AR085090A1 - Formulacion transdermica de testosterona, metodo de tratamiento - Google Patents

Formulacion transdermica de testosterona, metodo de tratamiento

Info

Publication number
AR085090A1
AR085090A1 ARP120100241A ARP120100241A AR085090A1 AR 085090 A1 AR085090 A1 AR 085090A1 AR P120100241 A ARP120100241 A AR P120100241A AR P120100241 A ARP120100241 A AR P120100241A AR 085090 A1 AR085090 A1 AR 085090A1
Authority
AR
Argentina
Prior art keywords
weight
formulation
long chain
chain fatty
testosterone
Prior art date
Application number
ARP120100241A
Other languages
English (en)
Inventor
Arnaud Grenier
Dario N Carrara
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44146428&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR085090(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of AR085090A1 publication Critical patent/AR085090A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Reivindicación 1: Una formulación transdérmica o a través de mucosa que comprende: 2% de peso de testosterona, Alcanol C2-4, polialcohol, y éter monoalquilo de dietilenglicol, en donde la mencionada formulación está sustancialmente libre de alcoholes grasos de cadena larga, ácidos grasos de cadena larga y ésteres grasos de cadena larga.Reivindicación 20: Una formulación transdérmica o a través de mucosa que comprende: 2% peso de testosterona, 44.0% peso de etanol, 20.0% peso de propilenglicol, 5.0% peso de éter monoetilo de dietilenglicol, 1.20% peso de carbómero, 0.35% peso de trietanolamina, 0.06% peso de disodio edetato y agua en donde la mencionada formulación está sustancialmente libre de alcoholes grasos de cadena larga, ácidos grasos de cadena larga y ésteres grasos de cadena larga. Reivindicación 22: Una formulación de cualquiera de las reivindicaciones 1 a 21, en donde la mencionada formulación está en la forma de un gel, loción, crema, atomizador, aerosol, ungüento, emulsión, suspensión, sistema de liposomas, laca, parche, venda, tableta bucal, tableta sublingual, supositorio, forma de dosis vaginal o vendaje oclusivo.
ARP120100241A 2011-01-26 2012-01-25 Formulacion transdermica de testosterona, metodo de tratamiento AR085090A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11152210 2011-01-26

Publications (1)

Publication Number Publication Date
AR085090A1 true AR085090A1 (es) 2013-09-11

Family

ID=44146428

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120100241A AR085090A1 (es) 2011-01-26 2012-01-25 Formulacion transdermica de testosterona, metodo de tratamiento

Country Status (28)

Country Link
US (2) US8895053B2 (es)
EP (2) EP2667851B1 (es)
JP (2) JP6012632B2 (es)
KR (1) KR101877476B1 (es)
CN (1) CN103327962B (es)
AR (1) AR085090A1 (es)
AU (1) AU2012210691B2 (es)
BR (1) BR112013018951B1 (es)
CA (1) CA2824941A1 (es)
DK (2) DK3072505T3 (es)
ES (2) ES2741744T3 (es)
HK (1) HK1192719A1 (es)
HR (2) HRP20160887T1 (es)
HU (3) HUE044327T2 (es)
IL (1) IL227454A (es)
JO (1) JO3755B1 (es)
LT (2) LT3072505T (es)
MX (1) MX340259B (es)
PL (2) PL2667851T3 (es)
PT (2) PT3072505T (es)
RS (2) RS54898B1 (es)
RU (1) RU2613891C2 (es)
SA (1) SA112330224B1 (es)
SI (2) SI3072505T1 (es)
TR (1) TR201909271T4 (es)
TW (1) TWI564029B (es)
WO (1) WO2012101016A1 (es)
ZA (1) ZA201305665B (es)

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US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
ES2617336T3 (es) 2010-10-27 2017-06-16 Ferring B.V. Procedimiento para la fabricación de degarelix y sus productos intermedios
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
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JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
CA2874927A1 (en) 2012-06-01 2013-12-05 Gregoire Schwach Manufacture of degarelix
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JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
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Also Published As

Publication number Publication date
TW201309341A (zh) 2013-03-01
EP2667851B1 (en) 2016-05-18
AU2012210691A1 (en) 2013-08-01
EP3072505A1 (en) 2016-09-28
PL3072505T3 (pl) 2019-12-31
HUE044327T2 (hu) 2019-10-28
PL2667851T3 (pl) 2017-01-31
BR112013018951A2 (pt) 2017-04-04
HRP20160887T1 (hr) 2016-09-23
CN103327962B (zh) 2016-04-27
HUE027453T4 (hu) 2018-12-28
PT2667851T (pt) 2016-07-26
IL227454A (en) 2017-02-28
NZ613029A (en) 2014-03-28
BR112013018951B1 (pt) 2020-03-10
SA112330224B1 (ar) 2015-02-22
MX340259B (es) 2016-07-04
HRP20191216T1 (hr) 2019-10-18
KR20140041431A (ko) 2014-04-04
JO3755B1 (ar) 2021-01-31
DK3072505T3 (da) 2019-08-12
KR101877476B1 (ko) 2018-07-11
LT3072505T (lt) 2019-08-26
US20130295166A1 (en) 2013-11-07
CN103327962A (zh) 2013-09-25
JP2017019819A (ja) 2017-01-26
TWI564029B (zh) 2017-01-01
RU2613891C2 (ru) 2017-03-21
US8895053B2 (en) 2014-11-25
JP6012632B2 (ja) 2016-10-25
AU2012210691B2 (en) 2016-05-12
JP2014503565A (ja) 2014-02-13
RU2013133082A (ru) 2015-03-10
RS54898B1 (sr) 2016-10-31
ZA201305665B (en) 2014-03-26
LTPA2018516I1 (lt) 2018-11-12
TR201909271T4 (tr) 2019-07-22
DK2667851T3 (en) 2016-07-25
EP2667851A1 (en) 2013-12-04
HUS1800036I1 (hu) 2018-09-28
IL227454A0 (en) 2013-09-30
MX2013008463A (es) 2013-10-03
HK1192719A1 (zh) 2014-08-29
US20150110856A1 (en) 2015-04-23
CA2824941A1 (en) 2012-08-02
SI2667851T1 (sl) 2016-07-29
EP3072505B1 (en) 2019-06-12
RS59012B1 (sr) 2019-08-30
HUE027453T2 (en) 2016-09-28
ES2741744T3 (es) 2020-02-12
WO2012101016A1 (en) 2012-08-02
SI3072505T1 (sl) 2019-08-30
PT3072505T (pt) 2019-07-04
ES2586122T3 (es) 2016-10-11

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