AR100238A1 - Método para producir l-aminoácidos en corinebacterias mediante el uso de un sistema de escisión de glicina - Google Patents

Método para producir l-aminoácidos en corinebacterias mediante el uso de un sistema de escisión de glicina

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Publication number
AR100238A1
AR100238A1 ARP150101304A ARP150101304A AR100238A1 AR 100238 A1 AR100238 A1 AR 100238A1 AR P150101304 A ARP150101304 A AR P150101304A AR P150101304 A ARP150101304 A AR P150101304A AR 100238 A1 AR100238 A1 AR 100238A1
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Argentina
Prior art keywords
glycine
scision
corinebacteria
producing
amino acids
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ARP150101304A
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English (en)
Inventor
Ochrombel Ines
Bathe Brigitte
HASSELMEYER Marleen
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Evonik Degussa Gmbh
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Priority to EP14166649.5A priority Critical patent/EP2940039A1/de
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of AR100238A1 publication Critical patent/AR100238A1/es
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    • C07K14/34Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
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Abstract

Cepa de Corynebacterium humireducens que comprende un sistema de escisión de glicina. Reivindicación 1: Un sistema de escisión de glicina que comprende las enzimas GcvP, GcvT y GcvH, caracterizado porque comprende al menos uno de los siguientes polipéptidos: (a) una enzima GcvP que presenta una identidad de secuencia de al menos 80% con la secuencia de acuerdo con SEQ ID Nº 40, (b) una enzima GcvT que presenta una identidad de secuencia de al menos 80% con la secuencia de acuerdo con SEQ ID Nº 42, (c) una enzima GcvH que presenta una identidad de secuencia de al menos 80% con la secuencia de acuerdo con SEQ ID Nº 38.
ARP150101304A 2014-04-30 2015-04-29 Método para producir l-aminoácidos en corinebacterias mediante el uso de un sistema de escisión de glicina AR100238A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14166649.5A EP2940039A1 (de) 2014-04-30 2014-04-30 Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems

Publications (1)

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AR100238A1 true AR100238A1 (es) 2016-09-21

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ARP150101304A AR100238A1 (es) 2014-04-30 2015-04-29 Método para producir l-aminoácidos en corinebacterias mediante el uso de un sistema de escisión de glicina

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Country Link
US (1) US20170051324A1 (es)
EP (2) EP2940039A1 (es)
JP (1) JP2017518034A (es)
KR (1) KR102260001B1 (es)
CN (1) CN106536724A (es)
AR (1) AR100238A1 (es)
BR (1) BR112016025069A2 (es)
ES (1) ES2705405T3 (es)
MX (1) MX367340B (es)
MY (1) MY181461A (es)
PL (1) PL3137492T3 (es)
RU (1) RU2713298C2 (es)
SG (1) SG11201608281RA (es)
WO (1) WO2015165740A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017011976A (es) 2015-03-18 2018-02-09 Basf Se Microorganismo recombinante para la produccion mejorada de quimicos finos.
KR20180086240A (ko) 2015-11-27 2018-07-30 에보닉 데구사 게엠베하 L-메티오닌을 제조하는 방법
CN107227283B (zh) * 2017-05-26 2021-01-15 廊坊梅花生物技术开发有限公司 一种谷氨酸棒杆菌及其构建方法与应用
EP3456833A1 (en) * 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
CN109797126B (zh) * 2017-11-17 2021-07-06 中国科学院微生物研究所 生产l-丝氨酸的重组菌及其构建方法
KR101999454B1 (ko) * 2017-12-19 2019-07-11 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌 생산방법
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
KR102175112B1 (ko) * 2019-04-22 2020-11-06 씨제이제일제당 주식회사 L-쓰레오닌 생산능이 강화된 미생물 및 이를 이용한 쓰레오닌 생산방법
KR102204917B1 (ko) * 2019-04-22 2021-01-20 씨제이제일제당 주식회사 L-히스티딘 생산능이 강화된 미생물 및 이를 이용한 히스티딘 생산방법
WO2021231874A1 (en) * 2020-05-15 2021-11-18 Psimos, Inc Composition for growth stimulation and resistance to stress factors for plants of the cannabaceae family
CN112063572A (zh) * 2020-09-22 2020-12-11 浙江工业大学 一种高产o-乙酰-l-高丝氨酸的重组大肠杆菌及其应用
KR102281367B1 (ko) * 2021-01-26 2021-07-22 씨제이제일제당 (주) 신규한 5,10-메틸렌테트라하이드로폴레이트 리덕타제 변이체 및 이를 이용한 l-발린 생산 방법
KR102281371B1 (ko) * 2021-04-07 2021-07-22 씨제이제일제당 (주) 신규한 글리세르알데히드-3-인산탈수소효소 변이체 및 이를 이용한 l-발린 생산 방법

