих биспецифических антител с применением общей легкой цепи |
| TW202423993A (zh) * | 2012-11-14 | 2024-06-16 | 美商再生元醫藥公司 | 重組細胞表面捕捉蛋白質 |
| CA2919174A1 (en) * | 2013-08-19 | 2015-02-26 | F. Hoffmann-La Roche Ag | Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography |
| US11261262B2 (en) * | 2013-09-03 | 2022-03-01 | Novimmune Sa | Readily isolated bispecific binding molecules with native format having mutated constant regions |
-
2016
- 2016-05-11 AU AU2016261854A patent/AU2016261854B2/en active Active
- 2016-05-11 PL PL16724805T patent/PL3294775T3/pl unknown
- 2016-05-11 EP EP21171963.8A patent/EP3885368A1/en not_active Withdrawn
- 2016-05-11 JP JP2017558949A patent/JP7240812B2/ja active Active
- 2016-05-11 ES ES16724805T patent/ES2881359T3/es active Active
- 2016-05-11 EP EP16724805.3A patent/EP3294775B1/en active Active
- 2016-05-11 CA CA2984010A patent/CA2984010A1/en active Pending
- 2016-05-11 US US15/152,135 patent/US10520511B2/en active Active
- 2016-05-11 WO PCT/US2016/031899 patent/WO2016183222A1/en not_active Ceased
- 2016-05-11 MA MA056416A patent/MA56416A/fr unknown
- 2016-05-11 MA MA043987A patent/MA43987A/fr unknown
- 2016-05-12 AR ARP160101379A patent/AR104610A1/es unknown
-
2019
- 2019-11-18 US US16/686,770 patent/US12158473B2/en active Active
-
2021
- 2021-06-02 JP JP2021092988A patent/JP7137663B2/ja active Active
-
2022
- 2022-05-05 AU AU2022203033A patent/AU2022203033B2/en not_active Expired - Fee Related
- 2022-09-02 JP JP2022139802A patent/JP2022171730A/ja active Pending
-
2024
- 2024-04-16 US US18/637,343 patent/US20240280587A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022203033B2 (en) | 2025-06-26 |
| US20170045527A1 (en) | 2017-02-16 |
| JP2022171730A (ja) | 2022-11-11 |
| CA2984010A1 (en) | 2016-11-17 |
| ES2881359T3 (es) | 2021-11-29 |
| JP2018528389A (ja) | 2018-09-27 |
| PL3294775T3 (pl) | 2021-12-13 |
| JP7137663B2 (ja) | 2022-09-14 |
| WO2016183222A1 (en) | 2016-11-17 |
| EP3885368A1 (en) | 2021-09-29 |
| US20200166522A1 (en) | 2020-05-28 |
| MA43987A (fr) | 2018-12-19 |
| EP3294775B1 (en) | 2021-07-14 |
| AU2022203033A1 (en) | 2022-05-26 |
| AU2016261854B2 (en) | 2022-05-26 |
| AU2016261854A1 (en) | 2017-11-09 |
| HK1252480A1 (zh) | 2019-05-24 |
| JP2021152544A (ja) | 2021-09-30 |
| MA56416A (fr) | 2022-05-04 |
| US10520511B2 (en) | 2019-12-31 |
| US12158473B2 (en) | 2024-12-03 |
| US20240280587A1 (en) | 2024-08-22 |
| WO2016183222A4 (en) | 2017-01-05 |
| EP3294775A1 (en) | 2018-03-21 |
| JP7240812B2 (ja) | 2023-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |