AR093046A2 - A HUMANIZED ANTIBODY THAT JOINS THE HUMAN CD20, OR A FRAGMENT OF THE SAME, A COMPOSITION, A MANUFACTURING ARTICLE, USE OF SUCH ANTIBODIES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT CANCER, SELF-IMMUNE DISEASES, AND EXTRACT A VECTOR GUEST CELL - Google Patents

A HUMANIZED ANTIBODY THAT JOINS THE HUMAN CD20, OR A FRAGMENT OF THE SAME, A COMPOSITION, A MANUFACTURING ARTICLE, USE OF SUCH ANTIBODIES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT CANCER, SELF-IMMUNE DISEASES, AND EXTRACT A VECTOR GUEST CELL

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Publication number
AR093046A2
AR093046A2 ARP130103770A ARP130103770A AR093046A2 AR 093046 A2 AR093046 A2 AR 093046A2 AR P130103770 A ARP130103770 A AR P130103770A AR P130103770 A ARP130103770 A AR P130103770A AR 093046 A2 AR093046 A2 AR 093046A2
Authority
AR
Argentina
Prior art keywords
human
antibody
manufacture
antibodies
composition
Prior art date
Application number
ARP130103770A
Other languages
Spanish (es)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32685285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR093046(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR093046A2 publication Critical patent/AR093046A2/en

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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

Un anticuerpo humanizado que se une al CD20 humano, o un fragmento ligante a antígenos del mismo, en donde el anticuerpo es efectivo para reducir las células B de primates in vivo, comprendiendo el anticuerpo en la región Variable de la cadena H (VH) al menos una secuencia CDR3 de la SEC. ID. Nº 12 de un anticuerpo CD20 anti-humano y esencialmente los residuos del marco (FR) de consenso humano de la cadena pesada humana subgrupo III (VHIII), una composición, un artículo de fabricación, un método para inducir apoptosis en células B in vivo, uso de dichos anticuerpos para la fabricación de un medicamento para tratar cáncer, enfermedades autoinmunes y artritis reumatoidea un ácido nucleico aislado que codifica dicho anticuerpo, un vector de expresión, una célula huésped, un método para producir un anticuerpo CD20, un polipéptido aislado y una formulación líquida.A humanized antibody that binds to human CD20, or an antigen-binding fragment thereof, wherein the antibody is effective in reducing primate B cells in vivo, the antibody comprising the Variable region of the H (VH) chain to the minus a CDR3 sequence of the SEC. ID. No. 12 of an anti-human CD20 antibody and essentially human consensus framework (FR) residues of the human heavy chain subgroup III (VHIII), a composition, an article of manufacture, a method for inducing apoptosis in B cells in vivo , use of said antibodies for the manufacture of a medicament for treating cancer, autoimmune diseases and rheumatoid arthritis an isolated nucleic acid encoding said antibody, an expression vector, a host cell, a method for producing a CD20 antibody, an isolated polypeptide and a liquid formulation

ARP130103770A 2002-12-16 2013-10-17 A HUMANIZED ANTIBODY THAT JOINS THE HUMAN CD20, OR A FRAGMENT OF THE SAME, A COMPOSITION, A MANUFACTURING ARTICLE, USE OF SUCH ANTIBODIES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT CANCER, SELF-IMMUNE DISEASES, AND EXTRACT A VECTOR GUEST CELL AR093046A2 (en)

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ARP130103770A AR093046A2 (en) 2002-12-16 2013-10-17 A HUMANIZED ANTIBODY THAT JOINS THE HUMAN CD20, OR A FRAGMENT OF THE SAME, A COMPOSITION, A MANUFACTURING ARTICLE, USE OF SUCH ANTIBODIES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT CANCER, SELF-IMMUNE DISEASES, AND EXTRACT A VECTOR GUEST CELL

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