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342308A (en) 1970-01-22 1974-01-03 Kyowa Hakko Kogyo Kk Production of threonine and lysine by fermentation
US5250434A (en) 1987-03-27 1993-10-05 Ajinomoto Co., Inc. Microorganisms for production of glutamic acid
DE3908201A1 (de) 1989-03-14 1990-09-27 Degussa Verfahren zur fermentativen herstellung von l-lysin
JP3023615B2 (ja) 1990-08-30 2000-03-21 協和醗酵工業株式会社 発酵法によるl―トリプトファンの製造法
DE4130867A1 (de) 1991-09-17 1993-03-18 Degussa Verfahren zur fermentativen herstellung von aminosaeuren
JPH05184366A (ja) 1992-01-14 1993-07-27 Mitsubishi Petrochem Co Ltd アスパルトキナーゼをコードする遺伝子dna及びその利用
JP3473042B2 (ja) 1992-04-28 2003-12-02 味の素株式会社 変異型アスパルトキナーゼ遺伝子
JPH06261766A (ja) 1993-03-16 1994-09-20 Mitsubishi Petrochem Co Ltd フィードバックインヒビションの解除されたアスパルトキナーゼをコードする遺伝子dna及びその利用
JPH0970291A (ja) 1995-06-30 1997-03-18 Ajinomoto Co Inc 人工トランスポゾンを用いた遺伝子増幅方法
DE19547361A1 (de) 1995-12-19 1997-06-26 Degussa Verfahren zur Herstellung von L-Aminosäuren durch Fermentation
JP4035855B2 (ja) 1996-06-05 2008-01-23 味の素株式会社 L−リジンの製造法
JP4168463B2 (ja) 1996-12-05 2008-10-22 味の素株式会社 L−リジンの製造法
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 L−リジンの製造法
US5990350A (en) 1997-12-16 1999-11-23 Archer Midland Company Process for making granular L-lysine
KR100671785B1 (ko) 1999-04-19 2007-01-19 교와 핫꼬 고교 가부시끼가이샤 신규한 탈감작형 아스파르토키나아제
JPWO2002097086A1 (ja) * 2001-05-29 2005-04-07 協和醗酵工業株式会社 工業的生産に有用な微生物
KR100943834B1 (ko) 2001-08-06 2010-02-24 에보니크 데구사 게엠베하 L-리신을 생산하는 코리네형 세균 및 코리네형 세균을 사용하여 l-리신을 생산하는 방법
WO2003040373A2 (en) 2001-08-06 2003-05-15 Degussa Ag Production of l-lysine by genetically modified corynebacterium glutamicum strains
WO2005021772A1 (en) 2003-08-29 2005-03-10 Degussa Ag Process for the preparation of l-lysine
CN101578361A (zh) * 2005-06-17 2009-11-11 米克罗比亚精密工程股份有限公司 改进的氨基酸和代谢物生物合成
RU2009134796A (ru) * 2007-02-19 2011-03-27 Эвоник Дегусса ГмБх (DE) Коринеформные бактерии, обладающие формиат-тгф-синтетазной активностью и/или активностью в отношении расщепления глицина
WO2009043372A1 (en) * 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield

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MY181461A (en) 2020-12-22
US20170051324A1 (en) 2017-02-23
JP2017518034A (ja) 2017-07-06
KR20160148006A (ko) 2016-12-23
WO2015165740A2 (de) 2015-11-05
PL3137492T3 (pl) 2019-05-31
WO2015165740A3 (de) 2016-02-25
CN106536724A (zh) 2017-03-22
EP3137492A2 (de) 2017-03-08
KR102260001B1 (ko) 2021-06-02
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BR112016025069A2 (pt) 2017-10-17
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