AR085499A1 - A YEAST CELL FOR THE PRODUCTION OF TERPENOS AND ITS USES - Google Patents

A YEAST CELL FOR THE PRODUCTION OF TERPENOS AND ITS USES

Info

Publication number
AR085499A1
AR085499A1 ARP120100637A ARP120100637A AR085499A1 AR 085499 A1 AR085499 A1 AR 085499A1 AR P120100637 A ARP120100637 A AR P120100637A AR P120100637 A ARP120100637 A AR P120100637A AR 085499 A1 AR085499 A1 AR 085499A1
Authority
AR
Argentina
Prior art keywords
cell
production
terpene
application
yeast cell
Prior art date
Application number
ARP120100637A
Other languages
English (en)
Original Assignee
Organobalance Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP11001629 priority Critical
Application filed by Organobalance Gmbh filed Critical Organobalance Gmbh
Publication of AR085499A1 publication Critical patent/AR085499A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02Preparation of hydrocarbons or halogenated hydrocarbons acyclic

Abstract

La presente solicitud se refiere a una célula de levadura, donde dicha célula comprende un gen funcional que codifica para hidroximetilglutaril-coenzima-A (HMG-CoA) reductasa soluble; uno o más gen(es) que codifican para esteril aciltransferasa(s) en dicha célula son defectuosos o delecionados; y dicha célula es prototrófica para por lo menos histidina, leucina o uracilo. Asimismo, la presente solicitud se refiere al uso de dicha célula para la producción de uno o más terpeno(s). Por añadidura, la presente solicitud se refiere a métodos para generar dicha célula y la producción de uno o más terpeno(s) y una composición farmacéutica o cosmética, un lubricante o aceite para transformadores que comprende dicho(s) terpeno(s).The present application relates to a yeast cell, wherein said cell comprises a functional gene encoding soluble hydroxymethylglutaryl-coenzyme-A (HMG-CoA) reductase; one or more gene (s) encoding sterile acyltransferase (s) in said cell are defective or deleted; and said cell is prototrophic for at least histidine, leucine or uracil. Also, the present application refers to the use of said cell for the production of one or more terpene (s). In addition, the present application relates to methods for generating said cell and the production of one or more terpene (s) and a pharmaceutical or cosmetic composition, a lubricant or oil for transformers comprising said terpene (s).
ARP120100637A 2011-02-28 2012-02-28 A YEAST CELL FOR THE PRODUCTION OF TERPENOS AND ITS USES AR085499A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11001629 2011-02-28

Publications (1)

Publication Number Publication Date
AR085499A1 true AR085499A1 (es) 2013-10-09

Family

ID=44262900

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120100637A AR085499A1 (es) 2011-02-28 2012-02-28 A YEAST CELL FOR THE PRODUCTION OF TERPENOS AND ITS USES

Country Status (9)

Country Link
US (1) US9051587B2 (es)
EP (1) EP2681313B1 (es)
JP (1) JP2014510524A (es)
KR (1) KR101944841B1 (es)
CN (1) CN103492558B (es)
AR (1) AR085499A1 (es)
ES (1) ES2582637T3 (es)
PL (1) PL2681313T3 (es)
WO (1) WO2012116783A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2770512B1 (en) 2013-02-21 2015-09-16 ABB Technology Ltd Renewable hydrocarbon based insulating fluid
CN103571763B (zh) * 2013-11-20 2015-08-19 江南大学 一株能自身合成萜类物质的酿酒酵母及其应用
WO2015121168A1 (de) * 2014-02-12 2015-08-20 Organobalance Gmbh Hefe-stamm und mikrobielles verfahren zur produktion von pentazyklischen triterpenen und/oder triterpenoiden
US20150240264A1 (en) * 2014-02-21 2015-08-27 Braskem S.A. Methods for co-production of a terpene, succinate and hydrogen
CN103849643A (zh) * 2014-03-11 2014-06-11 北京理工大学 一种利用蛋白支架提高酿酒酵母中鲨烯的合成方法
CN111699247A (zh) 2017-12-07 2020-09-22 齐默尔根公司 通过发酵产生(6e)-8-羟基香叶醇的经改造的生物合成途径
CN111868047A (zh) 2017-12-21 2020-10-30 齐默尔根公司 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物
KR101971976B1 (ko) 2018-02-12 2019-04-25 대한민국 겨울 우산 버섯 유래 테르펜 합성효소 유전자 및 상기 유전자가 삽입된 효모의 형질전환체
KR102022242B1 (ko) 2018-02-12 2019-09-18 대한민국 겨울 우산 버섯 유래 테르펜 합성효소 유전자 및 상기 유전자가 삽입된 돌연변이 효모의 형질전환체
CN110951631B (zh) * 2019-12-31 2021-03-02 江南大学 一株产香叶醇的葡萄汁有孢汉逊酵母及其发酵方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
EP0751222B1 (en) * 1995-06-29 2006-03-01 Takara Bio Inc. Gene encoding endoglycoceramidase
DE19744212B4 (de) * 1997-09-30 2006-01-19 Schering Ag Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen
EP1354955A4 (en) * 2000-12-28 2005-01-05 Toyota Motor Co Ltd PROCESS FOR PREPARING PRENYL ALCOHOL
ZA200700753B (en) * 2004-07-27 2008-05-28 Univ California Genetically modified host cells use of same for producing isoprenoid compounds
JP2008537878A (ja) * 2005-03-18 2008-10-02 マイクロビア, インコーポレイテッド 含油性酵母および真菌におけるカロテノイドの産生

Also Published As

Publication number Publication date
US20140057328A1 (en) 2014-02-27
KR20140033002A (ko) 2014-03-17
WO2012116783A2 (en) 2012-09-07
CN103492558B (zh) 2015-08-05
CN103492558A (zh) 2014-01-01
PL2681313T3 (pl) 2016-11-30
WO2012116783A3 (en) 2012-10-26
EP2681313A2 (en) 2014-01-08
JP2014510524A (ja) 2014-05-01
US9051587B2 (en) 2015-06-09
EP2681313B1 (en) 2016-04-20
ES2582637T3 (es) 2016-09-14
KR101944841B1 (ko) 2019-02-01

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